DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and Pdzph1

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_081277.1 Gene:Pdzph1 / 69239 MGIID:1916489 Length:1238 Species:Mus musculus


Alignment Length:1362 Identity:234/1362 - (17%)
Similarity:387/1362 - (28%) Gaps:569/1362 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   174 NMTNVHEEISFAGSAGGAGGTPEMLLRNTFQNESLYEGAARGAGSIGSNSSQHGTSFTSVESLRS 238
            |:.::.|:|.        |.|.|.:...|           |..|.:..|..::.|:         
Mouse    19 NVKDLEEDIK--------GHTSETVFHQT-----------RTLGKLKENGDENITA--------- 55

  Fly   239 DGEQTGGQQRAMTLPANARYGALPQGNSQGSHLHVLTSPSPSADSLTDTTNSSFATPPFSLSPVG 303
               ...|:|.:..|..|.:                   .:||..::..:..:.: ||| ::||  
Mouse    56 ---SINGKQNSSFLVKNEK-------------------QAPSDSTIHKSMENGY-TPP-AISP-- 94

  Fly   304 ESQGIDRWARVHAFEDVELPLP--------PVQLVKLPPPRQLVIRRQKSPRQDFGFSLRKAI-C 359
               .::....|..|.|.|..||        |..:..|.|.:...||..|....:......|:| |
Mouse    95 ---QLEEVLPVAMFNDREKSLPGKITTEDFPNTVEVLKPAKGKFIREVKCGAFNVHVETTKSIFC 156

  Fly   360 LDRTESLT-------------SPIFRPVIFAEPGAGGGATGLLPGDRLIKV------------NG 399
            ....::||             ..::|         |..:.|.....|.:..            .|
Mouse   157 KTGAQNLTKRRCPTCHQHYSVQQVWR---------GSKSRGHFSKHRTVLAEEFKRRVPSTYRRG 212

  Fly   400 TPVGELP--------REIIIEMIRNSGEAVTVEVQPVAELVELSKRCMAPSTATVEE-------- 448
            ....|:|        :||::|.| :..:...:.:.....:.:|:|....|...|.:|        
Mouse   213 VSRSEVPSVNISIVGKEIMVEYI-SKKQNTFINICHPNSIGKLTKHRRGPLKHTTDEPCESASQP 276

  Fly   449 -IDH------------------------SITNGNCNTLRRSASKRFKRQSRHENGNGGGEEGGAK 488
             |:|                        ::...|.:|:..|.|...:|:....|......:...:
Mouse   277 GINHPENQRLENQHQSSDAFHDAPCSVNAVQKENSDTIVVSLSSPPRREKEKPNTLPSAPDDSEE 341

  Fly   489 GVGHDLEADVADASQPERVWLV------HRGGFTAAIRLPTASS-------GRDEENKLSLRLLH 540
            |         ..|:.|::|..:      .:..|||...|||:|.       ...:.:|:||.   
Mouse   342 G---------ESATSPQKVLQITQDKPLEQHCFTADSCLPTSSETLRTTSLNNVDLSKMSLE--- 394

  Fly   541 NGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMA 605
                   |..||:::...:.|:.|:|..     ::.|..|..   .:|      || |..||.:.
Mouse   395 -------DSRDVDEERKNSSDVRENITP-----DSQVQPCTA---GTN------GP-LSAVNSII 437

  Fly   606 P----------------LSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMG 654
            |                |.|...|..:|  ||:.|:..|                          
Mouse   438 PIQDASGSEFSPLSFLTLQLLGAKADNM--GCRGEETLP-------------------------- 474

  Fly   655 RSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNT------------------- 700
              |.|..:|..........||........:.:|:.....:|..|||                   
Mouse   475 --GEGHESSNSLLFPVSEQAAKPSPLLSPSHRVSRCSEPVETTGNTFSFSQYIGVEREQEKVHYR 537

  Fly   701 ---KTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGR-------RLGHEHSFHIMTR 755
               |..|:::::...|.|.....|:..:..||..:|:|:....|.       ....:|:.|    
Mouse   538 LINKASLHNDSSSNIQPLERKDPQSPAVTIASCSILVPKSPLHGNIHSSVEWNQTEDHANH---- 598

  Fly   756 LLAGAAGLLQKELH-LENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIW 819
              |..|||.:.|:. :.:||:|       |.|.|            ..|.::...:|:.:...|.
Mouse   599 --AERAGLSRMEVPVMASITNE-------LEQSL------------ATQNYKESTVDSNSPMAIR 642

  Fly   820 SILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGV-------NLEDLSSAAFGLTQPN 877
            :...:..:|...|                    ..||..|.|       |.||       ||:.|
Mouse   643 NPRESTSYLENVG--------------------DDASQALPVVKNMCHRNFED-------LTREN 680

  Fly   878 APNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTS-SHTIASIMLID-- 939
                                            .:|..:.:..|.|....|| .||...:.|||  
Mouse   681 --------------------------------QNEICSQMDFLQNSSESTSVGHTTEKLFLIDKT 713

  Fly   940 --------------TPGFQN----PASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYA 986
                          |.|..|    ||.|.:.....       |.:|            :...||.
Mouse   714 LASDDDSNSNRDHKTCGLNNFQQEPAECQRTTSRV-------YCEE------------SGNQRYP 759

  Fly   987 QELVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTF 1051
            .|:         .|||..::    .:||.......|.....:.|:    |..|.|:......|  
Mouse   760 TEV---------SCHPVDIL----LSPQKQKALKDQNLEINNPRK----LSQELALRGGRASD-- 805

  Fly  1052 LERLFSHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSS 1116
                    |.:|.                          |::.|.|..::          .:|..
Mouse   806 --------GSQEE--------------------------AIEQWARRRQQ----------FKDGK 826

  Fly  1117 REEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSI-MLQVKFTVDG 1180
            |                    |.|..|          ||:..:||...:..:.: .:...|.|| 
Mouse   827 R--------------------CSSAGG----------SSVISNFTEGSITSDDVHSVDFGFRVD- 860

  Fly  1181 IIDTLRRTGTHFVHCYLLQHNAGKHTKYTAN------------GSPSSAAGQVSSEEEMVNVPLL 1233
                :...|.                 ||.|            |:|..:...:|.:...|.|   
Mouse   861 ----IEEKGF-----------------YTENFHSTAWVFRGDDGNPEDSPRCLSKKPRPVAV--- 901

  Fly  1234 RSQLRGSQVLEAARL----------HRLGFPESVPLLEF-----VRRFGLLAGDLASNKDVSVEQ 1283
            |.:        ..||          .|:.|.:.:.:.|.     ....||..||:          
Mouse   902 RER--------TVRLFKGTGDYPWGFRIQFSKPIVVTEVDTNSAAEEAGLQIGDV---------- 948

  Fly  1284 ILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQ----AFCRGYLARKKMS 1341
            :|:||..:|.|.....:..|.:.|    |:....|:.|| |.:..    ..|||||.::..|
Mouse   949 VLSVNGTEVTSVEHAEAVHLAKKG----LDILTMVVASD-ISRCPNTPWPTCRGYLHKRTHS 1005

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492 19/120 (16%)
MYSc 556..1317 CDD:214580 144/862 (17%)
MYSc_Myo18 575..1305 CDD:276837 139/831 (17%)
GBP_C <1540..1750 CDD:303769
COG1340 1565..1833 CDD:224259
coiled coil 1723..1734 CDD:293879
Pdzph1NP_081277.1 PDZ_signaling 903..981 CDD:238492 18/99 (18%)
PH-like 986..1093 CDD:302622 6/20 (30%)
PH 993..1094 CDD:278594 6/13 (46%)
PH-like 1123..1215 CDD:302622
PH 1125..1216 CDD:278594
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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