DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and Myo18b

DIOPT Version :10

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_083177.2 Gene:Myo18b / 74376 MGIID:1921626 Length:2605 Species:Mus musculus


Alignment Length:2394 Identity:699/2394 - (29%)
Similarity:1122/2394 - (46%) Gaps:404/2394 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 FMKKSAGDEDKERRKREKKLRKEA-----------------KGTSGGPGMGGVTGVTGSMSTDEL 51
            |:|:...:.:||  .:|.:.||.|                 ..|:..|..|.......|.||   
Mouse    37 FIKQLVRETEKE--SKEARRRKAAAFTAPEVEIPAVPTNQTNKTNNVPKPGSQQTSQDSSST--- 96

  Fly    52 LRLDEVRRSLKIRGR------------------RKEKEKLPSGITADYSADFFAALNADANGGSN 98
                 .:.|..|.|:                  .:.:|..|:|..|..:..|       ..|...
Mouse    97 -----TQNSADIPGKEPPGAGDKDSTPVTSTSGERPQESGPTGTPAKRTLPF-------KRGVRR 149

  Fly    99 GGA---VGAADPEQDRGNEEI----VASVMTHIESRASNGA--GVSVNYSEVTHSLLSGGLKNRF 154
            |..   |...|||..:.::::    |....|...::.|.|.  ||:...|....           
Mouse   150 GDVLLMVAKLDPELAKADQKVQPRDVPVDKTPAPAKDSGGTKKGVTTGTSSAPQ----------- 203

  Fly   155 LPPIPPKPPKRGI------LKGSRSNMTNVHEEISFAGSAGGAGGTPEMLLRNTFQNESLYEGAA 213
             |.:|.|...||:      .||.:..           |:.|.....|:.:.:...:::|..|...
Mouse   204 -PSMPEKTRTRGVGDTGQSTKGGKCQ-----------GTEGKGSRDPQTIGQKEGESQSTEEQGT 256

  Fly   214 RGAGSIGSNSSQHGTSFTS----VESLRSDGEQ--TGGQQRAMTLPANAR-YGAL---------P 262
            |.......|..|.||:...    .:.:..:.|.  .|.:.|.:..|...| :|..         |
Mouse   257 RSQAQEAGNKEQLGTAEKEGGGPPKKMEKEDEPKVAGAEVRPVEPPVPLRKWGGFLGWRSKWDSP 321

  Fly   263 QGNSQGSHLH-------VLTSPSPSADSLTDTTNSSFATPPFSLS-PVGESQGIDRWARVHAFED 319
            |...:.:..|       .|.||:      .|.:....|.|....| |.|:..|            
Mouse   322 QSKDRVTESHRKDEKTGDLQSPA------VDRSCGQLAEPTGQPSGPTGQPSG------------ 368

  Fly   320 VELPLPPVQLVKLPPPRQLVIRRQKSPRQDFGFSLRKAICLDRTESLTSPIFRPVIFAEP-GAGG 383
                          |..||    .:|..|..|          .|.....|..:|   |.| |...
Mouse   369 --------------PTGQL----SESTGQPSG----------PTGQPAGPTGQP---AGPTGQPA 402

  Fly   384 GATGLLPG------DRLIKVNG----------TPVGELPREI--IIEMIRN-------------- 416
            |.||...|      :..:|:.|          ||  ..|||:  :....:|              
Mouse   403 GPTGQPAGPTGQQQEAPVKMEGKVGRPQKKLVTP--RKPRELPGVAAKTQNPEESCKAPDRIPTT 465

  Fly   417 --SGEAVTVEVQPVAELVELSKRCMAPSTATVEEID--------H-----SITNGNCNTLRRSAS 466
              |.||...:.||.:.:....:    |...|.||:|        |     .:.....:|||....
Mouse   466 GISAEAAKRDGQPESRVQGAGE----PRVCTEEEVDVVKPQAEGHVESIPEVVMERLSTLRPMEE 526

  Fly   467 KRFKRQSRHENGNGGGEEGGAKGVGHD--LEADVADASQPERVWLVHRGGFT-AAIRLPTASSGR 528
            |:..     ::.:.||:.|.:.....|  .||        ::||||.:.||| |.:..|...:..
Mouse   527 KQIL-----QDPDRGGQSGDSDQAYEDRWYEA--------QKVWLVQKDGFTLATVLKPDEGTAD 578

  Fly   529 DEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTK 593
            ....::.|.:..:...:.|||:.|...|...||..||:..|..:||:||::.|.|||.:.|.:|.
Mouse   579 PPAGRVRLCIDADRTVIEVDEEQVHPANPSELDQAEDLASLVSVNESSVMNTLLQRYRAQLPYTC 643

  Fly   594 AGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGS 658
            :||.|:.:.|.......|.||.   || :.:.:|.||.||||.||.:|:..|||||::.:||||:
Mouse   644 SGPDLITLQPQTTTVPSSGKVP---RG-RQDGLPAHVTSLAQRAYWALLSQRRDQSIVALGRSGA 704

  Fly   659 GKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTG 723
            ||:|..:..|.:|...||:.:..::.||:.|..|:|.|||...|..:..|||...::||||:.||
Mouse   705 GKTTCCEQVLEHLVGMAGSVDGRVSVEKLRATFTVLRAFGCVSTGHSRRATRFAMVMSLDFNATG 769

  Fly   724 QIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKL 788
            ::.:|.||.:|.|..|..|:...|.:|.:.::||||....|:.||:|..: :|.|...:.|..|.
Mouse   770 RVTAAQLQTVLLENSRVARQPQGEGNFEVFSQLLAGMDVDLRTELNLHQM-AESSAFGMGLWSKP 833

  Fly   789 EDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAAR 853
            ||:.:||..|.:...|.|.|.|.....:.||.:||||||||.||..|:|     |.||.....|.
Mouse   834 EDKQKAATAFSQLRGAMELLGISEGEQQAIWRVLAAIYHLGAAGACKVG-----RKQFMRFEWAN 893

  Fly   854 KASGLLGVNLEDLSSAAF------------------GLTQPNAPNGGLSPSKSPTSDTGHEWAWE 900
            .|:..||.:.|:|::|.|                  || |.|....||..       ||    .|
Mouse   894 HAAEALGCDYEELNTATFKHHLRQIIEQMTSGPQRQGL-QDNEACSGLKM-------TG----VE 946

  Fly   901 CLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQNPASCGQQVGATLADLRHNYL 965
            |:|.:..|||.|...|||:||||...:...::||||::||||||||...|:...||..:|.:||.
Mouse   947 CVEGMASGLYQELFVAVVSLINRSFSSHHLSMASIMVVDTPGFQNPRHQGKDRAATFEELCYNYA 1011

  Fly   966 QERLQMLFHHTTLVAPRDRYAQELVEIEMDLASECHPGPLISLIDKAP-QNHVVRSSQRDLREHD 1029
            |||||:||:|.|.|:..:||.:|.:.:..|| .|..||..::::|:.| |.|:......:    |
Mouse  1012 QERLQLLFYHRTFVSTLERYKEEGIPVPFDL-PESSPGTTVAVVDQNPSQVHLPAGRGAE----D 1071

  Fly  1030 RRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDR-----EHHSLLRKCAGPRQFVLHHLQGTNPVL 1089
            ..|:.|:||||.....|:|.|.||||.:.:..:     |....:|.|..|.|..|.|..|.:||.
Mouse  1072 AGGLFWVLDEEVRVQGSSDSTVLERLRAAFEKKKEAGAEEPPSMRTCEQPLQCELFHQLGRDPVR 1136

  Fly  1090 YAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGT--QSLRR 1152
            |.:.||:|.::.:.....|..:||.|.|||:..|:   ..|.....| |.:.||||||  |:|.|
Mouse  1137 YDLTGWLRRAKPNLAALEAPQILQQSKREELQSLF---QARAKLPPV-CRAVAGLEGTSQQALHR 1197

  Fly  1153 VSSIRRSFTT--AGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYL---LQHNAGKHTKYTANG 1212
            ...:||:|.:  |.|||.:...|:|..:|.:|..|||:..||:||.:   ::..||:.|.     
Mouse  1198 SRVVRRAFASSLAAVKRKAPCAQIKLQMDALISLLRRSRLHFIHCLVPTTVESKAGQRTP----- 1257

  Fly  1213 SPSSAAGQ--VSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLAS 1275
            |||..:|.  |::|...:::|.||.||.||.:|||.||||.|:.|.:.|.:|.|||.:|...|..
Mouse  1258 SPSQPSGDQGVANEPTALDIPALRVQLAGSHILEALRLHRAGYAEHMGLAQFRRRFQVLDPALLK 1322

  Fly  1276 NKDVS---------VEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFC 1331
            ..|::         ||::|...:|:..:..:|.||:..::||:|.||.:|:.|:|..|:..||.|
Mouse  1323 KLDLTSEELDERKVVEELLKTLDLEKKAVAVGHSQVFLKAGVVSRLERQREKLVSRNIVLFQAAC 1387

  Fly  1332 RGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELL 1396
            ||:|:|::..:.:::.||..|||:|:..||.|:|||||.||..:.|||:.....|||:...|||.
Mouse  1388 RGFLSRQEYKKLKIRRLATLCIQKNLAVFLKVKDWPWWGLLASLRPLLSSTLGTEQLRAKEEELT 1452

  Fly  1397 MLRAKLEKIECDRSEVKAENQKLEAKLSELTVDLAEERSTAHIATERLEAETAERLKLEKELGDQ 1461
            :||.||:|.|..|||::.....||:|:::||.:||:||....:|.:.||:|.||||:..:|:.:.
Mouse  1453 LLRQKLQKSENSRSELRQNTDLLESKITDLTSELADERFKGDVACQALESERAERLQALREVQEL 1517

  Fly  1462 TNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDGVGGGV--YKLKYERVARELEFTKRRL 1524
            ..|.:.:|:...:::.:|..|:..:.|      |..|:...||.  ::::.:....|.:|.::||
Mouse  1518 KTKYQQVQDALGEVQKQLEEAQQRIQG------ANLEEKPAGGADEWQMRLDCAQMENDFLRKRL 1576

  Fly  1525 HTQHEHDLEQLVALKKHLEMKLSD---AYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNA 1586
            . |.|..|:..:..:..||.||.:   ||||.   :::..|.|||...:|.::.|.|:|||.|.:
Mouse  1577 Q-QCEERLDSEMKARTELEQKLGELQSAYEEA---KKMAHQLKRKCHHLTWDLEDTRVLLENQQS 1637

  Fly  1587 RNNLLEKKQRKFDAE-CQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEK 1650
            ||:.|||:|:|||.: .|:|.::: .|:..:|:..:|.:.::.|...|:|       .||.||::
Mouse  1638 RNHELEKRQKKFDLQLAQALGESM-FEKSLREKVSQENNGVRWELGQLQQ-------QLEQKEQE 1694

  Fly  1651 LASLQRELEEMTFGGGTEEEF-----------AQLRRSKNETERRAKEQEEELDEMAGQIQLLEQ 1704
            .:.|::|:|.:.   |.:.|.           |.|:....|.|..|.||::...:....|:.|||
Mouse  1695 ASKLKQEVERLQ---GQKRELLSCASVGDQGVASLKERVWELETNALEQQKIHSQQENTIKQLEQ 1756

  Fly  1705 AKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERR 1769
            .:.|.|:.:|.|::..:::.:.::||||:||.:..|:::.||.|||.|:||:.:.|.|||:||..
Mouse  1757 LRQRFELEIERMKQMHQKDREDQEEELEDVRQSCQKRLRQLEMQLEQEYEEKQVALHEKHDLEGL 1821

  Fly  1770 LSSMEDR-DRVDRDAEEALNQKLRRDLRKYKALLKDAQTQLERLK--ADTPGKTLIRQLRNQLED 1831
            :.::.|: ...|.|.|    ::||||||:..|||.|.|..|..::  ..:..|..:.::.:|||.
Mouse  1822 IGTLCDQIGHRDFDVE----KRLRRDLRRTHALLSDVQLLLATIEDSKTSISKEELEKVHSQLEQ 1882

  Fly  1832 AESARSLAMKARQTAEAELTEVQAMFDESHRARNDAEERANAAHRDRAELQAQIEENEEELGELM 1896
            :|:....|:|.::...|:|..:.:..:...|:::..:|:......:||:|..:|:|::.:|.:||
Mouse  1883 SEAKCEDALKTQKVLTADLENMHSELENVTRSKSLVDEQLYRLQFERADLLKRIDEDQGDLNDLM 1947

  Fly  1897 KKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQVAELQHRLDNVENLGDPSMAMMSKRLEL 1961
            :|:...:.|...:...:.|.:.:|.|.:.|:..|:||:...|.|:..:|. .....|::| |.|.
Mouse  1948 QKHKDLIAQSAADIGQIQELQLQLEETKKEKQKLREQLHMAQLRIQYLEQ-STVERAIVS-RQEA 2010

  Fly  1962 RTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEF 2026
            ...:||::.|.::....|.||.|.|.::::.|:..|::::...|.|.::..:..|:.|.:::.|.
Mouse  2011 IICDLENKTEFQKVQIKRFEVLVIRLRDSMIKMGEELSRAVKAEAQQRENSQYYQQRLEELKAEM 2075

  Fly  2027 HAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEEELSESDESLS 2091
            ..::.||:|:..|..:|||.||::.:....|:.||..:::||||||.|:     ||:..||....
Mouse  2076 QELAQREEEASRRCMELEKYVEELATVRQTLQTDLETSIRRIADLQAAL-----EEVVSSDSDTE 2135

  Fly  2092 SVGSISDLEDRLRPVHVKRSSQQSLN---------GSIGG----------------GGGSVVSST 2131
            ||.:..|..        .||.::..|         ||:..                .|.|||||:
Mouse  2136 SVQTAVDCS--------SRSGKEGDNVSVISSQPEGSLQSWMSCSLSLATDSVRIPSGQSVVSSS 2192

  Fly  2132 RTVVFEKDDNSPRITVTSPSSPHIHKLALAAKAIPANKPDTKPAASTRMELTVP 2185
                    .:|||::..:..|..:...:.|.........|...|.|..:....|
Mouse  2193 --------FHSPRVSEEAGDSERLRTASSALSGAWDAARDASKAGSASLHPVFP 2238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_canonical 337..426 CDD:483948 26/123 (21%)
COG5022 541..2019 CDD:227355 525/1539 (34%)
MYSc_Myo18 575..1305 CDD:276837 284/771 (37%)
Myo18bNP_083177.2 PHA03247 <55..472 CDD:223021 92/505 (18%)
COG5022 606..2126 CDD:227355 542/1587 (34%)
MYSc_Myo18 625..1361 CDD:276837 284/771 (37%)

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