DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and MYH14

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:XP_011525622.1 Gene:MYH14 / 79784 HGNCID:23212 Length:2043 Species:Homo sapiens


Alignment Length:1921 Identity:518/1921 - (26%)
Similarity:806/1921 - (41%) Gaps:456/1921 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   481 GGEEGGAKGVGHDLEADVADASQPERVWLVHR--------GGFTAAIRLPTASSGRDE-ENKLSL 536
            |...||..|.|          :.|:..|...|        .||.||       :.||| |.:..:
Human    73 GPSAGGGPGSG----------TSPQVEWTARRLVWVPSELHGFEAA-------ALRDEGEEEAEV 120

  Fly   537 RLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVV 601
            .|..:|.:|.:..|.:::.|.|.....||:.||..||||||||.||:||.|.||:|.:|...:|:
Human   121 ELAESGRRLRLPRDQIQRMNPPKFSKAEDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVI 185

  Fly   602 NPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKH 666
            ||...|.:|:|.:|.|:||.|..::|||||::.:.||||:::.|.|||::..|.||:||:.:.|.
Human   186 NPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQSILCTGESGAGKTENTKK 250

  Fly   667 ALNYLALAAG-----------------AYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQL 714
            .:.|||..|.                 :|.. :..:.:.| ..|||||||.||..|.|::|..:.
Human   251 VIQYLAHVASSPKGRKEPGVPASVSTVSYGE-LERQLLQA-NPILEAFGNAKTVKNDNSSRFGKF 313

  Fly   715 LSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSH 779
            :.::||..|.|..|:::..|.|:.||.|:...|.||||..:||.||...|:.:|.||..    ||
Human   314 IRINFDVAGYIVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPC----SH 374

  Fly   780 -------PFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLG 837
                   |..|..|:.|       .|..|:::...|....:.:..:..:::|:...|...:.:  
Human   375 YRFLTNGPSSSPGQERE-------LFQETLESLRVLGFSHEEIISMLRMVSAVLQFGNIALKR-- 430

  Fly   838 TGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECL 902
            ..:|.:....:.|||:|...|||:.:.|.|.|   |..|....|.....|:.|.    |.|...|
Human   431 ERNTDQATMPDNTAAQKLCRLLGLGVTDFSRA---LLTPRIKVGRDYVQKAQTK----EQADFAL 488

  Fly   903 EALVIGLYSEALAAVVALINRQICTSSHTIASIM-LIDTPGFQ----NPASCGQQVGATLADLRH 962
            |||....|......:|..:||.:..|....||.: ::|..||:    |          :...|..
Human   489 EALAKATYERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLN----------SFEQLCI 543

  Fly   963 NYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQ 1022
            ||..|:||.||:||..|..::.|.:|     .::..:||.      |.|.||:: |.|       
Human   544 NYTNEKLQQLFNHTMFVLEQEEYQREGIPWTFLDFGLDLQ------PCIDLIER-PAN------- 594

  Fly  1023 RDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLRKCAGPRQFVLHHLQGTNP 1087
                   ..|:|.|||||..:|.:.|.:|:|::....|........|.......|.:.|..|  .
Human   595 -------PPGLLALLDEECWFPKATDKSFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAG--K 650

  Fly  1088 VLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRR 1152
            |.|..:.|:..:.: |...|..:||..|:......::                 ..:||...|.:
Human   651 VDYKANEWLMKNMD-PLNDNVAALLHQSTDRLTAEIW-----------------KDVEGIVGLEQ 697

  Fly  1153 VSSI----------RRSFTTAGVKRNSIMLQV-KFTVDGIIDTLRRTGTHFVHCYLLQH--NAGK 1204
            |||:          |..|.|.|        |: |.::..::.||..|...||.|.:..|  .|||
Human   698 VSSLGDGPPGGRPRRGMFRTVG--------QLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGK 754

  Fly  1205 HTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL 1269
                                   :...|:..|||.:.|||..|:.|.|||..:...||.:|:.:|
Human   755 -----------------------LEPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYEIL 796

  Fly  1270 AGD-----LASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQA 1329
            ..:     ....|. :.|:::...|||...||:|.|:|.||:|||::||.:||:.::|.|:..||
Human   797 TPNAIPKGFMDGKQ-ACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQA 860

  Fly  1330 FCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEE 1394
            ..||||||:...:|:.|:.|:|.:|||..|:|.:|.|.||||..:|.|||.|.|.:|.|:...:|
Human   861 AARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQE 925

  Fly  1395 LL--------------------------------MLRAKLE---KIECDRSEVKAENQKLEAKLS 1424
            |.                                .|||:.|   :.|..|..:.|..|:||..:|
Human   926 LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVS 990

  Fly  1425 ELTVDLAEERS-TAHIATER-------------LEAETAERLKLEKELGDQTNKVKN-------L 1468
            ||...:.||.. :..:.||:             ||||...|.||:.|......|:|.       |
Human   991 ELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLL 1055

  Fly  1469 QETTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLE 1533
            ::...||..|....:..|...|.....|.|........:||||....::|...|:    .|...:
Human  1056 EDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRK----EEKGRQ 1116

  Fly  1534 QLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKF 1598
            :|..||:.|:.:.|:..|::|||:|...:.:.:..:...|:.......|::......|.|..|:.
Human  1117 ELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREA 1181

  Fly  1599 DAECQSLQDAVRQERQAKER-------YGREKDVLQAEKFTLEQTLADTRLDLEF---KEEKLAS 1653
            .|.....|:.:..||.|:.:       .|.|.:.|:.|   ||.||..|....|.   :|:::..
Human  1182 QAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGE---LEDTLDSTNAQQELRSKREQEVTE 1243

  Fly  1654 LQRELEEMT-------------FG---GGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLL 1702
            |::.|||.|             .|   |...|:..|.||.|...|:.....|.|:.|:..::..|
Human  1244 LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL 1308

  Fly  1703 -------EQAKLRLEMTL----------ETMRKEARRESQQRDEELEEVRG----------NGYK 1740
                   ||.:.|||:.|          |..|.||..:.|:...|||.|.|          ...|
Human  1309 QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSK 1373

  Fly  1741 KIKALECQLETEHEERTLL---LREKHELERRLSSME---------------DRDRVDRD---AE 1784
            ::.:.|.||   |:.:.||   .|.|..|..|:.:||               .|:|..|:   |:
Human  1374 ELSSTEAQL---HDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQ 1435

  Fly  1785 EALNQKLRRDLRKYKAL----------LKDAQTQLERLKADTP-------GKTLIRQLRNQLEDA 1832
            ..|::..||...:..||          .::|:...:||...|.       |:   |:|:.:|:||
Human  1436 AQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR---RRLQQELDDA 1497

  Fly  1833 ----ESARSL------------------------AMKARQTAEAELTEVQA-------MFDESHR 1862
                |..|.|                        |::.|:.||||..|.:|       ..:|...
Human  1498 TMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQE 1562

  Fly  1863 ARNDAEERANAAHRDRAELQAQIEENEEELGELMKKYSATVKQLNTEQINVSEAEFKLNEMEAER 1927
            ||.:.|.:..|.   ||||:|.: .:::::|:                 :|.|.|......|...
Human  1563 AREELERQNRAL---RAELEALL-SSKDDVGK-----------------SVHELERACRVAEQAA 1606

  Fly  1928 NNLKEQVAELQHRLDNVENLGDPSMAMMSKRLE-----LRT---KELESRLELEQATRARL---- 1980
            |:|:.||.||:..|...|:        ...|||     |:|   ::|:.|.|..:..|.:|    
Human  1607 NDLRAQVTELEDELTAAED--------AKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQL 1663

  Fly  1981 -EVQVNRHKE---------ALEKLQNEVTQSK----------------MREMQAQDVIKKSQKSL 2019
             :.:|.|.:|         |.:||:.|:.:.|                :|:||||  :|:..:.:
Human  1664 RDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQ--MKELWREV 1726

  Fly  2020 RDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEEELS 2084
            .:.|.....:.|:.:||..|.|.||.:|.:::.|.||.....|.|.|   |..:..:|.....||
Human  1727 EETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ---DRDEMADEVANGNLS 1788

  Fly  2085 ES---DESLSSVGSISDLEDRLRPVHVKRSSQQSLN 2117
            ::   :|.....|.:..||:.|..   ::|:.:.||
Human  1789 KAAILEEKRQLEGRLGQLEEELEE---EQSNSELLN 1821

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 238/812 (29%)
MYSc_Myo18 575..1305 CDD:276837 222/781 (28%)
GBP_C <1540..1750 CDD:303769 64/262 (24%)
COG1340 1565..1833 CDD:224259 86/362 (24%)
coiled coil 1723..1734 CDD:293879 4/10 (40%)
MYH14XP_011525622.1 Myosin_head 148..836 CDD:278492 229/792 (29%)
MYSc_Myh14_mammals 159..836 CDD:276893 222/781 (28%)
Myosin_tail_1 913..1993 CDD:279860 228/959 (24%)
GBP_C <1661..1761 CDD:303769 23/101 (23%)
coiled coil 1729..1746 CDD:293879 4/16 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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