DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and Pdzd2

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001074533.1 Gene:Pdzd2 / 68070 MGIID:1922394 Length:2796 Species:Mus musculus


Alignment Length:1058 Identity:206/1058 - (19%)
Similarity:317/1058 - (29%) Gaps:393/1058 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 NFMKKSAGDE-DKERRKREKKLR---KEAK-GTSGGPGMGGVTGVTGSMSTDELLRLDEVRRSLK 62
            |.:|..||.. ::....||.:||   .||. ..|........||.|...|:|.|.| :||.|..|
Mouse   271 NSLKDVAGPHLERSEADREAELRVPKTEAPLSDSNDKRRFSKTGKTNFQSSDSLAR-EEVGRIWK 334

  Fly    63 IRGRRKEKEKLPSGITADYSADFFAALNADANGG---------------SNGGAVGAADPEQDRG 112
            :. ..||.:                .|....:||               ..||| ...|.....|
Mouse   335 ME-LLKESD----------------GLGIQVSGGRGSKRSPHAIVVTQVKEGGA-AHRDGRLSLG 381

  Fly   113 NEEIVAS-----VMTHIES----RASNGAG--VSVNYSEVTHSLLSGGLKNRFLPPIPPKPPKRG 166
            :|.:|.:     .::|.|:    |::.|..  |..:.......||.  |.::.||          
Mouse   382 DELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKESSAEDLLK--LTSKSLP---------- 434

  Fly   167 ILKGSRSNMTNVHEEISF-------AGSAGGAGGTPEMLLRNTFQNESLYEGAARGAGSIGSN-- 222
                   ::|:..|:||.       ..:.....||....:|.|.......:.......|.|:|  
Mouse   435 -------DLTSSVEDISSWTDNEDQEAARDDEEGTGSAAVRGTMLGSEESQDVGSSEESKGNNLE 492

  Fly   223 SSQHGTSFTSVESLRSDG--------------EQTGGQQ-RAMTLPANARYGALPQ-----GNSQ 267
            |.:.|.|...::|..|.|              .:.|..: |.:.:..:.|..:|||     |.||
Mouse   493 SPKQGNSKMKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSTGTSQ 557

  Fly   268 GSHLHVLTSPSPSADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQLVKL 332
            ..|:     ...|..||:.|...|                                  |.:|:: 
Mouse   558 EYHI-----VKKSTRSLSTTHVES----------------------------------PWRLIR- 582

  Fly   333 PPPRQLVIRRQKSPRQDFGFSLRKAICLDRTESLTSPIFRPVIFAEPGAGGGATG-LLPGDRLIK 396
             |....:|...|...:..|||:.......|.:   ..||...||  |.......| |..||.::.
Mouse   583 -PSVISIIGLYKEKGKGLGFSIAGGRDCVRGQ---MGIFVKTIF--PNGSAAEDGRLKEGDEILD 641

  Fly   397 VNGTPVGELP-REII--IEMIRNSGEAVTVEVQPVAELVELSKRCMAPSTATVEEIDHSITNGNC 458
            |||.|:..|. :|.|  .:.||:....:||..           :.::||...            |
Mouse   642 VNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRT-----------KLLSPSLTP------------C 683

  Fly   459 NT---LRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVWLVHRGGFTAAIR 520
            :|   :.||:|..|       |.:||...||    |.|                  .||      
Mouse   684 STPTHMSRSSSPSF-------NSSGGAPAGG----GQD------------------EGG------ 713

  Fly   521 LPTASSGR---DEENKLSLRLLHNGEQ---LTVDEDDVEKQNSPALDLVEDIC------------ 567
              :||.||   ..::::.:.:..|.|.   |.:....:..:|||....:..:.            
Mouse   714 --SASLGRKAPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLS 776

  Fly   568 ---ELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVV----NPM--------------------- 604
               ::..:|..:|.|....:..:.|.....||..||:    ||.                     
Mouse   777 RGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEA 841

  Fly   605 -------APL---------SLYSEKVVSMF--------------RGCKTEDMPPHVYSLAQ---- 635
                   .||         ||.||..:|.:              .|.:.||.|...|..::    
Mouse   842 NSSPSLGTPLKSPSLAKKDSLLSESELSQYFVHDGQGSLSDFVVAGSEDEDHPGSGYETSEDGSL 906

  Fly   636 ----TAYRSLVETRRDQSLIFMG-RSGSG---KSTSFKHALNYLALAAGAYNNFINAEKVNALCT 692
                :|||...:.|.: ||:.:| :.|||   |..:.....:.........|..:...:|.    
Mouse   907 LTVPSAYRETGKARAN-SLVTLGSQRGSGLLHKQVTVARQASLPGSPQVLRNPLLRQRRVR---- 966

  Fly   693 ILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLL 757
                      |.:||.....:    |||..|.  ..||..:||   ..||.|..:.     ||. 
Mouse   967 ----------CYDSNDGSDDE----DFDGEGD--CVSLPGVLP---GPGRPLVQDD-----TRF- 1006

  Fly   758 AGAAGLLQKELHLENITSEDSHPFIS-------LSQKLEDRHRAANDFMRTVQAFETLNIDAKAV 815
              |.....|.:.:.........|.:|       |...|:..|                       
Mouse  1007 --ALATSSKSIDVNKQDERLQKPLVSKACSVPLLGSSLDSEH----------------------- 1046

  Fly   816 RGIWSILAAIYHLGIAG-------------VTKLGTGSTARTQFANPTAARKASGLLGVNLEDLS 867
                ||     |.|.||             ..|.|.|.:.|.:.:...::.|....:..:.:   
Mouse  1047 ----SI-----HGGTAGTPPKAASLPGSVETPKNGPGGSRRKEMSGSRSSPKLEYRVPADTQ--- 1099

  Fly   868 SAAFGLTQPNAPNGGLSP 885
                   .|.:|..|.||
Mouse  1100 -------SPRSPENGTSP 1110

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492 26/90 (29%)
MYSc 556..1317 CDD:214580 77/432 (18%)
MYSc_Myo18 575..1305 CDD:276837 73/398 (18%)
GBP_C <1540..1750 CDD:303769
COG1340 1565..1833 CDD:224259
coiled coil 1723..1734 CDD:293879
Pdzd2NP_001074533.1 PDZ_signaling 335..416 CDD:238492 17/98 (17%)
PDZ_signaling 591..672 CDD:238492 24/85 (28%)
PDZ_signaling 729..813 CDD:238492 13/83 (16%)
PHA03307 1050..>1355 CDD:223039 13/71 (18%)
PHA03247 <1197..1562 CDD:223021
PDZ_signaling 2581..2663 CDD:238492
PDZ 2709..2791 CDD:214570
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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