Protein Alignment Mhcl and loco

DIOPT Version :9

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_732773.1
• Gene: loco / 42672
• FlyBaseID: FBgn0020278
• Length: 1541
• Species: Drosophila melanogaster
• Alignment Length: 1871
• Identity: 354/1871 - (18%)
• Similarity: 596/1871 - (31%)
• Gaps: 695/1871 - (37%)

  Fly   261 LPQGNSQGSHLHVLTSPSPSADSLTDTTNSSFATPPFSLSPVG-ESQGIDRWARVHA---FEDVE 321
            ||...:.||  ..:.:.:.:|:..:...||..|....|.:|.| .||...|..:..|   :..:
  Fly     8 LPITGASGS--TAVGTGAAAAEDASPAANSGPAPISTSTTPSGSNSQQHQRRRKKRANYNYNGI- 69

  Fly   322 LPLPPVQLVKLPPPRQLVIRRQKSPRQDFGFSLR-----KAICLDRTESLTSPIFRPVIFAEPGA 381
                          |.:.:||..:   .|||::.     :..|              :|.:.|..
  Fly    70 --------------RTVEVRRGYN---GFGFTISGQQPCRLSC--------------IISSSPAE 103

  Fly   382 GGGATGLLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAVTVEVQPVAELVELSKRCMAPSTATV 446
               ..||..||.||.|||..|.:||.|.::::|.||..::.::   :||...        |.::.
  Fly   104 ---QAGLRSGDFLISVNGLNVSKLPHETVVQLIGNSFGSIRMQ---IAENYY--------SDSSD 154

  Fly   447 EEIDHSITNGNCNTLRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVWLVH 511
            ||..|:...|..    .:||.|.|.:..|
  Fly   155 EENAHATLRGQL----LAASLRHKPRFLH------------------------------------ 179

  Fly   512 RGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEAS 576
                                :|..|..|.|..|        :|.|.|  :.||     .:.:::|
  Fly   180 --------------------HKAKLHRLRNSPQ--------KKLNPP--EAVE-----PHKSKSS 209

  Fly   577 VLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEK------VVSMFRG-------CK------ 622
            ..|                |||..|....||:....|      |.:|.|.       |:
  Fly   210 PDH----------------PTLKPVLEDPPLTANLSKAADVANVSAMVRAVGSAALECRVIVGYL 258

  Fly   623 -TEDMPPHV-----YSLAQTAYRSLVETRRDQSLIFM----------GRSGSGKSTSFKHALNYL 671
             |.:||..:     ....::..|.|.:.:|..:::.|          ..||...:|.....||::
  Fly   259 GTIEMPKQISHSSKLQTVRSCIRKLRQEKRQPTIVLMCITPDSLSLQSSSGGVLATYSSARLNFV 323

  Fly   672 ALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPE 736
            :.::.:.|.|               ||     |.::|...||:........|..|:|
  Fly   324 SSSSESENRF---------------FG-----LVTSAVHNTQIEEEYEPSAGSAAAA-------- 360

  Fly   737 RQRAGRRLGH---EHSFHIM---TRLLAGAAGLLQ-KELHLE-------NITSE---DSHPFISL 784
                    ||   .||.|:.   |:|:..|..|.: .|..|:       |:..|   :|...::|
  Fly   361 --------GHISISHSCHVFVIDTKLIEHAQHLQRAHEFRLQCTRDPISNLCLEFPNNSEYVVNL 417

  Fly   785 SQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIY------HLGIAGVTK-------- 835
            .:.:... |......|:.||.......|.|..|   .:||.:      |..|:..|.
  Fly   418 VRSMYTM-RILPPASRSHQADYEAGAGAAAAGG---AVAAAHSPQPSNHSEISTTTSNSDSGIGF 478

  Fly   836 ------------------LGTGSTARTQFANPT--AARKASGLLGV--------NLEDLSS---- 868
                              .|.|:.|......||  |..:..|::|:        .:.|.|:
  Fly   479 NNDCTNISDRILVVDFLAAGAGAAAAAHAGPPTYPAPARPLGIVGIPDNRLTVRAMPDHSALLRS 543

  Fly   869 --AAFGLTQPN---------APNGGLSPSKS-------------------------------PTS 891
              |:..|.:||         :|...|:.::|                               |:.
  Fly   544 PPASSSLRRPNLLASFNLIQSPATNLTSTRSCDDVLNLFVDDSPRTLAAVASMDDISLHSAAPSL 608

  Fly   892 DTGHEWAWECLEALVIGLYSEALAAVVALINRQIC----TSSHTIASIMLIDTPGFQN------- 945
            |.||.:|..              |.|...:.|.:.    |:.|.: |..:...||.::
  Fly   609 DEGHTFAHP--------------ACVPRKMRRSLALETPTTPHKL-SAQVFGQPGSRHSLGFEAI 658

  Fly   946 -------PASCGQQVGATLADLR--HNYLQERLQMLFHHTTLVAPRDRYA-QELVEIEMDLASEC 1000
                   ..:|..|...|.|.|:  |...::|       |::.|....:. .|....|.||.:..
  Fly   659 DSVQSSVSGACMDQTMDTWASLQNLHKSHKDR-------TSMSASSSSHCLLEATNSEPDLGNRA 716

  Fly  1001 HPGPLISLIDKAPQNHVVRSSQRD--LREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDRE 1063
            .|.. .|...:|......|:.:.|  .:|..:.|....:...|....|::|.:::.|.
  Fly   717 LPAN-ASPFRRAWGQSSFRTPRSDKVAKEQQQLGQSSPVRRTASMNASDNDMYIKTLM------- 773

  Fly  1064 HHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSL 1128
                                        :|..::.||.    ::.:||||      :.::    |
  Fly   774 ----------------------------LDSDLKSSRS----QHQLSLLQ------VPKV----L 796

  Fly  1129 TRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSF-----TTAGVKRNSIMLQVKFTVDGIIDTLRRT 1188
            |..:.......|.|.....|.....||...||     ..||::..|..|:.:|:.:.|.
  Fly   797 TTPAPPSAITASVAAEGAAQDHGCPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAENIY------ 855

  Fly  1189 GTHFVHC---YLLQHNAGK-------HTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVL 1243
              .:..|   .||:..|.:       ..|:.||.|           .:.|||......|...::.
  Fly   856 --FWTACERYRLLESEADRVAQAREIFAKHLANNS-----------SDPVNVDSQARSLTEEKLA 907

  Fly  1244 EAARLHRLGFPESVPLLEFVRRFGLLAGDLASNKDV---SVEQILAVNELDVASYRIGPSQILFR 1305
            :||                              .|:   :.:||.::.:.|  ||:......|::
  Fly   908 DAA------------------------------PDIFAPAQKQIFSLMKFD--SYQRFIRSDLYK 940

  Fly  1306 SGVLSELEAKRDVLL-----SDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRD 1365
            |.|  |.|.|...|.     .|.:::.. |..|..::.|.|....::       |..|:.|
  Fly   941 SCV--EAEQKNQPLPYSGLDLDELLKTN-FHLGAFSKLKKSASNAED-------RRRKSLL---- 991

  Fly  1366 WPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQ------------- 1417
             ||             ||     ||        |:|..    ||:|:.|:.|
  Fly   992 -PW-------------HR-----KT--------RSKSR----DRTEIMADMQHALMPAPPVPQNA 1025

  Fly  1418 -------KLEAKLSELTVDLAEERST-----AHIATERLEAETAERLKLEKE-LGD------QTN 1463
                   ||....:.|: ||...||:     |..||....|.|.....|.:. |.|      ||.
  Fly  1026 PLTSASLKLVCGQNSLS-DLHSSRSSLSSFDAGTATGGQGASTESVYSLCRVILTDGATTIVQTR 1089

  Fly  1464 KVKNLQETTEKL--EMELICAKSDL--NGISEDEDAENEDGVGGGVYKLKYERVARELEF----- 1519
            ..:.:.|..|:|  :..|:....|:  .|.::..|.:....:..|...:...|||.:|:.
  Fly  1090 PGETVGELVERLLEKRNLVYPYYDIVFQGSTKSIDVQQPSQILAGKEVVIERRVAFKLDLPDPKV 1154

  Fly  1520 ------TKRRLH-------TQHEHDLEQLVALKKHLEMKLSDAYEEV------------VEQRQV 1559
                  .|::||       :::.:.:||:..:.:..::.: |..:.|            |.....
  Fly  1155 ISVKSKPKKQLHEVIRPILSKYNYKMEQVQVIMRDTQVPI-DLNQPVTMADGQRLRIVMVNSDFQ 1218

  Fly  1560 VGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKD 1624
            ||.......|.:..|..|        .:.:|.|...:.|:....|..||...|:      .|..|
  Fly  1219 VGGGSSMPPKQSKPMKPL--------PQGHLDELTNKVFNELLASKADAAASEK------SRPVD 1269

  Fly  1625 VLQAEKFTLEQTLADTRLDLEFKEEKLASLQRELEEMTFGGGTEEEFAQLRRSKNETERRAKEQE 1689
            :.     :::...|.:.....|  |::...||:      ||....  ::|.:.|.::...:::.|
  Fly  1270 LC-----SMKSNEAPSETSSLF--ERMRRQQRD------GGNIPA--SKLPKLKKKSTSSSQQSE 1319

  Fly  1690 EELDEMAGQIQLLEQ------AKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKK--IKALE 1746
            |     |...|.:..      |||:..:.|:.    ..|.::.:||.||     |.|:  :..||
  Fly  1320 E-----AATTQAVADPKKPIIAKLKAGVKLQV----TERVAEHQDELLE-----GLKRAQLARLE 1370

  Fly  1747 CQLETE-HEERTLLLREKHELERRLSSMEDRDRVDRDAEEALNQKLRRDLRKYKALLKDAQTQLE 1810
            .|..|| :.:....|:.|..|...:|.                      |||.:|.|    :.:.
  Fly  1371 DQRGTEINFDLPDFLKNKENLSAAVSK----------------------LRKVRASL----SPVS 1409

  Fly  1811 RLKADTPGKTLIRQLRNQLEDAESARSLA-MKARQTAEAEL---TEVQAMF 1857
            ::.| ||  |.|.|...:|....|.:.:: ||..|..|.:|   |:.|..|
  Fly  1410 KVPA-TP--TEIPQPAPRLSITRSQQPVSPMKVDQEPETDLPAATQDQTEF 1457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	24/91 (26%)
		MYSc	556..1317	CDD:214580	169/941 (18%)
		MYSc_Myo18	575..1305	CDD:276837	160/910 (18%)
		GBP_C	<1540..1750	CDD:303769	44/229 (19%)
		COG1340	1565..1833	CDD:224259	57/276 (21%)
		coiled coil	1723..1734	CDD:293879	4/10 (40%)
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	25/113 (22%)
		PTB_RGS12	251..391	CDD:269984	33/175 (19%)
		RGS_R12-like	828..941	CDD:188661	28/163 (17%)
		RGS12_RBD	1073..1145	CDD:176412	15/71 (21%)
		RBD	1144..1213	CDD:128731	9/69 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900