Protein Alignment Mhcl and MYH8

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_002463.2
• Gene: MYH8 / 4626
• HGNCID: 7578
• Length: 1937
• Species: Homo sapiens
• Alignment Length: 2054
• Identity: 470/2054 - (22%)
• Similarity: 787/2054 - (38%)
• Gaps: 644/2054 - (31%)

  Fly   530 EENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKA 594
            |..|:::: ...|..|||.||.|...|.|..|.:||:..:.:|:|..||:.|::|||:.:|:|.:
Human    58 EGGKVTVK-TEGGATLTVREDQVFPMNPPKYDKIEDMAMMTHLHEPGVLYNLKERYAAWMIYTYS 121

  Fly   595 GPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSG 659
            |...:.|||...|.:|..:||:.:||.|.::.|||::|::..||:.::..|.:||::..|.||:|
Human   122 GLFCVTVNPYKWLPVYKPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAG 186

  Fly   660 KSTSFKHALNYLALAA----------GAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQL 714
            |:.:.|..:.|.|..|          |.....:..:.::| ..:||||||.||..|.|::|..:.
Human   187 KTVNTKRVIQYFATIAVTGEKKKDESGKMQGTLEDQIISA-NPLLEAFGNAKTVRNDNSSRFGKF 250

  Fly   715 LSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSH 779
            :.:.|..||::|||.::..|.|:.|...:|..|.|:||..::.:.....|.:.|.:  .|:...:
Human   251 IRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPDLIEMLLI--TTNPYDY 313

  Fly   780 PFISLSQ----KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGS 840
            .|:|..:    .::|:    .:.|.|..|.:.|....:....|:.:..|:.|.|     .:....
Human   314 AFVSQGEITVPSIDDQ----EELMATDSAIDILGFTPEEKVSIYKLTGAVMHYG-----NMKFKQ 369

  Fly   841 TARTQFANP---TAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECL 902
            ..|.:.|.|   ..|.||:.|..:|..||..|   |..|....|....:|..|.    :..:..:
Human   370 KQREEQAEPDGTEVADKAAYLQSLNSADLLKA---LCYPRVKVGNEYVTKGQTV----QQVYNAV 427

  Fly   903 EALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRHN 963
            .||...:|.:....:|..||:|:.|.......|.::|..||:    |          :|..|..|
Human   428 GALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFN----------SLEQLCIN 482

  Fly   964 YLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQR 1023
            :..|:||..|:|...|..::.|.:|     .::..||||: |     |.||:|.
Human   483 FTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAA-C-----IELIEKP----------- 530

  Fly  1024 DLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ--FVLHHLQGT 1085
                   .|:..:|:||.::|.:.|.:|..:|: .|.|...:....:...|..:  |.|.|..||
Human   531 -------LGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHFSLIHYAGT 588

  Fly  1086 NPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSL 1150
              |.|.:.||:..::: |.....|.|.|.|:.:.:..|:              .::|..|...|.
Human   589 --VDYNITGWLDKNKD-PLNDTVVGLYQKSAMKTLASLF--------------STYASAEADSSA 636

  Fly  1151 RRVSSIRRSFTTAGVKRNSIMLQV-----KFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTA 1210
            ::           |.|:.....|.     :..::.::..||.|..|||.|.:
Human   637 KK-----------GAKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCII------------- 677

  Fly  1211 NGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL------ 1269
               |:......:.|.|:|     ..|||.:.|||..|:.|.|||..:...:|.:|:.:|
Human   678 ---PNETKTPGAMEHELV-----LHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIP 734

  Fly  1270 AGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGY 1334
            .|....:|..| |::||..::|...|:.|.:::.|::|:|..||..||..|:..|.:.||.|||:
Human   735 EGQFIDSKKAS-EKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAVCRGF 798

  Fly  1335 LAR---KKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELL 1396
            |.|   :||.|||.   |:.|||.||:||:.|:.|||.:|..::.|||....||:::.|..||..
Human   799 LMRVEYQKMLQRRE---ALFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQ 860

  Fly  1397 MLRAKLEKIECDRSEVK--------------------------AENQ---------KLEAKLSEL 1426
            ..:.:|.|.|..|.|::                          ||.:         :||||:.|:
Human   861 KTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEV 925

  Fly  1427 TVDLAEERS-TAHIATE--RLEAETAE-----------RLKLEKELGDQTNKVKN---------- 1467
            |....||.. .|.:..:  :||.|.:|           ..|:|||.....|||||
Human   926 TERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDE 990

  Fly  1468 -----------LQET--------------------------------------TEKLEMELICAK 1483
                       ||||                                      .:||.|:|..||
Human   991 TIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAK 1055

  Fly  1484 SDLNG---------------------------------IS--EDEDA------------------ 1495
            ..|.|                                 ||  |||.|
Human  1056 RKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEE 1120

  Fly  1496 ------------------------------ENEDGVGG--------------------------- 1503
                                          |..:..||
Human  1121 LGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEAT 1185

  Fly  1504 ------------------------------------------------------GVYKLK--YER 1512
                                                                  .:.|.|  .|:
Human  1186 LQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEK 1250

  Fly  1513 VARELEFTKRRLHTQHE------HDL------------------------------------EQL 1535
            :.|.||.....|.|:.|      :||                                    :|:
Human  1251 MCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQI 1315

  Fly  1536 VALKKHLEMK--------------------LSDAYEEVVE-----QRQV------VGQWKRK--- 1566
            ..||..||.:                    |.:.|||..|     ||.:      |.||:.|
Human  1316 EELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET 1380

  Fly  1567 ----------------------------------------AQKMTNEMNDLRMLLEEQNARNNLL 1591
                                                    .|::.||:.||.:.:|..||....|
Human  1381 DAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAAL 1445

  Fly  1592 EKKQRKFD---AECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEKLAS 1653
            :||||.||   :|.:...:..:.|.:|.::..|.   |..|.|.::....::...||....:..:
Human  1446 DKKQRNFDKVLSEWKQKYEETQAELEASQKESRS---LSTELFKVKNVYEESLDQLETLRRENKN 1507

  Fly  1654 LQRELEEMTFGGGTEEEFAQLRRSKNETERRAKEQEEE-------LDEMAGQIQLLEQAKLRLEM 1711
            ||:|:.::|      |:.|:..:..:|.|:..|:.|:|       |:|....::..|...||:::
Human  1508 LQQEISDLT------EQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQL 1566

  Fly  1712 TLETMRKEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERRLSSME-D 1775
            .|..::.|..|:..::|||:::::.|..:.::.::..|:.|...|...||.|.::|..|:.|| .
Human  1567 ELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQ 1631

  Fly  1776 RDRVDRDAEEALNQKLRRDLRKYKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAM 1840
            .:..:|.|.|:|     |:.|..:.:||:.|..|:            ..||.| ||.:...::..
Human  1632 LNHANRLAAESL-----RNYRNTQGILKETQLHLD------------DALRGQ-EDLKEQLAIVE 1678

  Fly  1841 KARQTAEAELTEVQAMFDESHRARN-------DAEERANAAH--------------RDRAELQAQ 1884
            :.....:||:.|:.|..:::.|:|.       ||.||....|              .|.::||::
Human  1679 RRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSE 1743

  Fly  1885 IEENEEELGELMKKYSATVKQLNTEQINVSEAEFKLNE-----MEAERNNLKEQVAELQHRLDNV 1944
            :||..:|.....:|    .|:..|:...::| |.|..:     :|..:.||::.|.:||||||..
Human  1744 VEEVIQESRNAEEK----AKKAITDAAMMAE-ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA 1803

  Fly  1945 ENLGDPSMAMMSKRLELRTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQ 2009
            |.|.........::||.|.:|||..:|.||...|.....:.:|:..:::|..:..:.:...::.|
Human  1804 EQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQ 1868

  Fly  2010 DVIKKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQA 2074
            |::.|.|..:                     |..:::.|:.|.:..|       .|.:...||..
Human  1869 DLVDKLQAKV---------------------KSYKRQAEEAEEQSNA-------NLSKFRKLQHE 1905

  Fly  2075 MEEEGEEELSESDESLSSVGSISDLEDRLRPVHVKRSSQ 2113
            :||  .||.::..||     .::.|..:.|.||.|.|::
Human  1906 LEE--AEERADIAES-----QVNKLRVKSREVHTKISAE 1937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	449/1947 (23%)
		MYSc_Myo18	575..1305	CDD:276837	193/769 (25%)
MYH8	NP_002463.2	Myosin_N	35..79	CDD:460670	8/21 (38%)
		MYSc_Myh8	102..769	CDD:276882	193/769 (25%)
		Actin-binding	658..680		8/37 (22%)
		Actin-binding	760..774		3/13 (23%)
		Myosin_tail_1	849..1926	CDD:460256	218/1143 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1126..1146		0/19 (0%)