DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and myo16

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:XP_001920958.3 Gene:myo16 / 563752 ZFINID:ZDB-GENE-070912-470 Length:1910 Species:Danio rerio


Alignment Length:1324 Identity:272/1324 - (20%)
Similarity:484/1324 - (36%) Gaps:410/1324 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   225 QHGTSFTSVESLRSDGEQTGGQQRAMTLPANARY-----GALPQGNSQG-SHLHVLTSP------ 277
            ::|...:||..::|        ||..|:.::.:.     |::.|.|..| :.||:.::.      
Zfish   203 ENGVDMSSVHQMKS--------QRCFTMMSDVKQLVSSGGSVNQQNDDGVTLLHIASASGYKEVV 259

  Fly   278 ----SPSADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQLVKLPPPRQL 338
                ...||.|  .::||:.||....:..|::..:.                  ||:|......|
Zfish   260 SVLLENGADVL--VSDSSYWTPLHLAAKYGQTHIVS------------------QLLKHKADPTL 304

  Fly   339 VIRRQKSPRQDFGFSLRKAICLDRTESL-----TSPIFRPVIFAEPGAGGGATGLLPGDRLIKVN 398
            :...|..| .|...:...|..|.|.|..     ..|...|....:..|.......||..:|..: 
Zfish   305 LNCNQDKP-SDIAATEHIAEMLLRAEEFWVQRQRDPSASPPQSEDHSAEANQDDNLPVKKLATM- 367

  Fly   399 GTPVGELPREIIIE---MIRNSGEAVTVEVQPVAELVELSKRCMAPSTATVEEIDHSITNGNCNT 460
            ..|:..  |:.::|   |.|:||.|:|                                      
Zfish   368 ALPISR--RDSLLEKEAMFRDSGGALT-------------------------------------- 392

  Fly   461 LRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVWLVHRGGFTAAIRLPTAS 525
                      :|:..:||                    .|.|.|                   ::
Zfish   393 ----------QQASLDNG--------------------LDGSYP-------------------SA 408

  Fly   526 SGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLI 590
            :|:.|:.||.                     .||.:  :|:..|..|.::|:|:.:::|:|::.|
Zfish   409 AGKLEQVKLM---------------------PPAPN--DDLASLSELTDSSLLYEMQKRFANDQI 450

  Fly   591 HTKAGPTLLVVNPMAPLSLYSEKVVSMF-----RGCKTEDMPPHVYSLAQTAYRSLVETRRDQSL 650
            :|..|..||::||...|.:||..|..::     |.|.:  :|||::|.|:.|:..:.:.||.|..
Zfish   451 YTYIGHILLLINPYKDLPIYSNLVSQLYLSSSGRLCSS--LPPHIFSSAERAFHMMFQERRPQCF 513

  Fly   651 IFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLL 715
            |..|.||||||.:.||.|.:|| |..:...|....::..:..||||||:.||.:|::.:|..:|:
Zfish   514 IISGESGSGKSVACKHILKHLA-ARSSPKGFALEPRMKHVNVILEAFGHAKTQMNTSGSRFIKLI 577

  Fly   716 SLDF-DQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSH 779
            ||.: |:...:....|...:.|:.|......|:.:|:|...:..|.:...:.:|:|.|:.:    
Zfish   578 SLQYCDKRKTLLRGRLYTYMLEKSRVICMPPHQQNFNIFYLMAEGLSAEEKSQLYLNNVLA---- 638

  Fly   780 PFISLSQKLEDRHRAAN-------------------DFMRTVQAFETLNIDAKAVRGIWSILAAI 825
                        ||..|                   ..:...||...|..:...|..::.:::|:
Zfish   639 ------------HRCLNTAAPGESPAVASACPQSREKLLALKQALRALGFNKLEVENVFVLISAL 691

  Fly   826 YHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPT 890
            .|||....|.|....||..  ::.....:.:|:|.|:.||||||.                   |
Zfish   692 LHLGDLRFTALTDADTAFV--SDLQLLDRVAGMLQVSSEDLSSAL-------------------T 735

  Fly   891 SDTGHEWAWECLEALVI------------------GLYSEALAAVVALINRQIC----TSSHTIA 933
            ||.      :|.:..||                  .||....:.:|..||..:.    |:.....
Zfish   736 SDV------QCFKGDVITRRHTVEMSNHHRDLLTKALYGRLFSLLVNNINFYLQGHEETTGDPAL 794

  Fly   934 SIMLIDTPGFQN-PASCGQQVGATLADLR-HNYLQERLQMLFHHTTLVAPRDRYAQELVEIE--M 994
            .|.::|..||:. ..:..:|:...:.:.| |.:..|.|.....|..|        ||.|.:|  .
Zfish   795 EISILDIFGFEEFQRNAYEQLCINMVNERIHQFTAEVLFQQEQHECL--------QEGVAMETLR 851

  Fly   995 DLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHY 1059
            .|.|:.   .::....:.||                 |:|.::|||:......:....:||....
Zfish   852 SLGSQT---AVLDFFFQKPQ-----------------GVLCIIDEESQSLRPCEVNLYKRLQIQL 896

  Fly  1060 GD--REHHSLLRKCA---------GPRQFVLHHLQGTNPVLYAVDGWVRHSRE-HPGIRNAVSLL 1112
            ..  .:..||..|..         || .|.:.|..|  .:.|.:.|.:..::: .|  :|.:.::
Zfish   897 DSSATDAVSLTTKDGNGNPPPKDQGP-SFTVTHFAG--KMTYDLTGSLDRNKDVLP--QNILFVM 956

  Fly  1113 QDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRN--------- 1168
            :.|....|::::...||: :|::|.......|.|.:.    :.|.:| ||....|:         
Zfish   957 KTSENVLIHQMFQCKLTQ-TGSLVPQHQRMKLRGPKG----TLINKS-TTLNPARDAKKYVELNK 1015

  Fly  1169 --------------------SIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGS 1213
                                ::.:|:|.::..|...|:....||:.|.                .
Zfish  1016 LLKKKGASSFLQRLERCGPITVAVQLKNSLCEITSKLQSCTPHFIQCV----------------R 1064

  Fly  1214 PSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLASN-K 1277
            |::|     |:.::.:...:.|||:...|||..|:.|.|:|..:....|:.|:..|...:.:: |
Zfish  1065 PNNA-----SKPDVFDSFHVSSQLQYVGVLEMVRMIRYGYPVRLSFSSFLSRYRELVDTIITDRK 1124

  Fly  1278 DVSVEQ----ILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARK 1338
            ..:.|:    ||...:|.  .:::|.|::..|......|. .|...|..:||..|...||:|||:
Zfish  1125 KATTEEKCRHILLHCKLQ--GWQMGNSKVFLRYWQADHLN-DRCHQLHRKIIICQKVMRGWLARQ 1186

  Fly  1339 KMSQR---RVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRA 1400
            ::.:|   |.|||.      ||:.||                     :..|.|.....:.|::: 
Zfish  1187 QVRRRLTSRKQELC------NVQRFL---------------------QGAEDLGLRTYDNLVIQ- 1223

  Fly  1401 KLEKIECDRSEVKAENQKLEAKLS 1424
                   :.:::..||.:|...:|
Zfish  1224 -------NAADIARENDRLRGHIS 1240

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492 22/94 (23%)
MYSc 556..1317 CDD:214580 189/857 (22%)
MYSc_Myo18 575..1305 CDD:276837 182/826 (22%)
GBP_C <1540..1750 CDD:303769
COG1340 1565..1833 CDD:224259
coiled coil 1723..1734 CDD:293879
myo16XP_001920958.3 ANK 88..186 CDD:238125
Ank_2 90..177 CDD:289560
ANK repeat 113..144 CDD:293786
Ank_2 118..273 CDD:289560 16/79 (20%)
ANK 141..296 CDD:238125 22/120 (18%)
ANK repeat 146..207 CDD:293786 1/3 (33%)
ANK repeat 242..273 CDD:293786 6/32 (19%)
Ank_2 247..329 CDD:289560 20/102 (20%)
ANK repeat 275..306 CDD:293786 8/48 (17%)
MYSc 424..1164 CDD:214580 187/848 (22%)
Motor_domain 435..1154 CDD:277568 182/826 (22%)
NYAP_N 1252..1641 CDD:292079
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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