DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and MYO18A

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001333694.1	Gene:	MYO18A / 399687	HGNCID:	31104	Length:	2058	Species:	Homo sapiens

Alignment Length:	2244	Identity:	836/2244 - (37%)
Similarity:	1263/2244 - (56%)	Gaps:	293/2244 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFNFMKKSAGDEDKERRKREKKLRKEAKGTSGGPGMGGVTGVTGSMSTDELLRLDEVRRSLKIRG 65
            |||.|||   |:||:..::|||.:||.|               ..||..||..|:|:  ||: ||
Human     1 MFNLMKK---DKDKDGGRKEKKEKKEKK---------------ERMSAAELRSLEEM--SLR-RG 44

  Fly    66 RRKEKEKLPSGITADYSADFFAALNADANGGSNGGAVGAADPEQDRGNEEIVASVMTHIESRASN 130
                                |..||..:...|.                       |.:|  .||
Human    45 --------------------FFNLNRSSKRESK-----------------------TRLE--ISN 64

  Fly   131 GAGVSVNYSEVTHSLLSGGLKNRFLPPIPPKPPKRGILKGSRSNMTNVHEEISFAGSAGGAGGTP 195
                                      |||.|     :..||..::|::..:
Human    65 --------------------------PIPIK-----VASGSDLHLTDIDSD-------------- 84

  Fly   196 EMLLRNTFQNESLYEGAARGAGSIGSNSSQHGTSFTSVESLRSDGEQTGGQQRAMTLPANARYGA 260
                            :.||:..:.|.   |.::.:|.:.|:  ||:  |..|...|...|::|:
Human    85 ----------------SNRGSVILDSG---HLSTASSSDDLK--GEE--GSFRGSVLQRAAKFGS 126

  Fly   261 LPQGNSQGSHLHVLTSPSPSADSLTDT-TNSSFATPPFSLSPVGE------------SQGIDR-W 311
            |.:.|||........|.....:|.::| |.|..:..|   ||..|            ..||.| .
Human   127 LAKQNSQMIVKRFSFSQRSRDESASETSTPSEHSAAP---SPQVEVRTLEGQLVQHPGPGIPRPG 188

  Fly   312 ARVHAFE------DVELPLPPVQLVKLPPPRQLVIRRQKSPRQDFGFSLRKAICLDRTESLTSPI 370
            .|..|.|      .|:|.||||  |.||||....:..|:.|..|||||||:...|||... ....
Human   189 HRSRAPELVTKKFPVDLRLPPV--VPLPPPTLRELELQRRPTGDFGFSLRRTTMLDRGPE-GQAC 250

  Fly   371 FRPVIFAEPGAGGG--ATGLLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAVTVEVQPVAELVE 433
            .|.|.|||||||..  |.||:|||||:::||..|....|:.|:||||.||::|.::|||:.||.|
Human   251 RRVVHFAEPGAGTKDLALGLVPGDRLVEINGHNVESKSRDEIVEMIRQSGDSVRLKVQPIPELSE 315

  Fly   434 LSKRCMAPSTATVEEIDHSITNGNCNTLRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDLEADV 498
            ||:..:......                ||..|......:.|.:.....||        .:.|:.
Human   316 LSRSWLRSGEGP----------------RREPSDLDSEAASHAHSQAKTEE--------QIAAEE 356

  Fly   499 ADASQPERVWLVHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLV 563
            | .::.|:||||||.||:.|.:|.:..... .|.|:.::|.|:|..|.||||||||.|:|:.|.:
Human   357 A-WNETEKVWLVHRDGFSLASQLKSEELNL-PEGKVRVKLDHDGAILDVDEDDVEKANAPSCDRL 419

  Fly   564 EDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPP 628
            ||:..|.||||:||||.|||||.::|:||.|||:|||:.|....::|||||:.||:||:.|||.|
Human   420 EDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLGPRGAPAVYSEKVMHMFKGCRREDMAP 484

  Fly   629 HVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAG-AYNNFINAEKVNALCT 692
            |:|::||||||:::.:|:|||:|.:|.|||||:||.:|.:.|||..|| :.|...:.||..||.|
Human   485 HIYAVAQTAYRAMLMSRQDQSIILLGSSGSGKTTSCQHLVQYLATIAGISGNKVFSVEKWQALYT 549

  Fly   693 ILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLL 757
            :||||||:.|.:|.||||.:|:|||||||.||:||||:|.:|.|:.|..||...|.:|::...||
Human   550 LLEAFGNSPTIINGNATRFSQILSLDFDQAGQVASASIQTMLLEKLRVARRPASEATFNVFYYLL 614

  Fly   758 AGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSIL 822
            |...|.|:.||||.::...:....:.|: |.|::.:||..|.:...|.:.|.|.....:..|.||
Human   615 ACGDGTLRTELHLNHLAENNVFGIVPLA-KPEEKQKAAQQFSKLQAAMKVLGISPDEQKACWFIL 678

  Fly   823 AAIYHLGIAGVTK------LGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAF-----GLTQP 876
            |||||||.||.||      .......|.|||....|:||:.|||.:||:||||.|     |.|..
Human   679 AAIYHLGAAGATKEAPEEQAEAAEAGRKQFARHEWAQKAAYLLGCSLEELSSAIFKHQHKGGTLQ 743

  Fly   877 NAPNGGLSPSKSPTSD-TGHEW-AWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLID 939
            .:.:....|.:|...| ||.:. |.||||.:..|||||....:|:|:||.:.:|.|::.|:|::|
Human   744 RSTSFRQGPEESGLGDGTGPKLSALECLEGMAAGLYSELFTLLVSLVNRALKSSQHSLCSMMIVD 808

  Fly   940 TPGFQNPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQELVEIEMDLASECHP-- 1002
            |||||||...|...||:..:|.|||.|:|||.|||..|.|...:||.:|.:|:..|   :..|
Human   809 TPGFQNPEQGGSARGASFEELCHNYTQDRLQRLFHERTFVQELERYKEENIELAFD---DLEPPT 870

  Fly  1003 GPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHY----GDRE 1063
            ...::.:|:|....:|||.   .|..:.||:||||:|||:.|.:::||.||||||:|    ||::
Human   871 DDSVAAVDQASHQSLVRSL---ARTDEARGLLWLLEEEALVPGASEDTLLERLFSYYGPQEGDKK 932

  Fly  1064 HHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSL 1128
            ..|.|...:.|..|:|.|..|||.|.|.|.||:.:::::|..:||..|||||.::.|:.|::|
Human   933 GQSPLLHSSKPHHFLLGHSHGTNWVEYNVTGWLNYTKQNPATQNAPRLLQDSQKKIISNLFLG-- 995

  Fly  1129 TRGSGAMVFCGSFAGLEGTQ--SLRRVSSIRRSFTT--AGVKRNSIMLQVKFTVDGIIDTLRRTG 1189
             |...|.|..||.|||||..  :|||.:|:|::|||  |.||:.|:.:|:|..||.:|||::::.
Human   996 -RAGSATVLSGSIAGLEGGSQLALRRATSMRKTFTTGMAAVKKKSLCIQMKLQVDALIDTIKKSK 1059

  Fly  1190 THFVHCYLLQHNAGKHTKYTANGSPSSAAG-QVSSEEEM--------------VNVPLLRSQLRG 1239
            .|||||:|.......       |.|.||:. :|||..|:              ::|||||:||||
Human  1060 LHFVHCFLPVAEGWA-------GEPRSASSRRVSSSSELDLPSGDHCEAGLLQLDVPLLRTQLRG 1117

  Fly  1240 SQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLAS---------NKDVSVEQILAVNELDVASY 1295
            |::|:|.|::|.|:|:.:...||.|||.:||..|..         ::..:||::|...:|:.:|.
Human  1118 SRLLDAMRMYRQGYPDHMVFSEFRRRFDVLAPHLTKKHGRNYIVVDERRAVEELLECLDLEKSSC 1182

  Fly  1296 RIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAF 1360
            .:|.|::.||:|.|:.||.:||...|..:...||.|||||||:...:|::|:||:||:|:|:|..
Human  1183 CMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCVQKNIKKN 1247

  Fly  1361 LAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLEAKLSE 1425
            ..|:|||||:|...|.||:.|..:|||::..:||:..||:||||.|.:|:|::..:.:||:::||
Human  1248 KGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISE 1312

  Fly  1426 LTVDLAEERSTAHIATERLEAETAERLKLEKELGDQTNKVKNLQETTEKLEMELICAK----SDL 1486
            ||.:|.:||:|...|::.|:|||||||:.|||:.:...:...|::..|.:|||::.|:    :::
Human  1313 LTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEI 1377

  Fly  1487 NGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSDAYE 1551
            ||..:|:||       ||.::|||||..||::|||:||..:.|..||.....|:.||.:|.|...
Human  1378 NGEVDDDDA-------GGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQA 1435

  Fly  1552 EVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAK 1616
            :..|.::.:.|.|:|.|::|.|:.|.::.||.|..||:.||||||:||:|.....:..::|:..:
Human  1436 DSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQR 1500

  Fly  1617 ERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEKLASLQRELEEMTFGGGTEE-EFAQLRRSKNE 1680
            |:..||||:|.||.|:|:|.|.:..:|:....:|:.||:.||::::.....:| ..|::::...:
Human  1501 EKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRD 1565

  Fly  1681 TERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKAL 1745
            .|.:.|:|||||||.||.||:||||||||||.:|.||:...:|.:.||||:||.|.:..||:|.:
Human  1566 LEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQM 1630

  Fly  1746 ECQLETEHEERTLLLREKHELERRLSSMEDR-DRVDRDAEEALNQKLRRDLRKYKALLKDAQTQL 1809
            |.|||.|:|::..:||||.|||.:|:::.|: :|.|.::|    ::||:||::.||||.|||..|
Human  1631 EVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESE----KRLRKDLKRTKALLADAQLML 1691

  Fly  1810 ERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHRARNDAEERANAA 1874
            :.||...|.|..|.||:||||::|...:.|:|||:..|.|:.::....|:..:|:...||:.:..
Human  1692 DHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRL 1756

  Fly  1875 HRDRAELQAQIEENEEELGELMKKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQVAELQH 1939
            .|::.|:|.::||::|::.|||||:.|.|.|.:.:...:::.:.:|.|...|:..|:|::..||.
Human  1757 QREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQS 1821

  Fly  1940 RLDNVE-NLGDPSMAMMSKRLELRTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKM 2003
            :::.:| ::.|.|:.   .|.|.:.:|||:|||.|:....|||...:|.||.:|||..|..|...
Human  1822 QVEFLEQSMVDKSLV---SRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIA 1883

  Fly  2004 REMQAQDVIKKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRI 2068
            .|.:.::..|:.|:.|||.:||...::.:|.|:..::.:||..:|.:|:...:|:.||:||.:||
Human  1884 AENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRI 1948

  Fly  2069 ADLQQAMEEEGEEELSESDESLSSVGSI---SDLEDRLRPVHVKRSSQQSLN---GSIGGGGGSV 2127
            .|||.|:|:|.|.:  |:::.::|.|..   |:||||:..|    .|..|.|   .......||:
Human  1949 GDLQAAIEDEMESD--ENEDLINSEGDSDVDSELEDRVDGV----KSWLSKNKGPSKAASDDGSL 2007

  Fly  2128 VSSTRTVVFEK-------DDNSPRITVTSPSSPH 2154
            .||:.|..::.       |::.|....:.|...|
Human  2008 KSSSPTSYWKSLAPDRSDDEHDPLDNTSRPRYSH 2041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	41/88 (47%)
		MYSc	556..1317	CDD:214580	345/808 (43%)
		MYSc_Myo18	575..1305	CDD:276837	329/777 (42%)
		GBP_C	<1540..1750	CDD:303769	86/210 (41%)
		COG1340	1565..1833	CDD:224259	118/269 (44%)
		coiled coil	1723..1734	CDD:293879	6/10 (60%)
MYO18A	NP_001333694.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34		18/50 (36%)
		Interaction with actin	114..118		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..167		8/29 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1469..1499		12/29 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1871..1920		15/48 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142544
Domainoid	1	1.000	531	1.000	Domainoid score	I279
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7977
Inparanoid	1	1.050	1269	1.000	Inparanoid score	I170
Isobase	1	0.950	-	0	Normalized mean entropy	S3984
OMA	1	1.010	-	-		QHG47553
OrthoDB	1	1.010	-	-		D23517at33208
OrthoFinder	1	1.000	-	-		FOG0007280
OrthoInspector	1	1.000	-	-		otm41969
orthoMCL	1	0.900	-	-		OOG6_105087
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5401
SonicParanoid	1	1.000	-	-		X3038
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750