DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and myh7l

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001070932.2 Gene:myh7l / 768300 ZFINID:ZDB-GENE-061027-393 Length:1936 Species:Danio rerio


Alignment Length:1867 Identity:467/1867 - (25%)
Similarity:796/1867 - (42%) Gaps:428/1867 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   461 LRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDL--EADVADASQP-ERVWLVHRGGFTAAIRLP 522
            ||:|..:|.:.|::                ..||  |..|.||.:. .:..:|.|.|        
Zfish    16 LRKSEKERLEAQTK----------------AFDLKKECFVPDAIEEFVKATVVSREG-------- 56

  Fly   523 TASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYAS 587
                     :|:::. ...|:.:||.|.||.:||.|..|.:||:..|.:|:|.:||..|::|||:
Zfish    57 ---------DKVTVE-TQGGKTVTVKEADVLQQNPPKFDKIEDMAMLTFLHEPAVLFNLKERYAA 111

  Fly   588 NLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIF 652
            .:|:|.:|...:.|||...|.:|:::||..:||.:..:.|||:||::..||:.::..|.:||::.
Zfish   112 WMIYTYSGLFCVTVNPYKWLPVYNQEVVIAYRGKERTEAPPHIYSISDNAYQYMLADRENQSILI 176

  Fly   653 MGRSGSGKSTSFKHALNYLALAAGA-------YNNFINAEKVNALCTILEAFGNTKTCLNSNATR 710
            .|.||:||:.:.|..:.|.|..|.:       .|.....:::......||||||.||..|.|::|
Zfish   177 TGESGAGKTVNTKRVIQYFASVAASGGKKDQDKNKGTLEDQIIQANPALEAFGNAKTIRNDNSSR 241

  Fly   711 MTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITS 775
            ..:.:.:.||..|::|||.::..|.|:.|...:|..|..:||..::|:...   .:.|.:..:||
Zfish   242 FGKFIRIHFDTRGKLASADIETYLLEKSRVTFQLKAERDYHIFYQILSNKK---PEILEMLLVTS 303

  Fly   776 ED-SHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTG 839
            .. .:.|||..:........:::.|.|..||:.|....:....::.:..||.|.|     .:...
Zfish   304 NPYDYAFISQGETTVPSIDDSDELMATDSAFDILGFTQEEKNSVYKLTGAIMHYG-----NMKFK 363

  Fly   840 STARTQFANPTA---ARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWE- 900
            ...|.:.|....   |.|::.|:|:|..||..   ||..|..             ..|:||..: 
Zfish   364 QKQREEQAEADGTEDADKSAYLMGLNSADLIK---GLCHPRV-------------KVGNEWVTKG 412

  Fly   901 --------CLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQV 953
                    .:.||...:|.:....:|..||:.:.|.......|.::|..||:    |        
Zfish   413 QNVQQVNYAIGALSKAVYEKMFLWMVVRINQSLETKQPRQYFIGVLDIAGFEIFDFN-------- 469

  Fly   954 GATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQELVEIE-----MDLASECHPGPLISLIDKAP 1013
              |...|..|:..|:||..|:|...|..::.|.:|.:|.|     |||.: |     |.||:|. 
Zfish   470 --TFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQA-C-----IDLIEKP- 525

  Fly  1014 QNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ- 1076
                             .|::.:|:||.::|.::|.||..:|: :|.|...:....|...|..: 
Zfish   526 -----------------MGIMSILEEECMFPKASDATFKAKLYDNHLGKSNNFQKPRLVKGKPEA 573

  Fly  1077 -FVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGS 1140
             |.|.|..||  |.|.::.|: ...|.|.....|.|.|.||.:.::.|:              .:
Zfish   574 HFALVHYAGT--VDYNINNWL-VKNEDPLNETVVGLYQKSSLKLLSNLF--------------AN 621

  Fly  1141 FAGLEGT-------------QSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHF 1192
            :||.:..             .|.:.||::.|.                 .::.::..||.|..||
Zfish   622 YAGADSATGDGGKKEKKKKGSSFQTVSALHRE-----------------NLNKLMTNLRSTHPHF 669

  Fly  1193 VHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESV 1257
            |.|.:                    ..:..:...|.| ||:..|||.:.|||..|:.|.|||..:
Zfish   670 VRCLI--------------------PNETKTPGAMEN-PLVMHQLRCNGVLEGIRICRKGFPNRI 713

  Fly  1258 PLLEFVRRFGLL------AGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKR 1316
            ...:|.:|:.:|      .|....:|. ..|::|...::|...||.|.:::.|::|:|.:||..|
Zfish   714 LYGDFKQRYRILNPAAIPEGQFIDSKK-GAEKLLGSLDIDHQQYRFGHTKVFFKAGLLGQLEEMR 777

  Fly  1317 DVLLSDRIIQLQAFCRGYLARK---KMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPL 1378
            |..||..|..:||..||.|:|.   ||.:||.   |:..||.||:||:||::|||.:|..::.||
Zfish   778 DERLSKIITGIQAKSRGLLSRAEYIKMVERRD---ALLVIQWNVRAFMAVKNWPWMKLFFKIKPL 839

  Fly  1379 LNVHRTEEQLKTANEELLMLRAKLEKIECDRSE------------------VKAENQKL------ 1419
            |.....|:::....||.|.|:....|.|..|.|                  |:||...|      
Zfish   840 LRSAEAEKEMANMKEEFLKLKEAYAKSEARRKELEEKMVTLLQEKNDLQLQVQAEQDNLCDAEER 904

  Fly  1420 -----------EAKLSELTVDLAEERSTAHIATERLEAE-TAERLKLEKELGDQTNKVKNLQETT 1472
                       |||..|||..|.:|        |.:.|| ||::.|||.|..:....:.:|:.|.
Zfish   905 CEGLIKNKIQMEAKAKELTERLEDE--------EEMNAELTAKKRKLEDECSELKKDIDDLELTL 961

  Fly  1473 EKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQ--- 1534
            .|:|.|....::.:..::|:..|.::              :..:|...|:.|...|:..|:.   
Zfish   962 AKVEKEKHATENKVKNLTEEMAALDD--------------IIAKLTKEKKALQEAHQQTLDDLQS 1012

  Fly  1535 -------LVALKKHLEMKLSDAYEEVVEQRQV---VGQWKRKAQ---KMTNEMNDLRMLLEEQNA 1586
                   |...|..||.::.|....:.:::::   :.:.|||.:   |:|.|     .:::.:|.
Zfish  1013 EEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLTQE-----SIMDLEND 1072

  Fly  1587 RNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEKL 1651
            :.. ||:|.:|.|.|...|...:..|:....:..::...|||....||:.|...|......|:..
Zfish  1073 KQQ-LEEKLKKKDFEISQLNSKIDDEQSIIIQLQKKLKELQARVEELEEELEAERAARAKVEKPR 1136

  Fly  1652 ASLQRELEEMT-----FGGGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEM 1711
            |.|.|||||::     .||.|.   ||:..:|   :|.|:.|:...|        ||:|.|:.|.
Zfish  1137 ADLARELEEISERLEEAGGATA---AQIEMNK---KREAEFQKLRRD--------LEEATLQHEA 1187

  Fly  1712 TLETMRKEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERRLSSME-- 1774
            |..|:||:......:..|:::.:     :::|.   :||.|..|..|      ||:...||||  
Zfish  1188 TAATLRKKQADSVAELGEQIDNL-----QRVKQ---KLEKEKSELRL------ELDDVASSMEHI 1238

  Fly  1775 -----DRDRVDRDAEEALNQKLRRDLRKYKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAES 1834
                 :.::|:|..|:.:|: .|....:|:..|.|..||..:|:|:..      :...|||:.||
Zfish  1239 VKSKTNMEKVNRTLEDQMNE-YRNKCEEYQRSLNDFTTQKAKLQAEND------EFSRQLEEKES 1296

  Fly  1835 ARSLAMKARQTAEAELTEVQAMFDESHRARNDAEERANAAHRDRAELQAQIEENEEELGEL---M 1896
            ..|...:.:.:...:|.:::...||..:|:|.......:|..|...|:.|.||.:|...||   |
Zfish  1297 LVSQLTRGKNSFSQQLEDLKRQLDEEIKAKNALAHALQSARHDTDLLREQYEEEQEAKAELQRSM 1361

  Fly  1897 KKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQVAELQ-----------------HRLDN- 1943
            .|.:..|.|..|:.  .::|..:..|:|..:..|.:::.|.:                 |||.| 
Zfish  1362 SKANTEVAQWRTKY--ETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE 1424

  Fly  1944 VENL------GDPSMAMMSKR--------LELRTKELESRLELEQATR-AR-LEVQV----NRHK 1988
            :|:|      .:.:.|.:.|:        .|.:.|..||:.|||.:.: || |..::    |.::
Zfish  1425 IEDLMVDVERSNTAAASLDKKQRHFDKIISEWKQKYEESQCELESSQKEARSLSTELFKLKNSYE 1489

  Fly  1989 EALEKLQNEVTQSKMREMQAQDV-------------IKKSQKSLRDMREEFHAVSSREQESLTR- 2039
            |:::.|:....::|:.:.:..|:             ::|.:|.|...:.|..|.....:.||.. 
Zfish  1490 ESMDHLETMKRENKILQEEISDLTEQLGEGGKTIHELEKVRKQLEQEKAEIQAALEEAEGSLEHE 1554

  Fly  2040 --------------RKDLEKKVEQMESEGAALKNDLRLALQRIAD-LQQAMEEEG---------- 2079
                          :.|:|:|:.:.:.|...:|.:    .||..| ||.|:|.|.          
Zfish  1555 EGKILRTQLEFNQIKADIERKLSEKDEEMEQVKRN----QQRTIDTLQSALESETHSRNEALRIK 1615

  Fly  2080 ---EEELSESDESLSSVG-SISDLEDRLRPV--HVKRSSQQSLNGSI 2120
               |.:|:|.:..||... ..::.:.:|:.|  |:| .||..|:.|:
Zfish  1616 KKMEGDLNEMEIQLSQANRQAAEAQKQLKSVQAHLK-DSQLQLDDSL 1661

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 207/811 (26%)
MYSc_Myo18 575..1305 CDD:276837 194/780 (25%)
GBP_C <1540..1750 CDD:303769 54/220 (25%)
COG1340 1565..1833 CDD:224259 76/282 (27%)
coiled coil 1723..1734 CDD:293879 1/10 (10%)
myh7lNP_001070932.2 Myosin_N 35..72 CDD:280832 10/54 (19%)
Myosin_head 87..766 CDD:278492 199/792 (25%)
MYSc_class_II 99..766 CDD:276951 194/780 (25%)
Myosin_tail_1 846..1923 CDD:279860 207/886 (23%)
RILP-like 961..1094 CDD:304877 29/152 (19%)
MM_CoA_mutase <1132..1293 CDD:294532 54/195 (28%)
MIT_CorA-like <1295..>1407 CDD:294313 27/113 (24%)
COG6 1372..>1505 CDD:303003 28/134 (21%)
ATP-synt_B <1500..1608 CDD:304375 22/111 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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