DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and dysc

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster

Alignment Length:	1328	Identity:	246/1328 - (18%)
Similarity:	374/1328 - (28%)	Gaps:	549/1328 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 ASNGAGVSVNYSEVTHSLLSGG--------LKNRFLP---------------PIPPKPPKRGILK 169
            ||.|.|.|:..::.:.|:.:||        |::...|               .|.| ||..|
  Fly    50 ASFGLGPSMGGTQSSSSVPTGGSAGLSGHHLRSSGAPGPSSFEAEDIGMAFGMISP-PPGSG--- 110

  Fly   170 GSRSNMTNVHEEISFAGSAGGAGGTPEMLLRNTFQNESLYEGAARGAGS-IGSNSSQHGTSFTSV 233
                         .:.||:..|||:     |......||     ||||. .|...|..|||:|.|
  Fly   111 -------------PYVGSSAAAGGS-----RVGNSTSSL-----RGAGGRSGLYYSPPGTSYTIV 152

  Fly   234 ES-------LRSDGEQTGGQQRAMTLPANARYGALPQGNSQGSHLHVLTSPSPSADSLTDTTNSS 291
            |.       ..|.|..|.|             |:||   .:||   ...|.||::.....|.
  Fly   153 ERPHSPHYYFNSAGVPTKG-------------GSLP---GRGS---AYLSSSPASHMAAGTA--- 195

  Fly   292 FATPPFSLSPVGESQGIDRWARVHAFE--DVELPLPPVQLVKLPPPRQLVIRRQKSPRQDFGFSL 354
             .|.|.|.:..|.|.|      .||..  :.:.|:.|.|::::....|    ....|...:.:|.
  Fly   196 -GTLPTSTAASGRSMG------QHASSNGNKKRPISPEQVLRMFGATQ----SSSVPTSSYHYSN 249

  Fly   355 RKAICLDRT---------ESLTSPIFR----------PVIF--------------AEPGAG---- 382
            ......|||         .|.|..|:|          |.|.              .:.|.|
  Fly   250 GGTRDRDRTGRRSPASSPPSTTHQIYRDRERERDRSVPNIHELTTRTVSMSRDQQIDHGFGICVK 314

  Fly   383 GG-------------------ATGLLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAVTVEVQPV 428
            ||                   ..||.|||.:::|||||...:          |..||:...||.:
  Fly   315 GGKDSGLGVYISRIEENSVAERAGLRPGDTILEVNGTPFTSI----------NHEEALKRCVQIL 369

  Fly   429 AELVELSKRCMAPSTATVEEIDHSITNGNCNTLRRSASKRFKRQSRHENGNGGGEEGGAKGVGHD 493
            ....::|....||.|.......|.....:.:.:..|.:.....|::   .........|.|.|..
  Fly   370 KSSRQISMTVRAPPTLNSTAPLHGFGPPSRDPMYASMAPPLHPQNQ---AAAAAAAAAASGAGLP 431

  Fly   494 LEADVADASQPERVWLVHRGGFTAAIRLPTASSGRDEENKLSLR----LLHNGEQL--------- 545
            .....:        |:...|...:.   |....||..|.:..:|    |:..|:.|
  Fly   432 FRQTCS--------WMDRHGRPASP---PMEYGGRRSERRDRIRRVELLIEPGQSLGLMIRGGVE 485

  Fly   546 --------TVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVN 602
                    .||:|.|..::  .|.:.::|.|   :|..|.|..........|.:.|.
  Fly   486 YGLGIFVTGVDKDSVADRS--GLMIGDEILE---VNGQSFLDVTHDEAVGQLKYHKR-------- 537

  Fly   603 PMAPLSLYSEKVVSMFRGCKTEDMPP-HVYSLAQTAYR------SLVETRRDQSLIFMGRSGSGK 660
                :||....|..:...|.:.:|.| ..||...|..|      ::||.:             .:
  Fly   538 ----MSLVIRDVGKVPHSCTSIEMEPWDAYSPTGTRARRKGQIATMVEEK-------------AR 585

  Fly   661 STSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQI 725
            |...:|....|:.....|:  ..|..::|...:|                   |..||..:...:
  Fly   586 SLLPRHHFASLSYYIAEYS--AKAMTIDAFVAVL-------------------LEMLDTYEKHTL 629

  Fly   726 ASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLED 790
            .:...:::.||.:               ||             :.|.:...:..|:      ..|
  Fly   630 VTEIRELVFPEDR---------------TR-------------YDELVYRRERDPY------SVD 660

  Fly   791 RHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKA 855
            |||...|..|.
  Fly   661 RHRRKGDPARD------------------------------------------------------ 671

  Fly   856 SGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVAL 920
               |.|..:||...|             :..:||:||:|       |...|..:|..
  Fly   672 ---LPVTADDLEIIA-------------ATGRSPSSDSG-------LGMTVTDIYKR-------- 705

  Fly   921 INRQICTSSHTIASIMLIDTPGFQ---NPASCGQQVGATLADLRHNYLQERLQMLFHHTT----- 977
                                |..|   .|.|.|.             :..|.|...|:.|
  Fly   706 --------------------PALQLPHRPMSAGP-------------ILHRSQPASHYQTGSNQS 737

  Fly   978 --LVAPRDRYAQELVEIEMDLASECHPGPLISLIDKA-PQNHVVRSSQRDLR------------- 1026
              .::|..:..|:....:...||..|.|.:...:... ..:|.:..||...|
  Fly   738 SSSLSPPQQQQQQQQHYQPHHASLRHLGGIGGNVGSGRHHHHPLGPSQLKFRQTKDNQQQEYGCD 802

  Fly  1027 EH-DRRGMLWLLDEEAIYPNSNDD--TFLER----------LFSHYGDREHHSLLRKCA------ 1072
            || .|||...||.|  ..|::..:  |.|.|          |....|.|.|.|:.|..|
  Fly   803 EHRTRRGSETLLPE--YEPDAEQELATKLSRSFDMKEEGGTLLGDKGVRRHQSMQRLSAEQNGGS 865

  Fly  1073 --------GPRQFVLHH------LQGTNPVL-YAVDGWVRHSREHPGIRNAVSLLQDSSREEINR 1122
                    .|.....|.      ::.|.|:| .|::|..  :.:||
  Fly   866 TTEQTHEHNPNVVPDHRGNLHITVKKTKPILGIAIEGGA--NTKHP------------------- 909

  Fly  1123 LYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRR---SFTTAGVKRNSIMLQVKFT-VDGIID 1183
                                       |.|:.:|..   :|...|::...::|:|..| |:|:
  Fly   910 ---------------------------LPRIINIHENGAAFEAGGLEVGQLILEVDGTKVEGL-- 945

  Fly  1184 TLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQV----LE 1244
                                 |.:..|.......|.:..:|...:.|...:|.|.....    ||
  Fly   946 ---------------------HHQEVARLIAECFANREKAEITFLVVEAKKSNLEPKPTALIFLE 989

  Fly  1245 AARLHRLGFPESVPL----LEFVRRFGL 1268
            |   |.|..|.|.||    |||:..:|:
  Fly   990 AX--HLLALPASDPLERQKLEFLYEWGI 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	28/142 (20%)
		MYSc	556..1317	CDD:214580	132/790 (17%)
		MYSc_Myo18	575..1305	CDD:276837	128/771 (17%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	20/95 (21%)
		PDZ_signaling	466..543	CDD:238492	17/93 (18%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	17/141 (12%)
		PDZ_signaling	886..971	CDD:238492	21/155 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900