DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and Myh2

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001128629.1 Gene:Myh2 / 691644 RGDID:620354 Length:1942 Species:Rattus norvegicus


Alignment Length:1998 Identity:470/1998 - (23%)
Similarity:838/1998 - (41%) Gaps:504/1998 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   542 GEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAP 606
            |..|||.||.:...|.|..|.:||:..:.:|:|.:||:.|::|||:.:|:|.:|...:.|||...
  Rat    67 GATLTVKEDQIFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKW 131

  Fly   607 LSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYL 671
            |.:|:.:||:.:||.|.::.|||::|::..||:.::..|.:||::..|.||:||:.:.|..:.|.
  Rat   132 LPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYF 196

  Fly   672 ALAAGAYNNFINAEKVNALCT-----------------ILEAFGNTKTCLNSNATRMTQLLSLDF 719
            |..|      :..||.....|                 :||||||.||..|.|::|..:.:.:.|
  Rat   197 ATIA------VTGEKKKEEVTSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHF 255

  Fly   720 DQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISL 784
            ..||::|||.::..|.|:.|...:|..|.|:||..::.:.....|.:.|.:  .|:...:||:|.
  Rat   256 GTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLI--TTNPYDYPFVSQ 318

  Fly   785 SQ----KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQ 845
            .:    .::|:    .:.|.|..|.:.|.........|:.:..|:.|.|     .:......|.:
  Rat   319 GEISVASIDDQ----EELMATDSAIDILGFTNDEKVSIYKLTGAVMHYG-----NMKFKQKQREE 374

  Fly   846 FANP---TAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVI 907
            .|.|   ..|.||:.|.|:|..||..|   |..|....|....:|..|.    |.....:.||..
  Rat   375 QAEPDGTEVADKAAYLQGLNSADLLKA---LCYPRVKVGNEYVTKGQTV----EQVTNAVGALAK 432

  Fly   908 GLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRHNYLQER 968
            .:|.:....:|..||:|:.|.......|.::|..||:    |          :|..|..|:..|:
  Rat   433 AMYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFN----------SLEQLCINFTNEK 487

  Fly   969 LQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREH 1028
            ||..|:|...|..::.|.:|     .::..||||: |     |.||:|.                
  Rat   488 LQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAA-C-----IELIEKP---------------- 530

  Fly  1029 DRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ--FVLHHLQGTNPVLY 1090
              .|:..:|:||.::|.:.|.:|..:|: .|.|...:....:...|..:  |.|.|..||  |.|
  Rat   531 --MGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVKGKAEAHFSLIHYAGT--VDY 591

  Fly  1091 AVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSS 1155
            .:.||:..::: |.....|.|.|.||.:.:..|:.|:.|..:.|     |..|.....:.::.||
  Rat   592 NITGWLDKNKD-PLNETVVGLYQKSSMKTLAYLFSGAQTAEAEA-----SSGGAAKKGAKKKGSS 650

  Fly  1156 IRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQ 1220
            .:   |.:.:.|.::        :.::..||.|..|||.|.:                |:.....
  Rat   651 FQ---TVSALFRENL--------NKLMTNLRSTHPHFVRCII----------------PNETKTP 688

  Fly  1221 VSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL------AGDLASNKDV 1279
            .:.|.|:|     ..|||.:.|||..|:.|.|||..:...:|.:|:.:|      .|....:|..
  Rat   689 GAMEHELV-----LHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQYIDSKKA 748

  Fly  1280 SVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLAR---KKMS 1341
            | |::|...::|...|:.|.:::.|::|:|..||..||..|:..|.:.||.|||:|||   :||.
  Rat   749 S-EKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQAMCRGFLARVEYQKMV 812

  Fly  1342 QRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIE 1406
            :||.   ::.|||.|::||:.|:.|||.:|..::.|||....||:::.|..||....:.:|.|.|
  Rat   813 ERRE---SIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSE 874

  Fly  1407 CDRSE------------------VKAENQ-----------------KLEAKLSELTVDLAEERST 1436
            ..|.|                  |:||.:                 :||||:.|:| :.||:.  
  Rat   875 AKRKELEEKMVSLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVT-ERAEDE-- 936

  Fly  1437 AHIATERLEAE-TAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDG 1500
                 |.:.|| ||::.|||.|..:....:.:|:.|..|:|.|....::.:..::|:     ..|
  Rat   937 -----EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE-----MAG 991

  Fly  1501 VGGGVYKLKYERVA---------RELE--------FTKRRLHTQHEHD-----LEQ-------LV 1536
            :...:.||..|:.|         .:|:        .||.::..:.:.|     |||       |.
  Rat   992 LDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1056

  Fly  1537 ALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAE 1601
            ..|:.||..|..|.|.:::......|...:.:|...||::|:..:|::.|....|:||.::..|.
  Rat  1057 RAKRKLEGDLKLAQESIMDIENEKQQLDERLKKKEFEMSNLQSKIEDEQAIGIQLQKKIKELQAR 1121

  Fly  1602 CQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLAD----TRLDLEFKEEKLASLQ---RELE 1659
            .:.|::.:..||.::.:..:::..|..|...:.:.|.:    |...:|..:::.|..|   |:||
  Rat  1122 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1186

  Fly  1660 EMTFG----------------GGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLR 1708
            |.|..                ....|:...|:|.|.:.|:...|.:.|:|::|..::.:.:||..
  Rat  1187 EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGN 1251

  Fly  1709 LEMTLETMRKE-----ARRESQQR-----------------------DE---------------- 1729
            ||....|:..:     ::.|.|||                       ||                
  Rat  1252 LEKMCRTLEDQVSELKSKEEEQQRLINDLTTQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1316

  Fly  1730 -ELEEVRGNGYKKIKAL------------ECQL-------------------------------- 1749
             ::||::....:::||.            :|.|                                
  Rat  1317 QQIEELKRQLEEEVKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANSEVAQWRTK 1381

  Fly  1750 -ETEHEERTLLLRE-KHELERRLSSMED---------------RDRVDRDAEE------------ 1785
             ||:..:||..|.| |.:|.:||.:.|:               :.|:..:.|:            
  Rat  1382 YETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAAC 1446

  Fly  1786 -ALNQKLRR-------------------------------DLRKYKALLKDAQTQLERLKADTPG 1818
             ||::|.|.                               :|.|.|...:::..|||.||.:  .
  Rat  1447 AALDKKQRNFDKILAEWKQKYEETHAELEASQKEARSLGTELFKMKNAYEESLDQLETLKRE--N 1509

  Fly  1819 KTLIRQLRNQLED-AESARSL--AMKARQTAEAELTEVQAMFDESHRARNDAEERANAAHRD--- 1877
            |.|.:::.:..|. ||..:.:  ..|.::..|.|..|:||..:|:..:....|.:......:   
  Rat  1510 KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQ 1574

  Fly  1878 -RAELQAQIEENEEELGELMKKYSATVKQLNT----------EQINV-SEAEFKLNEMEAERNNL 1930
             ::|:..:|.|.:||:.:|.:.:...|:.:.:          :.|.: .:.|..|||||.:.|:.
  Rat  1575 VKSEIDRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRIKKKMEGDLNEMEIQLNHA 1639

  Fly  1931 KEQVAE--------------LQHRLDNV----ENLGDPSMAMMSKRLELRTKELES-RLELEQAT 1976
            ....||              .|..||:.    |:|.: .:||:.:|..|...|:|. |..|||..
  Rat  1640 NRMAAEALRNYRNTQGILKDTQLHLDDALRGQEDLKE-QLAMVERRANLLQAEIEELRATLEQTE 1703

  Fly  1977 RAR----------------LEVQVNRHKEALEKLQNEVT--QSKMREM--QAQDVIKKSQKSLRD 2021
            |:|                |..|........:||:.:::  |.:|.::  :|::..:|::|::.|
  Rat  1704 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITD 1768

  Fly  2022 ---MREEFHAVSSREQESLTRRKDLEKKVEQM---------ESEGAAL---KNDLRLALQRIADL 2071
               |.||.    .:||::....:.::|.:||.         |:|..||   |..::....|:.:|
  Rat  1769 AAMMAEEL----KKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVREL 1829

  Fly  2072 QQAMEEEGE----------------EELS-ESDESLSSVGSISDLEDRL--RPVHVKRSSQQSLN 2117
            :..:|.|.:                :||: :::|...::..:.||.|:|  :....||.::::..
  Rat  1830 EGEVESEQKRNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1894

  Fly  2118 GSIGGGGGSVVSSTRTVVFEKDDNSPRITVTSPSSPHIHKLALAAKAI 2165
            .|     .:.:|..|.:..|.::...|..:   :...::||.:.::.:
  Rat  1895 QS-----NTNLSKFRKLQHELEEAEERADI---AESQVNKLRVKSREV 1934

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 212/802 (26%)
MYSc_Myo18 575..1305 CDD:276837 200/771 (26%)
GBP_C <1540..1750 CDD:303769 57/322 (18%)
COG1340 1565..1833 CDD:224259 79/441 (18%)
coiled coil 1723..1734 CDD:293879 7/50 (14%)
Myh2NP_001128629.1 Myosin_N 35..73 CDD:397036 3/5 (60%)
Motor_domain 100..773 CDD:419868 200/771 (26%)
Myosin_tail_1 853..1930 CDD:396244 221/1104 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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