DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and MYH7B

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_016883475.1	Gene:	MYH7B / 57644	HGNCID:	15906	Length:	2003	Species:	Homo sapiens

Alignment Length:	1829	Identity:	454/1829 - (24%)
Similarity:	780/1829 - (42%)	Gaps:	354/1829 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   505 ERVWLV-HRGGFTAAIRLPTASSGR-DEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDIC 567
            :|||:. .:..:..|.....|:.|| ..|.|       :.:.|.|.|.:::..|.|..||:||:.
Human    75 KRVWVPDEQDAYVEAEVKSEATGGRVTVETK-------DQKVLMVREAELQPMNPPRFDLLEDMA 132

  Fly   568 ELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYS 632
            .:.:||||||||.||||||..:|:|.:|...:.:||...|.:|:..||:.::|.:..|.|||:|:
Human   133 MMTHLNEASVLHNLRQRYARWMIYTYSGLFCVTINPYKWLPVYTASVVAAYKGKRRSDSPPHIYA 197

  Fly   633 LAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCT----- 692
            :|..||..::..|.:||::..|.||:||:.:.|..:.|.|:.|...:.  ..:|...|.|
Human   198 VADNAYNDMLRNRDNQSMLITGESGAGKTVNTKRVIQYFAIVAALGDG--PGKKAQFLATKTGGT 260

  Fly   693 ----------ILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHE 747
                      .:|||||.||..|.|::|..:.:.:.|..:|::|||.:...|.|:.|...:|..|
Human   261 LEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPSGKLASADIDSYLLEKSRVIFQLPGE 325

  Fly   748 HSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDA 812
            .|:|:..::|:|....|| ::.|.::...|.| |.|......|......:.:.|..|.:.|....
Human   326 RSYHVYYQILSGRKPELQ-DMLLLSMNPYDYH-FCSQGVITVDNMNDGEELIATDHAMDILGFSV 388

  Fly   813 KAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQPN 877
            ......:.|:.|:.|.|.....:......|...  ...:|.||:.|:||:..||..   ||..|.
Human   389 DEKCACYKIVGALLHFGNMKFKQKQREEQAEAD--GTESADKAAYLMGVSSGDLLK---GLLHPR 448

  Fly   878 APNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPG 942
            ...|    ::..|.....|.....:.||....|......:|:.||:.:.|.......|.::|..|
Human   449 VRVG----NEYVTKGQSVEQVVFAVGALAKATYDRLFRWLVSRINQTLDTKLPRQFFIGVLDIAG 509

  Fly   943 FQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLAS 998
            |:    |          :...|..|:..|:||..|:....|..::.|.:|     .::..:||.
Human   510 FEIFEFN----------SFEQLCINFTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDFGLDLQ- 563

  Fly   999 ECHPGPLISLIDKAPQNHVVRSSQRDLREHD------------RRGMLWLLDEEAIYPNSNDDTF 1051
                 |.|.||:|.          |.||..|            ..|:|.:|:||.::|.::|.:|
Human   564 -----PCIDLIEKV----------RRLRLSDVGGPHSYSFCSQPLGILSILEEECMFPKASDASF 613

  Fly  1052 LERLFSHYGDREHHSLLRKCAGPRQFVLH----HLQGTNPVLYAVDGWVRHSREHPGIRNAVSLL 1112
            ..:|:.::..:..:....:....|::..|    |..|..|  |::.||:..::: |.....|.:.
Human   614 RAKLYDNHAGKSPNFQQPRPDKKRKYQAHFEVVHYAGVVP--YSIVGWLEKNKD-PLNETVVPIF 675

  Fly  1113 QDSSREEINRL-------YIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSI 1170
            |.|.    |||       |.||          |.:.....|.:..|:.::   ||.|.....
Human   676 QKSQ----NRLLATLYENYAGS----------CSTEPPKSGVKEKRKKAA---SFQTVSQLH--- 720

  Fly  1171 MLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRS 1235
                |..::.::..||.|..|||.|.:...|.          :|.           :::..|:..
Human   721 ----KENLNKLMTNLRATQPHFVRCIVPNENK----------TPG-----------VMDAFLVLH 760

  Fly  1236 QLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL-----AGDLASNKDVSVEQILAVNELDVASY 1295
            |||.:.|||..|:.|.|||..:...:|.:|:.:|     ..|...:...:.|::|...:||...|
Human   761 QLRCNGVLEGIRICRQGFPNRLLYTDFRQRYRILNPSAIPDDTFMDSRKATEKLLGSLDLDHTQY 825

  Fly  1296 RIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAF 1360
            :.|.:::.|::|:|..||..||..|:..:..|||..||.|.|.:..:......|:..||.|::||
Human   826 QFGHTKVFFKAGLLGVLEELRDQRLAKVLTLLQARSRGRLMRLEYQRLLGGRDALFTIQWNIRAF 890

  Fly  1361 LAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLEAKLSE 1425
            .||::|.|.:|..::.|||...:.||:|.....||..||..|...|..|.|::..:..:..:.::
Human   891 NAVKNWSWMKLFFKMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKND 955

  Fly  1426 LTVDL---------AEERSTAHI--------------ATERLEAE-------TAERLKLEKELGD 1460
            |.:.|         ||||  .|:              .:||||.|       .|.|.|||.|..:
Human   956 LALQLQAEQDNLADAEER--CHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTE 1018

  Fly  1461 QTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVA----------- 1514
            ....:.:|:.|..|.|.|....::.:..::|:..|.:|     .|.:|..|:.|
Human  1019 LKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDE-----SVARLTKEKKALQEAHQQALGD 1078

  Fly  1515 ------RELEFTKRRLHTQH-----EHDLEQLVAL-------KKHLEMKLSDAYEEVVEQRQVVG 1561
                  |....||.:|..:.     |..|||...|       |:.||..|....|.|.:..|...
Human  1079 LQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQ 1143

  Fly  1562 QWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVL 1626
            |.:.|.:|..:|::.|.:.:|::......::||.::..|..:.|::.:..||.|:.|..:::...
Human  1144 QLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEA 1208

  Fly  1627 QAEKFTLEQTL-------ADTRLDLEFKEEKLASLQRELEEMTF--------------GGGTE-- 1668
            ..|...|.:.|       |..|.....:|.:|..|:|||||...              .|..|
Human  1209 ARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELG 1273

  Fly  1669 EEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLE---MTLETMRKEARRESQQRDEE 1730
            |:...|:|.:.:.|:...|...|:|::|..::.|.:||...|   .|.|....||:.:.::...:
Human  1274 EQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQ 1338

  Fly  1731 LEEV---RGNGYKKIKALECQLETEHEERTLLLREKHELERRLS--------SMED-RDRVDRD- 1782
            |.:.   ||           :|:||..|.:.||.||..|..:||        |:|: |.:::.:
Human  1339 LADASTQRG-----------RLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEES 1392

  Fly  1783 -AEEALN---QKLRRD---LRKYKALLKDAQTQLERL--KADTPGKTLIRQLRNQLE-DA----- 1832
             |:.||.   |.||.|   ||:......:||.:|:||  ||:..    :.|.|::.| ||
Human  1393 KAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAE----VAQWRSKYEADAIQRTE 1453

  Fly  1833 ---ESARSLAMK---ARQTAEAELTEVQAMFDESHRARNDAE------ERANAA----HRDRAEL 1881
               |:.:.||::   |.:..||...:..::.....|.:.::|      |||.:|    .:.:..|
Human  1454 ELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHL 1518

  Fly  1882 QAQIEENEEELGELMKKYSATVKQ---LNTEQINV----SEAEFKLNEMEAERNNLKEQVAELQH 1939
            :..:||...:..|:.::..|..::   |.||...:    .||...|..::.|..||:|::::|..
Human  1519 ERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTD 1583

  Fly  1940 RLD----NVENLGDPSMAMMSKRLELRT--KELESRLELEQATRARLEVQVNR------------ 1986
            ::.    :::.|.....|:..::.|::.  :|.|..||||:....|:::::::
Human  1584 QVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEK 1648

  Fly  1987 ----------HKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEF-HAV-SSREQESLTR 2039
                      |:.|:|.||..:........:|..:.||.:..|.|:..:. ||. .:.|.::.||
Human  1649 DEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATR 1713

  Fly  2040 RKDLEKKVEQ------------MESEGAALKNDLRLALQRIADLQQAMEEE------GEEELSES 2086
            ....:.|.||            :..:..||:....|....:.:|:.|:|:.      .|:||.|:
Human  1714 LMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEA 1778

  Fly  2087 DESLSSVGS 2095
            .|.|:.:.|
Human  1779 TERLNLLHS 1787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	209/812 (26%)
		MYSc_Myo18	575..1305	CDD:276837	195/781 (25%)
		GBP_C	<1540..1750	CDD:303769	54/238 (23%)
		COG1340	1565..1833	CDD:224259	82/324 (25%)
		coiled coil	1723..1734	CDD:293879	1/10 (10%)
MYH7B	XP_016883475.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910