DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and Myh14

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001258467.1 Gene:Myh14 / 71960 MGIID:1919210 Length:2033 Species:Mus musculus


Alignment Length:1987 Identity:526/1987 - (26%)
Similarity:843/1987 - (42%) Gaps:478/1987 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   497 DVADASQPERVWLVHR--------GGFTAAIRLPTASSGRDE-ENKLSLRLLHNGEQLTVDEDDV 552
            :|.....|:..|...|        .||.||       :.||| |.:..:.|..:|.:|.:..|.:
Mouse    35 NVGGPGGPQVEWTARRMVWVPSELHGFEAA-------ALRDEGEEEAEVELAESGRRLRLPRDQI 92

  Fly   553 EKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSM 617
            ::.|.|.....||:.||..||||||||.||:||.|.||:|.:|...:|:||...|.:|:|.:|.|
Mouse    93 QRMNPPKFSKAEDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEM 157

  Fly   618 FRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAA----GAY 678
            :||.|..::|||||::.:.||||:::.|.|||::..|.||:||:.:.|..:.|||..|    |..
Mouse   158 YRGKKRHEVPPHVYAVTEGAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSPKGRK 222

  Fly   679 NNFINAEKVNALC---TILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRA 740
            ...:..|....|.   .|||||||.||..|.|::|..:.:.::||..|.|..|:::..|.|:.||
Mouse   223 EPGVPGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDIAGYIVGANIETYLLEKSRA 287

  Fly   741 GRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSH-------PFISLSQKLEDRHRAANDF 798
            .|:...|.||||..:||.||...|:.:|.||..    ||       |..|..|:.|       .|
Mouse   288 IRQAKDECSFHIFYQLLGGAGEQLKADLLLEPC----SHYRFLTNGPSSSPGQERE-------LF 341

  Fly   799 MRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNL 863
            ..|:::...|.:..:.:..:...::|:...|...:.|  ..:|.:....:.|||:|...|||:.:
Mouse   342 QETLESLRVLGLLPEEITAMLRTVSAVLQFGNIVLKK--ERNTDQATMPDNTAAQKLCRLLGLGV 404

  Fly   864 EDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTS 928
            .|.|.|   |..|....|.....|:.|.    |.|...||||....|......:|..:||.:..|
Mouse   405 TDFSRA---LLTPRIKVGRDYVQKAQTK----EQADFALEALAKATYERLFRWLVLRLNRALDRS 462

  Fly   929 SHTIASIM-LIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE 988
            ....||.: ::|..||:    |          :...|..||..|:||.||:||..|..::.|.:|
Mouse   463 PRQGASFLGILDIAGFEIFQLN----------SFEQLCINYTNEKLQQLFNHTMFVLEQEEYQRE 517

  Fly   989 -----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSND 1048
                 .::..:||.      |.|.||:: |.|              ..|:|.|||||..:|.:.|
Mouse   518 GIPWTFLDFGLDLQ------PCIDLIER-PAN--------------PPGLLALLDEECWFPKATD 561

  Fly  1049 DTFLERLFSHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQ 1113
            .:|:|::....|........|.......|.:.|..|  .|.|....|:..:.: |...|..:||.
Mouse   562 KSFVEKVAQEQGSHPKFQRPRNLRDQADFSVLHYAG--KVDYKASEWLMKNMD-PLNDNVAALLH 623

  Fly  1114 DSS--------REEINRL----YIGSLTR---------GSGAM-VFCGSFAG--LEGTQSLRRVS 1154
            .|:        ::|...|    .:||...         ||||. ...||...  :||...|.:||
Mouse   624 QSTDRLTAEIWKDEQGGLQQFTLLGSFPSPSPGPAGRLGSGASPPGVGSLCAPTVEGIVGLEQVS 688

  Fly  1155 SI----------RRSFTTAGVKRNSIMLQV-KFTVDGIIDTLRRTGTHFVHCYLLQH--NAGKHT 1206
            |:          |..|.|.|        |: |.::..::.||..|...||.|.:..|  .|||  
Mouse   689 SLGDGPPGGRPRRGMFRTVG--------QLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGK-- 743

  Fly  1207 KYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAG 1271
                                 :...|:..|||.:.|||..|:.|.|||..:...||.:|:.:|..
Mouse   744 ---------------------LEPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYEILTP 787

  Fly  1272 D-----LASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFC 1331
            :     ....|. :.|:::...|||...||:|.|:|.||:|||::||.:||:.::|.|:..||..
Mouse   788 NAIPKGFMDGKQ-ACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAA 851

  Fly  1332 RGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELL 1396
            ||||||:...:|:.|:.|:|.:|||..|:|.:|:|.||||.::|.|||.|.|.:|.|:...:||.
Mouse   852 RGYLARRAFQRRQQQQSALRVMQRNCAAYLKLRNWQWWRLFIKVKPLLQVTRQDEVLQARAQELQ 916

  Fly  1397 M--------------LRAKLEKIECDRSEVKAENQKLEAKL----SELTVDLAEERSTAHIATER 1443
            .              |:.::.::|.:|:.: ||..:.||:|    .|....||..:....:....
Mouse   917 KVQELQQQSAREVGELQGRVAQLEEERTRL-AEQLRAEAELCSEAEETRARLAARKQELELVVTE 980

  Fly  1444 LEAETAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKL 1508
            |||...|..:..::|  |:.| |.||:..::||..|              :||.     |...||
Mouse   981 LEARVGEEEECSRQL--QSEK-KRLQQHIQELESHL--------------EAEE-----GARQKL 1023

  Fly  1509 KYERVARELEFTKRRLHTQHEHDL----EQLVALKKH---LEMKLSDAYEEVVEQRQVVGQWKRK 1566
            :.|:|..|.:..|      .|.||    :|...|.|.   ||.:|::...:..|:.:.|....:.
Mouse  1024 QLEKVTTEAKMKK------FEEDLLLLEDQNSKLSKERRLLEERLAEFSSQAAEEEEKVKSLNKL 1082

  Fly  1567 AQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQD-AVRQERQAKE---RYGREKDVLQ 1627
            ..|....::|:...|:::......|||.:|:.|.|...||: .|.|:::|:|   :.||::|.||
Mouse  1083 RLKYEATISDMEDRLKKEEKGRQELEKLKRRLDGESSELQEQMVEQKQRAEELLAQLGRKEDELQ 1147

  Fly  1628 AEKFTLEQT-----------------LADTRLDLEFKE--------------EKLASLQRELEEM 1661
            |.....|:.                 ||:.:.|||.:.              |:|.:|:.|||:.
Mouse  1148 AALLRAEEEGGARAQLLKSLREAQAGLAEAQEDLEAERVARAKAEKQRRDLGEELEALRGELEDT 1212

  Fly  1662 TFGGGTEEEFAQLRRSKNETE----RRAKEQE----------------EELDEMAGQIQ------ 1700
            ......::|.    |||.|.|    ::|.|:|                :.|.|||.|::      
Mouse  1213 LDSTNAQQEL----RSKREQEVTELKKALEEESRAHEVSMQELRQRHSQALVEMAEQLEQARRGK 1273

  Fly  1701 -LLEQAKLRLE----------MTLETMRKEARRESQQRDEELEEVRG----------NGYKKIKA 1744
             :.|:.:|.||          .:|:|.|:|..::.::.:.:|:||:|          ...:|::.
Mouse  1274 GVWEKTRLSLEAEVSELKAELSSLQTSRQEGEQKRRRLESQLQEVQGRSSDSERARSEAAEKLQR 1338

  Fly  1745 LECQLE------TEHEERTL------------------LLREKHELERRLSS------------- 1772
            .:.:||      :|.|.:.:                  ||:|:...:..|.|             
Mouse  1339 AQAELESVSTALSEAESKAIRLGKELSSAESQLHDTQELLQEETRAKLALGSRVRALEAEAAGLR 1403

  Fly  1773 --MED----RDRVDRDAE--EALNQKLRRDLRKYKALL-----------KDAQTQLERLKADTPG 1818
              ||:    |:|..|:.:  :|...:.||...:..|:|           ::|:|..:||...|..
Mouse  1404 EQMEEEVVARERAGRELQSTQAQLSEWRRRQEEEAAVLEAGEEARRRAAREAETLTQRLAEKTEA 1468

  Fly  1819 KTLI----RQLRNQLEDA---------------------------ESARSL-AMKARQTAEAELT 1851
            ...:    |:|:.:|:||                           |.|..| |::.|:..|||..
Mouse  1469 VERLERARRRLQQELDDATVDLGQQKQLLSTLEKKQRKFDQLLAEEKAAVLRAVEDRERIEAEGR 1533

  Fly  1852 EVQA-------MFDESHRARNDAEERANAAHRDRAELQA------QIEENEEELGELMKKYSATV 1903
            |.:|       ..:|...||.:.|.:..|.   ||||:|      .:.:|..||....|......
Mouse  1534 EREARALSLTRALEEEQEAREELERQNRAL---RAELEALLSSKDDVGKNVHELERARKAAEQAA 1595

  Fly  1904 KQLNTEQINVSEAEFKLNEMEAERNNLKEQVAEL--QHR--LDNVENLGDPSMAMMSKRL---EL 1961
            ..|.|:   |:|.|.:|...|..:..|:..|..|  ||.  |...::.|:.....::|:|   |:
Mouse  1596 SDLRTQ---VTELEDELTAAEDAKLRLEVTVQALKAQHERDLQGRDDAGEERRRQLAKQLRDAEV 1657

  Fly  1962 RTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEF 2026
            ...|...:..|..|.|.:||::       ||:|:.:.:.:...:.:|...:||.|..::::..|.
Mouse  1658 ERDEERKQRALAMAARKKLELE-------LEELKAQTSAAGQGKEEAVKQLKKMQVQMKELWREV 1715

  Fly  2027 HAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEE----ELSES- 2086
            ....|...|..|..::.|||::.:|:|...|:.:|..:.:.....||..:|..||    .||:: 
Mouse  1716 EETRSSRDEMFTLSRENEKKLKGLEAEVLRLQEELAASDRARRQAQQDRDEMAEEVASGNLSKAA 1780

  Fly  2087 --DESLSSVGSISDLEDRLRPVHVKRSSQQSLNGSIGGGGGSVVSSTRTVVFEKDDNSPRITVTS 2149
              :|.....|.:|.||:.|.                                |:.:||..:    
Mouse  1781 TLEEKRQLEGRLSQLEEELE--------------------------------EEQNNSELL---- 1809

  Fly  2150 PSSPHIHKLALAAKA----IPANKPDTKPAASTRMEL 2182
              ..|..||.|..::    :.|.:..:..|.|.|.:|
Mouse  1810 --KDHYRKLVLQVESLTTELSAERSFSAKAESGRQQL 1844

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 250/826 (30%)
MYSc_Myo18 575..1305 CDD:276837 234/795 (29%)
GBP_C <1540..1750 CDD:303769 66/294 (22%)
COG1340 1565..1833 CDD:224259 89/436 (20%)
coiled coil 1723..1734 CDD:293879 1/10 (10%)
Myh14NP_001258467.1 Myosin_head 104..825 CDD:278492 241/806 (30%)
MYSc_Myh14_mammals 115..825 CDD:276893 234/795 (29%)
Myosin_tail_1 902..1982 CDD:279860 228/1027 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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