DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and Myh10

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_006534552.1	Gene:	Myh10 / 77579	MGIID:	1930780	Length:	2007	Species:	Mus musculus

Alignment Length:	2134	Identity:	545/2134 - (25%)
Similarity:	882/2134 - (41%)	Gaps:	641/2134 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   496 ADVADASQPERVWL-VHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPA 559
            |..||.:..:.||: ..|.||.|      ||...:..:::.:.|..||::..|::||::|.|.|.
Mouse    25 ATQADWTAKKLVWIPSERHGFEA------ASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPK 83

  Fly   560 LDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTE 624
            ...|||:.||..||||||||.|:.||.|.||:|.:|...:|:||...|.:|||.::.|:||.|..
Mouse    84 FSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRH 148

  Fly   625 DMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAA----GAYNNFINAE 685
            :||||:|:::::|||.:::.|.|||::..|.||:||:.:.|..:.|||..|    |..::.|..|
Mouse   149 EMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPQE 213

  Fly   686 KVNAL-------------CTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPER 737
            ....:             ..|||:|||.||..|.|::|..:.:.::||.||.|..|:::..|.|:
Mouse   214 SPKPVKPQGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEK 278

  Fly   738 QRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTV 802
            .||.|:...|.:|||..:||:||...|:.:|.||..   :::.|:|.........:..::|..|:
Mouse   279 SRAVRQAKDERTFHIFYQLLSGAGEHLKSDLLLEGF---NNYRFLSNGYIPIPGQQDKDNFQETM 340

  Fly   803 QAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLS 867
            :|...:....:.:..:..:::::...|.....|  ..:|.:......|.|:|...|||:|:.:.:
Mouse   341 EAMHIMGFSHEEILSMLKVVSSVLQFGNISFKK--ERNTDQASMPENTVAQKLCHLLGMNVMEFT 403

  Fly   868 SAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTI 932
            .|   :..|....|.....|:.|.    |.|...:|||....|......:|..||:.:..:....
Mouse   404 RA---ILTPRIKVGRDYVQKAQTK----EQADFAVEALAKATYERLFRWLVHRINKALDRTKRQG 461

  Fly   933 AS-IMLIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE---- 988
            || |.::|..||:    |          :...|..||..|:||.||:||..:..::.|.:|
Mouse   462 ASFIGILDIAGFEIFELN----------SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEW 516

  Fly   989 -LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFL 1052
             .::..:||.      |.|.||:: |.|              ..|:|.|||||..:|.:.|.||:
Mouse   517 NFIDFGLDLQ------PCIDLIER-PAN--------------PPGVLALLDEECWFPKATDKTFV 560

  Fly  1053 ERLFSHYGDREHHSLLRKCAGPRQ------FVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSL 1111
            |:|....|.   ||..:|   |||      |.:.|..|  .|.|..|.|:..:.: |...|..:|
Mouse   561 EKLVQEQGS---HSKFQK---PRQLKDKADFCIIHYAG--KVDYKADEWLMKNMD-PLNDNVATL 616

  Fly  1112 LQDSSREEINRLY---IGSLTRGSGAMVFCGSFAGL-----EGTQSLRRVSSIRRSFTTAGVKRN 1168
            |..||...:..|:   |.::.|.|    |..|.:||     :....|.:|:.:..:...:..|..
Mouse   617 LHQSSDRFVAELWKDEIQTIQRAS----FYDSVSGLHEPPVDRIVGLDQVTGMTETAFGSAYKTK 677

  Fly  1169 SIMLQV-----KFTVDGIIDTLRRTGTHFVHCYLLQH--NAGKHTKYTANGSPSSAAGQVSSEEE 1226
            ..|.:.     |.::..::.|||.|..:||.|.:..|  .|||
Mouse   678 KGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGK---------------------- 720

  Fly  1227 MVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGD-----LASNKDVSVEQILA 1286
             ::..|:..|||.:.|||..|:.|.|||..:...||.:|:.:|..:     ....|. :.|:::.
Mouse   721 -LDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQ-ACERMIR 783

  Fly  1287 VNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVR 1351
            ..|||...||||.|:|.||:|||:.||.:||:.::|.||..||.||||||||..::::.|..|::
Mouse   784 ALELDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALK 848

  Fly  1352 CIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAEN 1416
            .:|||..|:|.:|.|.|||:..:|.|||.|.|.||:|:..:||||.::.|..|:|.:..|::.::
Mouse   849 VLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKH 913

  Fly  1417 Q----------------------------KLEAKLSEL---------TVDLAEERS--------- 1435
            |                            :|.||..||         .|:..|||:
Mouse   914 QQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKK 978

  Fly  1436 -TAHI--ATERLEAETAERLKLEKE-----------------LGDQTN----------------- 1463
             .|||  ..|:|:.|...|.||:.|                 |.||.:
Mouse   979 MQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEVLLLEDQNSKFIKEKKLMEDRIAECS 1043

  Fly  1464 --------------KVKNLQET-----------TEKLEMELICAKSDLNGIS---EDEDAE---- 1496
                          |::|.||.           .||...||..||..|:|.:   :|:.||
Mouse  1044 SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ 1108

  Fly  1497 ----------NEDGVGGG--------VYKLKYERVAREL-------------EFTKRRLHTQHEH 1530
                      .|:.:.|.        ::|....:|||||             |...|....:.:.
Mouse  1109 VDELKVQLTKKEEELQGALARGDDETLHKNNALKVARELQAQIAELQEDFESEKASRNKAEKQKR 1173

  Fly  1531 DL-EQLVALKKHLEMKL------------------------------------------SDAYEE 1552
            || |:|.|||..||..|                                          :.|.||
Mouse  1174 DLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEDETKNHEAQIQDMRQRHATALEE 1238

  Fly  1553 VVEQRQVVGQWK----------------------------------------------------- 1564
            :.||.:...::|
Mouse  1239 LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGD 1303

  Fly  1565 -------RKAQKMTNEMNDLRMLLEE---------------------------QNARNNL-LEKK 1594
                   .||.|:.||::::..||||                           :..|..| |..:
Mouse  1304 RLRVELAEKANKLQNELDNVSTLLEEAEKKGIKFAKDAAGLESQLQDTQELLQEETRQKLNLSSR 1368

  Fly  1595 QRKFDAECQSLQDAVRQERQAKERYGRE---------------------------------KDV- 1625
            .|:.:.|..|||:...:|.:|::...::                                 |||
Mouse  1369 IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDVE 1433

  Fly  1626 ---------------LQAEKFTLEQTLADTRLDLEF----------------------------- 1646
                           |:..|..|:|.|.|..:||:.
Mouse  1434 ALSQRLEEKVLAYDKLEKTKNRLQQELDDLTVDLDHQRQIVSNLEKKQKKFDQLLAEEKGISARY 1498

  Fly  1647 -------------KEEKLASLQRELEEMTFGGGTEEEFA-------------------------Q 1673
                         ||.|..||.|.|||..   ..:|||.                         :
Mouse  1499 AEERDRAEAEAREKETKALSLARALEEAL---EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE 1560

  Fly  1674 LRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNG 1738
            |.:||...|::.:|...:|:|:..::|..|.||||||:.::.|:.:..|:.|.|||:.||.:...
Mouse  1561 LEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL 1625

  Fly  1739 YKKIKALECQLETEHEERTLLLREKHELERRLSSMEDR-DRVDRDAEEALNQKLRRDLRKYKALL 1802
            .|:::.||.:||.|.::|.|.:..|.::|..|..:|.: :..::..:|.:.|     |||.:|.:
Mouse  1626 LKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ-----LRKLQAQM 1685

  Fly  1803 KDAQTQLERLKADTPGKTLIRQLRNQL--EDAESARSLAMKARQTAEAELTEVQAMFDESHRARN 1865
            ||.|.:||..:|.          |:::  :..||.:.|     ::.|||:.::|.....|.|||.
Mouse  1686 KDYQRELEEARAS----------RDEIFAQSKESEKKL-----KSLEAEILQLQEELASSERARR 1735

  Fly  1866 DAE--------ERANAAH------RDRAELQAQIEENEEELGE-------LMKKYSATVKQLNTE 1909
            .||        |.||:|.      .::..|:|:|.:.||||.|       |..::..|..|::|
Mouse  1736 HAEQERDELADEIANSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDT- 1799

  Fly  1910 QINVSEAEFKLN-EMEAERNNLKEQVAELQHRLDNVENLGDPSMAMMSKRLELRTKELESRL-EL 1972
                      || |:.|||:..::.        ||..           ::||.:.|||:::| ||
Mouse  1800 ----------LNTELAAERSAAQKS--------DNAR-----------QQLERQNKELKAKLQEL 1835

  Fly  1973 EQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDM-----REEFHAVSSR 2032
            |.|.:::.:..::..:..:.:|:.::.|.......|..::::::|.|:::     .|..||...:
Mouse  1836 EGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYK 1900

  Fly  2033 EQ--ESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEEELSESDESLSSVGS 2095
            ||  ::..|.|.|::::|:.|.| |...|..|..|||..|           :.:|::|.||.  .
Mouse  1901 EQMEKANARMKQLKRQLEEAEEE-ATRANASRRKLQRELD-----------DATEANEGLSR--E 1951

  Fly  2096 ISDLEDRLR---PVHVKRSSQQSLNGSIGGGGGSVVSS---TRTVVFEKDDNSP 2143
            :|.|::|||   |:..  ||.:|....:...|.|:..|   |.:...:.:|..|
Mouse  1952 VSTLKNRLRRGGPISF--SSSRSGRRQLHIEGASLELSDDDTESKTSDVNDTQP 2003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	240/813 (30%)
		MYSc_Myo18	575..1305	CDD:276837	223/782 (29%)
		GBP_C	<1540..1750	CDD:303769	77/455 (17%)
		COG1340	1565..1833	CDD:224259	90/414 (22%)
		coiled coil	1723..1734	CDD:293879	5/10 (50%)
Myh10	XP_006534552.1	Myosin_N	33..72	CDD:397036	11/44 (25%)
		MYSc_Myh10	99..802	CDD:276952	223/782 (29%)
		Myosin_tail_1	879..1959	CDD:396244	242/1146 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810