DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and Pdzk1

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001139473.1	Gene:	Pdzk1 / 59020	MGIID:	1928901	Length:	519	Species:	Mus musculus

Alignment Length:	383	Identity:	89/383 - (23%)
Similarity:	139/383 - (36%)	Gaps:	134/383 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 PRQLVIRRQKSPRQDFGFSLRKAICLDRTESLTSPIFRPVIFAEPGAGGGATGLLPGDRLIKVNG 399
            ||:..:.:|:.  |::||.|       |.|..|......||  |.|:.....|||.|||::::||
Mouse     7 PRECKLSKQEG--QNYGFFL-------RIEKDTDGHLIRVI--EEGSPAEKAGLLDGDRVLRING 60

  Fly   400 TPVGELPREIIIEMIRNSGEAVTVEV-------QPVAELVELSKRCMAPSTATVEEIDHSITNGN 457
            ..|.:.....::|::|.||.:||:.|       :.|...|:|            :|:|.|
Mouse    61 VFVDKEEHAQVVELVRKSGNSVTLLVLDGDSYEKAVKNQVDL------------KELDQS----- 108

  Fly   458 CNTLRRSASKRFKRQSRHENG--------------NGGGEEG-------GAKGV----------- 490
                :|.|:...|:.....||              ..|...|       |.|||
Mouse   109 ----QREAALNDKKPGPGMNGAVEPCAQPRLCYLVKEGNSFGFSLKTIQGKKGVYLTNIMPQGVA 169

  Fly   491 --------GHDLEA---DVADASQPERVWLVHRGGFTAAIRLPTASSGR-DEENK-------LSL 536
                    .|.:|.   :|.:||..|.|..|.:.|......|....:.| ..|.|       .||
Mouse   170 MKAGVLADDHLIEVNGENVENASHEEVVEKVTKSGSRIMFLLVDKETARCHSEQKTQFKRETASL 234

  Fly   537 RLLHNGEQLTVDE---------------------DDVEKQNSPA-------LDLVEDI--CELKY 571
            :||.:..::.|.:                     .|:| ..|||       .|||..:  ..::.
Mouse   235 KLLPHQPRVVVIKKGSNGYGFYLRAGPEQKGQIIKDIE-PGSPAEAAGLKNNDLVVAVNGKSVEA 298

  Fly   572 LNEASVLHCLRQRYASNLIHTKAG--PTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMP 627
            |:...|:..:|          |.|  .||||::..|. |:||....|....|:::::|
Mouse   299 LDHDGVVEMIR----------KGGDQTTLLVLDKEAE-SIYSLARFSPLLYCQSQELP 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	28/93 (30%)
		MYSc	556..1317	CDD:214580	22/83 (27%)
		MYSc_Myo18	575..1305	CDD:276837	15/55 (27%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
Pdzk1	NP_001139473.1	PDZ_signaling	7..87	CDD:238492	29/90 (32%)
		PDZ	132..212	CDD:214570	15/79 (19%)
		PDZ_signaling	242..320	CDD:238492	17/88 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..374
		PDZ_signaling	376..455	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	479..519
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900