DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and a

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster

Alignment Length:	1009	Identity:	192/1009 - (19%)
Similarity:	317/1009 - (31%)	Gaps:	333/1009 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   581 LRQRYASNLIHTK-------AGPTLLVVNPMAP--LSLYS-EKVVSMFRGCKTEDMPPHVYSLAQ 635
            |:|:...:|.|.:       |.||.|:.....|  :|:.| ::..|:.|..:....||.:|....
  Fly   115 LQQQQQQHLQHQQQQQPLRTATPTCLLSGRQTPSAISVMSLQEATSLHRQQQQPHQPPTIYVPVP 179

  Fly   636 TAYRSLVETRRDQSLIFM-----------------------------------------GRSGSG 659
            |...:.|.|....:.:.:                                         |.:.||
  Fly   180 TKLGNNVNTGNSSATLLLSYGSTSSIANLQQQQQQHAAQYQQYVAQRLHAASSSCLYEKGSNASG 244

  Fly   660 KSTSFK---------HALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLL 715
            .::|.|         |..:|..:.|.......:..|.|:| ...||..|:.:..|.|.:..:.
  Fly   245 GASSNKSSLSLTPNGHLPDYKLVTAMPVVVLDDEHKSNSL-PATEASRNSNSSSNMNGSSNSN-- 306

  Fly   716 SLDFDQTGQIASASLQVLLPER------QRAGRRL-----------GHE-HS-----FHIMTRLL 757
            |||...:...:.:|..:....|      :|..|:|           .|: ||     ||..|...
  Fly   307 SLDVSNSNSHSGSSTSLASTTRNVFTWGKRMSRKLDLLKRSDSPAAAHKSHSDLRSLFHSPTHHK 371

  Fly   758 AGAAGLLQKELHLENITSEDSHPFISLS-------------QKLEDRHRAANDFMRTVQAFETLN 809
            :|:.|.........:.:....|...|.|             :.::.||:......::||
  Fly   372 SGSGGSSGPSSAKASASPTGGHQNSSGSTTSTLKKCKSGPIETIKQRHQQQQQQQQSVQ------ 430

  Fly   810 IDAKAVRGIWSILAAIYHLGIAGVTKLGTG------STARTQF---ANPTAARK-------ASGL 858
                                     .:|||      ||...||   |.|..|.|       ::|:
  Fly   431 -------------------------DVGTGQSQSAQSTPTHQFQAAARPQKALKNFFHRIGSTGM 470

  Fly   859 LGVNLEDLSSAAFGLTQ--PNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGL-YSEALAAVVAL 920
            |.....:|..|:....|  |.|.....|.|.|..|.:.:....:..|.|.:.. ..|.....:|.
  Fly   471 LNHRSHNLLKASEAAQQATPAATTLYRSSSTSQLSSSSYVKCDDPTEGLNLQREQREQRLPRIAS 535

  Fly   921 INRQICTSSHTIASIMLIDTPG-------FQNPASCGQQVGATLADLRHN----------YLQER 968
            :....|.....::|.:...|..       ...|:|.....|.|....:|:          :|:.|
  Fly   536 LKSSSCDDIAKVSSCLTASTSSGSAAGSLGSPPSSAAAGGGGTANSGQHDPSRRGAFPYAFLRSR 600

  Fly   969 LQMLFHHTTLVAPRDRYAQELVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHD---- 1029
            |.:|        |.:.:...             ||.|...|.:..:.|  :..||||.:.:
  Fly   601 LSVL--------PEENHGNV-------------PGHLKQQIQRQREQH--QQHQRDLLQQEQTSS 642

  Fly  1030 ----RRGMLWLLDEEAIYPN-SNDDTFLERLFSHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVL 1089
                ||.     .|:|:..| |.:|:...:.:.....|     |..|.           .:|...
  Fly   643 PLPQRRS-----PEQAMLNNVSRNDSITSKDWEPLYQR-----LSSCL-----------SSNESG 686

  Fly  1090 YAVDGWVRHSREHPGIRNAVSL----LQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSL 1150
            |..||....:|    :.|.:|:    .:..:...:.|..:.||:...|..:..|...|| |..|.
  Fly   687 YDSDGGATGAR----LGNNLSISGGDTESIASGTLKRNSLISLSSSEGVGMGMGMSLGL-GAPST 746

  Fly  1151 RRVS------------------SIRRSFTTAGVKRNSIMLQVKFTVD--GIIDTLRRTGTHFVHC 1195
            |..|                  :|||.|       ..:.|:.|...|  ||:.:.:...|:
  Fly   747 RNSSICSAPVSLGGYNYDYETETIRRRF-------RQVKLERKCQEDYIGIVLSPKTVMTN---- 800

  Fly  1196 YLLQHNAGKHTKYTANGSPSSAA---GQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESV 1257
                .|..::........|...|   |::...:|:|||.  ...|||.|  ..|.:.||
  Fly   801 ----SNEQQYRYLIVELEPYGMAQKDGRLRLGDEIVNVN--GKHLRGIQ--SFAEVQRL------ 851

  Fly  1258 PLLEFVRRFGLLAGDLASNKDVSVEQILAVNELDVAS-----YRI-GPSQILFRSGVLSELEAKR 1316
                           |:|..|..::.::|.:|:...:     .|| |.|....|...:...:: .
  Fly   852 ---------------LSSFVDNCIDLVIAHDEVTTVTDFYTKIRIDGMSTQRHRLSYVQRTQS-T 900

  Fly  1317 DVLLSDRIIQLQAFCRGYLARKKMSQRRVQ-------ELAVRCIQRNVKAFLAVRDWPWWRLLVR 1374
            |.|.|.:.:|||             |.|:|       :.|....|.:.::..:|...|
  Fly   901 DSLSSMQSLQLQ-------------QERIQGHNTEQEQEAQGEDQCDARSMASVSTMP------- 945

  Fly  1375 VTPL-LNVHRTEE------QLKTANEELLMLRAK 1401
             ||: |..||...      .:.....|||..||:
  Fly   946 -TPMPLMQHRRSSTPRHSLDVGAPEHELLRRRAR 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	169/909 (19%)
		MYSc_Myo18	575..1305	CDD:276837	168/897 (19%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	24/122 (20%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900