DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and myh7bb

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_009295034.2	Gene:	myh7bb / 560945	ZFINID:	ZDB-GENE-090311-5	Length:	1935	Species:	Danio rerio

Alignment Length:	1816	Identity:	449/1816 - (24%)
Similarity:	793/1816 - (43%)	Gaps:	339/1816 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   505 ERVWLVHRGGFTAAIRLPTASSGRDE---ENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDI 566
            :|||:....  .|.|.:....:..|:   |.|       :|..|||.|:|:::.|.|..||:||:
Zfish    36 KRVWIPDEK--EAYIEVEIKDTDGDKVMVETK-------DGRMLTVKEEDIQQMNPPKFDLMEDM 91

  Fly   567 CELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVY 631
            ..|.:|||||||..|.:||:..:|:|.:|...:.|||...|.:||.:||:.::|.:..|:|||:|
Zfish    92 AMLTHLNEASVLFNLSRRYSFWMIYTYSGLFCVTVNPYKWLPVYSSEVVAAYKGKRRSDVPPHIY 156

  Fly   632 SLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLAL------AAGAYNNFINAEKVNAL 690
            |:|..||..:::.|.:||::..|.||:||:.:.|..:.|.|:      |.|.....:..:.:.|
Zfish   157 SIADNAYNDMLKNRENQSMLITGESGAGKTVNTKRVIQYFAIIAALGEAGGKKGGTLEDQIIEA- 220

  Fly   691 CTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTR 755
            ...:|||||.||..|.|::|..:.:.:.|..||::|||.:.:.|.|:.|...:...|.|:||..:
Zfish   221 NPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPTGKLASADIDIYLLEKSRVIFQQTGERSYHIYYQ 285

  Fly   756 LLAGAAGLLQKELHLENITSEDSHPF--------ISLSQKLEDRHRAANDFMRTVQAFETLNIDA 812
            :|:      .::..|:::....|:||        :.....::|    .::.:.|..|.:||....
Zfish   286 ILS------HRKPELQDMLLVSSNPFDYHFCSQGVITVDNMDD----GDELLATDHAMDTLGFTP 340

  Fly   813 KAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPT-AARKASGLLGVNLEDLSSAAFGLTQP 876
            :...|.:.|:..|.|.   |..|...........|:.| :|.|||.|:|::..||..   ||..|
Zfish   341 EEKYGCYKIVGGIMHF---GNMKFKVKQREEQAEADGTESADKASYLMGISSADLIK---GLLHP 399

  Fly   877 NAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTP 941
            ....|.....:..|.    |.....:.||....|......:|..||:.:.|:......|.::|..
Zfish   400 RVKVGNEYIVRGQTV----EQVTYAVGALAKATYDRMFKWLVGRINKTLYTAIPRQFFIGVLDIA 460

  Fly   942 GFQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLA 997
            ||:    |          ....:..|:..|:||..|:|...:..::.|..|     .::..:||.
Zfish   461 GFEIFEFN----------NFEQMCINFTNEKLQQFFNHHMFILEQEEYKTEGIEWTFIDFGLDLQ 515

  Fly   998 SECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDR 1062
            : |     |.||:|.                  .|:|.:|:||.::|.:.:.:|..:|:.:...:
Zfish   516 A-C-----IDLIEKP------------------LGILSILEEECMFPKATESSFKAKLYDNLLGK 556

  Fly  1063 EHHSLLRKCAGPRQFVLH----HLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRL 1123
            ..:.|..:....|::..|    |..|..|  |.::||:..:|: |.....|.:.|.||.:.::.|
Zfish   557 SPNFLKPRPDKKRKYDTHFELVHYAGVVP--YNINGWLDKNRD-PLNETVVGIFQRSSNKLMSSL 618

  Fly  1124 YIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRT 1188
            :...::..||:....||....:...|.:.||.:.                 |..::.::..||.|
Zfish   619 FENFISLDSGSEAKPGSKEKRKKGASFQTVSQLH-----------------KENLNKLMTNLRST 666

  Fly  1189 GTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGF 1253
            ..|||.|.:                |:.|     ....|:...|:..|||.:.|||..|:.|.||
Zfish   667 QPHFVRCII----------------PNEA-----KNPGMMEPFLVLHQLRCNGVLEGIRICRKGF 710

  Fly  1254 PESVPLLEFVRRFGLLAGDLASNKDV------SVEQILAVNELDVASYRIGPSQILFRSGVLSEL 1312
            |..:...||.:|:.:| ..||..:|.      :||::|...::|...|:.|.|::.|::|:|.:|
Zfish   711 PNRILYAEFKQRYRIL-NPLAIPEDTYVDSRKAVEKLLGSLDIDHTQYKFGHSKVFFKAGLLGQL 774

  Fly  1313 EAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTP 1377
            |..||..||..:..|||||||.|.|.:..:...::.|:..||.|::||.||::|||..|..::.|
Zfish   775 EDMRDERLSKVLTLLQAFCRGKLMRMERKRMMKEKEALMVIQWNIRAFYAVKNWPWMCLFFKIKP 839

  Fly  1378 LLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLEAKLSELTVDLAEERSTAHIATE 1442
            ||....||::|.|..||...|:..||:.|..|.|::.:...|..:.::|::.|..|:.....|.:
Zfish   840 LLRSAATEKELATLKEEFQKLKEALERSEVKRKELEEKQVSLVQEKNDLSLQLQAEQDNLADAED 904

  Fly  1443 RLEAETAERLKLEKELGDQTNKVKNLQETTE--------------KLEMELICAKSDLNGIS--- 1490
            |.......::::|       .|:|.|.|..|              |||.|.|..|.||:.:.
Zfish   905 RCNLLIKAKIQME-------GKIKELMERLEDEEEMNATILAKKRKLEDECIELKKDLDDLEITL 962

  Fly  1491 ---EDEDAENEDGVGGGVYKLKY--ERVARELEFTKRRLHTQHEHDLEQLVA----------LKK 1540
               |.|....|:.|...|.::..  |.::| |...|:.|...|:..||.|.:          .|.
Zfish   963 AKVEKEKHATENKVKNLVEEMAALDETISR-LSKEKKALQDAHQQALEDLQSEENKVNMLSKAKI 1026

  Fly  1541 HLEMKLSDAYEEVVEQRQV---VGQWKRKAQ-------------------------KMTNEMNDL 1577
            .||.::.|....:.::::|   :.:.|||.:                         |..:||..:
Zfish  1027 KLEQQVDDLEGSLEQEKKVRMDLERVKRKLEGDLKLSVESSMDLDNSKQQLEERLKKKDHEMVQI 1091

  Fly  1578 RMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLAD--- 1639
            ...:||:.|....|.||.::.....:.|::.:..||.|:.:..:::..:..|...|.:.|.:
Zfish  1092 GAKIEEEQALVIQLHKKIKELQTRIEELEEELEAERAARSKSEKQRSDVSRELEELSERLEEAGG 1156

  Fly  1640 -TRLDLEFKEEKLA---SLQRELEEMTFGGGTE----------------EEFAQLRRSKNETERR 1684
             |...:|..:::.|   .|:|:|||.:....|.                |:...|:|.|.:.|:.
Zfish  1157 ATTAQIEMNKKREADFIKLRRDLEEASLHHETTIAMLRRKHADTVAEMGEQLDNLQRVKQKLEKE 1221

  Fly  1685 AKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKALECQL 1749
            ..|...|.:::|..::.|.:||...|.... |.::...||:.:.|||:    .....:.:.:.:.
Zfish  1222 KAETRMECEDLASNVEHLSRAKTTTEKMCR-MYEDQLNESKTKIEELQ----RQLMDVTSQKARA 1281

  Fly  1750 ETEHEERTLLLREKHELERRL--------SSMEDRDRVDRDAEEALN------QKLRRD---LRK 1797
            :||..|.:..|.||..|..:|        .::|:..:...:..:|.|      |..|.|   ||:
Zfish  1282 QTESAEVSRRLEEKEVLVMQLQRTKIAFSQTVEELKKQLEEESKAKNSLAHAVQSSRHDCDLLRE 1346

  Fly  1798 YKALLKDAQTQLERL--KAD-------TPGKTLIRQLRNQLEDAESARSLAMKARQTA-EAELTE 1852
            .....::|:::|:|.  ||:       |..:|...|..::||||:......::..:.| ||...:
Zfish  1347 QFEEEQEAKSELQRALSKANIEIAQWRTKYETDAIQRTDELEDAKKKLVARLQGSEEAVEASNAK 1411

  Fly  1853 VQAMFDESHRARNDAE------ERANAA---------HRDR--AELQAQIEENEEELGELMKKYS 1900
            ..::....||.:.:.|      ||:||.         :.|:  :|.:.:.||.:.|| |..:|.|
Zfish  1412 CASLEKTKHRLQTEIEDLMVDLERSNAVAIALDKKQRNFDKVLSEWRQKFEETQSEL-EGSQKES 1475

  Fly  1901 ATVKQLNTEQINV----SEAEFKLNEMEAERNNLKEQVAELQ----------HRLDNVENLGDPS 1951
               :.|:||...:    .||..:|..::.|..||:|::.:|.          |.|:.::.:.|..
Zfish  1476 ---RSLSTELFKLKNSYEEALDQLETIKRENKNLQEEITDLTDQISQGNKTIHELEQMKKVLDHE 1537

  Fly  1952 MAMMSKRLELRTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQ 2016
            ...:...||    |.|..||.|::...|:::::::.|..:||...|      |:.:..::.:..|
Zfish  1538 KCDIQAALE----EAEGTLEHEESKTLRVQLELSQTKTEVEKKLAE------RDEEIDNLRRNHQ 1592

  Fly  2017 KSLRDMREEFHAVSSREQESLTRRKDLEKKVEQME----------SEGAALKNDLRLALQRIADL 2071
            ::|..|:....|.:....|::..:|.:|..:.:||          .|...:..:|:|   :|.||
Zfish  1593 RTLEGMQTTLDAETRARNEAIRVKKKMENDMNEMEIHLNHANRQAVESQKMVRNLQL---QIKDL 1654

  Fly  2072 QQAMEEEGE--EELSES-----------DESLSSVGSISDLEDRLRPV--HVKRSSQQSLN 2117
            |..::|...  |||.|.           ...|..:..:::..||:|.|  |....|.:.:|
Zfish  1655 QVELDESMHHCEELKEQVAVTERRNTLLSAELEELRGVAEQTDRMRKVAEHELLESSERVN 1715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	207/794 (26%)
		MYSc_Myo18	575..1305	CDD:276837	192/763 (25%)
		GBP_C	<1540..1750	CDD:303769	50/260 (19%)
		COG1340	1565..1833	CDD:224259	72/341 (21%)
		coiled coil	1723..1734	CDD:293879	5/10 (50%)
myh7bb	XP_009295034.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810