Protein Alignment Mhcl and grip2a

DIOPT Version :9

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: XP_017212845.1
• Gene: grip2a / 568084
• ZFINID: ZDB-GENE-081104-132
• Length: 1100
• Species: Danio rerio
• Alignment Length: 1437
• Identity: 269/1437 - (18%)
• Similarity: 440/1437 - (30%)
• Gaps: 567/1437 - (39%)

  Fly   188 AGGAGGTPEM----------LLRNTFQNESLYEGAARGAGSIGSNSS-----------QHGTSFT 231
            |||..|...|          ::|...:::..|   .:|:....|:||           |.|.  |
Zfish    29 AGGVKGKRRMFSFSLRCRIGVIRGRVKDDVPY---TKGSKDTASDSSGFTNRCSLADEQRGV--T 88

  Fly   232 SVESLRSDGEQTG----------GQQRAMTLPANARYGALPQGNSQ---GSHLHVLTSPSPSADS 283
            :||.::.:|...|          |:.|.    :|.|.|.|...:.|   |.::     .|.:..:
Zfish    89 TVELIKKEGSSLGLTISGGCDKEGKPRV----SNLRPGGLAARSDQLNVGDYI-----KSVNGIN 144

  Fly   284 LTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQLVKLPPPRQLVIRRQ----- 343
            |:...:....:   .|..:||          ....:||..|||.    .|.....||.:.
Zfish   145 LSKLRHDEIIS---MLKNIGE----------RVVLEVEYELPPF----APSNPCSVISKTIEVCL 192

  Fly   344 KSPRQDFGFSLRKAICLDRTESLTSPIFRPVI--FAEPGAGGGATGLL-PGDRLIKVNGTPVGEL 405
            :.....|||.||.....|..::      ||::  :..||......|.| .|||::.|||..|..
Zfish   193 EKEGNSFGFVLRGGFHEDWHKA------RPLVVTYVRPGGPADREGTLRAGDRVLSVNGVAVNR- 250

  Fly   406 PREIIIEMIRNSGEAVTVEVQPVAE---LVELSKRCMAPSTATVEEIDHSITNGNCNTLRRSASK 467
                     :...:|:|:.:|...|   |:|.....|                   :::::|:.
Zfish   251 ---------QKHADALTLIMQSSQEAFFLIEYDIMVM-------------------DSVQKSSG- 286

  Fly   468 RFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVWLVHRGGFTAAIRLPTASSGRDEEN 532
                                     .|:.|:|                        .|:|.....
Zfish   287 -------------------------PLQVDIA------------------------RSAGSVLGL 302

  Fly   533 KLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICE-------LKYLNEASVLHCLRQRYASNLI 590
            .||..|..|.:.:|:      ::..||  .|.|.|.       |..::..|..||.... |..|:
Zfish   303 SLSTSLYRNKQVITI------QKIKPA--SVADRCGALHAGDILLAIDGMSTEHCSLME-AQQLL 358

  Fly   591 HTKAGPTLLVVNPMAPLSLY-SEKVVSMFRGCK---------TEDMPPHVYSLAQTAYRSLVETR 645
            .:.:..|.|.:.|    ||: |:..|.:.|.|:         |..:|  .:....:|:.....|.
Zfish   359 SSSSELTKLEILP----SLHSSQDTVRVQRSCQRQWDSSENYTNALP--AFQKTPSAWSQTTPTP 417

  Fly   646 RDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATR 710
            ..:|:    .||...:||..|:.|     .|:.:.:.|...    .:.|.::.::..|   :||:
Zfish   418 SHRSV----SSGVSANTSGFHSYN-----CGSQSAYPNTYP----SSTLPSYPSSPRC---SATK 466

  Fly   711 MTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLEN--- 772
                                        |..||..|:.|..:.:..: ||.|   :.:|||:
Zfish   467 ----------------------------RRHRRKEHKSSLSLASSTV-GAGG---QVVHLESAEV 499

  Fly   773 ITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLG 837
            :...|  |......:|:.          .|.|.|.|:..| |:|
Zfish   500 LLRGD--PLTGFGLQLQG----------GVFATEPLSAPA-AIR--------------------- 530

  Fly   838 TGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECL 902
                    |..|....:..|:|.|....||.           ||      .||.|
Zfish   531 --------FIEPDTPAERCGVLQVGDRILSI-----------NG------IPTED---------- 560

  Fly   903 EALVIGLYSEA--LAAVVALINRQICTSSHTIASIMLIDTPGFQ--NPASCGQQVGATLADLRHN 963
                 |...||  |....||.|:........:|..::..:..||  .|...|.::|.|
Zfish   561 -----GTLEEANQLLRDAALANKIALEVEFDVAESVIPSSGTFQVKLPKRRGVELGIT------- 613

  Fly   964 YLQERLQMLFHHTTLVAPRDRYAQELVEIEMDLASECH------PGPLISLIDKAPQNHVVRSSQ 1022
                           ::...:..:.|:..|:...|..|      ||..:..||.      ||.
Zfish   614 ---------------ISASKKAGKPLIISEIQKGSIAHRIGTLEPGDRLLAIDN------VRL-- 655

  Fly  1023 RDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLRKCAGPRQFVLHHLQGTNP 1087
                  |..||     |||:......:..::.......|.                |..|:.:..
Zfish   656 ------DNCGM-----EEAMMVLQQAEGMVKLRIQKDEDN----------------LDELESSGS 693

  Fly  1088 VLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRG-----SGAM-----VFCGSFA 1142
            |::.|:     .:.|.|   .:.:....:.|..|.:.|.||||.     :||:     |...:..
Zfish   694 VIFTVE-----LKRHGG---PLGITISGTEEPFNPILISSLTRNGLAHRTGALHIGDRVLAINNM 750

  Fly  1143 GLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTK 1207
            .|:|    :.:|.......|||   :::.|::|...|.::|:.|
Zfish   751 SLKG----KPLSEAIHLLQTAG---DTVTLKIKKRSDPLLDSER--------------------- 787

  Fly  1208 YTANGSPSSAAGQVSSEEE----------------MVNVPLLRSQLRG--SQVLEA------ARL 1248
                ||||..|..||..|:                ....|.|.|.:..  |..|:|      ..:
Zfish   788 ----GSPSRTASCVSDMEDDRSDSFRRGKYSDLLRQTTPPSLDSAMDSWDSSALDAGYGSQGVYI 848

  Fly  1249 HRLGFPESVPLLEFVRRFGLLAGDLASNKDVSVEQILAVNELDVASYRIGPS---QILFRSGVLS 1310
            ||                                         .:.:.:.||   |...||.::|
Zfish   849 HR-----------------------------------------PSDFTLHPSDWRQTNHRSPLMS 872

  Fly  1311 ELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRV 1375
            ...|.|..:...|                                     |:..||.:   ...|
Zfish   873 RRPAHRPTVYDGR-------------------------------------LSEEDWTY---SGSV 897

  Fly  1376 TPLL--NVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLEAK-LSELTVDLAEERSTA 1437
            :|..  |.:.|     |..:|....:|..:...|.:||:..|   |||. :|..|:.|.|:
Zfish   898 SPACGHNYNST-----TDAQENYWSQALQDLETCGQSEILRE---LEATIMSGSTLSLGED---- 950

  Fly  1438 HIATERLEAETAERLKLEKELGDQTNKVKNLQETTEKLEMEL--ICAKSDLNGISEDEDAENEDG 1500
               .|:......:.|:|..| ....|..::|:|.:..:.:||  ||.:.|.:  |.|......||
Zfish   951 ---FEKQNESKTKFLELSPE-NTSVNTPEDLKENSPSVPLELHKICIQKDAD--SRDFGFSVSDG 1009

  Fly  1501 -VGGGVY 1506
             :..|||
Zfish  1010 LLEKGVY 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	23/94 (24%)
		MYSc	556..1317	CDD:214580	151/827 (18%)
		MYSc_Myo18	575..1305	CDD:276837	141/789 (18%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
grip2a	XP_017212845.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900