DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and Myo18b

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_083177.2 Gene:Myo18b / 74376 MGIID:1921626 Length:2605 Species:Mus musculus


Alignment Length:2394 Identity:699/2394 - (29%)
Similarity:1122/2394 - (46%) Gaps:404/2394 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 FMKKSAGDEDKERRKREKKLRKEA-----------------KGTSGGPGMGGVTGVTGSMSTDEL 51
            |:|:...:.:||  .:|.:.||.|                 ..|:..|..|.......|.||   
Mouse    37 FIKQLVRETEKE--SKEARRRKAAAFTAPEVEIPAVPTNQTNKTNNVPKPGSQQTSQDSSST--- 96

  Fly    52 LRLDEVRRSLKIRGR------------------RKEKEKLPSGITADYSADFFAALNADANGGSN 98
                 .:.|..|.|:                  .:.:|..|:|..|..:..|       ..|...
Mouse    97 -----TQNSADIPGKEPPGAGDKDSTPVTSTSGERPQESGPTGTPAKRTLPF-------KRGVRR 149

  Fly    99 GGA---VGAADPEQDRGNEEI----VASVMTHIESRASNGA--GVSVNYSEVTHSLLSGGLKNRF 154
            |..   |...|||..:.::::    |....|...::.|.|.  ||:...|....           
Mouse   150 GDVLLMVAKLDPELAKADQKVQPRDVPVDKTPAPAKDSGGTKKGVTTGTSSAPQ----------- 203

  Fly   155 LPPIPPKPPKRGI------LKGSRSNMTNVHEEISFAGSAGGAGGTPEMLLRNTFQNESLYEGAA 213
             |.:|.|...||:      .||.:..           |:.|.....|:.:.:...:::|..|...
Mouse   204 -PSMPEKTRTRGVGDTGQSTKGGKCQ-----------GTEGKGSRDPQTIGQKEGESQSTEEQGT 256

  Fly   214 RGAGSIGSNSSQHGTSFTS----VESLRSDGEQ--TGGQQRAMTLPANAR-YGAL---------P 262
            |.......|..|.||:...    .:.:..:.|.  .|.:.|.:..|...| :|..         |
Mouse   257 RSQAQEAGNKEQLGTAEKEGGGPPKKMEKEDEPKVAGAEVRPVEPPVPLRKWGGFLGWRSKWDSP 321

  Fly   263 QGNSQGSHLH-------VLTSPSPSADSLTDTTNSSFATPPFSLS-PVGESQGIDRWARVHAFED 319
            |...:.:..|       .|.||:      .|.:....|.|....| |.|:..|            
Mouse   322 QSKDRVTESHRKDEKTGDLQSPA------VDRSCGQLAEPTGQPSGPTGQPSG------------ 368

  Fly   320 VELPLPPVQLVKLPPPRQLVIRRQKSPRQDFGFSLRKAICLDRTESLTSPIFRPVIFAEP-GAGG 383
                          |..||    .:|..|..|          .|.....|..:|   |.| |...
Mouse   369 --------------PTGQL----SESTGQPSG----------PTGQPAGPTGQP---AGPTGQPA 402

  Fly   384 GATGLLPG------DRLIKVNG----------TPVGELPREI--IIEMIRN-------------- 416
            |.||...|      :..:|:.|          ||  ..|||:  :....:|              
Mouse   403 GPTGQPAGPTGQQQEAPVKMEGKVGRPQKKLVTP--RKPRELPGVAAKTQNPEESCKAPDRIPTT 465

  Fly   417 --SGEAVTVEVQPVAELVELSKRCMAPSTATVEEID--------H-----SITNGNCNTLRRSAS 466
              |.||...:.||.:.:....:    |...|.||:|        |     .:.....:|||....
Mouse   466 GISAEAAKRDGQPESRVQGAGE----PRVCTEEEVDVVKPQAEGHVESIPEVVMERLSTLRPMEE 526

  Fly   467 KRFKRQSRHENGNGGGEEGGAKGVGHD--LEADVADASQPERVWLVHRGGFT-AAIRLPTASSGR 528
            |:..     ::.:.||:.|.:.....|  .||        ::||||.:.||| |.:..|...:..
Mouse   527 KQIL-----QDPDRGGQSGDSDQAYEDRWYEA--------QKVWLVQKDGFTLATVLKPDEGTAD 578

  Fly   529 DEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTK 593
            ....::.|.:..:...:.|||:.|...|...||..||:..|..:||:||::.|.|||.:.|.:|.
Mouse   579 PPAGRVRLCIDADRTVIEVDEEQVHPANPSELDQAEDLASLVSVNESSVMNTLLQRYRAQLPYTC 643

  Fly   594 AGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGS 658
            :||.|:.:.|.......|.||.   || :.:.:|.||.||||.||.:|:..|||||::.:||||:
Mouse   644 SGPDLITLQPQTTTVPSSGKVP---RG-RQDGLPAHVTSLAQRAYWALLSQRRDQSIVALGRSGA 704

  Fly   659 GKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTG 723
            ||:|..:..|.:|...||:.:..::.||:.|..|:|.|||...|..:..|||...::||||:.||
Mouse   705 GKTTCCEQVLEHLVGMAGSVDGRVSVEKLRATFTVLRAFGCVSTGHSRRATRFAMVMSLDFNATG 769

  Fly   724 QIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKL 788
            ::.:|.||.:|.|..|..|:...|.:|.:.::||||....|:.||:|..: :|.|...:.|..|.
Mouse   770 RVTAAQLQTVLLENSRVARQPQGEGNFEVFSQLLAGMDVDLRTELNLHQM-AESSAFGMGLWSKP 833

  Fly   789 EDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAAR 853
            ||:.:||..|.:...|.|.|.|.....:.||.:||||||||.||..|:|     |.||.....|.
Mouse   834 EDKQKAATAFSQLRGAMELLGISEGEQQAIWRVLAAIYHLGAAGACKVG-----RKQFMRFEWAN 893

  Fly   854 KASGLLGVNLEDLSSAAF------------------GLTQPNAPNGGLSPSKSPTSDTGHEWAWE 900
            .|:..||.:.|:|::|.|                  || |.|....||..       ||    .|
Mouse   894 HAAEALGCDYEELNTATFKHHLRQIIEQMTSGPQRQGL-QDNEACSGLKM-------TG----VE 946

  Fly   901 CLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQNPASCGQQVGATLADLRHNYL 965
            |:|.:..|||.|...|||:||||...:...::||||::||||||||...|:...||..:|.:||.
Mouse   947 CVEGMASGLYQELFVAVVSLINRSFSSHHLSMASIMVVDTPGFQNPRHQGKDRAATFEELCYNYA 1011

  Fly   966 QERLQMLFHHTTLVAPRDRYAQELVEIEMDLASECHPGPLISLIDKAP-QNHVVRSSQRDLREHD 1029
            |||||:||:|.|.|:..:||.:|.:.:..|| .|..||..::::|:.| |.|:......:    |
Mouse  1012 QERLQLLFYHRTFVSTLERYKEEGIPVPFDL-PESSPGTTVAVVDQNPSQVHLPAGRGAE----D 1071

  Fly  1030 RRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDR-----EHHSLLRKCAGPRQFVLHHLQGTNPVL 1089
            ..|:.|:||||.....|:|.|.||||.:.:..:     |....:|.|..|.|..|.|..|.:||.
Mouse  1072 AGGLFWVLDEEVRVQGSSDSTVLERLRAAFEKKKEAGAEEPPSMRTCEQPLQCELFHQLGRDPVR 1136

  Fly  1090 YAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGT--QSLRR 1152
            |.:.||:|.::.:.....|..:||.|.|||:..|:   ..|.....| |.:.||||||  |:|.|
Mouse  1137 YDLTGWLRRAKPNLAALEAPQILQQSKREELQSLF---QARAKLPPV-CRAVAGLEGTSQQALHR 1197

  Fly  1153 VSSIRRSFTT--AGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYL---LQHNAGKHTKYTANG 1212
            ...:||:|.:  |.|||.:...|:|..:|.:|..|||:..||:||.:   ::..||:.|.     
Mouse  1198 SRVVRRAFASSLAAVKRKAPCAQIKLQMDALISLLRRSRLHFIHCLVPTTVESKAGQRTP----- 1257

  Fly  1213 SPSSAAGQ--VSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLAS 1275
            |||..:|.  |::|...:::|.||.||.||.:|||.||||.|:.|.:.|.:|.|||.:|...|..
Mouse  1258 SPSQPSGDQGVANEPTALDIPALRVQLAGSHILEALRLHRAGYAEHMGLAQFRRRFQVLDPALLK 1322

  Fly  1276 NKDVS---------VEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFC 1331
            ..|::         ||::|...:|:..:..:|.||:..::||:|.||.:|:.|:|..|:..||.|
Mouse  1323 KLDLTSEELDERKVVEELLKTLDLEKKAVAVGHSQVFLKAGVVSRLERQREKLVSRNIVLFQAAC 1387

  Fly  1332 RGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELL 1396
            ||:|:|::..:.:::.||..|||:|:..||.|:|||||.||..:.|||:.....|||:...|||.
Mouse  1388 RGFLSRQEYKKLKIRRLATLCIQKNLAVFLKVKDWPWWGLLASLRPLLSSTLGTEQLRAKEEELT 1452

  Fly  1397 MLRAKLEKIECDRSEVKAENQKLEAKLSELTVDLAEERSTAHIATERLEAETAERLKLEKELGDQ 1461
            :||.||:|.|..|||::.....||:|:::||.:||:||....:|.:.||:|.||||:..:|:.:.
Mouse  1453 LLRQKLQKSENSRSELRQNTDLLESKITDLTSELADERFKGDVACQALESERAERLQALREVQEL 1517

  Fly  1462 TNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDGVGGGV--YKLKYERVARELEFTKRRL 1524
            ..|.:.:|:...:::.:|..|:..:.|      |..|:...||.  ::::.:....|.:|.::||
Mouse  1518 KTKYQQVQDALGEVQKQLEEAQQRIQG------ANLEEKPAGGADEWQMRLDCAQMENDFLRKRL 1576

  Fly  1525 HTQHEHDLEQLVALKKHLEMKLSD---AYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNA 1586
            . |.|..|:..:..:..||.||.:   ||||.   :::..|.|||...:|.::.|.|:|||.|.:
Mouse  1577 Q-QCEERLDSEMKARTELEQKLGELQSAYEEA---KKMAHQLKRKCHHLTWDLEDTRVLLENQQS 1637

  Fly  1587 RNNLLEKKQRKFDAE-CQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEK 1650
            ||:.|||:|:|||.: .|:|.::: .|:..:|:..:|.:.::.|...|:|       .||.||::
Mouse  1638 RNHELEKRQKKFDLQLAQALGESM-FEKSLREKVSQENNGVRWELGQLQQ-------QLEQKEQE 1694

  Fly  1651 LASLQRELEEMTFGGGTEEEF-----------AQLRRSKNETERRAKEQEEELDEMAGQIQLLEQ 1704
            .:.|::|:|.:.   |.:.|.           |.|:....|.|..|.||::...:....|:.|||
Mouse  1695 ASKLKQEVERLQ---GQKRELLSCASVGDQGVASLKERVWELETNALEQQKIHSQQENTIKQLEQ 1756

  Fly  1705 AKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERR 1769
            .:.|.|:.:|.|::..:::.:.::||||:||.:..|:::.||.|||.|:||:.:.|.|||:||..
Mouse  1757 LRQRFELEIERMKQMHQKDREDQEEELEDVRQSCQKRLRQLEMQLEQEYEEKQVALHEKHDLEGL 1821

  Fly  1770 LSSMEDR-DRVDRDAEEALNQKLRRDLRKYKALLKDAQTQLERLK--ADTPGKTLIRQLRNQLED 1831
            :.::.|: ...|.|.|    ::||||||:..|||.|.|..|..::  ..:..|..:.::.:|||.
Mouse  1822 IGTLCDQIGHRDFDVE----KRLRRDLRRTHALLSDVQLLLATIEDSKTSISKEELEKVHSQLEQ 1882

  Fly  1832 AESARSLAMKARQTAEAELTEVQAMFDESHRARNDAEERANAAHRDRAELQAQIEENEEELGELM 1896
            :|:....|:|.::...|:|..:.:..:...|:::..:|:......:||:|..:|:|::.:|.:||
Mouse  1883 SEAKCEDALKTQKVLTADLENMHSELENVTRSKSLVDEQLYRLQFERADLLKRIDEDQGDLNDLM 1947

  Fly  1897 KKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQVAELQHRLDNVENLGDPSMAMMSKRLEL 1961
            :|:...:.|...:...:.|.:.:|.|.:.|:..|:||:...|.|:..:|. .....|::| |.|.
Mouse  1948 QKHKDLIAQSAADIGQIQELQLQLEETKKEKQKLREQLHMAQLRIQYLEQ-STVERAIVS-RQEA 2010

  Fly  1962 RTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEF 2026
            ...:||::.|.::....|.||.|.|.::::.|:..|::::...|.|.::..:..|:.|.:::.|.
Mouse  2011 IICDLENKTEFQKVQIKRFEVLVIRLRDSMIKMGEELSRAVKAEAQQRENSQYYQQRLEELKAEM 2075

  Fly  2027 HAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEEELSESDESLS 2091
            ..::.||:|:..|..:|||.||::.:....|:.||..:::||||||.|:     ||:..||....
Mouse  2076 QELAQREEEASRRCMELEKYVEELATVRQTLQTDLETSIRRIADLQAAL-----EEVVSSDSDTE 2135

  Fly  2092 SVGSISDLEDRLRPVHVKRSSQQSLN---------GSIGG----------------GGGSVVSST 2131
            ||.:..|..        .||.::..|         ||:..                .|.|||||:
Mouse  2136 SVQTAVDCS--------SRSGKEGDNVSVISSQPEGSLQSWMSCSLSLATDSVRIPSGQSVVSSS 2192

  Fly  2132 RTVVFEKDDNSPRITVTSPSSPHIHKLALAAKAIPANKPDTKPAASTRMELTVP 2185
                    .:|||::..:..|..:...:.|.........|...|.|..:....|
Mouse  2193 --------FHSPRVSEEAGDSERLRTASSALSGAWDAARDASKAGSASLHPVFP 2238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492 24/121 (20%)
MYSc 556..1317 CDD:214580 297/802 (37%)
MYSc_Myo18 575..1305 CDD:276837 284/771 (37%)
GBP_C <1540..1750 CDD:303769 70/224 (31%)
COG1340 1565..1833 CDD:224259 91/282 (32%)
coiled coil 1723..1734 CDD:293879 4/10 (40%)
Myo18bNP_083177.2 PHA03247 <55..472 CDD:223021 92/505 (18%)
COG5022 606..2126 CDD:227355 542/1587 (34%)
MYSc_Myo18 625..1361 CDD:276837 284/771 (37%)
CEP170_C 2123..>2365 CDD:373735 28/137 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 231 1.000 Domainoid score I2423
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm44019
orthoMCL 1 0.900 - - OOG6_105087
Panther 1 1.100 - - LDO PTHR45615
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3038
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
98.770

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