DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and pdzd3b

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001124259.1	Gene:	pdzd3b / 566852	ZFINID:	ZDB-GENE-081022-151	Length:	524	Species:	Danio rerio

Alignment Length:	481	Identity:	101/481 - (20%)
Similarity:	169/481 - (35%)	Gaps:	146/481 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 TGVTGSMSTDELLRLDEVRRSLKIRGRRKEKEKLPSGITADYSADFFAALNADANG-GSNGGAVG 103
            |.|:||...  .|.|||......:...|..:|...:.....:.......:..||:| |.|   :.
Zfish   106 TEVSGSQIC--FLVLDEKAYEQVVSEGRDLREMAKAARGEGWRPPHLCHIRKDAHGMGFN---IL 165

  Fly   104 AADPEQDRGNEEIVASVMTHIESRASNGAGV----------SVNYSEVTHSLLSGGLK------- 151
            ..:.|:.:       ..::.::..|:..|||          ....||:|||.:|..:|
Zfish   166 PVEGEKRK-------FAVSPVKGGAAERAGVRKGDHLIWIDGAMASELTHSAISKMVKKCSSHMT 223

  Fly   152 -------------NRFLPPIP--------PKPPKR----------GIL----KGSRSNMTNVHEE 181
                         .|.:|.:|        |..|:|          |.|    ||......::..|
Zfish   224 VLVIDSDTEKSYARRKMPILPAMADAENMPYRPQRLHLVMGPDGYGFLLRQEKGGAGRTVHMVRE 288

  Fly   182 ISFAGSAGGAGGTPEMLLRNTFQNESLYEGAARGAGSIGSNSSQHGTSFTSVESLRSDGEQTGGQ 246
            :. .||....||..|        .|.|.|        :...|:...:....|.::|..|:|
Zfish   289 VD-KGSPAELGGVKE--------GEMLLE--------VNGESTDPLSHKDVVSNIRQSGQQ---- 332

  Fly   247 QRAMTLPANARYGALPQGNSQGSHLHVLTSP------SPSADSLTDTTNSSFATPPFSLSPVGES 305
               :||..     ..|||....:.|.:  ||      .|||  |.:.......||..::.|| |.
Zfish   333 ---VTLTT-----MTPQGYDFYTKLGL--SPLLFCVDVPSA--LPEVKKEIPVTPKPAVPPV-EP 384

  Fly   306 QGIDRWARVHAFEDVELPLPPVQLVKLPPPRQLVIRRQKSPRQDFGFSLRKAICLDRTESLTSPI 370
            |           |:|::.         |..|:.::.|..:   .|||.|.   |:.:
Zfish   385 Q-----------EEVQIN---------PNVRRCILERSSA---GFGFHLG---CVQQ-------- 415

  Fly   371 FRPVIF---AEPGAGGGATGLLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAVT---VEVQPVA 429
             :|..|   ...|:.|.::||..||.:::|||..|.:...|.:|..::..||.::   |:.:...
Zfish   416 -KPGTFISQVAAGSPGQSSGLFQGDVVVEVNGQNVEKESLEDVIMHVKRGGETLSLLVVDQKGYD 479

  Fly   430 ELVELSKRCMAPSTATVEEIDHSITN 455
            .|.:..|........|:.|::.|:::
Zfish   480 WLKQNGKPVTLNKLETISEVEESVSS 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	23/92 (25%)
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
pdzd3b	NP_001124259.1	PDZ_signaling	44..118	CDD:238492	5/13 (38%)
		PDZ	148..227	CDD:214570	17/88 (19%)
		PDZ_signaling	264..336	CDD:238492	19/95 (20%)
		PDZ	393..473	CDD:214570	23/94 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900