DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and GRID2IP

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001138590.1 Gene:GRID2IP / 392862 HGNCID:18464 Length:1211 Species:Homo sapiens


Alignment Length:1458 Identity:268/1458 - (18%)
Similarity:430/1458 - (29%) Gaps:564/1458 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   348 QDFGFSLRKAICLDRTESLTSPIFRPVIFAEPGAGGGATGLLPGDRLIKVNGTPVGELPREIIIE 412
            :||||.|          ..:.|.|  |:....|:...|.||.|||::::|.|..||.|.||    
Human    15 EDFGFRL----------GGSGPCF--VLEVAKGSSAHAGGLRPGDQILEVEGLAVGGLSRE---- 63

  Fly   413 MIRNSGEAVTVEVQPVAELVELSKRC--MAPSTATVEEIDHSITNGN-------------C---- 458
                             .||.|::||  :.||...:...|.....|:             |    
Human    64 -----------------RLVRLARRCPRVPPSLGVLPAPDGGPGPGSGPAAPTTVLRAPRCGRGL 111

  Fly   459 ---------------NTLRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVW 508
                           :.:.|...::.:..||..:...|.:....:.|...|:...|:....:.||
Human   112 ALGRELLRLAGRKRPDAVHRERRRKAQEFSRKVDEILGDQPTAKEQVFAALKQFAAEQRVDDLVW 176

  Fly   509 LV-----------------------HRGGFTAAI------RLPTASSGRDEENKLSLRLLHNGEQ 544
            .:                       ||..|...:      :|..|...:..:.....|.....|:
Human   177 TLTLALPREACGPLLDNLRIFIPKKHRARFDEVVSQGLLGKLCRARRAQGAQRLRRSRSEERPER 241

  Fly   545 LTV-----------DEDD----------------------VEKQN-------------------- 556
            |.|           ||..                      |.|.|                    
Human   242 LLVSTRASAPPRRPDEPPPRRASLLVGGLAGPGGARRTVRVYKGNKSFGFTLRGHGPVWIESVLP 306

  Fly   557 -SPALDLVEDICELK------YLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKV 614
             |||     |...||      :||...:.:|...:..|.|..:.|.|||:|...:.|.:..|:.:
Human   307 GSPA-----DNAALKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFASDSDSL 366

  Fly   615 VSMFRGCKTEDMP-PHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAY 678
                      |.| |   |.|.|:.:.:.|. ...|:...||       :|...|.:|......|
Human   367 ----------DSPNP---SSALTSLQWVAEI-LPSSIRVQGR-------TFSQQLEHLLTPPERY 410

  Fly   679 NNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRR 743
                      .:|..||:|...:   |.:...:.....||......:.....|:|..|.|...:.
Human   411 ----------GVCRALESFFQHR---NIDTLIVDVYPVLDTPAKQVLWQFIYQLLTYEEQELCQE 462

  Fly   744 -----LGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISL-----------SQKLE--- 789
                 ||:       |.:.|..    :.||.||:..:.:..|..||           ||.||   
Human   463 KIACFLGY-------TAMTAEP----EPELDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGL 516

  Fly   790 ---------------DRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTG 839
                           ...|.|.|   .....||.|  .|.:..:::.|.:..:....|  |:||.
Human   517 SCGPSECPEMPLPLIPGERQAGD---GTSLPETPN--PKMMSAVYAELESRLNSSFKG--KMGTV 574

  Fly   840 STARTQFANP-----TAARKASGLLGVNLEDLSSAAF------GLTQPN--------------AP 879
            |.:|.....|     |..|..||:...:...|.|..:      ||..|:              ||
Human   575 SKSRASPPGPSPAVTTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAP 639

  Fly   880 N-----GGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLID 939
            :     |.:.|...|:.|.....:                       .|::.|.||.:.|   .|
Human   640 SPQPGPGPICPDSPPSPDPTRPPS-----------------------RRKLFTFSHPVRS---RD 678

  Fly   940 TPGFQNPASCGQQVG--ATLADLRHNYL---QERLQMLFHHTTLVAPRDRYAQELVEIEMDLASE 999
            |..|.:..|  :|:|  .|:.|   ::|   .:..:|.||..         ....|..|...||:
Human   679 TDRFLDVLS--EQLGPRVTIVD---DFLTPENDYEEMSFHDD---------QGSFVTNERSSASD 729

  Fly  1000 C----HPGPLI---SLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFS 1057
            |    ..|..:   |:.|..|...:.......|..||.:            |:|.         |
Human   730 CISSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAK------------PSSR---------S 773

  Fly  1058 HYGDREHHSLLRKCAGPRQFVLHHLQGTN-------------------PVLYAVDGWVRHSREHP 1103
            ..|.|          ||.|.:...|...:                   |:|....|..|....|.
Human   774 SDGSR----------GPAQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPMLSRGLGHRRSETSHM 828

  Fly  1104 GIR--------NAVSLL-----QDSSREEIN--------RLYIGSLTRGSGAMVFCGSFAGLEGT 1147
            .::        |:...:     :||..::::        .|:.|:.....          .:.|.
Human   829 SVKRLRWEQVENSEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPAK----------PVPGP 883

  Fly  1148 QSLRR-----VSSIRRSFTTAGVKRNSIML-----------QVKFTVDGIIDTLRRTGTHFVHCY 1196
            :..|:     :.|.::::.|      ||:|           ||..:    ::..|....|.....
Human   884 EPFRKKEVVEILSHKKAYNT------SILLAHLKLSPAELRQVLMS----MEPRRLEPAHLAQLL 938

  Fly  1197 LLQHNAGKHTKYTANGSPSSAAGQVSSEE----EMVNVP----LLRS------------QLRGS- 1240
            |...:|.:..:|.|.   ..|.|::|..:    :|::||    .|||            ::||| 
Human   939 LFAPDADEEQRYQAF---REAPGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSL 1000

  Fly  1241 QVLEAARLHRLGFPESVPLLEFVRRFG--LLAGDLASNKDVSVEQILAVNELDVASYRIGPSQIL 1303
            :.|..|.|......:...:||||...|  |..|...:||...                       
Human  1001 ECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTG----------------------- 1042

  Fly  1304 FRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPW 1368
            |:...|:||.:.:.|......:.:.|        |.:||...:.|..            .:|.|.
Human  1043 FKINFLTELNSTKTVDGKSTFLHILA--------KSLSQHFPELLGF------------AQDLPT 1087

  Fly  1369 WRLLVRV------TPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLEAKLSELT 1427
            ..|..:|      :.|.::|.|..:::.|.:.:                    :...|.|.:.:.
Human  1088 VPLAAKVNQRALTSDLADLHGTISEIQDACQSI--------------------SPSSEDKFAMVM 1132

  Fly  1428 VDLAEERSTAHIATERLEAETAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISED 1492
            ....|....|..|.:.|:.|..|      |||                        ..|....||
Human  1133 SSFLETAQPALRALDGLQREAME------ELG------------------------KALAFFGED 1167

  Fly  1493 EDAENEDGVGG--GVYKLKYERVARELE 1518
            ..|...:...|  ..:..|:||...:|:
Human  1168 SKATTSEAFFGIFAEFMSKFERALSDLQ 1195

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492 22/77 (29%)
MYSc 556..1317 CDD:214580 180/943 (19%)
MYSc_Myo18 575..1305 CDD:276837 167/885 (19%)
GBP_C <1540..1750 CDD:303769
COG1340 1565..1833 CDD:224259
coiled coil 1723..1734 CDD:293879
GRID2IPNP_001138590.1 PDZ_signaling 14..74 CDD:238492 27/91 (30%)
HN_L-delphilin-R1_like 133..212 CDD:259820 11/78 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..269 6/42 (14%)
PDZ_signaling 278..353 CDD:238492 18/79 (23%)
HN_L-delphilin-R2_like 389..468 CDD:259821 17/98 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 478..502 7/23 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..549 6/28 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 568..600 11/33 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..672 11/76 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 718..783 19/95 (20%)
FH2 820..1188 CDD:280362 81/483 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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