DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and Pdzk1

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_113900.1	Gene:	Pdzk1 / 65144	RGDID:	70924	Length:	523	Species:	Rattus norvegicus

Alignment Length:	313	Identity:	72/313 - (23%)
Similarity:	114/313 - (36%)	Gaps:	87/313 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 ARVHAFEDVELPLPPVQLVKLP-PPRQLVIRRQKSPRQDFGFSLRKAICLDRTESLTSPIFRPVI 375
            ||.|:.:..........|..|| .||.:||::..:   .:||.||..      ......|.:.:
  Rat   217 ARCHSEQKTPFKRETASLKLLPHQPRVVVIKKGSN---GYGFYLRAG------PEQKGQIIKDI- 271

  Fly   376 FAEPGAGGGATGLLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAVTV-----EVQPVAELVELS 435
              |||:...|.||...|.::.|||..|..|..:.::|||||.|:..|:     |...:..|...|
  Rat   272 --EPGSPAEAAGLKNNDLVVAVNGESVEALDHDSVVEMIRNGGDQTTLLVLDKEADRIYSLARFS 334

  Fly   436 K--RCM---------------------APSTATVEEI-DHSITNGNCNTLRRSASKRFKRQS-RH 475
            .  .|.                     ||.:||.|:: ||.  ...|..::...|..|...: |.
  Rat   335 PLLYCQSQELPNGSVKEAPAPISAPLEAPGSATTEDVGDHK--PKLCRLIKEDDSYGFHLNAIRG 397

  Fly   476 ENGN--------GGGEEGGAKGV-------GHDLEADVAD------ASQPERVWLVHRG----GF 515
            :.|:        |..::.|.:..       |.:::.:..|      .|..|.|.|:..|    .:
  Rat   398 QPGSFVKEVQQGGPADKAGLENEDIIIEVNGENVQDEPYDRVVERIKSSGEHVTLLVCGKVAYSY 462

  Fly   516 TAAIRLPTASS-------GRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALD 561
            ..|.::|..||       |.||:.:..    |:..:.|.|      .:.||.|
  Rat   463 FQAKKIPILSSLADPLVAGPDEKGETE----HDSAESTKD------SSHPARD 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	27/91 (30%)
		MYSc	556..1317	CDD:214580	3/6 (50%)
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
Pdzk1	NP_113900.1	PDZ_signaling	7..87	CDD:238492
		PDZ	132..212	CDD:214570
		PDZ_signaling	242..320	CDD:238492	27/89 (30%)
		PDZ	375..455	CDD:214570	13/81 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	479..523		9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900