DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and Myh13

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001074719.1 Gene:Myh13 / 544791 MGIID:1339967 Length:1938 Species:Mus musculus


Alignment Length:2013 Identity:490/2013 - (24%)
Similarity:834/2013 - (41%) Gaps:506/2013 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   530 EENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKA 594
            |.:|:.::.|.:.| ||::.|.|...|.|..|.:||:..:.:|:|.:||:.|::|||:.:|:|.:
Mouse    56 ENDKVIVKTLDDRE-LTLNSDQVFPMNPPKFDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYS 119

  Fly   595 GPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSG 659
            |...:.|||...|.:|:.:||:.:||.|.::.|||::|::..||:.::..|.:||::..|.||:|
Mouse   120 GLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGESGAG 184

  Fly   660 KSTSFKHALNYLALAA-----------GAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQ 713
            |:.:.|..:.|.|..|           |.....:..:.:.| ..:||||||.||..|.|::|..:
Mouse   185 KTVNTKRVIQYFATIAVTGDKKKEQQPGKMQGTLEDQIIQA-NPLLEAFGNAKTVRNDNSSRFGK 248

  Fly   714 LLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENI----T 774
            .:.:.|..||::|||.::..|.|:.|...:|..|.|:||..::::      .|:..|.::    |
Mouse   249 FIRIHFGATGKLASADIETYLLEKSRVTFQLSSERSYHIFYQIMS------NKKPELIDLLLIST 307

  Fly   775 SEDSHPFISLSQ----KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTK 835
            :....||:|..:    .::|    :.:.:.|..|.:.|....:...||:.:..|:.|.|     .
Mouse   308 NPFDFPFVSQGEVTVASIDD----SEELLATDNAIDILGFSPEEKVGIYKLTGAVMHYG-----N 363

  Fly   836 LGTGSTARTQFANP---TAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSP-----TSD 892
            :......|.:.|.|   ..|.||..|:|:|..::..   ||..|....|....:|..     |:.
Mouse   364 MKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLK---GLCCPRVKVGNEYVTKGQNVQQVTNS 425

  Fly   893 TGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQV 953
            .|         ||...:|.:....:|..||:|:.|.......|.::|..||:    |        
Mouse   426 VG---------ALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFN-------- 473

  Fly   954 GATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQELVEIE-----MDLASECHPGPLISLIDKAP 1013
              :|..|..|:..|:||..|:|...|..::.|.:|.:|.|     ||||: |     |.||:|. 
Mouse   474 --SLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAA-C-----IELIEKP- 529

  Fly  1014 QNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ- 1076
                             .|:..:|:||.::|.:.|.:|..:|: .|.|...:....:...|..: 
Mouse   530 -----------------MGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPTKGKAEA 577

  Fly  1077 -FVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRL---YIGSLTRGSGAMVF 1137
             |.|.|..||  |.|.:.||:..::: |.....|.|.|.||.:.::.|   |.|:....|..   
Mouse   578 HFSLVHYAGT--VDYNIAGWLDKNKD-PLNETVVGLYQKSSLKLLSFLFSNYAGAEAGDSAG--- 636

  Fly  1138 CGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNA 1202
             |...|.:...|.:.||::.|.                 .::.::..||.|..|||.|.:     
Mouse   637 -GKKGGKKKGSSFQTVSAVFRE-----------------NLNKLMTNLRSTHPHFVRCLI----- 678

  Fly  1203 GKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFG 1267
            ...||     :|.           :::..|:..|||.:.|||..|:.|.|||..:...:|.:|:.
Mouse   679 PNETK-----TPG-----------VMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYADFKQRYR 727

  Fly  1268 LL------AGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQ 1326
            :|      .|....:|:.| |::|...::|...:|.|.:::.|::|:|..||..||..|...:.:
Mouse   728 ILNASAIPEGQFIDSKNAS-EKLLNSIDVDREQFRFGHTKVFFKAGLLGLLEEMRDEKLVTLMTR 791

  Fly  1327 LQAFCRGYLAR---KKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQL 1388
            .||.|||||.|   |||.:||.   ::.|||.||::|:.|:.|||..|..::.|||.....|:::
Mouse   792 TQAVCRGYLMRVEFKKMMERRE---SIFCIQYNVRSFMNVKHWPWMNLFFKIKPLLKSAEAEKEM 853

  Fly  1389 KTANEELLMLRAKLEKIECDRSE------------------VKAENQ-----------------K 1418
            .|..|:....:..|.:.|..|.|                  |::|.:                 :
Mouse   854 ATMKEDFERAKEDLARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKIQ 918

  Fly  1419 LEAKLSELTVDLAEER--STAHIATERLEAETAERL------------KLEKELGDQTNKVKNLQ 1469
            ||||:.||...|.||.  ::..:|.:|...:....|            |:|||.....||||||.
Mouse   919 LEAKVKELNERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLS 983

  Fly  1470 ETTEKLEMELICAKSDLNGISE------DEDAENEDGVGGGV-YKLKYERVARELEFT---KRRL 1524
            |....||..:.....:...:.|      |:....||.|.|.: ..:|.|:...:||.:   :::|
Mouse   984 EEMTALEETISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINVKLEQQTDDLEGSLEQEKKL 1048

  Fly  1525 HTQHEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNN 1589
            ..    |||:   :|:.||..|..:.|.:::......|.:.|.:|...||:.|:..::::...:.
Mouse  1049 RA----DLER---VKRKLEGDLKMSQESIMDLENDTQQLEEKLKKKEFEMSQLQTRIDDEQVLSL 1106

  Fly  1590 LLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAE----KFTLEQTLADTRLDLEF---K 1647
            .|:||.::..|..:.|::.:..|...:.:..:::..|..|    ...||:....|...:|.   :
Mouse  1107 QLQKKIKELQARTEELEEEIEAEHTVRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKR 1171

  Fly  1648 EEKLASLQRELEEMTFG----------------GGTEEEFAQLRRSKNETERRAKEQEEELDEMA 1696
            |.:...|:|:|||.|..                ....|:...|:|.|.:.|:...|.:.|:|:||
Mouse  1172 ESEFQKLRRDLEEATLQHEATAATLRKKHADTVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMA 1236

  Fly  1697 GQIQLLEQAKLRLEMTLETMR----------------------KEARRESQQRD-----EELEEV 1734
            ..|:.:.::|..:|....::.                      ::||.::|..:     ||.|.:
Mouse  1237 SNIETVSKSKSNMERMCRSVEDQFNEIKAKDDQQTQLIHDLNMQKARLQTQNGELSHQVEEKESL 1301

  Fly  1735 RGNGYKKIKALECQLE---TEHEERTL-----------------LLRE--------KHELERRLS 1771
            .....|..:||..|||   .:.||.|.                 ||||        |.||:|.||
Mouse  1302 VSQLTKSKQALTQQLEELKRQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALS 1366

  Fly  1772 SME----------DRDRVDR-----DAEEALNQKLRR-------------DLRKYKALLK----D 1804
            ...          :.|.:.|     :|::.|.|:|:.             .|.|.|..|:    |
Mouse  1367 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTEASNSKCASLEKTKQRLQGEVDD 1431

  Fly  1805 AQTQLERLKADTPGKTLIRQLRN-----------------QLEDAE-SARSLA---MKARQTAE- 1847
            ....|||  |:|...||.::.||                 :||.|: .:|||:   .|.|...| 
Mouse  1432 LMLDLER--ANTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTEIFKMRNAYEE 1494

  Fly  1848 ----------------AELTEVQAMFDESHRARNDAEERANAAHRDRAELQAQIEENEEEL---- 1892
                            .|::::.....|:.:...:.|:......:::::|||.:||.|..|    
Mouse  1495 VVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEVEKTKKQVEQEKSDLQAALEEVEGSLEHEE 1559

  Fly  1893 --------------GELMKKYSATVKQLNTEQI------------NVSEAEFK------------ 1919
                          .||.:|  .|.|....|||            :|.:||.:            
Mouse  1560 SKILRVQLELSQVKSELDRK--VTEKDEEIEQIKRNSQRAVEAMQSVLDAEIRSRNDALRLKKKM 1622

  Fly  1920 ---LNEMEAERNNLKEQVAELQHRLDNVE--------NLGD---------PSMAMMSKRLELRTK 1964
               |||||.:.::...||||.|..|..|:        :|.|         ..:|::.:|..|..:
Mouse  1623 EGDLNEMEIQLSHANRQVAETQKHLRTVQGQLKDSQLHLDDAQRSNEDLKEQLAIVERRNGLLQE 1687

  Fly  1965 ELES-RLELEQATRAR----------------LEVQ----VNRHKEA---LEKLQNEVTQSKMRE 2005
            |||. ::.|||..|.|                |..|    :|..|:.   |.:.|.||..|....
Mouse  1688 ELEEMKVALEQTERTRRLSEQELLDSSDRVQLLHSQNTSLINTKKKLEADLAQCQAEVENSIQES 1752

  Fly  2006 MQAQDVIKKSQKSLRDMREEFHAVSSREQES---LTR-RKDLEKKVEQM-----ESEGAAL---K 2058
            ..|::..||:......|.||.    .:||::   |.| :|:||:.|:.:     |:|..||   |
Mouse  1753 RNAEEKAKKAITDAAMMAEEL----KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK 1813

  Fly  2059 NDLRLALQRIADLQQAMEEE---GEEELS--------------ESDESLSSVGSISDLEDRLRPV 2106
            ..::....|:.:|:..::.|   |.|.|.              :::|...::..:.||.|:|: .
Mouse  1814 KQIQKLEARVRELESELDAEQKRGAEALKGAHKYERKVKEMTYQAEEDRKNILRLQDLVDKLQ-A 1877

  Fly  2107 HVKRSSQQSLNGSIGGGGGSVVSSTRTVVFEKDDNSPRITVTSPSSPHIHKLALAAKAIPANK 2169
            .||...:|:....  ....:.:|..|.|..|.::...|..:   :...::||...::.:...|
Mouse  1878 KVKSYKRQAEEAE--EQANTQLSRCRRVQHELEEAEERADI---AESQVNKLRAKSRDVGGQK 1935

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 211/808 (26%)
MYSc_Myo18 575..1305 CDD:276837 199/777 (26%)
GBP_C <1540..1750 CDD:303769 52/259 (20%)
COG1340 1565..1833 CDD:224259 84/394 (21%)
coiled coil 1723..1734 CDD:293879 4/15 (27%)
Myh13NP_001074719.1 Myosin_N 36..73 CDD:280832 6/17 (35%)
Myosin_head 88..770 CDD:278492 203/789 (26%)
MYSc_Myh13 100..770 CDD:276887 199/777 (26%)
Myosin_tail_1 850..1927 CDD:279860 240/1097 (22%)
DUF342 <1506..1582 CDD:302792 13/77 (17%)
TMPIT 1744..>1837 CDD:285135 25/96 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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