DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and MYH3

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_002461.2 Gene:MYH3 / 4621 HGNCID:7573 Length:1940 Species:Homo sapiens


Alignment Length:1954 Identity:481/1954 - (24%)
Similarity:813/1954 - (41%) Gaps:494/1954 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   530 EENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKA 594
            ::.|:::....| ..|.|..:||...|.|..|.:||:..|.:|||.:||:.|:.||.|.:|:|.:
Human    56 QDGKVTVETEDN-RTLVVKPEDVYAMNPPKFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYS 119

  Fly   595 GPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSG 659
            |...:.|||...|.:|:.:||..:||.|.::.|||::|::..||:.::..|.:||::..|.||:|
Human   120 GLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAG 184

  Fly   660 KSTSFKHALNYLALAAGA---------------YNNFINAEKVNALCTILEAFGNTKTCLNSNAT 709
            |:.:.|..:.|.|..|..               .:..|:|.      .:||||||.||..|.|::
Human   185 KTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISAN------PLLEAFGNAKTVRNDNSS 243

  Fly   710 RMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENIT 774
            |..:.:.:.|..||::|||.::..|.|:.|...:|..|.|:||..::|:.....|.:.|.:  .|
Human   244 RFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLI--TT 306

  Fly   775 SEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTG 839
            :...:||||..:.|......|.:.:.|..|.:.|....:...|::.:..|:.|.|     .:...
Human   307 NPYDYPFISQGEILVASIDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYG-----NMKFK 366

  Fly   840 STARTQFANP---TAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWEC 901
            ...|.:.|.|   ..|.|.:.|:|:|..||..|   |..|....|....:|..|.|..|    ..
Human   367 QKQREEQAEPDGTEVADKTAYLMGLNSSDLLKA---LCFPRVKVGNEYVTKGQTVDQVH----HA 424

  Fly   902 LEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRH 962
            :.||...:|.:....:|..||:|:.|.......|.::|..||:    |          :|..|..
Human   425 VNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYN----------SLEQLCI 479

  Fly   963 NYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQ 1022
            |:..|:||..|:|...|..::.|.:|     .::..||||: |     |.||:|.          
Human   480 NFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAA-C-----IELIEKP---------- 528

  Fly  1023 RDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ--FVLHHLQG 1084
                    .|:..:|:||.::|.:.|.:|..:|: .|.|...:....:...|..:  |.|.|..|
Human   529 --------MGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFSLIHYAG 585

  Fly  1085 TNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQS 1149
            |  |.|:|.||:..::: |.....|.|.|.||...:..||              .:||..:....
Human   586 T--VDYSVSGWLEKNKD-PLNETVVGLYQKSSNRLLAHLY--------------ATFATADADSG 633

  Fly  1150 LRRVSSIR-RSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGS 1213
            .::|:..: .||.|       :....:..::.::..||.|..|||.|.:            .|.:
Human   634 KKKVAKKKGSSFQT-------VSALFRENLNKLMSNLRTTHPHFVRCII------------PNET 679

  Fly  1214 PSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL------AGD 1272
            .:..|.:.|         |:..|||.:.|||..|:.|.|||..:...:|.:|:.:|      .|.
Human   680 KTPGAMEHS---------LVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQ 735

  Fly  1273 LASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLAR 1337
            ...:|. :.|::||..::|...|:.|.:::.|::|:|..||..||..|:..|.:.||.|||:|.|
Human   736 FIDSKK-ACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLAKLITRTQAVCRGFLMR 799

  Fly  1338 ---KKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLR 1399
               :||.|||.   ::.|||.|:::|:.|:.|||.:|..::.|||....||:::.|..||....:
Human   800 VEFQKMVQRRE---SIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTK 861

  Fly  1400 AKLEKIECDRSE------------------VKAENQ-----------------KLEAKLSELTVD 1429
            .:|.|.|..|.|                  |:||::                 :||||:.|:| :
Human   862 DELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVT-E 925

  Fly  1430 LAEERSTAHIATERLEAE-TAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDE 1493
            .||:.       |.:.|| ||::.|||.|..:....:.:|:.|..|:|.|....::.:..::|: 
Human   926 RAEDE-------EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE- 982

  Fly  1494 DAENEDGVGGGVYKLKYERVA-------------------RELEFTKRRLHTQHEHDLE------ 1533
                ..|:...:.||..|:.|                   ..|..||.:|..|.| |||      
Human   983 ----LSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVE-DLESSLEQE 1042

  Fly  1534 -----QLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEK 1593
                 .|...|:.||..|..|.|.:::......|...:.:|...|...|:..:|::.......:|
Human  1043 KKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQK 1107

  Fly  1594 KQRKFDAECQSLQDAVRQERQAKER-------YGREKDVLQAEKFTLEQTLADTRLDLEFKEE-K 1650
            |.::..|..:.|::.:..||..:.:       |.||.:.| :|:......:..|:::|..|.| :
Human  1108 KIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEEL-SERLEEAGGVTSTQIELNKKREAE 1171

  Fly  1651 LASLQRELEEMTFG----------------GGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQI 1699
            ...|:|:|||.|..                ....|:...|:|.|.:.|:...|.:.|:|:::..:
Human  1172 FLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSM 1236

  Fly  1700 QLLEQAKLRLE---MTLETMRKEARRESQQRDEELEEVRGNGYK--------------------- 1740
            :.:.::|..||   .|||....|||.::::....|.|:.....:                     
Human  1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQ 1301

  Fly  1741 ----------KIKALECQLETEHEERTL-------------LLRE--------KHELERRLSSME 1774
                      :.:.|:.|||.|::.:..             ||||        |.||:|.||...
Human  1302 LSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKAN 1366

  Fly  1775 ----------DRDRVDR----------------DAEE---------------------------- 1785
                      :.|.:.|                |:||                            
Human  1367 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMV 1431

  Fly  1786 ----------ALNQKLR---RDLRKYKALLKDAQTQLE-RLKADTPGKTLIRQLRNQLED----- 1831
                      ||::|.|   :.|.::|...:::|.:|| .||......|.:.:|:|..|:     
Human  1432 DVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQL 1496

  Fly  1832 ---------------------AESARSL--AMKARQTAEAELTEVQAMFDESHRARNDAEERANA 1873
                                 ||:.:::  ..|:|:..|.|..::|...:|:..|....|.:...
Human  1497 ETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILR 1561

  Fly  1874 AHRD----RAELQAQIEENEEELGELMKKYSATVK----QLNTEQINVSEA-------EFKLNEM 1923
            ...:    ::|:..:|.|.:||:.:|.:.|..||:    .|:.|..:.:||       |..|||:
Human  1562 IQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEI 1626

  Fly  1924 EAERNNLKEQVAELQHRLDNVE--------NLGD---------PSMAMMSKRLELRTKELES-RL 1970
            |.:.::...|.||....|.:|:        :|.|         ..:|::.:|..|...|:|. |.
Human  1627 EIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRA 1691

  Fly  1971 ELEQATRAR----------------LEVQ---VNRHKEALE----KLQNEVTQSKMREMQAQDVI 2012
            .|||..|||                |..|   :...|:.||    :||:||..:......|::..
Human  1692 TLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKA 1756

  Fly  2013 KKSQKSLRDMREEFHAVSSREQES---LTR-RKDLEKKVEQM-----ESEGAAL---KNDLRLAL 2065
            ||:......|.||.    .:||::   |.| :|:||:.|:.:     |:|..||   |..::...
Human  1757 KKAITDAAMMAEEL----KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1817

  Fly  2066 QRIADLQQAMEEEGEE------------------ELS-ESDESLSSVGSISDLEDRLRPVHVKRS 2111
            .||.:|:  .|.|||:                  ||: :|:|...:|..:.||.|:|: |.||..
Human  1818 TRIRELE--FELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQ-VKVKSY 1879

  Fly  2112 SQQS 2115
            .:|:
Human  1880 KRQA 1883

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 214/797 (27%)
MYSc_Myo18 575..1305 CDD:276837 200/766 (26%)
GBP_C <1540..1750 CDD:303769 52/267 (19%)
COG1340 1565..1833 CDD:224259 79/440 (18%)
coiled coil 1723..1734 CDD:293879 1/10 (10%)
MYH3NP_002461.2 Myosin_N 36..73 CDD:280832 3/17 (18%)
Myosin_head 88..767 CDD:278492 206/778 (26%)
MYSc_Myh3 100..767 CDD:276878 200/766 (26%)
Actin-binding 656..678 7/33 (21%)
Actin-binding 758..772 3/13 (23%)
GrpE 843..>962 CDD:295646 31/126 (25%)
Myosin_tail_1 847..1924 CDD:279860 231/1059 (22%)
BAR <956..1063 CDD:299863 25/112 (22%)
MIT_CorA-like <1296..>1408 CDD:294313 20/111 (18%)
COG6 1373..>1506 CDD:303003 20/132 (15%)
TMPIT 1739..>1850 CDD:285135 29/116 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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