Protein Alignment Mhcl and Pard3b

DIOPT Version :9

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: XP_006496361.1
• Gene: Pard3b / 72823
• MGIID: 1919301
• Length: 1238
• Species: Mus musculus
• Alignment Length: 1145
• Identity: 222/1145 - (19%)
• Similarity: 364/1145 - (31%)
• Gaps: 407/1145 - (35%)

  Fly  1125 IGSLTRGSGAMVFC---GSFAGLEGTQSLRRVSSIRRSFTTA------GVKRNSIMLQVKFTVD- 1179
            :|...||......|   |.|...|....:..|..:.::|..|      .:|..|::|.|....:
Mouse   264 LGLFIRGIEENSRCKQEGLFQENECIVKINNVELLDKTFAQAQDVFRQAMKSPSVILHVLLPQNR 328

  Fly  1180 -----GIIDTLRRTGTHFVHCYLLQHNAGKHTKYT--ANGSPSSAAGQV----SSEEEMVNVPLL 1233
                 .:|..|...|         .::....||..  |.|.|...|..:    |.|.|....|
Mouse   329 EQYEKSVIGPLNIFG---------NNDGASRTKAAPPARGKPGLKAVHLTRASSPEGEEPASP-- 382

  Fly  1234 RSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLASNKDVSVEQI----------LAVN 1288
                   |..::.|:.|||...|.|.|..:..||       |.|:....:|          ..|.
Mouse   383 -------QQSKSPRVPRLGRKPSSPSLSPLMGFG-------SKKNAKKIKIDLKKGPEGLGFTVV 433

  Fly  1289 ELDVASYRIGPSQILFRSGVLSELEAKRDVLL--SDRIIQLQAFCRGYLARKKMSQRRVQELAVR 1351
            ..|.:.:..||   :|...:|.:..|.:|..|  .|||:::..
Mouse   434 TRDSSIHGPGP---IFVKNILPKGAAVKDGRLQSGDRILEVNG---------------------- 473

  Fly  1352 CIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAEN 1416
               |:|..                       ||:|:|      :.|||:
Mouse   474 ---RDVTG-----------------------RTQEEL------VAMLRS---------------- 490

  Fly  1417 QKLEAKLSELTVDLAEERSTAHIATERLEA---------ETAERLKLEKELGDQTN-------KV 1465
                .|..| ||.|...|.........|:.         |::|:|.||..|.|..:       |.
Mouse   491 ----TKQGE-TVSLVIARQEGSFLPRELKGEPDCYALSLESSEQLTLEIPLNDSGSAGLGVSLKG 550

  Fly  1466 KNLQETTEKLEMELICAKSDLNGISEDEDAE---NED--GVGGGVYKLKYERVARELEFTKRRLH 1525
            ...:||...|.   |..||.::|.:..:|..   |:.  .|.|.....|....|.|   |.||..
Mouse   551 NKSRETGTDLG---IFIKSIIHGGAAFKDGRLRMNDQLIAVNGETLLGKSNHEAME---TLRRSM 609

  Fly  1526 TQHEH--DLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWKR------KAQKMTNEMNDLRML-- 1580
            :...:  .:.|||.|::.         |..:|:....|...|      :....|:..||..:|
Mouse   610 SMEGNIRGMIQLVILRRP---------ERPLEELSECGALSRPGFENCQEALSTSRRNDSSILYP 665

  Fly  1581 ---LEEQNARNNLLEKKQRKFDAECQ-----------SLQD------------------------ 1607
               ...|:.|.:||.......:.|..           .|:|
Mouse   666 FGTYSPQDKRKDLLLPSDGWAENEVPPSPPPHPALEWGLEDFSHSSGVDSTGYFPDQHVNFRTVT 730

  Fly  1608 AVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLD---LEF-------KEEKLASLQRELEE-- 1660
            .|||......:..:..|::..|...  |:|||.|.|   .:|       |...|.|||..:.|
Mouse   731 PVRQPELINLKASKSMDLVPDEGKV--QSLADRRSDSPGKDFGPTLGLKKSSSLESLQTAVAEVR 793

  Fly  1661 ------------MTFGGGTEEEF-AQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMT 1712
                        |..|.|..|.| |.:.:|.:..|....:...:....:|...|..::..:....
Mouse   794 KNDLPFHRPRPHMVRGRGCNESFRAAIDKSYDGPEEADADGLSDKSSRSGHTALNCESAPQGNPE 858

  Fly  1713 LETMRKEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERRLSSMEDRD 1777
            |:.:..:|:  :.::.:|.|:.:|.|  |:|..|.:|:.|||
Mouse   859 LDNVENKAK--NIKKTKEKEKKKGKG--KLKVKEKKLKEEHE----------------------- 896

  Fly  1778 RVDRDAEEALNQKLRRDLRKYKALLKDAQTQLERL-KADTPGKTLIRQLRNQLEDAESARSLAMK 1841
                |||    :|::|  :.:.|:|:..:.:.::: ||:..|
Mouse   897 ----DAE----RKMKR--KGFGAMLRFGKKKDDKVGKAEQKG----------------------- 928

  Fly  1842 ARQTAEAELTEVQAMFDESHRARNDAEERANAAHRDRAELQAQIEENEEELGELMKKYSATVKQL 1906
            |:::...|..|::.|.:|        .||..|.|::..|.||:      .|.:.....:..|..:
Mouse   929 AQKSGHPEEEELERMKEE--------RERIGAKHQELREKQAR------GLVDYATAVTGPVHDM 979

  Fly  1907 NTEQINVSEAEFKLNEMEAERNNLKEQVAELQHRLDNVENLGDP----SMAMMSKRLELRTKELE 1967
            :.::::.:.|..         |:.:|..|..     ||.....|    .:|.......|....||
Mouse   980 DDDEMDPNYARV---------NHFREPCASA-----NVFRSPSPLRAGPLAYPRDGRPLSPDHLE 1030

  Fly  1968 SRLELEQATRARLEVQVNR--HKEAL--------------EKLQNEVTQSKMRE--MQAQDVIKK 2014
            .           |..:||:  |..||              :||:.|..|:: ||  :..:|...:
Mouse  1031 G-----------LYAKVNKPYHPPALADSGRPMAGTTDRIQKLRKEYYQAR-REGFLLYEDENTR 1083

  Fly  2015 SQKSLRDMREEFHAVSSREQESLT---RRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAME 2076
            ::.|..|:|    .||.:..:..|   |.:.:|::...:...|:|...|...|..|
Mouse  1084 ARPSDHDLR----WVSGKGPDGSTHNLRFEGMERQYASLPRGGSADPVDYLTASPR--------- 1135

  Fly  2077 EEGEEELSESDESLSSVGSISDLE----DRLRPVHVKRSS 2112
                             |..:|.|    ....|||..|.|
Mouse  1136 -----------------GRYNDRELPYYPGPHPVHAPRGS 1158

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	47/222 (21%)
		MYSc_Myo18	575..1305	CDD:276837	44/210 (21%)
		GBP_C	<1540..1750	CDD:303769	52/280 (19%)
		COG1340	1565..1833	CDD:224259	63/339 (19%)
		coiled coil	1723..1734	CDD:293879	2/10 (20%)
Pard3b	XP_006496361.1	DUF3534	2..74	CDD:338230
		PDZ_signaling	236..323	CDD:238492	13/58 (22%)
		PDZ	415..504	CDD:214570	27/166 (16%)
		PDZ_signaling	536..624	CDD:238492	23/93 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900