DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and grip1

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:XP_009298419.1 Gene:grip1 / 558006 ZFINID:ZDB-GENE-041210-125 Length:1191 Species:Danio rerio


Alignment Length:1199 Identity:225/1199 - (18%)
Similarity:376/1199 - (31%) Gaps:435/1199 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   333 PPPRQLVIRRQKSPRQDFGFSLRKAICLDRTESLTSPIF---------RPVI--FAEPGAGGGAT 386
            ||...|.||||..|.:..|.|   .:.|.:.|..|..:.         :|.:  ..:.|....:.
Zfish    58 PPDGALAIRRQSIPDEFKGTS---TVELIKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSD 119

  Fly   387 GLLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAVTVEVQPVAELVELSKRCMAPSTATVEEIDH 451
            .|..||.:..|||..:.:...:.||.:::|.||.|.:||:     .||....:..|....:.::.
Zfish   120 QLNVGDYIKSVNGINLTKFRHDEIISLLKNVGERVVLEVE-----YELPPVSVQGSGVMFKNVEV 179

  Fly   452 SITNGNCNTLRRSASKRFKRQSRHENGN-------GGGEEGGAKGVGHDLEADVADASQPERVWL 509
            ::                     |:.||       ||..|...|             |:|..:..
Zfish   180 TL---------------------HKEGNTFGFVIRGGAHEDRNK-------------SRPVTITT 210

  Fly   510 VHRGGFTAAIRLPTASSGRDEENKLSLR--LLH---NGEQLTVDEDDVEKQNSPALDLVEDICEL 569
            :..||  .|.|..|...|   :..||:.  .||   :.|.:::    :::....|..|:|     
Zfish   211 IRPGG--PADREGTIKPG---DRLLSIDGIRLHGASHAEAMSI----LKQCGQEATLLIE----- 261

  Fly   570 KYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLA 634
               .:.||:         :.:.|.:||.|:.|......||......||:  |..:.:        
Zfish   262 ---YDVSVM---------DSVATASGPLLVEVAKSMGSSLGLALSTSMY--CNKQVI-------- 304

  Fly   635 QTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGN 699
                  :::..:..|:  ..|.|:      .||.:::....|....:         ||:.||   
Zfish   305 ------IIDKVKPASI--ADRCGA------LHAGDHILSVDGTSMEY---------CTLAEA--- 343

  Fly   700 TKTCLNSNATRMTQLLSLDFDQTGQIASASLQV---LLPERQRAGRRLGHEH-SFHIMTRLLAGA 760
                        ||||          ||||..|   :||..|......|.|| .....||.|...
Zfish   344 ------------TQLL----------ASASEHVKMEILPHHQTRLALKGPEHVKVQRSTRPLPWE 386

  Fly   761 AGLLQKELHLENITSEDSH--PFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILA 823
            :|           |:.:|:  |:                     |.:.|.:.|..          
Zfish   387 SG-----------TNNNSNFLPY---------------------QHYNTYHPDQS---------- 409

  Fly   824 AIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQ-----------PN 877
               |           ....:|..:||.        ||.:....|.:|:.|:.           |.
Zfish   410 ---H-----------SQAKKTSPSNPP--------LGSSFSPTSMSAYSLSSLNMNTLPRTMYPT 452

  Fly   878 APNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEAL---AAVVALINRQI----------CTSS 929
            :|.|.:...|....|.....:   |.:..:||..:.:   ...|.||:..|          ..::
Zfish   453 SPRGTMMRRKLKKKDYKSSMS---LASSTVGLAGQVVHTETTEVTLISDSIMGFGIQLQGGVFAT 514

  Fly   930 HTIASIMLIDTPGFQNPAS-CG-QQVGATLADL-----RHNYLQERLQMLFHHTTLVAPRDR--Y 985
            .|::|..||......:||. || .|:|..:..:     ..:.|:|..|:|         ||.  .
Zfish   515 ETLSSPPLIAYIDPDSPAERCGILQIGDRILSINGIPTEDSTLEETNQLL---------RDSSIT 570

  Fly   986 AQELVEIEMDLASEC-------------HPGPLISLIDKAPQNH------VVRSSQRDLREHDRR 1031
            ::..:|||.|:|...             .||..:.:...:|.:.      ::...::....| |.
Zfish   571 SKVTLEIEFDVAESVIPSSGTFHVKLPKKPGVELGITISSPSSRKPGDALIISDIKKGSVAH-RT 634

  Fly  1032 GMLWLLDEEAIYPNSN-DDTFLERLFSHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVLYA--VD 1093
            |.|.|.|:.....|.. |:..:|         :...:|::|....:..:...:..:.||.|  ||
Zfish   635 GTLELGDKLLAIDNIRLDNCSME---------DAVQILQQCEDLVKLKIRKDEDNSGVLRAGSVD 690

  Fly  1094 GWVRHSREHPGIRNAVSLL------QDSS-----------------------REEINRLYIGSLT 1129
                        |||..||      |::|                       .|..:.:.|.|||
Zfish   691 ------------RNARVLLACVADEQETSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLT 743

  Fly  1130 RG-----SGAM--------VFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGI 1181
            :|     :||:        :...|..|...::::..:.....|.|....|:..:......:|.|.
Zfish   744 KGGLAERTGAIHIGDRILAINSNSLKGKPLSEAIHLLQMAGESVTLKIKKQGELPSPKPPSVTGR 808

  Fly  1182 IDTLRRTGTHFVHCYLLQ---HNAGKHTKYTANGSPS-------------------------SAA 1218
            ::.|..          |:   ..|||.:...:...||                         .|:
Zfish   809 LNNLSD----------LEDDGQKAGKLSDIYSTTIPSVDSAVESWDGSAIDATFSTQAPTGFQAS 863

  Fly  1219 GQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLASNKDVSVEQ 1283
            |......|..|....|..|   ..:.::|......|:          ||:...|. .....|...
Zfish   864 GYSFHSHEWRNAKPSRGSL---SPVNSSRQRNNILPD----------FGIGVDDW-DRPSASGAS 914

  Fly  1284 ILAVNELDVASYRIG-----PSQ-------------ILFRSGVLSELEAKRDVLLSDRIIQLQAF 1330
            .|....:..:.:.:|     |.|             ...:||:|.|||.|.|.||:.|.:.:.|.
Zfish   915 TLPTGLISDSRFTVGHDGTEPDQEENFWSQALEDLETCGQSGILRELEDKPDRLLNKRNLAILAT 979

  Fly  1331 ---------------CRGYLARKKMSQRR 1344
                           .|.:|.|:...|.|
Zfish   980 IMSGSSLSLNHDPAPTRSHLGRQASFQER 1008

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492 25/97 (26%)
MYSc 556..1317 CDD:214580 163/909 (18%)
MYSc_Myo18 575..1305 CDD:276837 153/878 (17%)
GBP_C <1540..1750 CDD:303769
COG1340 1565..1833 CDD:224259
coiled coil 1723..1734 CDD:293879
grip1XP_009298419.1 PDZ_signaling 79..159 CDD:238492 18/79 (23%)
PDZ_signaling 178..261 CDD:238492 22/125 (18%)
PDZ_signaling 276..359 CDD:238492 27/140 (19%)
PDZ_signaling 490..578 CDD:238492 21/96 (22%)
PDZ_signaling 591..675 CDD:238492 14/93 (15%)
PDZ_signaling 711..792 CDD:238492 12/80 (15%)
PDZ_signaling 1053..1133 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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