DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and GOPC

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_065132.1	Gene:	GOPC / 57120	HGNCID:	17643	Length:	462	Species:	Homo sapiens

Alignment Length:	494	Identity:	102/494 - (20%)
Similarity:	176/494 - (35%)	Gaps:	131/494 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1500 GVGGGVYKLKYERVARELEFTKRRLHTQ---HEHDLEQL-VALKKHLEM-KLSDAYEEVVEQRQV 1559
            |..|||...::..|. |.||.|..:...   .|.|.:|. :..:...:| .||..:.::..:.|.
Human    23 GAPGGVSMFRWLEVL-EKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQS 86

  Fly  1560 VGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQ-DAVRQERQAKERYGREK 1623
            |.|...|.:.   ::.||:..|.|..|...:|||     :...|.|| .:::.:..||.....:.
Human    87 VSQINHKLEA---QLVDLKSELTETQAEKVVLEK-----EVHDQLLQLHSIQLQLHAKTGQSADS 143

  Fly  1624 DVLQAEKFTLEQTLADTRLDLEF-KEEKLASLQRELEEMTFGGGTEEEFAQLRRSKNETERR--- 1684
            ..::|:  ....::.:...:||. |:||:...|.|.|            .:|.|.:||..||
Human   144 GTIKAK--LSGPSVEELERELEANKKEKMKEAQLEAE------------VKLLRKENEALRRHIA 194

  Fly  1685 ------------AKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGN 1737
                        ||..::||.....|||||.:                            :::|.
Human   195 VLQAEVYGARLAAKYLDKELAGRVQQIQLLGR----------------------------DMKGP 231

  Fly  1738 GYKKIKALECQLETE---HEERTLL--LREKHELERRLSSMEDRDRVDRDAEEALNQKLRRDLRK 1797
            .:.|   |..|||.|   |..:|::  .|.:::|:|.:.:....|
Human   232 AHDK---LWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHD-------------------- 273

  Fly  1798 YKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHR 1862
                    |..|::.:...|    ||::....||.|.........::..      |..:..|.|.
Human   274 --------QDSLKKSQGVGP----IRKVLLLKEDHEGLGISITGGKEHG------VPILISEIHP 320

  Fly  1863 ARNDAEERANAAHRDRAELQAQIEENEEELGELMKKYSATVKQLNTEQINVSEAEFKLNEMEAER 1927
            .:  ..:|....|...|.|..    |...|.:...|.:.|:......:|.. |..:...|::::.
Human   321 GQ--PADRCGGLHVGDAILAV----NGVNLRDTKHKEAVTILSQQRGEIEF-EVVYVAPEVDSDD 378

  Fly  1928 NNLKEQVAELQHR----LDNVENLGDPSMAMMSKRLELR 1962
            .|: |...|..||    ||.:|..|:|..:......|::
Human   379 ENV-EYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIK 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769	48/227 (21%)
		COG1340	1565..1833	CDD:224259	58/289 (20%)
		coiled coil	1723..1734	CDD:293879	0/10 (0%)
GOPC	NP_065132.1	bZIP_2	<166..199	CDD:285017	12/44 (27%)
		PDZ_signaling	286..368	CDD:238492	18/94 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..449
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900