DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and Dlg5

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:XP_017171686.1 Gene:Dlg5 / 71228 MGIID:1918478 Length:1931 Species:Mus musculus


Alignment Length:1020 Identity:205/1020 - (20%)
Similarity:351/1020 - (34%) Gaps:305/1020 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1342 QRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNV---------HRTEEQLKTANEELLM 1397
            |||  ||..:|.|...:|...|.         .|..||..         .:.:|:...|..|||:
Mouse     4 QRR--ELLAQCQQSLAQAMTEVE---------AVLGLLEAAGALSPGERRQLDEEAGGAKAELLL 57

  Fly  1398 -------------LRAKLEKIECDRSEVKAEN------QKLE------AKLSELTVDLAEERSTA 1437
                         |||.|||.:.....:...|      |..|      :.||.:..|.....|.:
Mouse    58 QLLLAKEQDHFQDLRAALEKTQPHLLPILYLNGVVGPPQSTEGAGSTYSVLSIMPSDSESSSSLS 122

  Fly  1438 HIATE------------------------RLEAETAERLKLEKELGDQTN-------KVKNLQET 1471
            .:.|.                        :|...|.||.:|.|.|...|:       ....|...
Mouse   123 SVGTTGKAPSPPPLLTEQQANDTVENLSIQLRLMTRERNELRKRLAFATHGATFDKRPYHRLNPD 187

  Fly  1472 TEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQLV 1536
            .|:|:::.:.|.|||..:........:          :.|.||:|.:|    .||.|...|....
Mouse   188 YERLKIQCVRAMSDLQSLQNQHTNALK----------RCEEVAKETDF----YHTLHSRLLSDQT 238

  Fly  1537 ALKKHLEMKLSDAYEEVVEQRQVVGQ-W---KRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRK 1597
            .||..::| |.....::..:|.::.| |   ||..::...|:.|||...::....|...|...:.
Mouse   239 QLKDDVDM-LRRENGKLRRERNLLQQSWEDMKRLREEDQKEIGDLRAQQQQVLKHNGSSEILNKL 302

  Fly  1598 FDAECQSLQ------DAVRQERQAK-----------ERYGREKDVLQAEKFTLEQTLADTRLDLE 1645
            :|.....|:      ||:|:....|           |:.|.|...||.:...|.|. .||.:.|:
Mouse   303 YDTAMDKLEVVKKDYDALRKRYSEKVAMHNSDLSRLEQLGEENQRLQKQTEMLTQQ-RDTAIQLQ 366

  Fly  1646 ----FKEEKLASLQRELEEMTFGGG--------TEEEFAQLRRSKNETERRAKEQEEELDEMAGQ 1698
                ....:..::..||.:.|....        .:.|..:||..:.:|.:.:::.:||.|.:..:
Mouse   367 HQCALSLRRFETIHHELSKATAQNKDLQWEMELLQSELTELRSKQVKTAKESEKYKEERDAVYSE 431

  Fly  1699 IQLL---------EQAKLRLEMTL-ETMRKEARRESQQRDEELEEVR----------GNGYKKIK 1743
            .:|:         |..||:.|:.| |:..|.:..|.:...||:|.:|          |...|:::
Mouse   432 YKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAASEEMEALRQIKDTVTMDAGRANKEVE 496

  Fly  1744 ALECQLETEHEERTLLLREKHELE-RRLSSMEDRDRV--DRDAEEALNQKLRRDLRKYKALLKDA 1805
            .|..|.:...:|....|:|....: ||..:.::||::  :||:...|...|||:           
Mouse   497 ILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRE----------- 550

  Fly  1806 QTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHRARNDA--- 1867
                                                 |..|.:||.|.....|::.:.:||.   
Mouse   551 -------------------------------------RDRAVSELAEALRSLDDTRKQKNDVSRE 578

  Fly  1868 -EERANAAHRDRAELQAQIEENEEELGELMKKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLK 1931
             :|..:..||::.|.|.   |.|....:||...|      :...|:....|::...:|.||..  
Mouse   579 LKELNSCVHREQMECQL---EKEARFRQLMAHSS------HDSAIDTDSMEWETEVVEFERET-- 632

  Fly  1932 EQVAELQHRLDNVENLGDPSM--------------AMMSKRLE-----LRTKELE-SRLELEQAT 1976
            |.:.......|..|.:.:|..              ::...||.     ||..::: ...:.:||.
Mouse   633 EDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRVNDWLLRINDVDLINKDKKQAI 697

  Fly  1977 RARL------EVQVNRHKEALEKLQN--EVTQSKMREMQAQD-------------------VIKK 2014
            :|.|      .:.|.|.|....|:..  .:..|..:..:.||                   ..|:
Mouse   698 KALLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQKGSRPQDSGISLENGVYAAAVVPGSPAAKE 762

  Fly  2015 SQKSLRDMREEFHAV-----SSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQA 2074
            ...::.|.....:.:     |..|.|||.|                :.::.|.|:|.::  ..|:
Mouse   763 GSLAVGDRIVAINGIALDNKSLNECESLLR----------------SCQDSLTLSLLKV--FPQS 809

  Fly  2075 MEEEGE---EELSESDESLSSVGSISDLEDRLRPVHVKRSSQQSLNGSIGGGGGSVVSSTRTVVF 2136
            ....|:   |.:.:||..||......:::     .|.||:..|..|            ||:|.:|
Mouse   810 SSWSGQNIFENIKDSDRMLSCRAHGPEVQ-----AHNKRNLLQHNN------------STQTDIF 857

  Fly  2137 EKD--DNSPRITVTSPSSPHIHKLALAAKAIPANKPDTKPAASTR 2179
            ..|  ::...:..:..||..:|| ..:..:.|.: |...|:.|.|
Mouse   858 YTDRLEDRKELGHSGGSSSFLHK-PFSGSSSPVS-PQACPSTSER 900

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580
MYSc_Myo18 575..1305 CDD:276837
GBP_C <1540..1750 CDD:303769 56/262 (21%)
COG1340 1565..1833 CDD:224259 63/319 (20%)
coiled coil 1723..1734 CDD:293879 4/10 (40%)
Dlg5XP_017171686.1 Takusan 129..213 CDD:368141 15/83 (18%)
Smc <141..564 CDD:224117 100/486 (21%)
PDZ_signaling 625..712 CDD:238492 15/88 (17%)
PDZ_signaling <741..800 CDD:238492 9/74 (12%)
PDZ 1357..1439 CDD:214570
dbPDZ_assoc 1437..1512 CDD:374667
PDZ 1513..1594 CDD:214570
SH3_DLG5 1610..1672 CDD:212794
GuKc 1744..1920 CDD:214504
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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