DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and dlg5a

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:XP_005156738.1 Gene:dlg5a / 569065 ZFINID:ZDB-GENE-030131-3149 Length:1961 Species:Danio rerio


Alignment Length:903 Identity:184/903 - (20%)
Similarity:325/903 - (35%) Gaps:257/903 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1456 KELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFT 1520
            |||..|.:  :||.|:....: .||...|....:||.|..|.:........|::        :..
Zfish     6 KELLHQCH--QNLLESITDAD-RLIELLSKSGSLSEQEAFELDQNCSSSAEKVE--------QLL 59

  Fly  1521 KRRLHTQHEHDLEQLVALKK---HLEMKL------------------------------------ 1546
            |..::.|.:|.||..|||:|   ||...|                                    
Zfish    60 KMLMNKQSDHFLELCVALEKTYPHLYSALFSNGGGPADHHSGSTYSVLSTMPSDSESSSSLSSVG 124

  Fly  1547 ----------------SDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLL-------EEQNARN 1588
                            ||:.:.::.|          .:::|.|.::||..|       ...:.|.
Zfish   125 TKASSPPPALSDTRPASDSLDTILFQ----------LKQVTRERDELRKRLALASPGTTFDDCRP 179

  Fly  1589 N--------LLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDV--LQAEKFTLEQTLADTRLD 1643
            |        .|:.:..|..|:.||||:...:..:..|...:|.|.  :|..:...|||       
Zfish   180 NSKPGHDYERLKTQCTKAMADLQSLQNQHTKTLKRCEEAVKEADYYHIQHSRLLSEQT------- 237

  Fly  1644 LEFKEEKLASLQRELEEMTFGGGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLR 1708
             :.||| :..|:||..::|      .|...|::|..|..|...|.:.|:.:|    :|.:|..:|
Zfish   238 -QLKEE-MEVLKRENTKLT------REHNHLKQSCEELRRLHSEDQREVADM----RLQQQQVIR 290

  Fly  1709 LEMTLETMRKEARRESQQRDEELEEVRG--NGYKKIKALECQLETEHEERTLLLREKHELERRLS 1771
            ...:.|.:.|       ..|..::::.|  ..|..:.....:..:.|......|.:..|..|||.
Zfish   291 ENGSSEVLNK-------LYDTAMDKLEGVKKEYDVLSKRYSEKVSSHNTDLSRLEQVEEENRRLQ 348

  Fly  1772 SMEDRDRVDRDA----EEALNQKLRR------DLRKYKALLKDAQTQLERLKADTPGKTLIRQLR 1826
            ...|.....||.    ::..:..:||      :|.|..|..|:.|.::|||:::      :.:.:
Zfish   349 KQIDALLKQRDTAIQYQQQWSTSMRRFDSVQQELNKASAQNKELQREMERLQSE------VTRYK 407

  Fly  1827 N----QLEDAESARS----------LAMKARQTAEAELTEVQAMFDESH-RARNDAEERANAAHR 1876
            |    .::|.|..:.          |.|..|.....|:.::|...:.:. |.:|.:.||..|:..
Zfish   408 NFQLKAVKDGEKYKEERDSVFNEYRLIMSERDQVIKEVDKLQTELEAAEARLKNTSSERMVASEE 472

  Fly  1877 ---DRAELQAQIEENEE---ELGELMKKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQVA 1935
               .|.||.:.:.:.:.   |..||::||...||.....|..:|:|...:..:..||:..:::..
Zfish   473 LEALRQELNSSLVDRDRAICERNELLEKYCHEVKDKAEAQKELSQACKDIETVREERDVARKERT 537

  Fly  1936 ELQHRLDNVENLGDPSMAMMSKRLELRTKELESRLELEQATRARLEVQVNRHK-EALEKLQNEVT 1999
            |...:.|.          ::.:..:.|.|:..:.|::|   ||..|:.:.|.: ||:.:...|..
Zfish   538 EAIIQRDQ----------LLREYYQARQKQDSATLDME---RANKEIDILRKQCEAMSQELKEAV 589

  Fly  2000 Q----SKMRE---MQAQDVIKKSQKSLRDM-----REEFHAVSSREQESLTRRKDLEKKVEQMES 2052
            |    :|.|.   .|.:|.|...::|:|.:     ||...|||.. .::|....|:.|:......
Zfish   590 QEAEVAKCRRDWAFQERDKIVAERESIRTLCDNLRRERDRAVSDL-ADALRNLDDMRKQRNDAAR 653

  Fly  2053 EGAALKNDLRLALQRIADLQQAMEE------------EGEEELSE-----SDESLSSV------- 2093
            |...||..:...|.:.|...|.|..            |.|.|:.|     .|..|.::       
Zfish   654 ELKELKEKMESQLDKEARFCQLMAHSSHDSAIDTDSLEWETEVVEFEKDRDDMDLKAMGFDIAEG 718

  Fly  2094 -------------------GSISD----LEDRLRPVH----VKRSSQQSLNGSIGGG-------- 2123
                               |||:|    :.|.|..::    ..:..:|.:...:.||        
Zfish   719 VNDPYLPGDCGIFVSRVDKGSIADGRLRVNDWLLKINDVDLTNKDRKQVIKAVLNGGGLINMVVR 783

  Fly  2124 -----GGSVVSSTR-TVVFEKD-----DNSPRITVTSPSSPHIHK--LALAAKAIPAN 2168
                 ||.:|:|.. .::..||     :....:...:|.||...:  |.:..:.|..|
Zfish   784 RRKSLGGRLVTSVHINLIGHKDAGIALEGGVFVAGIAPGSPAAREGSLTIGDRLIAIN 841

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580
MYSc_Myo18 575..1305 CDD:276837
GBP_C <1540..1750 CDD:303769 51/283 (18%)
COG1340 1565..1833 CDD:224259 65/300 (22%)
coiled coil 1723..1734 CDD:293879 1/10 (10%)
dlg5aXP_005156738.1 CARD 9..88 CDD:260018 23/89 (26%)
Takusan 128..211 CDD:282652 17/92 (18%)
Taxilin 295..627 CDD:286771 74/357 (21%)
RILP-like 338..460 CDD:304877 26/127 (20%)
SH3BP5 444..648 CDD:283045 51/217 (24%)
PDZ_signaling 696..783 CDD:238492 12/86 (14%)
PDZ_signaling 793..866 CDD:238492 10/49 (20%)
PDZ 1381..1463 CDD:214570
dbPDZ_assoc 1461..1541 CDD:293216
PDZ 1541..1623 CDD:214570
SH3_DLG5 1639..1701 CDD:212794
Guanylate_kin 1780..1949 CDD:279019
NK 1794..1950 CDD:302627
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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