DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and ush1c

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_009296312.1	Gene:	ush1c / 564412	ZFINID:	ZDB-GENE-060312-41	Length:	586	Species:	Danio rerio

Alignment Length:	448	Identity:	88/448 - (19%)
Similarity:	154/448 - (34%)	Gaps:	152/448 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 RVHAFEDVELPLPP----VQLVKLPPPRQLVIRRQKSPRQD------FGFSLRKAICLDRTESLT 367
            |:..|:.:. ||.|    ||..:|.|.|.   |:.|..|.|      .|.|:|..:      ...
Zfish    55 RLPLFDAIR-PLIPLKHQVQYDQLTPKRS---RKLKEVRLDRTHPEGLGLSVRGGL------EFG 109

  Fly   368 SPIFRPVIFAEPGAGGGATGLLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAVTVEVQPVAELV 432
            |.:|...|..:..||.  .||..||.::::||..:.....|.:|.:|:.. :.|:::|:.|.
Zfish   110 SGLFISQIVKDGQAGN--VGLQVGDEIVRINGYSISSCIHEEVINLIKTK-KTVSLKVRHVG--- 168

  Fly   433 ELSKRCMAPSTATVEE------IDHSITNG--NCNTLRRSASKRFKRQSRHENGNGGGEE----- 484
                  |.|..::.:|      :|..::..  ..|::...||.             ||.|
Zfish   169 ------MIPVKSSSDEPLKWQFVDQFVSESGEKSNSIAGLASI-------------GGNEIKEKK 214

  Fly   485 -----GGAKGVGHDLEADVADASQPER-----VWLVHRGGFTAAIRLPTAS-----SGRDEEN-- 532
                 .|.||:|      ::.:|.|.:     |..|..|..:|.:.|....     :|.:..|
Zfish   215 VFLSLVGTKGMG------ISISSGPTKKPGIYVSNVKPGSLSAEVGLQVGDQIVEVNGVEFTNLS 273

  Fly   533 -KLSLRLLHNGEQLTV-------------DEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQ 583
             :.::|:|.:...||:             ||:.:..:....||..|.:.:.|...|.:.:...:|
Zfish   274 HQEAVRVLKSSRSLTITVLTGAGSELFMTDEERLAVEARHELDRQELMHQKKVALETNKIVKEQQ 338

  Fly   584 -------------------RYASNLIHTKAG-------------------------------PTL 598
                               ||...:...:|.                               ||.
Zfish   339 EKERQRKMEISQKAAEEEERYRKEMERIEAAEKKHHKEWEDDWGSKEKKKSVSPAASPSPPPPTR 403

  Fly   599 LVVNPMAPLSL---YSEKVVSMFRGCKTEDMPPH-VYSLAQTAYRS--LVETRRDQSL 650
            |..:|....|.   |.|:....|:. ..:|..|| :::..|.|.|.  |:..:::..|
Zfish   404 LAPSPKPKTSTADSYEEETGEGFQK-YVDDFDPHSMFTAEQIAGRDVRLLRIKKEGKL 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	22/92 (24%)
		MYSc	556..1317	CDD:214580	25/151 (17%)
		MYSc_Myo18	575..1305	CDD:276837	20/132 (15%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
ush1c	XP_009296312.1	harmonin_N	2..80	CDD:259819	8/25 (32%)
		PDZ_signaling	85..165	CDD:238492	21/88 (24%)
		PDZ_signaling	212..292	CDD:238492	17/85 (20%)
		RILP-like	317..>379	CDD:304877	7/61 (11%)
		PDZ_signaling	447..534	CDD:238492	3/14 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900