DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and Ush1c

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_710143.2	Gene:	Ush1c / 72088	MGIID:	1919338	Length:	910	Species:	Mus musculus

Alignment Length:	325	Identity:	66/325 - (20%)
Similarity:	128/325 - (39%)	Gaps:	75/325 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1437 AHIATERLEAETAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDGV 1501
            :|:....|.||..      .|.|||..:|..:..|.       :..|..:|.:............
Mouse   239 SHVKPGSLSAEVG------LETGDQIVEVNGIDFTN-------LDHKEAVNVLKSSRSLTISIVA 290

  Fly  1502 GGGVYKLKYERVARELEFTKR-RLHTQHEHDLE-QLVALKKHLEMKLSDAYEEVVEQRQVVGQWK 1564
            |.|          |||..|.| ||....:.:|: |.:.::|.|.|:.:    ::::::|.:.:.:
Mouse   291 GAG----------RELFMTDRERLEEARQRELQRQELLMQKRLAMESN----KILQEQQEMERQR 341

  Fly  1565 RK--AQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQ 1627
            ||  |||...|....|..:|:       :.:::.||             ::|.||.:|.::.::.
Mouse   342 RKEIAQKAAEENERYRKEMEQ-------ISEEEEKF-------------KKQWKEDWGSKEQLIL 386

  Fly  1628 AEKFTLEQTLADTRLDLEF-----KEEKLASLQRELEEMTFGGGTEEEFAQLRRSKNETERRAK- 1686
            .:..|.|......|....|     .:.|..:::::.:|..  ....:....||::|.|.|...|
Mouse   387 PKTITAEVHPVPLRKPKSFGWFYRYDGKFPTIRKKAKEKK--KAKYDSLQDLRKNKKELEFEQKL 449

  Fly  1687 -EQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKALECQLE 1750
             :::||:.|...|:::               .:.|:..|:...|:|||.....|...:..:.:||
Mouse   450 YKEKEEMLEKEKQLKI---------------NRLAQEVSETEREDLEESEKTQYWVERLCQTRLE 499

Fly 1751 1750
Mouse 500 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769	41/218 (19%)
		COG1340	1565..1833	CDD:224259	39/195 (20%)
		coiled coil	1723..1734	CDD:293879	4/10 (40%)
Ush1c	NP_710143.2	N-terminal domain. /evidence=ECO:0000250\|UniProtKB:Q9Y6N9	1..86
		harmonin_N	2..80	CDD:259819
		PDZ_signaling	85..165	CDD:238492
		Mediates interaction with MYO7B. /evidence=ECO:0000250\|UniProtKB:Q9Y6N9	194..833		66/325 (20%)
		PDZ_signaling	209..289	CDD:238492	12/62 (19%)
		Cgr1	<309..>358	CDD:281823	12/52 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..688
		PDZ_signaling	751..838	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	890..910
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900