DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and Syn1

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster

Alignment Length:	785	Identity:	157/785 - (20%)
Similarity:	239/785 - (30%)	Gaps:	280/785 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 LVKLPPPRQLVIRRQKSPRQD-----------FGFSLRKAICLDRTESLTSPIFRPVIFAEP--- 379
            |.:.||..|..|.:|.||...           .|...|..:.|: |:.|...:......|:|
  Fly     7 LGRTPPAAQQPIPQQHSPSPSGLRCGNMETRVRGAWYRVLVTLE-TDFLAVSLDESCEAAQPSND 70

  Fly   380 --------------------GAGGGATGLLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAVTVE 424
                                |||||.||          .|...|.||         ||.....:.
  Fly    71 GQSTTLNGTLGSNHSGGGGGGAGGGGTG----------GGGQNGTLP---------NSASLQGMN 116

  Fly   425 VQPVAELVELSKRCMAPSTATVEEIDHSITNGNCNTLRRSASKRFKRQSRHENGNGGGEEGGAKG 489
            :|..                   |:|.|.:|.|.:           |.....|.|..|:.||.
  Fly   117 IQDT-------------------ELDGSASNDNGD-----------RDPCLNNNNNAGDGGGM-- 149

  Fly   490 VGHDLEADVAD--ASQPERVWLV--HRGGFTAAIRLPTASSGRDEENKLSLR------------- 537
               |: .||.|  |:|...|.::  ...|...:|:     .||  ||::.:.
  Fly   150 ---DM-CDVPDHVANQKRHVRIIKSDNNGLGISIK-----GGR--ENRMPILISKIFRGMAADQA 203

  Fly   538 ---------LLHNGEQL---TVDED-DVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNL 589
                     |..|||:|   |.||. ...|::...:||     |:|:|.|.:...    |.||
  Fly   204 KGLYVGDAILTVNGEELRDATHDEAVRALKRSGRVVDL-----EVKFLREVTPYF----RKAS-- 257

  Fly   590 IHTKAGPTL--LVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIF 652
            |.::.|..|  ..:.|:.|             |..|....|.....|.|.|..|..|...::|
  Fly   258 IISEVGWELQRAFLCPLGP-------------GVPTSPPAPKTTPRADTRYIPLQLTHLARNL-- 307

  Fly   653 MGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSL 717
                                       .:|:.|.   .|..|.:.....:|:...|.....|:.
  Fly   308 ---------------------------KYIDPEN---RCFELHSPDGVHSCILRAADSAEALVW- 341

  Fly   718 DFDQTGQIASASLQVLLPERQRAGRRLGHE--HSFHIMTRL----LAGAAG-------------- 762
             |:........|.|..|.|..||...|..|  |...:..|:    .:|:||
  Fly   342 -FNALHSAMGTSTQRALAEANRALTNLIGELKHIGWLSKRMSGGGSSGSAGGGAASGGSGTSNSV 405

  Fly   763 ----LLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILA 823
                |:.......:.:|::|..::.:...:.:|.         .:.:|:.....:|    ||...
  Fly   406 VAGELVSPSGRSSSESSDESDKWLPIFVAVTERE---------FRIYESAPWSVEA----WSRPL 457

  Fly   824 AIYHLGIAGVTKLGTGSTARTQFANPTAAR--KASGLLGVNL-----EDLSSAAFGLTQPNAPNG 881
            .||.|....:...|..|:...|.......|  .|.|:|...|     .|:::.|..|.|
  Fly   458 EIYALATTRLAGAGNNSSLNGQQTTVFCVRCGTARGVLVYWLRSETHRDMAAWARSLVQ------ 516

  Fly   882 GLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQNP 946
                ......:...|:::.|       |:......:|..|||          ...|.|..||. |
  Fly   517 ----GSHQAVNYQREFSFRC-------LFQGRQCQLVVHINR----------GFFLYDCGGFA-P 559

  Fly   947 ASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQELV-------EIEMDLASECHPGP 1004
            .:      .|:|..:....|      |....|....|..|:.|.       |||:|:  ||.|.|
  Fly   560 TT------PTVATAKTQLWQ------FAFDKLKGSADDGARMLYLDFGEDGEIELDM--ECCPKP 610

  Fly  1005 LISLI 1009
            ::.::
  Fly   611 VVFVV 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	24/120 (20%)
		MYSc	556..1317	CDD:214580	95/494 (19%)
		MYSc_Myo18	575..1305	CDD:276837	89/475 (19%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	5/31 (16%)
		PDZ_signaling	163..244	CDD:238492	19/92 (21%)
		PHsplit_syntrophin	<293..351	CDD:269960	13/91 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900