DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and grid2ipb

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_009304908.1	Gene:	grid2ipb / 559717	ZFINID:	ZDB-GENE-040724-161	Length:	1383	Species:	Danio rerio

Alignment Length:	1610	Identity:	291/1610 - (18%)
Similarity:	480/1610 - (29%)	Gaps:	588/1610 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 LPPPRQLVIRRQK---SPRQD--FGFSLRKAICLDRTESLTSPIFRPVIFAE--PGAGGGATGLL 389
            :||...:|.|.|:   :|..|  |||:: ...|             |::..:  |.:..|.:||.
Zfish    70 IPPSIGVVSRIQQMDITPGPDGRFGFTI-VGDC-------------PLLVEDCSPCSPAGRSGLR 120

  Fly   390 PGDRLIKVNGTPV--GELPREII------------------------------------------ 410
            .||.:::|||.||  .|:...:|
Zfish   121 AGDYVMEVNGIPVKHHEMAAALIKASQGRTLRLGVLCMGSRQKRSSGSLEGLQKDTDGMRQDRKH 185

  Fly   411 --IEMIRNSGEAVTVEVQPVAELVELSKRCMA-----------PSTATVEE-------------- 448
              :|..|...|.:..|.:...:|..:.|:..|           |...|.||
Zfish   186 KALEFNRRVEEILRNEPEVKEKLFAVLKQFAAERKVDWLASVLPDILTTEEQQQLISNIRIFIPK 250

  Fly   449 ---------IDHSITNGNC---------NTLRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDLE 495
                     :..|:.|..|         |.||||.|     |..||...|...   |..|..|..
Zfish   251 KHRQRFDEAVSQSLINRMCRSKSLGEPQNRLRRSRS-----QDHHERPQGSKR---ASSVPRDTG 307

  Fly   496 ADVADASQP-----------------ERVWLVHRG----GFTAAIRLPTASSGRDEENKLSLRLL 539
            .:.|...:.                 :|...|:||    |||.....|
Zfish   308 DEPAQNDRTLRKSNTMIPTQYVSGVNQRTIRVYRGKKSFGFTLRGHAP----------------- 355

  Fly   540 HNGEQLTVDEDDVEKQNSPALDLVEDICELK------YLNEASVLHCLRQRYASNLIHTKAGPTL 598
                   |..|.| ...|||     :.|.||      :||...:.:|..::..|.|..:.|.|:|
Zfish   356 -------VWIDSV-MPGSPA-----EACGLKTGDRILFLNGLDMRNCSHEKVVSMLQGSGAMPSL 407

  Fly   599 LV---------------VNPMAPLS----LYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVET 644
            :|               ..|.||.|    |.|.:.|:       |.:||
Zfish   408 VVEEGPVDYPQSDSEPEETPSAPRSRSPALSSLQWVA-------EILPP---------------- 449

  Fly   645 RRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNAT 709
                |:...||       :|...|.:|......|          .:|..||.|...:   |.:..
Zfish   450 ----SIRVHGR-------TFSQQLEHLLTLQERY----------TICKALETFFQHR---NVDTL 490

  Fly   710 RMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENIT 774
            .:.....||......|.....|:|..|.|        ||....:.|.|...:.  :.|:..|...
Zfish   491 IVDVFPVLDTPAKQLIWQFIYQLLTYEEQ--------EHCKTKIARFLGFKSA--EPEVGAETHR 545

  Fly   775 SEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVT----- 834
            ...|......|.|...|.|:::|                      .|:..  |||:...|
Zfish   546 RSSSMRVSGTSHKNTVRERSSDD----------------------CIIGT--HLGMGTFTDPVTP 586

  Fly   835 ---KLGTGSTARTQFANPTAARKASGLLGVNLE-------DLSSAAFGLTQPNAPNGGLSPSKSP 889
               :.|.|    |.|..   :...|.:.||..|       ..|.:....:.|.|...||:.|.:.
Zfish   587 EERQCGDG----TSFPE---SPDLSHMTGVYTELGNVYPVKSSQSLQSHSSPRAAGMGLAESNTY 644

  Fly   890 TSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQNP-ASCGQQV 953
            |....|..|......|       :|....:....|..|...|:||...:|:    || .|.....
Zfish   645 TQSFTHSTAGNRKSGL-------SLTWTDSFPGPQFETYQQTVASPDSVDS----NPYVSLDSPP 698

  Fly   954 GATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQELVEIEMDLASECHPGPLISLID--KAPQNH 1016
            .:.|.....:.|.:|.::.   |....||.|...:.    :|..|| ..|..::::|  |..:|.
Zfish   699 ASPLPSDELSPLPQRRKLF---TFSRPPRSRDTDKF----LDALSE-QLGHRVNIVDDFKGGEND 755

  Fly  1017 VVRSSQRDLRE-----HDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDR-------------- 1062
            ....|.:|.:|     |:       |...:...:|:.|......:|...|.
Zfish   756 YEEMSFQDEQEVNMLPHE-------LSSASSEDHSSSDDSTSVSYSSGSDHIPPPPQSPPPPPPP 813

  Fly  1063 ------------------------EHHSLLR-KCAGPRQFV-----LHHLQGTNPVLYAVDGWVR 1097
                                    :||.::. ....||.|:     ||.:..|...|.|.....|
Zfish   814 LQFTDSPSPLPITPEHLPQPPPAFQHHPIIAPPPPPPRPFLANRPSLHKVLPTREELRAQHSHPR 878

  Fly  1098 HSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTT 1162
            .|...|..:..:.|.|..:.         .:.:.|............:.|:......||.:|..|
Zfish   879 RSSPQPSSQPILQLHQPKAH---------PILQSSPHTSPQPPHTSAQHTRLQHPSQSIYQSQQT 934

  Fly  1163 AGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQV------ 1221
                                 |:.||...      |......|::.:......:.:.:|
Zfish   935 ---------------------TVPRTSPS------LTKQKSLHSQPSQQSFEGTLSSKVPPPPPP 972

  Fly  1222 -----------------SSEEEMVNVPLLR-SQLRGS------QVLEAARLHRLGFPESVPLLEF 1262
                             :|:...::|..|| .|:..|      |:.:....|:|.  :.|..|:.
Zfish   973 PLPPPCDPPPLPKPSPKASDNNHMSVKRLRWEQVENSEGTIWGQLGDDPDYHKLS--DMVKYLDL 1035

  Fly  1263 VRRFGLLAGDLA---------SNKDVSVEQIL----AVN-ELDVASYRIGPSQILFRSGVLSELE 1313
            ...||.....::         :.|...|.:||    |.| .:.:|..::.|.::
Zfish  1036 DLYFGTQRNSISLPEPTFLPENLKKKDVVEILSHKKAYNASILIAHLKLAPKEL----------- 1089

  Fly  1314 AKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCI------QRNVKAFLAVRDWPWWRLL 1372
              ||:|::                  ||..|::...::.:      ...||.|
Zfish  1090 --RDILMT------------------MSTERLEPAHIKQLLLYAPDDEEVKQF------------ 1122

  Fly  1373 VRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLEAKLSELTV-DLAEERST 1436
                    .|..::..|.:..:..:|:..|         |.....:|.:.|.:.|| :..||...
Zfish  1123 --------QHYDQDPAKLSEPDQFVLQMLL---------VPEYKTRLRSLLFKTTVQEKTEEMRA 1170

  Fly  1437 AH--IATERLEAETAERL-KLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENE 1498
            |:  |....||.:.::|| |:.:.:....|.:.|.|..|.|      .....:|.::|....:..
Zfish  1171 AYECIYKASLELKNSKRLAKILEFVLAMGNYLNNGQPKTNK------TTGFKINFLTELNTTKTV 1229

  Fly  1499 DGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQW 1563
            ||....::.|     |:.|        .||   ..:|:...:.|   ::......|.||.:
Zfish  1230 DGKSTFLHIL-----AKSL--------CQH---FPELLGFSRDL---ITVPLAAKVNQRTI---- 1271

  Fly  1564 KRKAQKMTNEMNDLRMLLEE-QNARNNLLEKKQRKFDA-------EC----QSL----QDAVRQE 1612
                   |.:::|:...::: :.|...:....:.:|.|       .|    |||    |.|:.:.
Zfish  1272 -------TADLSDVHSTIQDIRTACVKIPATAEDRFAAVMSSFLENCHPAVQSLDSLQQRAMDEF 1329

  Fly  1613 RQAKERYGREKDVLQAEKF---------TLEQTLADTRLDLEFKEEKLAS 1653
            .:....:|.:..|...|.|         ..|:.|::|:.....|..::||
Zfish  1330 HKVASYFGEDSKVTTTETFFGIFAEFISKFERALSETQGTENPKSPRIAS 1379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	27/139 (19%)
		MYSc	556..1317	CDD:214580	160/896 (18%)
		MYSc_Myo18	575..1305	CDD:276837	152/859 (18%)
		GBP_C	<1540..1750	CDD:303769	25/139 (18%)
		COG1340	1565..1833	CDD:224259	21/114 (18%)
		coiled coil	1723..1734	CDD:293879
grid2ipb	XP_009304908.1	PDZ_signaling	9..69	CDD:238492
		PDZ_signaling	80..156	CDD:238492	21/89 (24%)
		HN_L-delphilin-R1_like	183..262	CDD:259820	11/78 (14%)
		PDZ_signaling	335..410	CDD:238492	25/104 (24%)
		HN_L-delphilin-R2_like	451..530	CDD:259821	21/106 (20%)
		FH2	995..1360	CDD:280362	81/462 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900