Protein Alignment Mhcl and myo18aa

DIOPT Version :9

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: XP_009303852.2
• Gene: myo18aa / 566880
• ZFINID: ZDB-GENE-080425-5
• Length: 2508
• Species: Danio rerio
• Alignment Length: 2237
• Identity: 757/2237 - (33%)
• Similarity: 1196/2237 - (53%)
• Gaps: 325/2237 - (14%)

  Fly     9 AGDEDKERRKREKKLRKEAKGTSGGPGMGGVTGVTGSMSTDELLRLDEVRRSLKIRGRRKEKEKL 73
            :|..:::|.:....|..|..........|.:.|..|||.:|.|     .||.|.:..:...:||.
Zfish    43 SGPTERQRGEPSTPLNPERPMNIDQRSSGSINGRQGSMESDTL-----ARRGLNLANKTGSEEKQ 102

  Fly    74 PSGITADYSA---DFFAALNADANGGSNGGAVGAADPEQDRGNEEIVASVMTHIESRASNG-AGV 134
            .:..:...::   ...::::.||........:|.|..::.|..........|..||:...| :..
Zfish   103 STATSVPKTSRPLQASSSVDGDALAFGLTSLMGRARSKEHRSRSRATERKETQEESQERTGESET 167

  Fly   135 SVNYSEVTHSLLSGGLK-NRFLPPIPPKPPKRGILKGSRSNMTNVHEEISFAGSAGGAGGTPEML 198
            .....:::....|...| :...||:...|||:..|                         ||.
Zfish   168 PTEEPQLSVPATSPPPKADPLAPPVGFLPPKQNPL-------------------------TPP-- 205

  Fly   199 LRNTFQNESLYEGAARGAGSIGSNSSQHGTSFTSVESLRSDGEQTGGQQRAMTLPANARYGALPQ 263
                             ||.|                       ...:...:..||    |.:|:
Zfish   206 -----------------AGFI-----------------------PAAKPNLLAPPA----GFIPK 226

  Fly   264 GNSQGSHLHVLTSPSPSADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELP---LP 325
            .||.       |.|:|:.|         ..|||...:|..::.        .:.:.|..|   .|
Zfish   227 PNSS-------TQPTPNPD---------HPTPPSGFNPASKAN--------LSTQSVPKPDPLAP 267

  Fly   326 PVQLVKLPPPRQLVIRRQKSPRQDFGFSLRKAICLDRTESLTSPIFRPVI--FAEPGAGGGATGL 388
            |...  ||||::                       |...|:...|.:|.:  .|.|      ||.
Zfish   268 PAGF--LPPPKR-----------------------DPFPSVPGFIPKPKVDPLAPP------TGF 301

  Fly   389 LPGDRLI-----------KVNGTPVGELPREIIIEMIRNSGEAVTVEVQPVAELVELSKRCMAPS 442
            :|..|::           |.:..|.|:||.:  |..|.|...:   :|.|..|
Zfish   302 IPASRMVAVRKPEVKGVSKPSAAPAGKLPSQ--ISTITNQQGS---QVMPTPE------------ 349

  Fly   443 TATVEEIDHSITNGNCNTLRRSASKRFKRQSRHENGNGGGEEGGAKG---------VGHD----- 493
                   :|                      :|...|...|...||.         ..|:
Zfish   350 -------NH----------------------KHLEQNFSAERPPAKAAEDPVAILQAAHEAACLS 385

  Fly   494 -------LEADVADASQPERVWLVHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDD 551
                   |.|:.| ....|:|||||:.||:.|.:|.| .:|...|.|:.:||.|:|..|.|||||
Zfish   386 KVKTEEQLAAEKA-WYNTEKVWLVHKDGFSLATQLKT-DTGSLPEGKVKIRLEHDGTLLEVDEDD 448

  Fly   552 VEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVS 616
            |||.|..:.|.|||:..|.||||:|:||.|||||..|||||.|||.||::||:...::|||||:.
Zfish   449 VEKANPLSYDRVEDLSSLLYLNESSILHSLRQRYGGNLIHTYAGPNLLLINPLCSPAMYSEKVMQ 513

  Fly   617 MFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNF 681
            ||:||:.|:..||::::||:||..|:.||:||:::.:|||||||:|:.:|.|.||...|.:....
Zfish   514 MFKGCRREETAPHIFAVAQSAYHQLLTTRQDQTIVLLGRSGSGKTTNTQHLLQYLVTIAASSGKV 578

  Fly   682 INAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGH 746
            .:|||..|:.|:||||||..|.:|.||:|.:.::||||||.||:||||:|.:|.|:.|..||...
Zfish   579 YSAEKWQAVYTVLEAFGNCSTAMNGNASRFSHIVSLDFDQAGQVASASVQTMLLEKFRVTRRPEG 643

  Fly   747 EHSFHIMTRLLAGAAGLLQKELHLENITSEDS---HPFISLSQKLEDRHRAANDFMRTVQAFETL 808
            |.||::...|:|||...|:.|||..::....:   ||    ..||:|:.:|...|.:...|.:.|
Zfish   644 ESSFNVFYYLMAGADAALKTELHFNHLAENSTFGLHP----PSKLDDKQKATQQFTKLQAAMKVL 704

  Fly   809 NIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGL 873
            .:..:.::.:|.||.||||||.||.|| .|.:..|.|||....|:||:.|||.:||:||||.|
Zfish   705 GVSPEELKTVWLILGAIYHLGAAGATK-ETDAAGRKQFARHEWAQKAAYLLGCSLEELSSAIF-- 766

  Fly   874 TQPNAPNG--------GLSPSKSPTSDTGH----EWAWECLEALVIGLYSEALAAVVALINRQIC 926
                .|.|        .|.||   |.||.|    ..|.||||::..|||||....:::||||.:.
Zfish   767 ----KPQGKGTLPRSASLRPS---TEDTDHAASKATAAECLESMAAGLYSELFTLIISLINRALK 824

  Fly   927 TSSHTIASIMLIDTPGFQNPASCGQQV--GATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQEL 989
            :|.|::.|::::||||||||.....|:  .||..:|.|||.|||||.||...|.|...:||.:|.
Zfish   825 SSQHSLCSLLIVDTPGFQNPRQVKTQIQRSATFEELCHNYAQERLQTLFQERTFVKELERYKEEN 889

  Fly   990 VEIEMDLASECHPGP--LISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFL 1052
            :||.:|   :..|.|  .:::||::....:||:..   |..:.||:.||::||.:.|..:::|.|
Zfish   890 IEITLD---DLEPSPSRSVAVIDQSSSQTLVRTLS---RTDEARGLFWLMEEEVLQPGGSEETLL 948

  Fly  1053 ERLFSHYGDRE----HHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQ 1113
            :||||:||..|    .|:::.|......|||.|..||:.|.|...||:..:|.:|..:||.:||.
Zfish   949 QRLFSYYGPAEGESTGHTVVLKSENTNHFVLGHSHGTDWVEYDTYGWLNLARLNPTPQNAANLLL 1013

  Fly  1114 DSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSL--RRVSSIRRSFTT--AGVKRNSIMLQV 1174
            :|.::.|:.:::|   |.|.|.|..||.|||||...|  ||.:|:|::|||  |.||:.|:.||:
Zfish  1014 NSQKKSISGMFVG---RSSSAAVLTGSIAGLEGVSQLAMRRATSMRKTFTTGMAAVKKKSLCLQI 1075

  Fly  1175 KFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRG 1239
            |..||.::||:||:..|||||.|.:...     ..|.|||..:......:   ::|.|||:|:.|
Zfish  1076 KLQVDALLDTIRRSKVHFVHCLLPRAEV-----LRAAGSPDESCDPGLMQ---IDVALLRAQIHG 1132

  Fly  1240 SQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLASN-------KDV--SVEQILAVNELDVASY 1295
            .::|::.|::|.|:|:.:...||.|||.:||..|...       ||.  :||::|...||:.:||
Zfish  1133 FKLLDSLRIYRQGYPDHMVFSEFRRRFDVLAPHLTKKLGRNYIVKDEKRAVEELLESLELEKSSY 1197

  Fly  1296 RIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAF 1360
            .:|.|::.||:|.:::|||:||......|...||.|||:|:|:...:|::|:||:||:|:|:|..
Zfish  1198 HMGLSRVFFRAGTVAKLEAQRDEHTRQNITLFQAACRGFLSRQAFKKRKIQDLAIRCVQKNIKKN 1262

  Fly  1361 LAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLEAKLSE 1425
            ..|:|||||:|...|.||:.|..||||::..:||::.::.|||::|.:|:|::..:.:||::::|
Zfish  1263 RGVKDWPWWKLFTTVRPLVEVQLTEEQIRGKDEEIMHMKLKLERVEKERNELRLTSDRLESRITE 1327

  Fly  1426 LTVDLAEERSTAHIATERLEAETAERLKLEKELGDQTNKVKNLQETTEKLEMELICAK----SDL 1486
            ||.:|::||:||...::.||.||:|||:|||::.|...|...|::.||.:|||::.|:    |||
Zfish  1328 LTAELSDERNTAESTSQLLETETSERLRLEKDMKDLQVKFDALKKQTESMEMEIMEARLLRASDL 1392

  Fly  1487 NGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSDAYE 1551
            ||..:|.|.::     ||.::|||||..|:.||||::|..:.:..||.....|:|||.||:|...
Zfish  1393 NGEMDDGDDDS-----GGEWRLKYERAIRDTEFTKKKLQQEMDDKLETEQQNKRHLERKLADLQA 1452

  Fly  1552 EVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAK 1616
            :..|.::.|.|.|:|.|::..|:.|.::.||.|..||:.||:||||||.:...:|:.:::||..:
Zfish  1453 DQEESQRSVQQLKKKCQRLAAELQDTKLHLENQEGRNHELERKQRKFDVDKSQVQEELQKERNQR 1517

  Fly  1617 ERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEKLASLQRELEEMTFGGGTEE-EFAQLRRSKNE 1680
            |:..||:|:|.:|.||::|.|.:...:|.....|:..|:.||::::.....:| ..|::::...:
Zfish  1518 EKLSRERDMLTSEMFTIKQQLQEKDTELCTVSLKVEQLESELQDLSSQESKDEASHAKVKKQLRD 1582

  Fly  1681 TERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKAL 1745
            .|.:.|:|||||||.||.||:||||||||||.:|.:|:...:|...:|||:||:|.:..||:|.:
Zfish  1583 LEAKVKDQEEELDEQAGSIQMLEQAKLRLEMEMERLRQTHSKELDSKDEEVEEIRLSCSKKLKQM 1647

  Fly  1746 ECQLETEHEERTLLLREKHELERRLSSMEDRDRV-DRDAEEALNQKLRRDLRKYKALLKDAQTQL 1809
            |.|||.|:.::..:||:|.:||.:|  |..:::| .:|.|  ..::||:||::.|.||.|||..|
Zfish  1648 EVQLEEEYADKQRVLRDKRDLESKL--MTAQEQVGQKDVE--TEKRLRKDLKRTKVLLADAQIML 1708

  Fly  1810 ERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHRARNDAEERANAA 1874
            :.:|::.|.|..|..|:|:||::|.|.:.|:|||::.|.|:.::....|:..:|:...||:.:..
Zfish  1709 DHMKSNVPSKREIATLKNKLEESEFACAAAVKARKSMELEIEDLHIQMDDISKAKMSLEEQLSRL 1773

  Fly  1875 HRDRAELQAQIEENEEELGELMKKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQVAELQH 1939
            .|::.:||::.||::|::.|||||:.|.|.|...:...:|:.:.::.|...|:..:::::..||.
Zfish  1774 QREKNDLQSRFEEDQEDMNELMKKHKAAVAQSTRDLAQISDLQTQVEEAMKEKQEIQDKLHSLQS 1838

  Fly  1940 RLDNVENLGDPSMAMMS--KRLELRTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSK 2002
            :|:..|.    ||...|  .|.|.:.:|||::||.|:....|||..|.|.||.|||:..|..|..
Zfish  1839 QLEFQEQ----SMVEKSLVSRQEAKIRELETKLEYERTQTKRLESLVTRLKENLEKMTEERDQRV 1899

  Fly  2003 MREMQAQDVIKKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQR 2067
            ..|.:.:|..|:.|:.:||::||...:|.:|.|:..::.:||..:|.:|:...:|:.||:||.:|
Zfish  1900 GCENREKDQNKRLQRQIRDIKEEMTELSKKEAEASRKKHELEMDIESLEAANQSLQADLKLAFKR 1964

  Fly  2068 IADLQQAMEEEGEEELSESDESLSSVGSISDLEDRLRPVHVKRSSQQSLNGSIG---GGGGSVVS 2129
            |.|||.|||:|.|   ::.|:.|  :.|:.|:..:.:....|...:..::..:.   .|..|::|
Zfish  1965 IGDLQAAMEDEME---TDDDDDL--INSLQDMVTKYQKRKNKTGDESDMDSEVEDRVDGVKSLLS 2024

  Fly  2130 ----STRTVVFEKDDNSPRITVTSPSS 2152
                ||:|:    .|:.|:.|...|:|
Zfish  2025 KSKGSTKTL----SDDGPQKTTRHPNS 2047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	18/99 (18%)
		MYSc	556..1317	CDD:214580	327/796 (41%)
		MYSc_Myo18	575..1305	CDD:276837	311/765 (41%)
		GBP_C	<1540..1750	CDD:303769	84/210 (40%)
		COG1340	1565..1833	CDD:224259	106/269 (39%)
		coiled coil	1723..1734	CDD:293879	5/10 (50%)
myo18aa	XP_009303852.2	Atrophin-1	<36..373	CDD:331285	87/506 (17%)
		Myosin_head	397..1944	CDD:332202	634/1592 (40%)
		MYSc_Myo18	472..1207	CDD:276837	311/765 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575254
Domainoid	1	1.000	574	1.000	Domainoid score	I210
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7977
Inparanoid	1	1.050	1235	1.000	Inparanoid score	I179
OMA	1	1.010	-	-		QHG47553
OrthoDB	1	1.010	-	-		D23517at33208
OrthoFinder	1	1.000	-	-		FOG0007280
OrthoInspector	1	1.000	-	-		otm26389
orthoMCL	1	0.900	-	-		OOG6_105087
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3038
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.810