DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and MYH4

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_060003.2 Gene:MYH4 / 4622 HGNCID:7574 Length:1939 Species:Homo sapiens


Alignment Length:2047 Identity:469/2047 - (22%)
Similarity:788/2047 - (38%) Gaps:648/2047 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   542 GEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAP 606
            |..:||.||.|...|.|..|.:||:..:.:|:|.:||:.|::|||:.:|:|.:|...:.|||...
Human    67 GATVTVKEDQVFSMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKW 131

  Fly   607 LSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYL 671
            |.:|:.:||:.:||.|.::.|||::|::..||:.::..|.:||::..|.||:||:.:.|..:.|.
Human   132 LPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYF 196

  Fly   672 AL------------AAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQ 724
            |.            |:|.....:..:.::| ..:||||||.||..|.|::|..:.:.:.|..||:
Human   197 ATIAVTGEKKKEEPASGKMQGTLEDQIISA-NPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 260

  Fly   725 IASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQ--- 786
            :|||.::..|.|:.|...:|..|.|:||..::|:..    :.||....:.:.:.:.|..:||   
Human   261 LASADIETYLLEKSRVTFQLKAERSYHIFYQILSNK----KPELIEMLLITTNPYDFAFVSQGEI 321

  Fly   787 ---KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFAN 848
               .::|:    .:.|.|..|.:.|...|.....|:.:..|:.|.|     .:......|.:.|.
Human   322 TVPSIDDQ----EELMATDSAVDILGFTADEKVAIYKLTGAVMHYG-----NMKFKQKQREEQAE 377

  Fly   849 P---TAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLY 910
            |   ..|.||:.|..:|..||..:   |..|....|....:|..|.    :..:..:.||...:|
Human   378 PDGTEVADKAAYLTSLNSADLLKS---LCYPRVKVGNEFVTKGQTV----QQVYNAVGALAKAIY 435

  Fly   911 SEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQM 971
            .:....:|..||:|:.|.......|.::|..||:    |          :|..|..|:..|:||.
Human   436 EKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFN----------SLEQLCINFTNEKLQQ 490

  Fly   972 LFHHTTLVAPRDRYAQELVEIE-----MDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRR 1031
            .|:|...|..::.|.:|.:|.|     ||||: |     |.||:|.                  .
Human   491 FFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAA-C-----IELIEKP------------------M 531

  Fly  1032 GMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ--FVLHHLQGTNPVLYAVD 1093
            |:..:|:||.::|.:.|.:|..:|: .|.|...:....:...|..:  |.|.|..||  |.|.:.
Human   532 GIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKPEAHFSLVHYAGT--VDYNIA 594

  Fly  1094 GWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLT---RGSGAMVFCGSFAGLEGTQSLRRVSS 1155
            ||:..::: |.....|.|.|.|:.:.:..|:.|:.|   .|.|     |...|.:...|.:.||:
Human   595 GWLDKNKD-PLNETVVGLYQKSAMKTLAFLFSGAQTAEAEGGG-----GKKGGKKKGSSFQTVSA 653

  Fly  1156 IRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQ 1220
            :.|.                 .::.::..||.|..|||.|.:                |:.....
Human   654 LFRE-----------------NLNKLMTNLRSTHPHFVRCII----------------PNETKTP 685

  Fly  1221 VSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL------AGDLASNKDV 1279
            .:.|.|:|     ..|||.:.|||..|:.|.|||..:...:|.:|:.:|      .|....:|..
Human   686 GAMEHELV-----LHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSKKA 745

  Fly  1280 SVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLAR---KKMS 1341
            | |::|...|:|...|:.|.:::.|::|:|..||..||..|:..|.:.||.|||:|.|   :||.
Human   746 S-EKLLGSIEIDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLITRTQAICRGFLMRVEFRKMM 809

  Fly  1342 QRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIE 1406
            :||.   ::.|||.|::||:.|:.|||.:|..::.|||....||:::....||....:.:|.|.|
Human   810 ERRE---SIFCIQYNIRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTE 871

  Fly  1407 CDRSEVK--------------------------AENQ---------KLEAKLSELTVDLA-EERS 1435
            ..|.|::                          ||.:         :||||:.|:|.... ||..
Human   872 AKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEI 936

  Fly  1436 TAHIATE--RLEAETAE-----------RLKLEKELGDQTNKVKNL------------------- 1468
            .|.:..:  :||.|.:|           ..|:|||.....||||||                   
Human   937 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK 1001

  Fly  1469 ------QETTEKLEME------LICAKS-------DLNGISEDE--------------------- 1493
                  |:|.:.|:||      |..||:       ||.|..|.|                     
Human  1002 ALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLA 1066

  Fly  1494 -----DAENE------------------------------------------------------- 1498
                 |.||:                                                       
Human  1067 QESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERA 1131

  Fly  1499 -----------------------DGVGGGV----------------------------------- 1505
                                   :..||..                                   
Human  1132 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAAL 1196

  Fly  1506 ------------------------------------------------YKLKYERVAR------- 1515
                                                            .|..:|::.|       
Human  1197 RKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLS 1261

  Fly  1516 --------------ELEFTKRRLHTQ--------HEHD-------------LEQLVALKKHLEMK 1545
                          ||...|.||||:        .|.|             .:|:..||:.||.:
Human  1262 EIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEE 1326

  Fly  1546 --------------------LSDAYEEVVE-----QRQV------VGQWKRK------------- 1566
                                |.:.|||..|     ||.:      |.||:.|             
Human  1327 TKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELE 1391

  Fly  1567 ------------------------------AQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFD-- 1599
                                          .|::.||:.||.:.:|..||....|:||||.||  
Human  1392 EAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKV 1456

  Fly  1600 -AECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEKLASLQRELEEMT- 1662
             ||.:...:..:.|.:|.::..|.   |..|.|.::....::...||..:.:..:||:|:.::| 
Human  1457 LAEWKQKYEETQAELEASQKESRS---LSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTE 1518

  Fly  1663 --FGGG-----TEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEA 1720
              ..||     .|:...||...|:|.:...:|.|..|:...|:|       ||:::.|..::.|.
Human  1519 QIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKI-------LRIQLELNQVKSEI 1576

  Fly  1721 RRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERRLSSME-DRDRVDRDAE 1784
            .|:..::||||::::.|..:.:::::..|:.|...|...||.|.::|..|:.|| ..:..:|.|.
Human  1577 DRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAA 1641

  Fly  1785 EALNQKLRRDLRKYKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAE 1849
            |||     |:||..:.:|||.|..|:            ..:|.| :|.:...::..:.....:||
Human  1642 EAL-----RNLRNTQGILKDTQLHLD------------DAIRGQ-DDLKEQLAMVERRANLMQAE 1688

  Fly  1850 LTEVQAMFDESHRARN-------DAEERANAAH--------------RDRAELQAQIEENEEELG 1893
            :.|::|..:.:.|.|.       ||.||....|              .|.:::|.::|:..:|..
Human  1689 VEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEAR 1753

  Fly  1894 ELMKKYSATVKQLNTEQINVSEAEFKLNE-----MEAERNNLKEQVAELQHRLDNVENLGDPSMA 1953
            ...:|    .|:..|:...::| |.|..:     :|..:.|:::.|.:||.|||..|.|......
Human  1754 NAEEK----AKKAITDAAMMAE-ELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGK 1813

  Fly  1954 MMSKRLELRTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQKS 2018
            ...::||.|.:||||.:|.||.........:.:|:..:::|..:..:.:...::.||::.|.|  
Human  1814 KQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQ-- 1876

  Fly  2019 LRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEE-E 2082
                               |:.|..:::.|:.|.:.       .:.|.:...||..:||..|. :
Human  1877 -------------------TKVKAYKRQAEEAEEQS-------NVNLAKFRKLQHELEEAKERAD 1915

  Fly  2083 LSESDESLSSVGSISDLEDRLRPVHVKRSSQQ 2114
            ::||        .::.|..:.|.||.|..|::
Human  1916 IAES--------QVNKLRVKSREVHTKVISEE 1939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 212/802 (26%)
MYSc_Myo18 575..1305 CDD:276837 200/771 (26%)
GBP_C <1540..1750 CDD:303769 64/294 (22%)
COG1340 1565..1833 CDD:224259 78/322 (24%)
coiled coil 1723..1734 CDD:293879 4/10 (40%)
MYH4NP_060003.2 Myosin_N 36..73 CDD:280832 2/5 (40%)
Myosin_head 88..770 CDD:278492 204/783 (26%)
MYSc_Myh4 100..770 CDD:276879 200/771 (26%)
Actin-binding. /evidence=ECO:0000250 659..681 8/37 (22%)
Actin-binding. /evidence=ECO:0000250 761..775 3/13 (23%)
Myosin_tail_1 850..1927 CDD:279860 216/1145 (19%)
RILP-like 965..1098 CDD:304877 26/132 (20%)
MIT_CorA-like <1299..>1411 CDD:294313 17/111 (15%)
COG6 1376..>1511 CDD:303003 27/137 (20%)
DUF342 <1670..1767 CDD:302792 19/100 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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