DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and myh11a

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_021332550.1	Gene:	myh11a / 554168	ZFINID:	ZDB-GENE-050531-1	Length:	1983	Species:	Danio rerio

Alignment Length:	2110	Identity:	518/2110 - (24%)
Similarity:	851/2110 - (40%)	Gaps:	651/2110 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   499 ADASQPERVWL-VHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDL 562
            ||.|..:.||: ..:.||      .:||...:..:::.:.|:.||:::||::||::|.|.|....
Zfish    27 ADWSAKKLVWVPSEKHGF------ESASIKEEHGDEVLVELMDNGKKITVNKDDIQKMNPPKFSK 85

  Fly   563 VEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMP 627
            |||:.||..||||||||.||:||.|.||:|.:|...:||||...|.:||||::.|::|.|..::|
Zfish    86 VEDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVVNPYKMLPIYSEKIIEMYKGKKRHEVP 150

  Fly   628 PHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAY------------NN 680
            ||:||:...|||::::.|.|||::..|.||:||:.:.|..:.|||:.|.::            ..
Zfish   151 PHIYSITDNAYRNMMQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDMSAQQSGQQ 215

  Fly   681 FINAEKVNALC---TILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGR 742
            |...|....|.   .|||||||.||..|.|::|..:.:.::||.||.|..|:::..|.|:.|..|
Zfish   216 FAYGELEKQLLQANPILEAFGNAKTIKNDNSSRFGKFIRINFDVTGFIVGANIETYLLEKSRCIR 280

  Fly   743 RLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFET 807
            :...|.:|||...::||....|::||.|||.   :::.|:|........::....:..|::|.|.
Zfish   281 QAKTERAFHIFYYMVAGTKDKLREELLLENF---NNYRFLSAGHVQIPGNQDDEMYDETMEAMEI 342

  Fly   808 LNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFG 872
            :....:....:..:::.:..||.....|  ..:..:....:.|||:|...|.|:|:.|.:.|
Zfish   343 MGFSVEERADVLKVVSTVLQLGNIEFKK--ERNQEQATMPDNTAAQKVCHLQGINVTDFTRA--- 402

  Fly   873 LTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIM- 936
            :..|....|.....|:.|.    |.|...:|||...:|......::..:|:.:..:....||.:
Zfish   403 ILTPRIKVGREVVQKAQTK----EQADFAIEALAKAMYERLFRWILLRVNKALDKTKRQGASFLG 463

  Fly   937 LIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEI 992
            ::|..||:    |          :...|..||..|:||.||:||..:..::.|.:|     .::.
Zfish   464 ILDIAGFEIFENN----------SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDF 518

  Fly   993 EMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFS 1057
            .:||.      |.|.||:               |.::..|:|.|||||..:|.:.|.:|:|:|.:
Zfish   519 GLDLQ------PCIELIE---------------RPNNPPGILALLDEECWFPKATDVSFVEKLCN 562

  Fly  1058 HYGDREHHSLLRKCAGPRQ------FVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSS 1116
            .:.   :|:   |.|.|:|      |.:.|..|.  |.|....|:..:.: |...|..:||.:||
Zfish   563 THA---NHT---KFAKPKQLKDKTEFSVQHYAGR--VDYNAVAWLTKNMD-PLNDNVTALLNNSS 618

  Fly  1117 REEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGI 1181
            ..     ::..|.:.:..:|      |||....:....:...|.|..|:.|....| .|.::..:
Zfish   619 NP-----FVQDLWKDADRVV------GLETIAKMSDSLAPSASKTKKGMFRTVGQL-YKESLAKL 671

  Fly  1182 IDTLRRTGTHFVHCYLLQH--NAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLE 1244
            :.||..|..:||.|.:..|  .|||                       ::..|:..|||.:.|||
Zfish   672 MTTLHNTQPNFVRCIIPNHEKRAGK-----------------------LDAHLVLEQLRCNGVLE 713

  Fly  1245 AARLHRLGFPESVPLLEFVRRFGLLAGDLASNKDVSVEQ--ILAVNELDVAS--YRIGPSQILFR 1305
            ..|:.|.|||..:...||.:|:.:||.:......:..:|  .|.:..||:..  ||||.|:|.||
Zfish   714 GIRICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACCLMIKHLDIDPNLYRIGQSKIFFR 778

  Fly  1306 SGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWR 1370
            :|||::||.:||:.::..||..|:..||:||||..::|:.|..|::.||||..|:|.:|:|.|||
Zfish   779 TGVLAQLEEERDLKITVIIIAFQSQARGFLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWR 843

  Fly  1371 LLVRVTPLLNVHRTEEQLKTANEEL---------------------------------------- 1395
            |..:|.|||.|.|.||::....|||
Zfish   844 LFTKVKPLLQVTRQEEEMSLKEEELQKAKESAQKFEIELKDIALKHTQLMDERNQLQEKLQAETE 908

  Fly  1396 ---------------------------------------LMLRAK-------------------- 1401
                                                   |.:..|
Zfish   909 LYAEAEEMRVRLASKKQELEEILHEMEARLEEEEDRGAALQMEKKKMHEQIKDLEEHLEEEEDAR 973

  Fly  1402 ----LEKIECD----------------RSEVKAENQKLEAKLSELTVDLAEERSTAHIAT----- 1441
                |||:.||                .::::.|.:.||.::::.:.:||||...:...|
Zfish   974 QKLQLEKVTCDAKIKKLEDDILIMDDQNNKLQKERKILEERIADFSSNLAEEEEKSKNLTKLKNK 1038

  Fly  1442 -ERLEAETAERLKLEKELGDQTNKVK--------NLQETTEKLEMELICAKSDLNGISEDEDA-- 1495
             |.:.:|...|||.|::...:.:|.|        :|||....|:.::...|:.|....|:..|
Zfish  1039 HESMISELEVRLKKEEKTRQELDKAKRKLEAESNDLQEQIADLQAQIADLKAQLAKKEEELQAAL 1103

  Fly  1496 ---ENEDGVGGGVYK---------------LKYERVAR-ELEFTKRRLHTQHEHDLEQLVALKKH 1541
               |:|.|......|               |:.||.|| :.|.|||.|.       |:|.|||..
Zfish  1104 ARLEDETGQKNNALKKIRELEGHISDLQEDLESERAARNKAEKTKRDLG-------EELEALKSE 1161

  Fly  1542 LE------------------------------------------MKLSDAYEEVVEQ-------- 1556
            ||                                          .|.:.|.||:.||
Zfish  1162 LEDTLDTTATQQELRAKREQEVTLLKRAIEDESRVHEAQVQEMRQKHTQALEELTEQLEQSKRVK 1226

  Fly  1557 ---------------------------RQVVGQWKRKAQ-------------------------K 1569
                                       :|.|...|:|.:                         |
Zfish  1227 VNLEKAKQALEKETSELHVELRSLTQGKQDVEHKKKKLEGQLADLQSRFNDSERHKAELGDRVSK 1291

  Fly  1570 MTNEMNDLRMLLEEQNARNNLLEK----------------------------KQRKFDAECQSLQ 1606
            :|.|:..:..||.|...:|..|.|                            |.|:.:.:..:||
Zfish  1292 ITVELESVTNLLNEAEGKNIKLSKDVASLSSQVQDTQELLAEETRQKLQLSTKLRQIEDDRNALQ 1356

  Fly  1607 DAVRQERQAK---ERY---------------------------GREK------------------ 1623
            :.:.:|.:||   ||:                           |:::
Zfish  1357 EQLDEEAEAKRNVERHVSTLNIQLSDFKKKLEEMTGNVELLEEGKKRLQRDLEAANTQFEEKAAA 1421

  Fly  1624 -DVLQAEKFTLEQTLADTRLDLE------------------------------------------ 1645
             |.|:..|..|:|.|.||.:||:
Zfish  1422 YDKLEKTKNRLQQELEDTLMDLDNQRQLVSNLEKKQKKFDQMLAEEKSISSKYADERDRAEAEAR 1486

  Fly  1646 FKEEKLASLQRELEEMTFGGGTEEEFA-------------------------QLRRSKNETERRA 1685
            .||.|..||.|.|||   .....|||.                         :|.:||...|.:.
Zfish  1487 EKETKALSLARALEE---AQEAREEFERANKALRAEMEDLVSSKDDVGKNVHELEKSKRGLEAQV 1548

  Fly  1686 KEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKALECQLE 1750
            :|.:.:|:|:..::|..|.||||||:.::.::.:..|:.|.|||:.||.:....|:::.||.:||
Zfish  1549 EEMKTQLEELEDELQAAEDAKLRLEVNMQALKAQFERDLQGRDEQGEEKKRQLVKQVRELETELE 1613

  Fly  1751 TEHEERTLLLREKHELERRLSSMEDR-DRVDRDAEEALNQKLRRDLRKYKALLKDAQTQLERLKA 1814
            .|.::||.|...|.:||..|..:|.: :..::..:||:.|     |||.:|.:||.|
Zfish  1614 DERKQRTALAASKKKLEGDLKDLEGQIETSNKGRDEAIKQ-----LRKLQAQMKDFQ-------- 1665

  Fly  1815 DTPGKTLIRQLRNQLEDAESARSLAM-------KARQTAEAELTEVQAMFDESHRARNDAE-ER- 1870
                        .:|:||.:||...:       :..:|.||||.::|.....:.||:...| ||
Zfish  1666 ------------RELDDAHAAREEVLSSAKENERKAKTLEAELLQLQEDLAAAERAKKQVEAERD 1718

  Fly  1871 -------ANAAHR-----DRAELQAQIEENEEELGELMKKYSATVKQLNTEQIN------VSEAE 1917
                   :||:.:     ::..|:|:|::.||||.|         :|.|.|.:|      ..:.:
Zfish  1719 ELADELASNASGKSALSDEKRRLEAKIQQLEEELEE---------EQGNMEMLNDRLRKSAQQVD 1774

  Fly  1918 FKLNEMEAERNN----------LKEQVAELQHRLDNVENLGDPSMAMMSKRLELRTKELESRLEL 1972
            ...||::|||..          ::.|..||:.:|..:||............||.:..:||.:||
Zfish  1775 QLTNELQAERTTSQKNESARQLMERQNKELKAKLQEMENQVKSKFKSSISALEAKVAQLEEQLE- 1838

  Fly  1973 EQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQESL 2037
                      |.:|.|:...|...: ...|::||..|         :.|.|::......:..::.
Zfish  1839 ----------QESRDKQNTAKAVRQ-KDKKLKEMMTQ---------VEDERKQAEQYKDQADKAT 1883

  Fly  2038 TRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEEELSESDESLSSVGSISDLEDR 2102
            .|.|.|::::|:.|.|.           |||...::.::.| .:|.:|:::::|.  .::.|:.:
Zfish  1884 ARVKQLKRQLEESEEES-----------QRITAARRKLQRE-LDEATETNDAMSR--EVNSLKSK 1934

  Fly  2103 LRPVHVKRSSQQSLNGSIGGGG--GSVVSS 2130
            ||..: :.||..|.....||||  |.:.||
Zfish  1935 LRRGN-ETSSFSSTPRRTGGGGRRGIIDSS 1963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	232/797 (29%)
		MYSc_Myo18	575..1305	CDD:276837	215/766 (28%)
		GBP_C	<1540..1750	CDD:303769	78/455 (17%)
		COG1340	1565..1833	CDD:224259	90/437 (21%)
		coiled coil	1723..1734	CDD:293879	5/10 (50%)
myh11a	XP_021332550.1	Myosin_N	32..71	CDD:308391	10/44 (23%)
		MYSc_class_II	98..778	CDD:276951	215/766 (28%)
		Myosin_tail_1	855..1935	CDD:307627	226/1158 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810