DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and Myo28B1

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster


Alignment Length:1910 Identity:409/1910 - (21%)
Similarity:693/1910 - (36%) Gaps:561/1910 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   505 ERVWLVHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQN-SPALDL------ 562
            |.|| |.....|:...:|           ...|::...:..|:..||..||. .||.|:      
  Fly    11 EYVW-VKPQNTTSEFAVP-----------FGARIVRTEKTQTLVCDDRNKQFWVPAGDVLKAMHI 63

  Fly   563 -----VEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCK 622
                 |||:..|..|.|.::|..|:.|||..||:|..|..|:.:||...|.:|:.:.:.::|...
  Fly    64 TSQEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKS 128

  Fly   623 TEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKV 687
            ..::|||:::::..|::.|...:.:|.::..|.||:||:.|.|..|.|||..:|.: ::|..:.:
  Fly   129 LAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKH-SWIEQQII 192

  Fly   688 NALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHI 752
            .| ..|:|||||.||..|.|::|..:.:.:.|...|.|..|.:|..|.|:.|...:...|.::||
  Fly   193 EA-NPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHI 256

  Fly   753 MTRLLAGAAGLLQKELHLENITSEDSHPFISLSQ----KLEDRHRAANDFMRTVQAFETLNIDAK 813
            ...:|||.:...::.|.|:..:....|   .|:|    .|..| ..|.||.....|.:.|:...:
  Fly   257 FYCMLAGLSTAERERLKLQEQSPSQYH---YLAQGGCFTLPGR-GDAKDFADIRAAMKVLSFKPE 317

  Fly   814 AVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQPNA 878
            .|..|.|:||||.|||....|.....:.|..:..:....::.:.|||:.:..|::|   |||...
  Fly   318 EVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAA---LTQRTI 379

  Fly   879 PNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTS-SHTIASIMLIDTPG 942
            ...|    :..|:....|.|.|..:|.|..||......:|..||..|... ...:.||.::|..|
  Fly   380 FVHG----EHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFG 440

  Fly   943 FQNPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQELV---EIEMDLASECHPGP 1004
            |:|..:      .:...|..||..|.||..|........:|.|..|.:   .||.....:     
  Fly   441 FENFDN------NSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQ----- 494

  Fly  1005 LISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLR 1069
            ::.||...|.|                 ::.|:|||:.:|...|.|.||:|...:|:|..: :..
  Fly   495 ILDLIGMKPMN-----------------LMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIY-VKG 541

  Fly  1070 KCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGA 1134
            |......|.:.|..|.  |:|...|::..:|:                                 
  Fly   542 KTTQTSLFGIRHYAGV--VMYNPLGFLEKNRD--------------------------------- 571

  Fly  1135 MVFCGSFAGLEGTQSLRRVSSIRRS--------------FTTAGVKRNSIMLQVKFTVDGIIDTL 1185
                 ||:|     .||.:  ::||              ..|| .|:.::.::.:.::|.::.||
  Fly   572 -----SFSG-----DLRTL--VQRSTNKYLVDIFPHEMPMDTA-KKQPTLCVKFRNSLDMLMRTL 623

  Fly  1186 RRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHR 1250
            .:...:|:.|.       |..:|              .|.:..:..|...|||.|.::|.||:.|
  Fly   624 SQAHPYFIRCI-------KPNEY--------------KEPKNFDKELCVRQLRYSGMMETARIRR 667

  Fly  1251 LGFPESVPLLEFVRRFGLLAGDLASNKDVSVEQI---------------------LAVNELDVAS 1294
            .|:|.......||.|:.||...:...:.....::                     |.:.:.|.||
  Fly   668 AGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKLARQICEVALPADSDRQYGKTKLFLRDEDDAS 732

  Fly  1295 YRIGPSQILFRSGVLSELEAKRDVLL-------SDRIIQLQAFCRGYLARKKMSQRR-------- 1344
            ..:..||::.:|.|..:...:| ||.       .:.||.:|.:.||.|.|:|....|        
  Fly   733 LELQRSQLMLKSIVTIQRGIRR-VLFRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGA 796

  Fly  1345 ---VQELA-----VRC----IQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTAN----E 1393
               .|:|.     |||    :|...:.:|..:|:. .:||.|...  |..:.||.||.|.    |
  Fly   797 CIAAQQLTTKFTMVRCRTIKLQALSRGYLVRKDFQ-KKLLERRKQ--NQLKKEELLKLAKMKEAE 858

  Fly  1394 ELLMLRAKLEKIECDRSEVK----AENQKLEAKLSE----LTVDLAEERSTAHIATERLEAETAE 1450
            |||.|:...|:.|.::.|.:    .|.|:|:|:.:.    ....:.::|.|..:..|..:|.|.:
  Fly   859 ELLRLQQLKEQKEREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQ 923

  Fly  1451 --------------RLKLEKELGDQTNKVKNLQETTEKLEMELI----------------CAKSD 1485
                          ...|.........::..:.|:...:::|..                .|...
  Fly   924 ARNSLPPPPTTLIVAAPLPTRPASAVTRINTIPESPGTIDVESSKQMVDDVFRFLNDEPDAALRK 988

  Fly  1486 LNGISEDEDAENEDGV-------------------GGGVYKLKYERVARELEFTKRRLHTQHEHD 1531
            ||.||..:.......|                   |||. ..::||...:....|      |||.
  Fly   989 LNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGA-TAQHERKPLKKSLLK------HEHP 1046

  Fly  1532 LEQLVALKKHLE-MKLSDAYEEVVEQRQVVGQWKRKAQKMTNE--MNDLRMLLEEQNARNNLL-- 1591
            ::::.:....|. ::......:||....:        ....||  |:||..||...::....|  
  Fly  1047 IDEMASKAIWLTILRFMGDLPDVVSSPTL--------HVFDNENLMSDLASLLNTSDSYKPRLFV 1103

  Fly  1592 EKKQRKFDAECQSLQDAVRQERQAKERYGREKDV----LQAEKFTLEQTLADTRLDLEFKEEKLA 1652
            .:.||:......|      .|::|:|.|....:|    |:...|.:...:....|    ::|.||
  Fly  1104 RQSQRRIPKPLAS------GEKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNSL----RDEILA 1158

  Fly  1653 SLQRELEEMTFGGGTEEEFAQLRRSKNETER-------------RAKEQEEELDEMAGQIQLLEQ 1704
            .:.::|              .|..|::...|             .:||.|..|.      ..::|
  Fly  1159 QICKQL--------------YLNPSRSSYSRGWLLLSLCLSCFPPSKEFEPHLR------SFMKQ 1203

  Fly  1705 AKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERR 1769
            ...:|:.|          .|.||   ||....||.:      ||..:..|...  :|.:|.|...
  Fly  1204 GTAQLQAT----------PSLQR---LERTLVNGPR------CQPPSLFELHA--IRGRHPLRLD 1247

  Fly  1770 LSSMEDRDR---VD--RDAEEALNQ---------------------KLRRDLRKYKALLKDAQTQ 1808
            :..|:.:.|   ||  ..|.||:||                     || ..|...:..:.||.::
  Fly  1248 IHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKL-MPLGAGQEHVLDAISE 1311

  Fly  1809 LERLKADTPGKTLIR----------------------QLRNQLEDAE----SARSLAM------- 1840
            .|:.:.|.|.|..||                      |:.|.|:..|    |.:.:||       
  Fly  1312 CEQRQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKCGEYRCRSEKDIAMVCALACF 1376

  Fly  1841 ------KARQTAEAELTE--------------------VQAMFDES---HRARND----AEERAN 1872
                  :..:...:|:|.                    :.|.:::|   ...:||    |::||.
  Fly  1377 VEYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSYVKEEQNDLLLEAQKRAK 1441

  Fly  1873 A-----AH---------------RDRAELQAQ-------------IEENEEELGELMKKYSATVK 1904
            .     ||               ::..:||:.             |:|.|:.|....  :|..:|
  Fly  1442 EDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLFLIDETEQVLASCC--FSEVLK 1504

  Fly  1905 QLNTEQINVSEAEFKLNEMEAERNNLKEQVAELQ-------HRLDNVENLGDPSMAMMSKRLELR 1962
                  ::| |::.||:.|..:..|...|.:..|       :.|||:.......:|         
  Fly  1505 ------VHV-ESDDKLHVMTFQHVNFVLQCSSAQDANEVINYMLDNLRQRSSYGVA--------- 1553

  Fly  1963 TKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQD----------------- 2010
                     |:......||..:..:...|.:.:..||.:::....|||                 
  Fly  1554 ---------LDPVVEGDLEDCLVLNPGDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQWGQFLAGN 1609

  Fly  2011 -----VIKKSQKSLRDMREE--FHA---------VSSREQESLTRRKDLEKKVEQMESEGA---- 2055
                 .:.|..:.|:|:..|  |..         .|.|.|.::::..:...: |.::|:.|    
  Fly  1610 VRVLATLTKPSEKLQDILREGRFQEPPKPTPRANYSRRRQHNISQLAESHFR-EPLDSDKAPLSK 1673

  Fly  2056 ----ALKNDLRLALQRIADL-QQAM 2075
                .||..|..|:.::..| |||:
  Fly  1674 FSPEPLKAPLLKAVVKVPPLFQQAL 1698

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 198/815 (24%)
MYSc_Myo18 575..1305 CDD:276837 187/772 (24%)
GBP_C <1540..1750 CDD:303769 45/231 (19%)
COG1340 1565..1833 CDD:224259 69/336 (21%)
coiled coil 1723..1734 CDD:293879 5/10 (50%)
Myo28B1NP_723294.1 MYSc 62..737 CDD:214580 191/785 (24%)
MYSc_Myo7 81..726 CDD:276832 182/755 (24%)
IQ 765..785 CDD:197470 8/19 (42%)
DUF4355 827..>887 CDD:290964 19/62 (31%)
MyTH4 1031..1239 CDD:295320 52/272 (19%)
B41 1248..1429 CDD:214604 31/181 (17%)
FERM_N 1248..>1288 CDD:286467 9/39 (23%)
FERM_B-lobe 1342..1429 CDD:271216 11/86 (13%)
PH-like 1454..1547 CDD:302622 19/101 (19%)
MyTH4 1674..1819 CDD:214535 8/25 (32%)
B41 1827..2032 CDD:214604
FERM_N 1829..>1877 CDD:286467
FERM_M 1936..2032 CDD:278785
FERM_C2_MyoVII 2028..2121 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466242
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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