DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and myhz1.2

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:XP_005171981.1 Gene:myhz1.2 / 799300 ZFINID:ZDB-GENE-070705-73 Length:1937 Species:Danio rerio


Alignment Length:2009 Identity:475/2009 - (23%)
Similarity:820/2009 - (40%) Gaps:508/2009 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   533 KLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPT 597
            |:::..|...|:....||||...|.|..|.:||:..:.:|||.|||:.|::|||:.:|:|.:|..
Zfish    59 KVTVITLDTKEERVAKEDDVHPMNPPKFDKIEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLF 123

  Fly   598 LLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKST 662
            ...|||...|.:|..:||:.:||.|..:.|||::|::..||:.::..|.:||::..|.||:||:.
Zfish   124 CATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTV 188

  Fly   663 SFKHALNYLAL------------AAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLL 715
            :.|..:.|.|.            |||.....:. :::.|...:|||:||.||..|.|::|..:.:
Zfish   189 NTKRVIQYFATVAVQGPEKKKEQAAGKMQGSLE-DQIIAANPLLEAYGNAKTVRNDNSSRFGKFI 252

  Fly   716 SLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHP 780
            .:.|..:|::|||.::..|.|:.|...:|..|..:||..:::...    :.||....:.:.:.:.
Zfish   253 RIHFGTSGKLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNH----KPELIEMTLITTNPYD 313

  Fly   781 FISLSQ------KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTG 839
            |...||      .::|:    .:.:.|..|.:.|..:.:...||:....|:.|.|     .:...
Zfish   314 FPMCSQGQITVASIDDK----EELVATDTAIDILGFNNEEKMGIYKFTGAVLHHG-----NMKFK 369

  Fly   840 STARTQFANPTA---ARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWEC 901
            ...|.:.|.|..   |.|...|||:|..|:..|   |..|....|....:|..|...    .:..
Zfish   370 QKQREEQAEPDGTEEADKIGYLLGLNSADMLKA---LCYPRVKVGNEFVTKGQTVPQ----VYNS 427

  Fly   902 LEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRH 962
            :.||...:|......:|..||:.:.|.......|.::|..||:    |          ::..|..
Zfish   428 VSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFN----------SMEQLCI 482

  Fly   963 NYLQERLQMLFHHTTLVAPRDRYAQ-----ELVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQ 1022
            |:..|:||..|:|...|..::.|.:     |.::..||||: |     |.||:|.          
Zfish   483 NFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAA-C-----IELIEKP---------- 531

  Fly  1023 RDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLRKCAG---PR--------Q 1076
                    .|:..:|:||.::|.:.|.:|..:|:..:        |.||..   |:        .
Zfish   532 --------LGIFSILEEECMFPKATDTSFKNKLYDQH--------LGKCNAFQKPKPAKGKAEAH 580

  Fly  1077 FVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSF 1141
            |.|.|..||  |.|.:.||:..::: |...:.|.|.|.||.:.:..||...:....|     |..
Zfish   581 FSLVHYAGT--VDYNISGWLDKNKD-PLNESVVQLYQKSSVKLLATLYPPVVEETGG-----GKK 637

  Fly  1142 AGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHT 1206
            .|.:...|::.|||                 |.:..:..::..||.|..|||.|.:         
Zfish   638 GGKKKGGSMQTVSS-----------------QFRENLGKLMTNLRSTHPHFVRCLI--------- 676

  Fly  1207 KYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL-- 1269
                   |:.     |....::...|:..|||.:.|||..|:.|.|||..:...:|.:|:.:|  
Zfish   677 -------PNE-----SKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNA 729

  Fly  1270 ----AGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAF 1330
                .|....||..| |::|...:::...||.|.:::.|::|:|..||..||..|:..:...||.
Zfish   730 SVIPEGQFIDNKKAS-EKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEMRDEKLASLVTMTQAL 793

  Fly  1331 CRGYLARK---KMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTAN 1392
            ||.||.|:   ||::||.   |:..||.||::|:.|:.|||.::..::.|||....||::|.|..
Zfish   794 CRAYLMRREFVKMTERRD---AIYTIQYNVRSFMNVKHWPWMKVYYKIKPLLKSAETEKELATMK 855

  Fly  1393 EELLMLRAKLEKIECDRSEVKAENQKLEAKLSELTVDL-------------AEERSTAHI----- 1439
            |:.:..:..|.|.|..:.|::   :|:.|.|.|.. ||             ||||....|     
Zfish   856 EDFVKCKEDLAKAEAKKKELE---EKMVALLQEKN-DLQLAVASESENLSDAEERCEGLIKSKIQ 916

  Fly  1440 -------ATERLEAE-------TAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGIS 1490
                   .|||||.|       ||::.|||.|..:....:.:|:.|..|:|.|....::.:..::
Zfish   917 LEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 981

  Fly  1491 EDEDAENEDGVGGGVYKLKYERVARE-------------------LEFTKRRLHTQ---HEHDLE 1533
            |:..|::|     .:.||..|:.|.:                   |..:|.:|..|   .|..||
Zfish   982 EEMAAQDE-----SIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLE 1041

  Fly  1534 Q-------LVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLL 1591
            |       |...|:.||..|..|.|.:::......|.:.|.:|...|.:.|...:|::.:....|
Zfish  1042 QEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQL 1106

  Fly  1592 EKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLAD----TRLDLEF---KEE 1649
            :||.::..|..:.|::.:..||.|:.:..:::..|..|...:.:.|.:    |...:|.   :|.
Zfish  1107 QKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREA 1171

  Fly  1650 KLASLQRELEEMTFG----------------GGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQ 1698
            :...|:|:|||.|..                ....|:...|:|.|.:.|:...|.:.|:|:::..
Zfish  1172 EFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSN 1236

  Fly  1699 IQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRG-----------NG-------------- 1738
            ::.:.:||..||....|:..:......:.||.|.::..           ||              
Zfish  1237 MEAVAKAKANLEKMCRTLEDQLSEIKSKNDENLRQLNDLSAQRARLQTENGEFGRQLEEKEALVS 1301

  Fly  1739 ---------YKKIKALECQLETEHEERTL-------------LLRE--------KHELERRLSSM 1773
                     .::|:.|:.|:|.|.:.:..             ||||        |.||:|.:|..
Zfish  1302 QLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKA 1366

  Fly  1774 E----------DRDRVDRDAE-------------------EALNQK---LRRDLRKYKALLKDAQ 1806
            .          :.|.:.|..|                   ||:|.|   |.:..::.:..::|..
Zfish  1367 NSEVAQWRTKYETDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLM 1431

  Fly  1807 TQLERLKADTPGKTLIRQLRN-----------------QLEDAE-SARSLA-------------- 1839
            ..:||  |:.....|.::.||                 :||.|: .||||:              
Zfish  1432 IDVER--ANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETL 1494

  Fly  1840 ------MKARQTAEAELTEVQAMFDESHRARNDAEERANAAHRDRAELQAQIEENE--------- 1889
                  .:..:..:.|::::.....|:.::.::.|:...|...::||:|..:||.|         
Zfish  1495 DQLETLKRENKNLQQEISDLTEQIGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESK 1559

  Fly  1890 ------------EELGELMKKYSATVKQL--NTEQINVS--------------------EAEFKL 1920
                        .|:...:.:....::|:  |:::|..|                    :.|..|
Zfish  1560 ILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDL 1624

  Fly  1921 NEMEAERNNLKEQVAELQHRLDNVE--------NLGD---------PSMAMMSKRLELRTKELES 1968
            ||||.:.::...|.||.|.:|.||:        :|.|         ..:||:.:|..|...|:|.
Zfish  1625 NEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEE 1689

  Fly  1969 -RLELEQATRARLEVQ--------------------VNRHKEA---LEKLQNEVTQSKMREMQAQ 2009
             |..|||..|.|...:                    :|..|:.   |.::|:||..:......|:
Zfish  1690 LRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAE 1754

  Fly  2010 DVIKKSQKSLRDMREEFHAVSSREQES---LTR-RKDLEKKVEQM-----ESEGAAL---KNDLR 2062
            |..||:......|.||.    .:||::   |.| :|:||..|:.:     |:|..|:   |..|:
Zfish  1755 DKAKKAITDAAMMAEEL----KKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQLQ 1815

  Fly  2063 LALQRIADLQQAMEEEGE----------------EELS-ESDESLSSVGSISDLEDRLRPVHVKR 2110
            ....|:.:|:..:|.|..                :||: :::|...:|..:.||.|:|: :.||.
Zfish  1816 KLESRVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQ-LKVKA 1879

  Fly  2111 SSQQSLNGSIGGGGGSVVSSTRTVVFEKDDNSPRITVTSPSSPHIHKLALAAKAIPANK 2169
            ..:||....  ....|.:|..|.|..|.::...|..:   :...::|  |.||:..:.|
Zfish  1880 YKRQSEEAE--EQANSHLSKLRKVQHELEEAEERADI---AESQVNK--LRAKSRDSGK 1931

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 207/807 (26%)
MYSc_Myo18 575..1305 CDD:276837 194/776 (25%)
GBP_C <1540..1750 CDD:303769 52/266 (20%)
COG1340 1565..1833 CDD:224259 74/394 (19%)
coiled coil 1723..1734 CDD:293879 3/10 (30%)
myhz1.2XP_005171981.1 Myosin_N 35..74 CDD:308391 3/14 (21%)
MYSc_class_II 101..768 CDD:276951 194/776 (25%)
SMC_N 848..1925 CDD:330553 230/1099 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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