DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and MYH10

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_011522177.1	Gene:	MYH10 / 4628	HGNCID:	7568	Length:	2037	Species:	Homo sapiens

Alignment Length:	2107	Identity:	537/2107 - (25%)
Similarity:	870/2107 - (41%)	Gaps:	638/2107 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   496 ADVADASQPERVWL-VHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPA 559
            |..||.:..:.||: ..|.||.|      ||...:..:::.:.|..||::..|::||::|.|.|.
Human    55 ATQADWTAKKLVWIPSERHGFEA------ASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPK 113

  Fly   560 LDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTE 624
            ...|||:.||..||||||||.|:.||.|.||:|.:|...:|:||...|.:|||.::.|:||.|..
Human   114 FSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRH 178

  Fly   625 DMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAA----GAYNNFINAE 685
            :||||:|:::::|||.:::.|.|||::..|.||:||:.:.|..:.|||..|    |..::.|..|
Human   179 EMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPQE 243

  Fly   686 KVNAL-------------CTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPER 737
            ....:             ..|||:|||.||..|.|::|..:.:.::||.||.|..|:::..|.|:
Human   244 SPKPVKHQGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEK 308

  Fly   738 QRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTV 802
            .||.|:...|.:|||..:||:||...|:.:|.||..   :::.|:|.........:..::|..|:
Human   309 SRAVRQAKDERTFHIFYQLLSGAGEHLKSDLLLEGF---NNYRFLSNGYIPIPGQQDKDNFQETM 370

  Fly   803 QAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLS 867
            :|...:....:.:..:..:::::...|.....|  ..:|.:......|.|:|...|||:|:.:.:
Human   371 EAMHIMGFSHEEILSMLKVVSSVLQFGNISFKK--ERNTDQASMPENTVAQKLCHLLGMNVMEFT 433

  Fly   868 SAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTI 932
            .|   :..|....|.....|:.|.    |.|...:|||....|......:|..||:.:..:....
Human   434 RA---ILTPRIKVGRDYVQKAQTK----EQADFAVEALAKATYERLFRWLVHRINKALDRTKRQG 491

  Fly   933 AS-IMLIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE---- 988
            || |.::|..||:    |          :...|..||..|:||.||:||..:..::.|.:|
Human   492 ASFIGILDIAGFEIFELN----------SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEW 546

  Fly   989 -LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFL 1052
             .::..:||.      |.|.||:: |.|              ..|:|.|||||..:|.:.|.||:
Human   547 NFIDFGLDLQ------PCIDLIER-PAN--------------PPGVLALLDEECWFPKATDKTFV 590

  Fly  1053 ERLFSHYGDREHHSLLRKCAGPRQ------FVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSL 1111
            |:|....|.   ||..:|   |||      |.:.|..|  .|.|..|.|:..:.: |...|..:|
Human   591 EKLVQEQGS---HSKFQK---PRQLKDKADFCIIHYAG--KVDYKADEWLMKNMD-PLNDNVATL 646

  Fly  1112 LQDSSREEINRLY---IGSLTRGSGAMVFCGSFAGL-----EGTQSLRRVSSIRRSFTTAGVKRN 1168
            |..||...:..|:   |.::.|.|    |..|.:||     :....|.:|:.:..:...:..|..
Human   647 LHQSSDRFVAELWKDEIQNIQRAS----FYDSVSGLHEPPVDRIVGLDQVTGMTETAFGSAYKTK 707

  Fly  1169 SIMLQV-----KFTVDGIIDTLRRTGTHFVHCYLLQH--NAGKHTKYTANGSPSSAAGQVSSEEE 1226
            ..|.:.     |.::..::.|||.|..:||.|.:..|  .|||
Human   708 KGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGK---------------------- 750

  Fly  1227 MVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGD-----LASNKDVSVEQILA 1286
             ::..|:..|||.:.|||..|:.|.|||..:...||.:|:.:|..:     ....|. :.|:::.
Human   751 -LDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQ-ACERMIR 813

  Fly  1287 VNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVR 1351
            ..|||...||||.|:|.||:|||:.||.:||:.::|.||..||.||||||||..::::.|..|::
Human   814 ALELDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALK 878

  Fly  1352 CIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAEN 1416
            .:|||..|:|.:|.|.|||:..:|.|||.|.|.||:|:..:||||.::.|..|:|.:..|::.::
Human   879 VLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKH 943

  Fly  1417 Q----------------------------KLEAKLSEL---------TVDLAEERS--------- 1435
            |                            :|.||..||         .|:..|||:
Human   944 QQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKK 1008

  Fly  1436 -TAHI--ATERLEAETAERLKLEKE-----------------LGDQTN----------------- 1463
             .|||  ..|:|:.|...|.||:.|                 |.||.:
Human  1009 MQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1073

  Fly  1464 --------------KVKNLQET-----------TEKLEMELICAKSDLNGISED-ED-------- 1494
                          |::|.||.           .||...||..||..|:|.:.| :|
Human  1074 SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ 1138

  Fly  1495 --------AENEDGVGGG--------VYKLKYERVAREL-------------EFTKRRLHTQHEH 1530
                    |:.|:.:.|.        ::|....:|.|||             |...|....:.:.
Human  1139 IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKR 1203

  Fly  1531 DL-EQLVALKKHLEMKL------------------------------------------SDAYEE 1552
            || |:|.|||..||..|                                          :.|.||
Human  1204 DLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEE 1268

  Fly  1553 VVEQRQVVGQWK----------------------------------------------------- 1564
            :.||.:...::|
Human  1269 LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGD 1333

  Fly  1565 -------RKAQKMTNEMNDLRMLLEE---------------------------QNARNNL-LEKK 1594
                   .||.|:.||::::..||||                           :..|..| |..:
Human  1334 RLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSR 1398

  Fly  1595 QRKFDAECQSLQDAVRQERQAKERYGR-------------------------------------- 1621
            .|:.:.|..|||:...:|.:|::...:
Human  1399 IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE 1463

  Fly  1622 -------EK----DVLQAEKFTLEQTLADTRLDLEF----------------------------- 1646
                   ||    |.|:..|..|:|.|.|..:||:.
Human  1464 ALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARY 1528

  Fly  1647 -------------KEEKLASLQRELEEMTFGGGTEEEFA-------------------------Q 1673
                         ||.|..||.|.|||..   ..:|||.                         :
Human  1529 AEERDRAEAEAREKETKALSLARALEEAL---EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE 1590

  Fly  1674 LRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNG 1738
            |.:||...|::.:|...:|:|:..::|..|.||||||:.::.|:.:..|:.|.|||:.||.:...
Human  1591 LEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL 1655

  Fly  1739 YKKIKALECQLETEHEERTLLLREKHELERRLSSMEDR-DRVDRDAEEALNQKLRRDLRKYKALL 1802
            .|:::.||.:||.|.::|.|.:..|.::|..|..:|.: :..::..:|.:.|     |||.:|.:
Human  1656 IKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ-----LRKLQAQM 1715

  Fly  1803 KDAQTQLERLKADTPGKTLIRQLRNQL--EDAESARSLAMKARQTAEAELTEVQAMFDESHRARN 1865
            ||.|.:||..:|.          |:::  :..||.:.|     ::.|||:.::|.....|.|||.
Human  1716 KDYQRELEEARAS----------RDEIFAQSKESEKKL-----KSLEAEILQLQEELASSERARR 1765

  Fly  1866 DAE--------ERANAAH------RDRAELQAQIEENEEELGE-------LMKKYSATVKQLNTE 1909
            .||        |..|:|.      .::..|:|:|.:.||||.|       |..::..|..|::|
Human  1766 HAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDT- 1829

  Fly  1910 QINVSEAEFKLN-EMEAERNNLKEQVAELQHRLDNVENLGDPSMAMMSKRLELRTKELESRL-EL 1972
                      || |:.|||:..::.        ||..           ::||.:.|||:::| ||
Human  1830 ----------LNAELAAERSAAQKS--------DNAR-----------QQLERQNKELKAKLQEL 1865

  Fly  1973 EQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDM-----REEFHAVSSR 2032
            |.|.:::.:..::..:..:.:|:.::.|.......|..::::::|.|:::     .|..||...:
Human  1866 EGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYK 1930

  Fly  2033 EQ--ESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEEELSESDESLSSVGS 2095
            ||  ::..|.|.|::::|:.|.| |...|..|..|||..|           :.:|::|.||.  .
Human  1931 EQMEKANARMKQLKRQLEEAEEE-ATRANASRRKLQRELD-----------DATEANEGLSR--E 1981

  Fly  2096 ISDLEDRLR---PVHV--KRSSQQSLN 2117
            :|.|::|||   |:..  .||.::.|:
Human  1982 VSTLKNRLRRGGPISFSSSRSGRRQLH 2008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	240/813 (30%)
		MYSc_Myo18	575..1305	CDD:276837	223/782 (29%)
		GBP_C	<1540..1750	CDD:303769	77/455 (17%)
		COG1340	1565..1833	CDD:224259	90/414 (22%)
		coiled coil	1723..1734	CDD:293879	5/10 (50%)
MYH10	XP_011522177.1	Myosin_N	64..102	CDD:280832	11/43 (26%)
		Myosin_head	117..832	CDD:278492	231/794 (29%)
		MYSc_Myh10	129..832	CDD:276952	223/782 (29%)
		Myosin_tail_1	909..1989	CDD:279860	240/1146 (21%)
		DUF342	<1105..1194	CDD:302792	19/88 (22%)
		DUF2317	<1172..1283	CDD:302887	22/110 (20%)
		COG5134	<1399..1527	CDD:227463	18/127 (14%)
		GBP_C	<1565..1671	CDD:303769	29/105 (28%)
		coiled coil	1661..1671	CDD:293879	5/9 (56%)
		DUF106	<1706..>1757	CDD:303007	19/70 (27%)
		DUF2570	1834..>1928	CDD:305162	23/112 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810