DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and lnx2a

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001106696.2	Gene:	lnx2a / 553331	ZFINID:	ZDB-GENE-060228-2	Length:	737	Species:	Danio rerio

Alignment Length:	898	Identity:	168/898 - (18%)
Similarity:	264/898 - (29%)	Gaps:	353/898 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 GLKNRFLPPIPPKPPKRGILKGSRSNMTNVHEEISFAGSAGGAGG-----TPEMLLRNTFQNESL 208
            |.::|.....|||.|:           |.:.|:.....:...|..     |.|..:.|....||.
Zfish   153 GSEDRVTATNPPKSPQ-----------TEIKEDTPSPPAGSNACNNVPTWTEEPGIDNPAFEEST 206

  Fly   209 YEGAARGAGSIGSNSSQHGTSFTSVESLRSDGEQTGGQQRAMTLPANARYG-----ALPQGNSQG 268
            .|.:..|. .......:...|...:..||:....:.|.....|||.:|..|     :||:|..
Zfish   207 EEDSVHGL-ECALPRVKRPLSNPCIHLLRTGSSASSGWDFVETLPLSAEEGCVKLPSLPEGEI-- 268

  Fly   269 SHLHVLTSPSPSADSLTDTTNSSFATPPFS---LSPVGESQGIDRWARVHAFEDVELPLPPVQLV 330
                              ||.....|.|:|   :|.||.:               |.||..|
Zfish   269 ------------------TTIEVHRTNPYSEMGISIVGGN---------------ETPLINV--- 297

  Fly   331 KLPPPRQLVIRRQKSPRQDFGFSLRKAICLDRTESLTSPIFRPVIFAEPGAGGGATGLLPGDRLI 395
                    ||:.                           ::|..:.|..|.      ||.||:::
Zfish   298 --------VIQE---------------------------VYRDGVIARDGR------LLAGDQIL 321

  Fly   396 KVNGTPVGELPREIIIEMIRNSGEAVTVEVQPVAEL---VELSKRCMA-PSTATVEEIDHSITNG 456
            :||...:..:|...          |.:...:|.|.|   |...:||.| |..||..      ..|
Zfish   322 QVNNVDISNVPHNF----------ARSTLARPCATLQLTVLRERRCSARPPAATAS------PKG 370

  Fly   457 NCNTLRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVWLVHRGGFTAAIRL 521
            :..::|.:..||           ...|:.|.|.|....||.|......|       ||..|
Zfish   371 SPASIRITLHKR-----------ESSEQLGIKLVRRTDEAGVFILDLLE-------GGLAA---- 413

  Fly   522 PTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYA 586
                  :|.      ||..|...|.|:|.|: :..:|.|             .|.::....:|.
Zfish   414 ------KDG------RLCSNDRVLAVNEHDL-RHGTPEL-------------AAQIIQASGERV- 451

  Fly   587 SNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLI 651
             ||:.:::....:.|:..:.|:          |...:.|   |:..|..||..|.|.:      :
Zfish   452 -NLLISRSSKQTMAVHTGSTLT----------RDIWSHD---HIPPLPSTATPSPVPS------L 496

  Fly   652 FMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLS 716
            .:.||.:.:..|                                      .|:|.....:|
Zfish   497 HLARSSTQRDLS--------------------------------------QCVNCKEKHIT---- 519

  Fly   717 LDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPF 781
                               .::.....||       ||  :||..|....||.:
Zfish   520 -------------------VKKEPHESLG-------MT--VAGGRGSKSGELPI----------- 545

  Fly   782 ISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAG--VTKLGTGSTART 844
                            |:.:||....|:.|.:..||  .:|     |.|.|  :|.|.......|
Zfish   546 ----------------FVTSVQPHGCLSRDGRIKRG--DVL-----LSINGQDLTYLSHSEAVGT 587

  Fly   845 QFANPTAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGL 909
            ..::.|:.       .|.|:     |..:|....|  ||.....|..:..::.:|.....|.:||
Zfish   588 LKSSATSC-------SVQLK-----ALEVTMVEEP--GLDEELLPPHENDYDASWSPSWVLWLGL 638

  Fly   910 YSEALAAVVALINRQICTS-----------SHT-----IASIMLIDTPG-FQNPASCGQQV---- 953
            .|...::...::.|....|           :|:     |.:|:| .||. :.....||..:
Zfish   639 PSYLHSSHEIVLRRSHPGSWGFSIVGGYEENHSNQAFFIKTIVL-GTPAYYDGRLKCGDMIVAVN 702

  Fly   954 GATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQELVEIEMDLASECHPGPLI 1006
            |.:.|.:.|:.|...|:         ..|.|.|..:|.         .||.||
Zfish   703 GLSTAGMSHSALVPMLK---------EQRSRVALTVVS---------WPGSLI 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	13/86 (15%)
		MYSc	556..1317	CDD:214580	82/474 (17%)
		MYSc_Myo18	575..1305	CDD:276837	80/455 (18%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
lnx2a	NP_001106696.2	zf-RING_2	49..87	CDD:290367
		PDZ	267..353	CDD:214570	29/174 (17%)
		PDZ_signaling	375..455	CDD:238492	28/129 (22%)
		PDZ_signaling	515..600	CDD:238492	26/157 (17%)
		PDZ_signaling	646..730	CDD:238492	18/93 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900