DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and lnx1

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_005160562.1	Gene:	lnx1 / 561226	ZFINID:	ZDB-GENE-030131-9439	Length:	769	Species:	Danio rerio

Alignment Length:	194	Identity:	42/194 - (21%)
Similarity:	73/194 - (37%)	Gaps:	35/194 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 RYGALPQG-----NSQGSHLHVLTSPS---PSADSLTDTTNSSFATPPFSLSPVGESQGIDRWAR 313
            |||| |:.     .:....:|.:.|..   |:.|.|.:...:....||:  |||
Zfish   469 RYGA-PEHAALLIQASEDRVHFIVSRQTHIPAPDILQEAPWNMEGPPPY--SPV----------- 519

  Fly   314 VHAFEDVELPLPPVQLVKLPPPRQLVIRRQKSPRQDFGFSLRKAICLDRTESLTSPIFRPVIFAE 378
                 |:|..|  :...:.|...:..:...|.|....|.::...:   .:.....|::  |...:
Zfish   520 -----DIEHTL--LDSCQKPACYEKTVTLLKEPHDSLGMTVAGGM---SSRGWDLPVY--VTNVD 572

  Fly   379 P-GAGGGATGLLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAVTVEVQPVAELVELSKRCMAP 441
            | |..|....:..||.|:.|||..:..:.|...:..::|:...|.::|..:....|.|..||.|
Zfish   573 PNGVVGQEGSIRKGDILLNVNGVDLTGVTRSEAVANLKNTSSPVVLQVLEMRPPNESSLDCMPP 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	17/87 (20%)
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
lnx1	XP_005160562.1	RING	57..93	CDD:214546
		PDZ_signaling	297..381	CDD:238492
		PDZ_signaling	411..491	CDD:238492	6/22 (27%)
		PDZ_signaling	536..621	CDD:238492	17/89 (19%)
		DegQ	<548..621	CDD:223343	15/77 (19%)
		PDZ_signaling	678..762	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900