DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and Grip1

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:XP_006514294.1 Gene:Grip1 / 74053 MGIID:1921303 Length:1185 Species:Mus musculus


Alignment Length:1238 Identity:231/1238 - (18%)
Similarity:388/1238 - (31%) Gaps:393/1238 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   159 PPKPPKRG----ILKGSRSNMTNVHEEISFAGSAGGAGGTPEMLLRNTFQNESLYEGAAR----- 214
            |.:||::.    ..:..|:.|.    .:||....        .:||...::||.|..:|.     
Mouse    38 PLQPPEQSPCVHFAREQRARMI----AVSFKCRC--------QILRRLTKDESPYTKSASQTKPP 90

  Fly   215 -GAGSIGSNS-SQHGTSFTSVESLRSDGEQTG----------GQQRAMTLPANARYGALPQGNSQ 267
             ||.::...| .:.....|.||.::.:|...|          |:.|.    :|.|.|.:...:.|
Mouse    91 DGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRV----SNLRQGGIAARSDQ 151

  Fly   268 ---GSHLHVLTSPSPSADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQL 329
               |.::..:     :..:|....:....:   .|..|||          ....:||..||||.:
Mouse   152 LDVGDYIKAV-----NGINLAKFRHDEIIS---LLKNVGE----------RVVLEVEYELPPVSV 198

  Fly   330 VKLPPPRQLVIRRQKSPRQDFGFSLRKAICLDRTESLTSPIFRPVIF--AEPGAGGGATGLL-PG 391
            .......:.|..........|||.:|.....||.:|      |||:.  ..||......|.: ||
Mouse   199 QGSSVMFRTVEVTLHKEGNTFGFVIRGGAHDDRNKS------RPVVITCVRPGGPADREGTIKPG 257

  Fly   392 DRLIKVNGTPVGELPREIIIEMIRNSGEAVTVEVQ--------------PVAELVELSKRCMAPS 442
            |||:.|:|..:........:.:::..|:..|:.::              |:  |||::|   .|.
Mouse   258 DRLLSVDGIRLLGTTHAEAMSILKQCGQEATLLIEYDVSVMDSVATASGPL--LVEVAK---TPG 317

  Fly   443 TATVEEIDHSITNGNCNTLRRSASKRFKRQSRHENGNGGGEEGGAKGVG-HDLEAD--------V 498
            .:    :..::|...|...:.....:.|..|.       .:..||..|| |.|..|        :
Mouse   318 AS----LGVALTTSVCCNKQVIVIDKIKSASI-------ADRCGALHVGDHILSIDGTSMEYCTL 371

  Fly   499 ADASQPERVWLVHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTV-DEDDVEKQNSPALDL 562
            |:|:|           |.|         ...::.||.: |.|:..:|.: ..|.|:.|.|.    
Mouse   372 AEATQ-----------FLA---------NTTDQVKLEI-LPHHQTRLALKGPDHVKIQRSD---- 411

  Fly   563 VEDICELKYLNEASVLHCLRQR----YASNL--IHT-------------------------KAGP 596
                               ||.    :|||.  :||                         .:.|
Mouse   412 -------------------RQHPWDAWASNQCGVHTNHHHNTYHPDHCRVPALTFPKALPPNSPP 457

  Fly   597 TLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQ--TAYRSLVETRRDQSLIFMGRSGSG 659
            .::..:....:|.||...::|      ..:|..:||.:.  |..|..::.:..:|.:.:..|..|
Mouse   458 AMVPSSSPTSMSAYSLSSLNM------GTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVG 516

  Fly   660 KSTSFKHA-LNYLALAAGAYNNF----------------------INAEKVNALCTILE------ 695
            .:....|. ...:.|.|.....|                      |.|:.....|.:|:      
Mouse   517 LAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVM 581

  Fly   696 ----------AFGNTKTCLNSNATRMTQLLSLDFDQTGQI--ASASLQVLLPERQR--------- 739
                      .|......|..::......|.::||....:  :|.:..|.||::..         
Mouse   582 AINGIPTEDSTFEEANQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHSVELGITISS 646

  Fly   740 -AGRRLGHEHSF-HIMTRLLAGAAGLLQ--------KELHLENITSEDSHPFISLSQKLE----- 789
             :.|:.|..... .|....:|...|.|:        ..:.|:|.:.||:   :.:.|:.|     
Mouse   647 PSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDA---VQILQQCEDLVKL 708

  Fly   790 ---------DRHRAANDFMRTV-----------------QAFETLNIDAKAVRGIWSILAAIYHL 828
                     |...::...:.||                 :.|:.:.|.:....|:.....|| |:
Mouse   709 KIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAI-HI 772

  Fly   829 G--IAGVTKLG---------------TGSTARTQFANPTAARKA-----------SGLLGVNLED 865
            |  |..:....               .|.|...:....|.|:.|           ||.||...||
Mouse   773 GDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPIPGHSGDLGDGEED 837

  Fly   866 LSSAAFGLTQPNAPNGGLS---PSKSPTSDTG-HEWAWECLEALVIGLYSEALAAVVALINRQIC 926
            .|        |....|.||   ||..|:.|:. ..|....::| ..|.............|....
Mouse   838 PS--------PIQKPGKLSDAYPSTVPSVDSAVDSWDGSGIDA-SYGSQGSTFQTSGYNYNTYDW 893

  Fly   927 TSSHTIASIMLIDTPGFQNPASCGQQ------------VGAT---LADLRHNYLQERLQML--FH 974
            .|.....|:..:..|..|.....|..            |||:   .|:...|:..:.|:.|  ..
Mouse   894 RSPKQRTSLSPVPKPRSQTYPDVGLSNEDWDRSTASGFVGASDSADAEQEENFWSQALEDLETCG 958

  Fly   975 HTTLVAPRDRYAQELVEI-EMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLD 1038
            .:.::...:..|...|.: .|.|.:....|..:||..:||   :.||.               |.
Mouse   959 QSGILRELEEKADRRVSLRNMTLLATIMSGSTMSLNHEAP---MARSQ---------------LG 1005

  Fly  1039 EEAIYPNSNDDTFLERLFS--HYGDREHHSLLRKCAGPRQFVLH-------HLQGTNPV-LYAVD 1093
            .:|        :|.||..|  ||......:.|....|.:...|.       .:....|| |:.|.
Mouse  1006 RQA--------SFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVT 1062

  Fly  1094 GWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIR- 1157
            .:.....|..|...|..||:..       :|:.:: |.:|.    |...||:....|.:|:.:| 
Mouse  1063 LYKDSGMEDFGFSVADGLLEKG-------VYVKNI-RPAGP----GDVGGLKPYDRLLQVNHVRT 1115

  Fly  1158 RSF 1160
            |.|
Mouse  1116 RDF 1118

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492 23/89 (26%)
MYSc 556..1317 CDD:214580 139/790 (18%)
MYSc_Myo18 575..1305 CDD:276837 138/771 (18%)
GBP_C <1540..1750 CDD:303769
COG1340 1565..1833 CDD:224259
coiled coil 1723..1734 CDD:293879
Grip1XP_006514294.1 PDZ_signaling 110..190 CDD:238492 16/101 (16%)
PDZ_signaling 209..292 CDD:238492 22/88 (25%)
PDZ_signaling 307..390 CDD:238492 24/119 (20%)
PDZ_signaling 526..614 CDD:238492 10/87 (11%)
PDZ_signaling 627..711 CDD:238492 15/86 (17%)
PDZ_signaling 727..808 CDD:238492 12/81 (15%)
PDZ_signaling 1058..1138 CDD:238492 18/73 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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