DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and bbg

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster

Alignment Length:	949	Identity:	177/949 - (18%)
Similarity:	346/949 - (36%)	Gaps:	269/949 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1409 RSEVKAENQKLEAK---LSELTVD-LAEERSTAHIATERLEAETAERLKLEKELGDQTNKVKNLQ 1469
            :||...:..|:|..   |::||.| :|:..::|..|..|.|..|.:    .:|:...::.....|
  Fly   786 KSEESKKLPKMEVNAGGLAQLTDDKIADHDASATRADTRDEVTTNQ----TQEISSSSSSSVKSQ 846

  Fly  1470 ETTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLK-YERVARELEFTKRRLHTQHEHDLE 1533
            :||....:......|     |....:.:...:....:||: ||                ...|:
  Fly   847 KTTTTTRVTTTKTSS-----SSSSSSCSSTVIPDVAFKLQPYE----------------ERDDI- 889

  Fly  1534 QLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNE-MNDLRMLLEEQNAR---------- 1587
                        ||:....:.|:|:|:.:.|..::..|.: :.....|:...|::
  Fly   890 ------------LSEPITTIHEERRVLSEQKTLSESRTRDALTGEEQLVTSANSKSSSARFKKIS 942

  Fly  1588 --NNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKE-- 1648
              :|||:....: |.:.|.|...:.||...:||....:|....::.||  ||::....|..||
  Fly   943 SNDNLLDLGDEQ-DMQEQPLTATITQESSLRERLECPQDNQSIDRGTL--TLSERGKQLSEKEGL 1004

  Fly  1649 ---------EKLASLQRELEEMTFGGG------------TEEEFAQLRRSKNETERRAKEQEEEL 1692
                     ||.:.|:.: :.:...||            .|.|.::.....|:.|::..::.|:.
  Fly  1005 TTYTECETSEKESYLEGQ-QVLNGKGGFVSQDENSDQPTYEREVSETLTIVNDGEKQVTKKLEQN 1068

  Fly  1693 DEMAG-----------QIQLLEQAKLRLEMTLETMRKEARR-------------------ESQQR 1727
            .|:||           :.:.|||...:|..:.:.::|||.:                   ::::.
  Fly  1069 KEIAGKKGAKLLKKTDEERRLEQEAQKLIESYQKVKKEAEKLYKLELADDDQGFDLSAFEQAEEE 1133

  Fly  1728 D-----EELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERRLSSMEDRDRVDRDAEEAL 1787
            |     ||::||:.:...|:   :.|:|.|.:....::.|        ..:||.::..::..:..
  Fly  1134 DKPEVSEEIKEVKDSQPVKV---DIQIEEEVKTPNQVIGE--------VKVEDVNKEIKETVQVS 1187

  Fly  1788 NQKLRRDLR--------KYKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQ 1844
            .|:::::::        .:|:..||...:|:.:|.:.  |...:.||.|:::.|:.:.:..:.:.
  Fly  1188 QQEIKKEVKVSHQETKETFKSEEKDESNELKIVKEEV--KVTHQDLREQIQEIEAVKVVHKEVKV 1250

  Fly  1845 TAE-AELTEVQAMFDESHRARNDAEERANAAHRDRAELQA----QIE----ENEEELGELMKKYS 1900
            ..| |::|..     .||:........:...|::.:.|.|    ::|    ..|::||.::.|:
  Fly  1251 IKESAKVTTT-----TSHKQATKEVIISKEDHKNDSALPAVSTTKVEIISPPLEDDLGYVLHKH- 1309

  Fly  1901 ATVKQLNTEQINVSEAEFKLNEMEAE----RNNLKEQVAELQHRLDNVENLGDPSMA---MMSKR 1958
                 :...|..|..|...|.:.:.:    .|..|..|           ||..|..|   :.|||
  Fly  1310 -----IIFPQEKVKTAPTPLPKPKPKPPVPTNKPKMPV-----------NLTKPKSAPPPVPSKR 1358

  Fly  1959 LEL-----RTKELESRLELEQA----TRARLEVQVNRHKE----------ALEKLQNEVTQSKMR 2004
            .||     :....:.|..||.|    ...|:.|.|.:..|          |...|.|....||..
  Fly  1359 SELSGSGGKPTPTQRRGSLETAQPPKPLERIIVGVEQRDEPEKPQPIINLASVDLPNVAPNSKQA 1423

  Fly  2005 EMQAQDVIKKSQKSL--------------RDMREEFHAVSSREQE-------------SLTRRKD 2042
            .::...|::.....|              :|:.:|.:.:.|....             |.|...|
  Fly  1424 TVETTPVVEMPPDELQFESHQLPDDGEKEKDLHQESNDLLSGSSSSSVTTPITTPILVSATSSMD 1488

  Fly  2043 LEKKVEQMES----------------EGAALKNDLRLALQRIADLQQAMEEEGEEELSESDESLS 2091
            ..:.|.::.:                |.||..:.:.|..:...|::...|   ...|:...|..|
  Fly  1489 SVQSVIEVVNGMPIISNQQTDDDDIDEVAAYDDGMHLEAEGTKDVRPVQE---VTTLTLDREHES 1550

  Fly  2092 SVGSISDLEDRLRPVHVKRSSQQSLNGSIGGGGGSVVSSTRTVVFEKDDNSPRITVTSPSSPHI- 2155
            .:|::|:       .|...||...:|.|......:::||:    .:|  .|.....|.|::|.|
  Fly  1551 DLGTLSN-------HHSNISSISGINASSNIPAATLISSS----IKK--TSTEAATTKPAAPQIP 1602

  Fly  2156 HKLALAAKAIPANKPDTKPAASTRMELTVPAGQHNGHNA 2194
            .|:.|.             :::|....|.....|:.|.|
  Fly  1603 GKMELL-------------SSNTGTTTTTTTATHHLHQA 1628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769	54/280 (19%)
		COG1340	1565..1833	CDD:224259	63/346 (18%)
		coiled coil	1723..1734	CDD:293879	3/15 (20%)
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375	7/24 (29%)
		PDZ_signaling	2331..2413	CDD:238492
		PDZ_signaling	2553..2634	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900