DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and Myh15

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001159682.1	Gene:	Myh15 / 667772	MGIID:	3643515	Length:	1925	Species:	Mus musculus

Alignment Length:	1946	Identity:	459/1946 - (23%)
Similarity:	787/1946 - (40%)	Gaps:	487/1946 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   505 ERVWLVHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICEL 569
            ::.|:  ..|..|.|......||.|.:..:..|   :||.:.:.||.:::.|...|:::||:..|
Mouse    31 KKCWV--PDGKNAYIEAEVKESGDDGQVIVETR---DGEIMRIKEDKLQQMNPEELEMIEDLSML 90

  Fly   570 KYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLA 634
            .|||||||||.||:||...:|:|.:|...:.:||...|.:|.::|::.::..:..::|||::::|
Mouse    91 LYLNEASVLHTLRRRYDHWMIYTYSGIFCVAINPYKWLPVYQKEVMAAYKRKRRSEVPPHIFAVA 155

  Fly   635 QTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAG---AYNNFINAE----KVNALCT 692
            ..|::.::....:||::|.|.|||||:.:.|..:.|.|..|.   ......|.|    |:|.|
Mouse   156 NRAFQDMLRNGENQSIVFTGESGSGKTVNTKLIIQYFATMAAISEPKKKLGNLEDQIVKMNPL-- 218

  Fly   693 ILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLL 757
             ||||||.||..|.|::|..:|:.:.|...|.::.|.:|:...|:.|...:...|.::||..::|
Mouse   219 -LEAFGNAKTQKNDNSSRFGKLIRIHFGARGTLSFADIQIYFLEKSRVVYQQPGERNYHIFYQIL 282

  Fly   758 AGAAGLLQKELHLENITSEDSHPF---ISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIW 819
            :|...|  :.:.|.:....|.|..   :...:.|:|    |.:|:.|.:|.:.|........|.:
Mouse   283 SGNQEL--RNMLLVSTNPSDFHICSCGVVAVESLDD----AKEFLATEKAIDVLGFLPDEKFGCY 341

  Fly   820 SILAAIYHLGIAGVTKLGTGSTARTQFANPTA-ARKASGLLGVNLEDLSSAAFGLTQPNAPNGGL 883
            .::.||.|.   |..|...........|:.|. |.||:.|:|::..:|..   ||..|....|
Mouse   342 KLVGAIMHF---GNLKFKRNLREEQLEADGTENADKAAFLMGIHASELLK---GLIYPRIKVG-- 398

  Fly   884 SPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICT--SSHTIASIMLIDTPGFQ-- 944
              ::..|.....:.....:.||...:|......:||.:|:.:..  :||....|  :||.||:
Mouse   399 --NEYVTRSQNLQQVTYAVGALSQSIYERMFQWLVARMNQVLDAKLTSHFFVGI--LDTTGFEIL 459

  Fly   945 --NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECHP 1002
              |          :|..|..|:..|:||..|:....:..::.|.:|     .::..:|:.: |
Mouse   460 DYN----------SLEQLCINFTNEKLQQFFNQQLFILEQEEYRKEGLDWLSIDYGLDVQA-C-- 511

  Fly  1003 GPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSL 1067
               |..|:|.                  .|:..:|:||.:.|.:.|..|..:||.|:..:.  :.
Mouse   512 ---IDFIEKP------------------MGIFSILEEECMLPKATDQMFKTKLFDHHFGKS--AY 553

  Fly  1068 LRKCAGPRQ-----FVLHHLQGTNPVLYAVDGWVRHSREHPGIRN--AVSLLQDSSREEINRLYI 1125
            .:....|.:     |.|.|..|..|  |.:.||:..::   |:.|  .|:|||.||.:.:..|:.
Mouse   554 FQTPTSPEKNFEVHFELAHYAGVVP--YNISGWIGKNK---GLLNETVVALLQKSSNKVLANLFT 613

  Fly  1126 GSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGT 1190
            ..:..||.:..  |.....:|| |...::|:.                 |..::.::..|:.|..
Mouse   614 KDIIAGSASQF--GEKTHKKGT-SFHLITSLH-----------------KENINKLMTDLKSTAP 658

  Fly  1191 HFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPE 1255
            |||.|.    |..|      |..|.           :::..|:..|||.:.|||..|:....||.
Mouse   659 HFVRCI----NPNK------NKIPG-----------VMDPFLVLQQLRCNGVLEGIRVCCEAFPS 702

  Fly  1256 SVPLLEFVRRFGLLAGDLAS-NKDVS----VEQILAVNELDVASYRIGPSQILFRSGVLSELEAK 1315
            .:...:|.:|:.:|...:.| :|.||    .|::|...|:|...|:.|.:::.|::.:|.:||.:
Mouse   703 WMLYDDFKQRYWILNPRIFSKSKFVSSRKATEEVLDFLEIDHPHYQCGVTKVFFKAFILDQLEER 767

  Fly  1316 RDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLN 1380
            ||..:|......||..||.|.|....:...:..|:..||.|::||:||::.||..|..::.||..
Mouse   768 RDEKISKVFTLFQARARGKLMRITFQKILEERDALALIQENIRAFIAVKNCPWMGLFFKIKPLAK 832

  Fly  1381 VHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLEAKLSELTVDLAEERSTAHIATERLE 1445
            .....|::....||...|:..||..|..|.|:|.:...|..:.::|.:.|..|:.|...:.|:.|
Mouse   833 SVGAGEEIAGLKEECAQLQKALESSESQREELKTKQVSLVQEKNDLRLQLQAEQETLANSEEQCE 897

  Fly  1446 AETAERLKLEKELGDQTNKVKNLQETTEKL-------------------EMELICAKSD------ 1485
            :....:::||.::.:.:.:|:..:|...:|                   ::|.|.|||:
Mouse   898 SLIKSKVELEVKIKELSRQVEEEEEINSELTARGRKLEDECSELKKEIYDLEAILAKSEKGKCAA 962

  Fly  1486 ---LNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLS 1547
               :..::|:..:.||:     |.||  .||.::.:.|:::...|...:.|:|..:.| ..:||:
Mouse   963 EHKVRNLTEEVHSLNEE-----VSKL--SRVVKDAQETQQQTQEQLHIEEEKLSNMSK-ANLKLA 1019

  Fly  1548 ---DAYEEVVEQ----RQVVGQWKRKAQ---KMTNE----MNDLRMLLEEQ-------------- 1584
               |..|..:|:    |....:.|||.|   ||..|    :...|..|.||
Mouse  1020 QQIDVLEGDLERERKARMKCEREKRKLQDELKMNQEGAENLESSRQKLAEQLRKKEFEMGQMNSK 1084

  Fly  1585 --NARNNL--LEKKQRKFDAECQSLQDAVRQERQAKERYGREK-DVLQAEKFTLEQTLADTRLDL 1644
              |.:|.:  |:|..::......:|::.:..||..:.:..||| |::|               ||
Mouse  1085 VENEKNQVSQLQKMVKELQTHILNLKEELESERTIRAKVEREKGDLVQ---------------DL 1134

  Fly  1645 EFKEEKLASLQRELEEMTFGGGT-----------EEEFAQLRRSKNETERR--------AKEQEE 1690
            |       .|...|||   .|||           |..|.:|.....||.|.        .|...|
Mouse  1135 E-------DLNERLEE---AGGTSLAQMEITKQQEARFQKLHHDMEETTRHFEATSASLKKRHAE 1189

  Fly  1691 ELDEMAGQIQLLEQAKLRLEM-------------------------------------------- 1711
            .|.|:.||::.|:|.:|.||.
Mouse  1190 NLAELEGQVEHLQQVRLVLEQDKSDLQLQVDDLLNRVDQMARAKANAEKLCGLYERRLNEANTKL 1254

  Fly  1712 --------TLETMRKEARRESQQRDEELEE----------VRGNGYKKIKALECQLETEHEERTL 1758
                    .|.|.:.:.:.||.:..:.|||          .:.|..::::.|..|||.|...::.
Mouse  1255 DEVTQLAHDLTTQKTKLQSESGEFFKRLEEKEALISQLSREKSNFTRQVEELRAQLEEESRSQSA 1319

  Fly  1759 -------------LLRE--------KHELERRLS-----SMEDRDRVDRDAEEALNQKLRRDLRK 1797
                         ||||        |.||.|.||     :::.|.:.:.||.:. .:.|....:|
Mouse  1320 LSHALQSAKHDYDLLREQYEEEQEVKAELHRALSKGNKETVQWRAKYEHDAMQR-TEDLEEAKKK 1383

  Fly  1798 YKALLKDAQTQLERLKADTPGKTLIR-----QLRNQLEDAESARSLAM----------KARQTAE 1847
            ....|::|...:|...|........|     :|.:.|.|...|||:|.          ||..:.:
Mouse  1384 LAIRLQEAAEAMEVSNAKNASLERARHRLQLELGDALSDLGKARSVAAALGQKQQHSDKALTSWK 1448

  Fly  1848 AELTEVQAMFDESHRA-----------RNDAEERANAAH---RDRAELQAQI-------EENEEE 1891
            .:|.|.|.:...|.:.           |...||...|..   |...:||.||       .|..:.
Mouse  1449 QKLDETQELLQASQKETRALSSEVLTFRQACEESTEAQETLKRQNQDLQEQICSLTNQVREGIKN 1513

  Fly  1892 LGELMKKYSATVKQLNTE----------------------QINVSEA----EFKLNEMEAERNNL 1930
            |.| ::|....::|..||                      |:.:|||    |.||:|.|.|...|
Mouse  1514 LAE-VEKAKKLIEQEKTEVQVRLEETEGALERNESKILRFQLELSEAKAELERKLSEKEEEAERL 1577

  Fly  1931 KEQ----VAELQHRLDNVENLGDPSMAMMSKRLELRTKELESRL-----ELEQATRA-------- 1978
            :|:    :..||..|| :|.........:.|::|...||:|.:|     ::.|.|||
Mouse  1578 REKHQQAMGSLQSNLD-LEASSRIEATRLRKKMEGDLKEMEIQLCAANRQVSQMTRALGQLQGQM 1641

  Fly  1979 -----RLEVQVNRHKEALEK----------LQNEVTQSKMREMQAQDVIKKSQKSLRDMREEFHA 2028
                 :|:..:.::|:..|:          ||:|:.:.:..:.|.:...|.::|.|.:..|..:.
Mouse  1642 KDLHQQLDDSIYQNKDLKEQVALAEQRTVLLQSELEELRTLQEQTERGRKLAEKELLEATERINL 1706

  Fly  2029 VSSREQESLTRRKDLEKKVEQMESEGAAL---------------------------KNDLRLALQ 2066
            ..::....|:::|.||..|.|::.|...:                           :.|....|:
Mouse  1707 FHTQNTSLLSQKKKLEADVAQVQKEAGEMLQACQKAEEKAKKTAAEAANMSEELKKEQDTNAHLE 1771

  Fly  2067 R--------IADLQQAMEEEGEEELSESDESLSSVGSISDLEDRLRPV------HVKRSSQ 2113
            |        |.|||:.::|      :|....|.|...|..||.|:|.:      .|:||::
Mouse  1772 RMRKNMEQTIKDLQKRLDE------AEQTAVLGSKKQIQKLESRVRDLEGELESEVRRSAE 1826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	203/794 (26%)
		MYSc_Myo18	575..1305	CDD:276837	190/763 (25%)
		GBP_C	<1540..1750	CDD:303769	67/323 (21%)
		COG1340	1565..1833	CDD:224259	85/405 (21%)
		coiled coil	1723..1734	CDD:293879	5/20 (25%)
Myh15	NP_001159682.1	Myosin_N	31..69	CDD:280832	10/42 (24%)
		Myosin_head	84..757	CDD:278492	197/775 (25%)
		MYSc_Myh15_mammals	96..757	CDD:276892	190/763 (25%)
		Myosin_tail_1	838..1914	CDD:279860	222/1031 (22%)
		NBP1	<1004..>1136	CDD:285709	35/154 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810