Protein Alignment Mhcl and myhz1.2

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: XP_005171981.1
• Gene: myhz1.2 / 799300
• ZFINID: ZDB-GENE-070705-73
• Length: 1937
• Species: Danio rerio
• Alignment Length: 2009
• Identity: 475/2009 - (23%)
• Similarity: 820/2009 - (40%)
• Gaps: 508/2009 - (25%)

  Fly   533 KLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPT 597
            |:::..|...|:....||||...|.|..|.:||:..:.:|||.|||:.|::|||:.:|:|.:|..
Zfish    59 KVTVITLDTKEERVAKEDDVHPMNPPKFDKIEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLF 123

  Fly   598 LLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKST 662
            ...|||...|.:|..:||:.:||.|..:.|||::|::..||:.::..|.:||::..|.||:||:.
Zfish   124 CATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTV 188

  Fly   663 SFKHALNYLAL------------AAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLL 715
            :.|..:.|.|.            |||.....:. :::.|...:|||:||.||..|.|::|..:.:
Zfish   189 NTKRVIQYFATVAVQGPEKKKEQAAGKMQGSLE-DQIIAANPLLEAYGNAKTVRNDNSSRFGKFI 252

  Fly   716 SLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHP 780
            .:.|..:|::|||.::..|.|:.|...:|..|..:||..:::...    :.||....:.:.:.:.
Zfish   253 RIHFGTSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNH----KPELIEMTLITTNPYD 313

  Fly   781 FISLSQ------KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTG 839
            |...||      .::|:    .:.:.|..|.:.|..:.:...||:....|:.|.|     .:...
Zfish   314 FPMCSQGQITVASIDDK----EELVATDTAIDILGFNNEEKMGIYKFTGAVLHHG-----NMKFK 369

  Fly   840 STARTQFANPTA---ARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWEC 901
            ...|.:.|.|..   |.|...|||:|..|:..|   |..|....|....:|..|...    .:..
Zfish   370 QKQREEQAEPDGTEEADKIGYLLGLNSADMLKA---LCYPRVKVGNEFVTKGQTVPQ----VYNS 427

  Fly   902 LEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRH 962
            :.||...:|......:|..||:.:.|.......|.::|..||:    |          ::..|..
Zfish   428 VSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFN----------SMEQLCI 482

  Fly   963 NYLQERLQMLFHHTTLVAPRDRYAQ-----ELVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQ 1022
            |:..|:||..|:|...|..::.|.:     |.::..||||: |     |.||:|.
Zfish   483 NFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAA-C-----IELIEKP---------- 531

  Fly  1023 RDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLRKCAG---PR--------Q 1076
                    .|:..:|:||.::|.:.|.:|..:|:..:        |.||..   |:        .
Zfish   532 --------LGIFSILEEECMFPKATDTSFKNKLYDQH--------LGKCNAFQKPKPAKGKAEAH 580

  Fly  1077 FVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSF 1141
            |.|.|..||  |.|.:.||:..::: |...:.|.|.|.||.:.:..||...:....|     |..
Zfish   581 FSLVHYAGT--VDYNISGWLDKNKD-PLNESVVQLYQKSSVKLLATLYPPVVEETGG-----GKK 637

  Fly  1142 AGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHT 1206
            .|.:...|::.|||                 |.:..:..::..||.|..|||.|.:
Zfish   638 GGKKKGGSMQTVSS-----------------QFRENLGKLMTNLRSTHPHFVRCLI--------- 676

  Fly  1207 KYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL-- 1269
                   |:.     |....::...|:..|||.:.|||..|:.|.|||..:...:|.:|:.:|
Zfish   677 -------PNE-----SKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNA 729

  Fly  1270 ----AGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAF 1330
                .|....||..| |::|...:::...||.|.:::.|::|:|..||..||..|:..:...||.
Zfish   730 SVIPEGQFIDNKKAS-EKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEMRDEKLASLVTMTQAL 793

  Fly  1331 CRGYLARK---KMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTAN 1392
            ||.||.|:   ||::||.   |:..||.||::|:.|:.|||.::..::.|||....||::|.|..
Zfish   794 CRAYLMRREFVKMTERRD---AIYTIQYNVRSFMNVKHWPWMKVYYKIKPLLKSAETEKELATMK 855

  Fly  1393 EELLMLRAKLEKIECDRSEVKAENQKLEAKLSELTVDL-------------AEERSTAHI----- 1439
            |:.:..:..|.|.|..:.|::   :|:.|.|.|.. ||             ||||....|
Zfish   856 EDFVKCKEDLAKAEAKKKELE---EKMVALLQEKN-DLQLAVASESENLSDAEERCEGLIKSKIQ 916

  Fly  1440 -------ATERLEAE-------TAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGIS 1490
                   .|||||.|       ||::.|||.|..:....:.:|:.|..|:|.|....::.:..::
Zfish   917 LEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 981

  Fly  1491 EDEDAENEDGVGGGVYKLKYERVARE-------------------LEFTKRRLHTQ---HEHDLE 1533
            |:..|::|     .:.||..|:.|.:                   |..:|.:|..|   .|..||
Zfish   982 EEMAAQDE-----SIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLE 1041

  Fly  1534 Q-------LVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLL 1591
            |       |...|:.||..|..|.|.:::......|.:.|.:|...|.:.|...:|::.:....|
Zfish  1042 QEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQL 1106

  Fly  1592 EKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLAD----TRLDLEF---KEE 1649
            :||.::..|..:.|::.:..||.|:.:..:::..|..|...:.:.|.:    |...:|.   :|.
Zfish  1107 QKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREA 1171

  Fly  1650 KLASLQRELEEMTFG----------------GGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQ 1698
            :...|:|:|||.|..                ....|:...|:|.|.:.|:...|.:.|:|:::..
Zfish  1172 EFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSN 1236

  Fly  1699 IQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRG-----------NG-------------- 1738
            ::.:.:||..||....|:..:......:.||.|.::..           ||
Zfish  1237 MEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQLNDLSAQRARLQTENGEFGRQLEEKEALVS 1301

  Fly  1739 ---------YKKIKALECQLETEHEERTL-------------LLRE--------KHELERRLSSM 1773
                     .::|:.|:.|:|.|.:.:..             ||||        |.||:|.:|..
Zfish  1302 QLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKA 1366

  Fly  1774 E----------DRDRVDRDAE-------------------EALNQK---LRRDLRKYKALLKDAQ 1806
            .          :.|.:.|..|                   ||:|.|   |.:..::.:..::|..
Zfish  1367 NSEVAQWRTKYETDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLM 1431

  Fly  1807 TQLERLKADTPGKTLIRQLRN-----------------QLEDAE-SARSLA-------------- 1839
            ..:||  |:.....|.::.||                 :||.|: .||||:
Zfish  1432 IDVER--ANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETL 1494

  Fly  1840 ------MKARQTAEAELTEVQAMFDESHRARNDAEERANAAHRDRAELQAQIEENE--------- 1889
                  .:..:..:.|::::.....|:.::.::.|:...|...::||:|..:||.|
Zfish  1495 DQLETLKRENKNLQQEISDLTEQIGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESK 1559

  Fly  1890 ------------EELGELMKKYSATVKQL--NTEQINVS--------------------EAEFKL 1920
                        .|:...:.:....::|:  |:::|..|                    :.|..|
Zfish  1560 ILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDL 1624

  Fly  1921 NEMEAERNNLKEQVAELQHRLDNVE--------NLGD---------PSMAMMSKRLELRTKELES 1968
            ||||.:.::...|.||.|.:|.||:        :|.|         ..:||:.:|..|...|:|.
Zfish  1625 NEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEE 1689

  Fly  1969 -RLELEQATRARLEVQ--------------------VNRHKEA---LEKLQNEVTQSKMREMQAQ 2009
             |..|||..|.|...:                    :|..|:.   |.::|:||..:......|:
Zfish  1690 LRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAE 1754

  Fly  2010 DVIKKSQKSLRDMREEFHAVSSREQES---LTR-RKDLEKKVEQM-----ESEGAAL---KNDLR 2062
            |..||:......|.||.    .:||::   |.| :|:||..|:.:     |:|..|:   |..|:
Zfish  1755 DKAKKAITDAAMMAEEL----KKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQLQ 1815

  Fly  2063 LALQRIADLQQAMEEEGE----------------EELS-ESDESLSSVGSISDLEDRLRPVHVKR 2110
            ....|:.:|:..:|.|..                :||: :::|...:|..:.||.|:|: :.||.
Zfish  1816 KLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQ-LKVKA 1879

  Fly  2111 SSQQSLNGSIGGGGGSVVSSTRTVVFEKDDNSPRITVTSPSSPHIHKLALAAKAIPANK 2169
            ..:||....  ....|.:|..|.|..|.::...|..:   :...::|  |.||:..:.|
Zfish  1880 YKRQSEEAE--EQANSHLSKLRKVQHELEEAEERADI---AESQVNK--LRAKSRDSGK 1931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	430/1820 (24%)
		MYSc_Myo18	575..1305	CDD:276837	194/776 (25%)
myhz1.2	XP_005171981.1	Myosin_N	33..78	CDD:460670	5/18 (28%)
		MYSc_class_II	101..768	CDD:276951	194/776 (25%)
		Myosin_tail_1	848..1925	CDD:460256	230/1099 (21%)