DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and MYH6

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_002462.2 Gene:MYH6 / 4624 HGNCID:7576 Length:1939 Species:Homo sapiens


Alignment Length:2041 Identity:463/2041 - (22%)
Similarity:786/2041 - (38%) Gaps:634/2041 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   529 DEENKLSLRLL-----------HNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLR 582
            |:|..:..::|           .||:.:||.||.|.:||.|..|.:||:..|.:|:|.:||..|:
Human    42 DKEEFVKAKILSREGGKVIAETENGKTVTVKEDQVLQQNPPKFDKIEDMAMLTFLHEPAVLFNLK 106

  Fly   583 QRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRD 647
            :|||:.:|:|.:|...:.|||...|.:|:.:||:.:||.|..:.|||::|::..||:.::..|.:
Human   107 ERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDREN 171

  Fly   648 QSLIFMGRSGSGKSTSFKHALNYLALAA-----GAYNNFINAEK------VNALCTILEAFGNTK 701
            ||::..|.||:||:.:.|..:.|.|..|     |..:| .||.|      :......||||||.|
Human   172 QSILITGESGAGKTVNTKRVIQYFASIAAIGDRGKKDN-ANANKGTLEDQIIQANPALEAFGNAK 235

  Fly   702 TCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQK 766
            |..|.|::|..:.:.:.|..||::|||.::..|.|:.|...:|..|.::||..::|:.....|..
Human   236 TVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLD 300

  Fly   767 ELHLENITSEDSHPFISLSQ----KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYH 827
            .|.:.|  :...:.|:|..:    .::|    :.:.|.|..||:.|...::...|::.:..||.|
Human   301 MLLVTN--NPYDYAFVSQGEVSVASIDD----SEELMATDSAFDVLGFTSEEKAGVYKLTGAIMH 359

  Fly   828 LGIAGVTKLGTGSTARTQFANPTA---ARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSP 889
            .|     .:......|.:.|.|..   |.|::.|:|:|..||..   ||..|....|    ::..
Human   360 YG-----NMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLK---GLCHPRVKVG----NEYV 412

  Fly   890 TSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCG 950
            |.....:..:..:.||...:|.:....:|..||..:.|.......|.::|..||:    |     
Human   413 TKGQSVQQVYYSIGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFN----- 472

  Fly   951 QQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLID 1010
                 :...|..|:..|:||..|:|...|..::.|.:|     .::..|||.: |     |.||:
Human   473 -----SFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQA-C-----IDLIE 526

  Fly  1011 KAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGP 1074
            |.                  .|::.:|:||.::|.:.|.||..:|: :|.|...:....|...|.
Human   527 KP------------------MGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGK 573

  Fly  1075 RQ--FVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVF 1137
            ::  |.|.|..||  |.|.:.||:..::: |.....|:|.|.||.:.:..|:....|..:|.   
Human   574 QEAHFSLIHYAGT--VDYNILGWLEKNKD-PLNETVVALYQKSSLKLMATLFSSYATADTGD--- 632

  Fly  1138 CG-SFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHN 1201
            .| |..|.:...|.:.||::.|.                 .::.::..||.|..|||.|.:    
Human   633 SGKSKGGKKKGSSFQTVSALHRE-----------------NLNKLMTNLRTTHPHFVRCII---- 676

  Fly  1202 AGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRF 1266
                      .:...|.|       :::.||:..|||.:.|||..|:.|.|||..:...:|.:|:
Human   677 ----------PNERKAPG-------VMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRY 724

  Fly  1267 GLL------AGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRII 1325
            .:|      .|....::. ..|::|:..::|...|:.|.:::.|::|:|..||..||..||..|.
Human   725 RILNPVAIPEGQFIDSRK-GTEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIIT 788

  Fly  1326 QLQAFCRGYLAR---KKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQ 1387
            ::||..||.|.|   ||:.:||.   |:..||.|::||:.|::|||.:|..::.|||....||::
Human   789 RMQAQARGQLMRIEFKKIVERRD---ALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKE 850

  Fly  1388 LKTANEELLMLRAKLEKIE-------------------------------------CDR------ 1409
            :.|..||...::..|||.|                                     ||:      
Human   851 MATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKI 915

  Fly  1410 --------------------SEVKAENQKLEAKLSELTVD------------------------- 1429
                                :|:.|:.:|||.:.|||..|                         
Human   916 QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 980

  Fly  1430 ----------------------------------------------------------------- 1429
                                                                             
Human   981 TEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKK 1045

  Fly  1430 ----------------------------------------------------------------L 1430
                                                                            |
Human  1046 VRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKL 1110

  Fly  1431 AEERSTAHIATERLEAETAERLKLEK--------------------------------------- 1456
            .|.::......|.||||...|.|:||                                       
Human  1111 KENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQK 1175

  Fly  1457 ----------------------------ELGDQTNKVKNLQETTEKLEME--------------- 1478
                                        |||:|   :.|||...:|||.|               
Human  1176 MRRDLEEATLQHEATAAALRKKHADSVAELGEQ---IDNLQRVKQKLEKEKSEFKLELDDVTSNM 1237

  Fly  1479 --LICAKSDLNGISED-EDAENEDGVGGGVYKLKYERVAREL-EFTKRRLHTQHEHD-------- 1531
              :|.||::|..:|.. ||..||       |::|.|...|.| :||.:|...|.|:.        
Human  1238 EQIIKAKANLEKVSRTLEDQANE-------YRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEE 1295

  Fly  1532 ---------------LEQLVALKKHLEMK--------------------LSDAYEEVVE-----Q 1556
                           .:|:..||:.||.:                    |.:.|||..|     |
Human  1296 KEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQ 1360

  Fly  1557 RQV------VGQWKRKAQ-------------------------------------------KMTN 1572
            |.:      |.||:.|.:                                           ::.|
Human  1361 RVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQN 1425

  Fly  1573 EMNDLRMLLEEQNARNNLLEKKQRKFD---AECQSLQDAVRQERQAKERYGREKDVLQAEKFTLE 1634
            |:.||.:.:|..||....|:||||.||   ||.:...:..:.|.::.::..|.   |..|.|.|:
Human  1426 EIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARS---LSTELFKLK 1487

  Fly  1635 QTLADTRLDLE-FKEEKLASLQRELEEMT----FGGGTEEEFAQLRR----SKNETERRAKEQEE 1690
            ....::...|| ||.|. .:||.|:.::|    .||....|..::|:    .|.|.:...:|.|.
Human  1488 NAYEESLEHLETFKREN-KNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEA 1551

  Fly  1691 ELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEE 1755
            .|:...|:|       ||.::....::.|..|:..::|||:|:.:.|..:.:.:|:..|:.|...
Human  1552 SLEHEEGKI-------LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRS 1609

  Fly  1756 RTLLLREKHELERRLSSME-DRDRVDRDAEEALNQKLRRDLRKYKALLKDAQTQLE---RLKADT 1816
            |..:||.|.::|..|:.|| .....:|.|.||     ::.::..::||||.|.||:   |...|.
Human  1610 RNEVLRVKKKMEGDLNEMEIQLSHANRMAAEA-----QKQVKSLQSLLKDTQIQLDDAVRANDDL 1669

  Fly  1817 PGKTLIRQLRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHRARNDAE-------ERANAA 1874
            .....|.:.||.|                .:|||.|::|:.:::.|:|..||       ||....
Human  1670 KENIAIVERRNNL----------------LQAELEELRAVVEQTERSRKLAEQELIETSERVQLL 1718

  Fly  1875 HRDRAELQAQIEENEEELGELMKKYSATVKQL-NTEQ---INVSEAEFKLNEMEAE--------- 1926
            |.....|..|.::.|.:|.:|..:....|::. |.|:   ..:::|.....|::.|         
Human  1719 HSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1783

  Fly  1927 -RNNLKEQVAELQHRLDNVENLGDPSMAMMSKRLELRTKELESRLELEQATRARLEVQVNRHKEA 1990
             :.|:::.:.:||||||..|.:.........::||.|.:|||..||.||...|.....:.:.:..
Human  1784 MKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERR 1848

  Fly  1991 LEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGA 2055
            :::|..:..:.|...::.||::.|.|..::..:.:......:...:|::.:.::.::::.|....
Human  1849 IKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERAD 1913

  Fly  2056 ALK---NDLRLALQRIADLQQAMEEE 2078
            ..:   |.||...:.|...|:..:||
Human  1914 IAESQVNKLRAKSRDIGAKQKMHDEE 1939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 210/797 (26%)
MYSc_Myo18 575..1305 CDD:276837 197/766 (26%)
GBP_C <1540..1750 CDD:303769 65/295 (22%)
COG1340 1565..1833 CDD:224259 80/326 (25%)
coiled coil 1723..1734 CDD:293879 4/10 (40%)
MYH6NP_002462.2 Myosin_N 35..72 CDD:280832 6/29 (21%)
Myosin_head 87..768 CDD:278492 202/778 (26%)
MYSc_class_II 99..768 CDD:276951 197/766 (26%)
Actin-binding 657..679 7/35 (20%)
Actin-binding 759..773 3/13 (23%)
Myosin_tail_1 848..1925 CDD:279860 208/1118 (19%)
SPEC 881..1043 CDD:295325 11/161 (7%)
MM_CoA_mutase <1134..1295 CDD:294532 32/170 (19%)
MIT_CorA-like <1297..>1409 CDD:294313 16/111 (14%)
TMPIT 1740..>1832 CDD:285135 22/91 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1826..1849 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1909..1939 6/29 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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