Protein Alignment Mhcl and MYH2

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_060004.3
• Gene: MYH2 / 4620
• HGNCID: 7572
• Length: 1941
• Species: Homo sapiens
• Alignment Length: 2009
• Identity: 474/2009 - (23%)
• Similarity: 848/2009 - (42%)
• Gaps: 504/2009 - (25%)

  Fly   530 EENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKA 594
            |..|:::: ...|..|||.:|.|...|.|..|.:||:..:.:|:|.:||:.|::|||:.:|:|.:
Human    56 EGGKVTVK-TEGGATLTVKDDQVFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYS 119

  Fly   595 GPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSG 659
            |...:.|||...|.:|..:||:.:||.|.::.|||::|::..||:.::..|.:||::..|.||:|
Human   120 GLFCVTVNPYKWLPVYKPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAG 184

  Fly   660 KSTSFKHALNYLA------------LAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMT 712
            |:.:.|..:.|.|            :.:|.....:..:.::| ..:||||||.||..|.|::|..
Human   185 KTVNTKRVIQYFATIAVTGEKKKEEITSGKIQGTLEDQIISA-NPLLEAFGNAKTVRNDNSSRFG 248

  Fly   713 QLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSED 777
            :.:.:.|..||::|||.::..|.|:.|...:|..|.|:||..::.:.....|.:.|.:  .|:..
Human   249 KFIRIHFGTTGKLASADIETYLLEKSRVVFQLKAERSYHIFYQITSNKKPELIEMLLI--TTNPY 311

  Fly   778 SHPFISLSQ----KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGT 838
            .:||:|..:    .::|:    .:.|.|..|.:.|....:....|:.:..|:.|.|     .|..
Human   312 DYPFVSQGEISVASIDDQ----EELMATDSAIDILGFTNEEKVSIYKLTGAVMHYG-----NLKF 367

  Fly   839 GSTARTQFANP---TAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWE 900
            ....|.:.|.|   ..|.||:.|..:|..||..|   |..|....|....:|..|.    |....
Human   368 KQKQREEQAEPDGTEVADKAAYLQSLNSADLLKA---LCYPRVKVGNEYVTKGQTV----EQVSN 425

  Fly   901 CLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLR 961
            .:.||...:|.:....:||.||:|:.|.......|.::|..||:    |          :|..|.
Human   426 AVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGVLDIAGFEIFDFN----------SLEQLC 480

  Fly   962 HNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSS 1021
            .|:..|:||..|:|...|..::.|.:|     .::..||||: |     |.||:|.
Human   481 INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAA-C-----IELIEKP--------- 530

  Fly  1022 QRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ--FVLHHLQ 1083
                     .|:..:|:||.::|.:.|.:|..:|: .|.|...:....:...|..:  |.|.|..
Human   531 ---------MGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHFALIHYA 586

  Fly  1084 GTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLT-RGSGAMVFCGSFA---GL 1144
            |.  |.|.:.||:..::: |.....|.|.|.|:.:.:.:|:.|:.| .|.||    |..|   |.
Human   587 GV--VDYNITGWLEKNKD-PLNETVVGLYQKSAMKTLAQLFSGAQTAEGEGA----GGGAKKGGK 644

  Fly  1145 EGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYT 1209
            :...|.:.||::.|.                 .::.::..||.|..|||.|.:
Human   645 KKGSSFQTVSALFRE-----------------NLNKLMTNLRSTHPHFVRCII------------ 680

  Fly  1210 ANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL----- 1269
                |:......:.|.|:|     ..|||.:.|||..|:.|.|||..:...:|.:|:.:|
Human   681 ----PNETKTPGAMEHELV-----LHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAI 736

  Fly  1270 -AGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRG 1333
             .|....:|..| |::||..::|...|:.|.:::.|::|:|..||..||..|:..|.:.||.|||
Human   737 PEGQFIDSKKAS-EKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQARCRG 800

  Fly  1334 YLAR---KKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEEL 1395
            :|||   ::|.:||.   |:.|||.|:::|:.|:.|||.:|..::.|||....||:::.|..||.
Human   801 FLARVEYQRMVERRE---AIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEF 862

  Fly  1396 LMLRAKLEKIECDRSE------------------VKAENQ-----------------KLEAKLSE 1425
            ..::.:|.|.|..|.|                  |:||.:                 :||||:.|
Human   863 QKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKE 927

  Fly  1426 LTVDLAEERSTAHIATERLEAE-TAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGI 1489
            :| :.||:.       |.:.|| ||::.|||.|..:....:.:|:.|..|:|.|....::.:..:
Human   928 VT-ERAEDE-------EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 984

  Fly  1490 SEDEDAENEDGVGGGVYKLKYERVA---------RELE--------FTKRRLHTQHEHD-----L 1532
            :|:     ..|:...:.||..|:.|         .:|:        .||.::..:.:.|     |
Human   985 TEE-----MAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL 1044

  Fly  1533 EQ-------LVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNL 1590
            ||       |...|:.||..|..|.|.:::......|...|.:|...|:::|:..:|::.|....
Human  1045 EQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQ 1109

  Fly  1591 LEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLAD----TRLDLEFKEEKL 1651
            |:||.::..|..:.|::.:..||.::.:..:::..|..|...:.:.|.:    |...:|..:::.
Human  1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE 1174

  Fly  1652 ASLQ---RELEEMTFG----------------GGTEEEFAQLRRSKNETERRAKEQEEELDEMAG 1697
            |..|   |:|||.|..                ....|:...|:|.|.:.|:...|.:.|:|::|.
Human  1175 AEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLAS 1239

  Fly  1698 QIQLLEQAKLRLE---MTLETMRKE--ARRESQQR-----------------------DE----- 1729
            .::.:.:||..||   .|||....|  ::.|.|||                       ||
Human  1240 NVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALV 1304

  Fly  1730 ------------ELEEVRGNGYKKIKAL------------ECQL--------------------- 1749
                        ::||::....::|||.            :|.|
Human  1305 SQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369

  Fly  1750 ------------ETEHEERTLLLRE-KHELERRLSSMED---------------RDRVDRDAEE- 1785
                        ||:..:||..|.| |.:|.:||.:.|:               :.|:..:.|:
Human  1370 ANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1434

  Fly  1786 ------------ALNQKLRR-------------------------------DLRKYKALLKDAQT 1807
                        ||::|.|.                               :|.|.|...:::..
Human  1435 MLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLD 1499

  Fly  1808 QLERLKADTPGKTLIRQLRNQLED-AESARSL--AMKARQTAEAELTEVQAMFDESHRARNDAEE 1869
            |||.||.:  .|.|.:::.:..|. ||..:.:  ..|.::..|.|..|:||..:|:..:....|.
Human  1500 QLETLKRE--NKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEG 1562

  Fly  1870 RANAAHRD----RAELQAQIEENEEELGELMKKYSATVKQLNT----------EQINV-SEAEFK 1919
            :......:    ::|:..:|.|.:||:.:|.:.:...|:.:.:          :.|.: .:.|..
Human  1563 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGD 1627

  Fly  1920 LNEMEAERNNLKEQVAE------------------LQHRLDNVENLGDPSMAMMSKRLELRTKEL 1966
            |||||.:.|:.....||                  |...|.:.|:|.: .:||:.:|..|...|:
Human  1628 LNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKE-QLAMVERRANLLQAEI 1691

  Fly  1967 ES-RLELEQATRAR----------------LEVQVNRHKEALEKLQNEVT--QSKMREM--QAQD 2010
            |. |..|||..|:|                |..|........:||:.:::  |.:|.::  :|::
Human  1692 EELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARN 1756

  Fly  2011 VIKKSQKSLRD---MREEFHAVSSREQESLTRRKDLEKKVEQM---------ESEGAAL---KND 2060
            ..:|::|::.|   |.||.    .:||::....:.::|.:||.         |:|..||   |..
Human  1757 AEEKAKKAITDAAMMAEEL----KKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQ 1817

  Fly  2061 LRLALQRIADLQQAMEEEGE----------------EELS-ESDESLSSVGSISDLEDRL--RPV 2106
            ::....|:.:|:..:|.|.:                :||: :::|...::..:.||.|:|  :..
Human  1818 IQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVK 1882

  Fly  2107 HVKRSSQQSLNGSIGGGGGSVVSSTRTVVFEKDDNSPRITVTSPSSPHIHKLALAAKAI 2165
            ..||.::::...|     .:.::..|.:..|.::...|..:   :...::||.:.::.:
Human  1883 SYKRQAEEAEEQS-----NTNLAKFRKLQHELEEAEERADI---AESQVNKLRVKSREV 1933

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	439/1816 (24%)
		MYSc_Myo18	575..1305	CDD:276837	201/770 (26%)
MYH2	NP_060004.3	Myosin_N	33..77	CDD:460670	7/21 (33%)
		MYSc_Myh2_mammals	100..772	CDD:276877	201/770 (26%)
		Actin-binding. /evidence=ECO:0000250	661..683		8/37 (22%)
		Actin-binding. /evidence=ECO:0000250	763..777		3/13 (23%)
		Myosin_tail_1	852..1929	CDD:460256	223/1104 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1128..1149		3/20 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1155..1174		3/18 (17%)