Protein Alignment Mhcl and jar

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Alignment Length: 1345
• Identity: 288/1345 - (21%)
• Similarity: 512/1345 - (38%)
• Gaps: 314/1345 - (23%)

  Fly   564 EDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPL-SLYSEKVVSMFRGCKTEDMP 627
            :|.|||..||||:.|..|:.||..:.|:|.....|:.|||...: .||:...:..:.|....::|
  Fly    60 DDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELP 124

  Fly   628 PHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLAL---AAGAYNNFINAEKVNA 689
            |||:::|..|.|.:...:..||:|..|.||:||:.|.|:.|.||..   :||....     |:..
  Fly   125 PHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIET-----KILD 184

  Fly   690 LCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMT 754
            ...:||||||.||..|:|::|..:.:.:.:|...|:....:...|.|:.|...:...|.::|:..
  Fly   185 ANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFY 249

  Fly   755 RLLAGAAGLLQKELHL----------------ENITSEDSHPFISLSQKLEDRHRAANDFMRTVQ 803
            .|||||...|:.:|.|                .|..:|...|....|:..:.:....:..:...|
  Fly   250 MLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQ 314

  Fly   804 AFETLNIDAKAVR---------GIWSILAAIYHLGIAGVTKLGTGSTARTQF--ANPTAARKASG 857
            .|.  |:|....|         ||:|::||:.|||.....::........|.  |:..:....||
  Fly   315 HFH--NLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSG 377

  Fly   858 LLGVNLEDLSSAAFGLTQPNAPNGG------LSPSKSPTSDTGHEWAWECLEALVIGLYSEALAA 916
            ||||:..:|.:|...... .:..||      :.|.|...:....       :||...:||.....
  Fly   378 LLGVDQTELRTALVSRVM-QSKGGGFKGTVIMVPLKIYEASNAR-------DALAKAIYSRLFDR 434

  Fly   917 VVALINRQICTSSHTIASIMLIDTPGFQNPASCGQQVGATLADLRH---NYLQERLQMLFHHTTL 978
            :|.|||:.|...:... .|.::|..||:.         .|:.....   ||..|:||..|:...|
  Fly   435 IVGLINQSIPFQASNF-YIGVLDIAGFEY---------FTVNSFEQFCINYCNEKLQKFFNDNIL 489

  Fly   979 VAPRDRYAQELVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIY 1043
            ...::.|.:|.:.:           |.|:..|.  |:.:      :|.|....|:..|||||:..
  Fly   490 KNEQELYKREGLNV-----------PEITFTDN--QDII------ELIEAKSNGIFTLLDEESKL 535

  Fly  1044 PNSNDDTFLERLFSHYGDREH-------------------HSLLRKCAGPRQFVLHHLQGTNPVL 1089
            |..:        :||:....|                   |..||...|   |::.|..|.  |.
  Fly   536 PKPS--------YSHFTAEVHKSWANHYRLGLPRSSRLKAHRTLRDEEG---FLVRHFAGA--VC 587

  Fly  1090 YAVDGWVRHSRE--HPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRR 1152
            |..:.::..:.:  |..:.   .|:|:.....:..|:..            ||...:.|
  Fly   588 YNTEQFIEKNNDALHASLE---GLVQECDNPLLQTLFPS------------GSSTSVRG------ 631

  Fly  1153 VSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSA 1217
                :.:|.:.|.|       .|..:..:::.|.:.||:|:.|  ::.|: |.......||
  Fly   632 ----KLNFISVGSK-------FKTQLGELMEKLEQNGTNFIRC--IKPNS-KMIDRQFEGS---- 678

  Fly  1218 AGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRF-GLLAGDLAS-NKDVS 1280
                          |..:||:.|..:....|...|:|..|...:....: .:|..:|.| .....
  Fly   679 --------------LALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPARTF 729

  Fly  1281 VEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSD--RIIQLQAFCRGYLARKKMSQR 1343
            .|.:.....|....::.|.:::.||.|...|.:.   ::.||  .::.:.|..:.:|.|.:..:.
  Fly   730 CEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDR---IMRSDPENMLAIVAKVKKWLIRSRWVKS 791

  Fly  1344 RVQELAV-----------RCI---QRNVKAFLAVRDW-PWWRLLVRVTPL-LNVHRTEE---QLK 1389
            .:..|.|           :|:   ||..:.|||.:.. |.::.:.::..: .|..:|.|   .||
  Fly   792 ALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLK 856

  Fly  1390 TANEELL--------MLRAKLEKIECD----RSEVKAENQKLEAKLSELTVDLAEERSTAHIATE 1442
            ...||::        .:...::||:.:    :.|:.:....:.|.:::|||||..:      ..|
  Fly   857 MGREEIISGVNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTK------LKE 915

  Fly  1443 RLEAETAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYK 1507
            :.:||..|||:..:|..:.....|..:|..::                  |:.||:        :
  Fly   916 QQQAEEQERLRKIQEALEAERAAKEAEEQRQR------------------EEIENK--------R 954

  Fly  1508 LKYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSD--AYEEVVEQ------------RQ 1558
            ||.|...|......:||. |.|.|....:||::.||.:..|  .|.:.:||            .:
  Fly   955 LKAEMETRRKAAEAQRLR-QEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANE 1018

  Fly  1559 VVGQWKRKAQKMTNEMNDL--------------------RMLLEEQNARNNLLEKKQRKFDA--- 1600
            ..||.:.....:.|.:||.                    |.|.:.:|.|.......::|:|.
  Fly  1019 SNGQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGKQKYDLSKW 1083

  Fly  1601 ECQSLQDAVRQE------RQAKERYGREKDVLQA------EKFTLEQTLADTR--LDLEFKEEKL 1651
            :...|:||:...      ...::.:.|...|..|      ::.|:::.....|  ::..||:..|
  Fly  1084 KYSELRDAINTSCDIELLEACRQEFHRRLKVYHAWKAKNRKRTTMDENERAPRSVMEAAFKQPPL 1148

  Fly  1652 ASLQRELEEMTFGGGTEEEFAQLRRSKNETERR------------AKEQEEELDE-----MAGQI 1699
            .   :.::|:............:|.:..:..:|            |::.|...|:     :||..
  Fly  1149 V---QPIQEIVTAQHRYFRIPFMRANAPDNTKRGLWYAHFDGQWIARQMELHADKPPILLVAGTD 1210

  Fly  1700 QLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKA 1744
            . ::..:|.||.|..|.::.|.....:.:.|.|...|..||.:.|
  Fly  1211 D-MQMCELSLEETGLTRKRGAEILEHEFNREWERNGGKAYKNLGA 1254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	288/1345 (21%)
		MYSc_Myo18	575..1305	CDD:276837	176/792 (22%)
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670
		MYSc_Myo6	71..754	CDD:276833	176/792 (22%)
		CBD_MYO6-like	765..913	CDD:409646	30/153 (20%)
		ERM_helical	<954..1020	CDD:466641	17/66 (26%)
		MYO6_MIU_linker	1002..1093	CDD:480843	16/90 (18%)
		MyUb_Myo6	1076..1116	CDD:439319	7/39 (18%)
		Myosin-VI_CBD	1160..1246	CDD:465157	15/86 (17%)