DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and MYH1

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_005954.3 Gene:MYH1 / 4619 HGNCID:7567 Length:1939 Species:Homo sapiens


Alignment Length:2049 Identity:461/2049 - (22%)
Similarity:787/2049 - (38%) Gaps:652/2049 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   542 GEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAP 606
            |..:||.:|.|...|.|..|.:||:..:.:|:|.:||:.|::|||:.:|:|.:|...:.|||...
Human    67 GATVTVKDDQVFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKW 131

  Fly   607 LSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYL 671
            |.:|:.:||:.:||.|.::.|||::|::..||:.::..|.:||::..|.||:||:.:.|..:.|.
Human   132 LPVYNAEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYF 196

  Fly   672 ALAAGAYNNFINAEKVNALCT-----------------ILEAFGNTKTCLNSNATRMTQLLSLDF 719
            |..|      :..||.....|                 :||||||.||..|.|::|..:.:.:.|
Human   197 ATIA------VTGEKKKEEVTSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHF 255

  Fly   720 DQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISL 784
            ..||::|||.::..|.|:.|...:|..|.|:||..::::.....|.:.|.:  .|:...:.|:|.
Human   256 GTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLI--TTNPYDYAFVSQ 318

  Fly   785 SQ----KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQ 845
            .:    .::|:    .:.|.|..|.|.|...:.....|:.:..|:.|.|     .:......|.:
Human   319 GEITVPSIDDQ----EELMATDSAIEILGFTSDERVSIYKLTGAVMHYG-----NMKFKQKQREE 374

  Fly   846 FANP---TAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVI 907
            .|.|   ..|.||:.|..:|..||..|   |..|....|....:|..|.    :..:..:.||..
Human   375 QAEPDGTEVADKAAYLQNLNSADLLKA---LCYPRVKVGNEYVTKGQTV----QQVYNAVGALAK 432

  Fly   908 GLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRHNYLQER 968
            .:|.:....:|..||:|:.|.......|.::|..||:    |          :|..|..|:..|:
Human   433 AVYDKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFN----------SLEQLCINFTNEK 487

  Fly   969 LQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREH 1028
            ||..|:|...|..::.|.:|     .::..||||: |     |.||:|.                
Human   488 LQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAA-C-----IELIEKP---------------- 530

  Fly  1029 DRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ--FVLHHLQGTNPVLY 1090
              .|:..:|:||.::|.:.|.:|..:|: .|.|...:....:...|..:  |.|.|..||  |.|
Human   531 --MGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKPEAHFSLIHYAGT--VDY 591

  Fly  1091 AVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSS 1155
            .:.||:..::: |.....|.|.|.|:.:.:..|::|:  .|:.|....|...|.:...|.:.||:
Human   592 NIAGWLDKNKD-PLNETVVGLYQKSAMKTLALLFVGA--TGAEAEAGGGKKGGKKKGSSFQTVSA 653

  Fly  1156 IRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQ 1220
            :.|.                 .::.::..||.|..|||.|.:                |:.....
Human   654 LFRE-----------------NLNKLMTNLRSTHPHFVRCII----------------PNETKTP 685

  Fly  1221 VSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL------AGDLASNKDV 1279
            .:.|.|:|     ..|||.:.|||..|:.|.|||..:...:|.:|:.:|      .|....:|..
Human   686 GAMEHELV-----LHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSKKA 745

  Fly  1280 SVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLAR---KKMS 1341
            | |::|...::|...|:.|.:::.|::|:|..||..||..|:..|.:.||.|||:|||   :||.
Human   746 S-EKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQLITRTQAMCRGFLARVEYQKMV 809

  Fly  1342 QRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTE-------EQLKTANEELLMLR 1399
            :||.   ::.|||.||:||:.|:.|||.:|..::.|||....||       |:.:...|||....
Human   810 ERRE---SIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTE 871

  Fly  1400 AKLEKIE------------------------------CDR------------------------- 1409
            ||.:::|                              ||:                         
Human   872 AKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEI 936

  Fly  1410 -SEVKAENQKLEAKLSELTVDL------------------------------------------- 1430
             :|:.|:.:|||.:.|||..|:                                           
Human   937 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK 1001

  Fly  1431 --------------AEE------------------------------------------------ 1433
                          |||                                                
Human  1002 ALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLA 1066

  Fly  1434 -RSTAHIAT------------------------------------------------ERLEAETA 1449
             .||..|..                                                |.:|||.|
Human  1067 QESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERA 1131

  Fly  1450 ERLKLEK---------------------------------------------------------- 1456
            .|.|.||                                                          
Human  1132 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATL 1196

  Fly  1457 ---------ELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDGVG---GGVYKL- 1508
                     |||:|   :.|||...:|||.|    ||::. :..|:.|.|.:.|.   |.:.|: 
Human  1197 RKKHADSVAELGEQ---IDNLQRVKQKLEKE----KSEMK-MEIDDLASNMETVSKAKGNLEKMC 1253

  Fly  1509 ---------------KYERVARELEFTKRRLHTQ--------HEHD-------------LEQLVA 1537
                           :.:|:..:|...:.||.|:        .|.|             .:|:..
Human  1254 RALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEE 1318

  Fly  1538 LKKHLEMK--------------------LSDAYEEVVE-----QRQV------VGQWKRK----- 1566
            ||:.||.:                    |.:.|||..|     ||.:      |.||:.|     
Human  1319 LKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDA 1383

  Fly  1567 --------------------------------------AQKMTNEMNDLRMLLEEQNARNNLLEK 1593
                                                  .|::.||:.||.:.:|..||....|:|
Human  1384 IQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDK 1448

  Fly  1594 KQRKFD---AECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEKLASLQ 1655
            |||.||   ||.:...:....|.:|.::..|.   |..|.|.::....::...||..:.:..:||
Human  1449 KQRNFDKILAEWKQKCEETHAELEASQKESRS---LSTELFKIKNAYEESLDQLETLKRENKNLQ 1510

  Fly  1656 RELEEMT---FGGGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMR 1717
            :|:.::|   ..||  :...:|.:.|.:.|:...|.:..|:|....::..|...||:::.|..::
Human  1511 QEISDLTEQIAEGG--KRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVK 1573

  Fly  1718 KEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERRLSSME-DRDRVDR 1781
            .|..|:..::|||:::::.|..:.:::::..|:.|...|...:|.|.::|..|:.|| ..:..:|
Human  1574 SEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANR 1638

  Fly  1782 DAEEALNQKLRRDLRKYKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTA 1846
            .|.|||     |:.|..:|:|||.|..|:            ..||:| ||.:...::..:.....
Human  1639 MAAEAL-----RNYRNTQAILKDTQLHLD------------DALRSQ-EDLKEQLAMVERRANLL 1685

  Fly  1847 EAELTEVQAMFDESHRARN-------DAEERANAAH--------------RDRAELQAQIEENEE 1890
            :||:.|::|..:::.|:|.       ||.||....|              .|.:::|.::|:..:
Human  1686 QAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQ 1750

  Fly  1891 ELGELMKKYSATVKQLNTEQINVSEAEFKLNE-----MEAERNNLKEQVAELQHRLDNVENLGDP 1950
            |.....:|    .|:..|:...::| |.|..:     :|..:.||::.|.:||||||..|.|...
Human  1751 EARNAEEK----AKKAITDAAMMAE-ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK 1810

  Fly  1951 SMAMMSKRLELRTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKS 2015
            ......::||.|.:|||..:|.||.........:.:|:..:::|..:..:.:...::.||::.|.
Human  1811 GGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKL 1875

  Fly  2016 QKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGE 2080
            |..:                     |..:::.|:.|.:.       .:.|.:...:|..:||  .
Human  1876 QAKV---------------------KSYKRQAEEAEEQS-------NVNLSKFRRIQHELEE--A 1910

  Fly  2081 EELSESDESLSSVGSISDLEDRLRPVHVKRSSQQ 2114
            ||.::..||     .::.|..:.|.||.|..|::
Human  1911 EERADIAES-----QVNKLRVKSREVHTKIISEE 1939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 209/802 (26%)
MYSc_Myo18 575..1305 CDD:276837 197/771 (26%)
GBP_C <1540..1750 CDD:303769 60/289 (21%)
COG1340 1565..1833 CDD:224259 75/317 (24%)
coiled coil 1723..1734 CDD:293879 3/10 (30%)
MYH1NP_005954.3 Myosin_N 36..73 CDD:280832 2/5 (40%)
Myosin_head 88..770 CDD:278492 201/783 (26%)
MYSc_Myh1_mammals 100..770 CDD:276875 197/771 (26%)
Actin-binding. /evidence=ECO:0000250 659..681 8/37 (22%)
Actin-binding. /evidence=ECO:0000250 761..775 3/13 (23%)
Myosin_tail_1 850..1927 CDD:279860 210/1147 (18%)
RILP-like 965..1098 CDD:304877 6/132 (5%)
MIT_CorA-like <1299..>1411 CDD:294313 17/111 (15%)
DUF342 <1506..1582 CDD:302792 18/77 (23%)
DUF342 <1670..1767 CDD:302792 19/100 (19%)
TMPIT 1744..>1853 CDD:285135 30/113 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.