DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and myh6

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_942118.1 Gene:myh6 / 386711 ZFINID:ZDB-GENE-031112-1 Length:1936 Species:Danio rerio


Alignment Length:1865 Identity:446/1865 - (23%)
Similarity:806/1865 - (43%) Gaps:392/1865 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   461 LRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDLEAD--VADASQPERVWLVHRGGFTAAIRLPT 523
            ||:|..:|.:.|:|                ..|::.:  |.|    |:|..| :|      ::..
Zfish    16 LRKSDKERLEAQTR----------------AFDIKTECFVVD----EKVEYV-KG------QIQN 53

  Fly   524 ASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASN 588
            ...|     |:::: ..:|..:||.:.||..||.|..|.:||:..|.:|:|.:||..|::|||:.
Zfish    54 KDGG-----KVTVK-TEDGRTVTVKDGDVHPQNPPKFDKIEDMAMLTFLHEPAVLFNLKERYAAW 112

  Fly   589 LIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFM 653
            :|:|.:|...:.|||...|.:|...||:.:||.|..:.|||::|::..||:.::..|.:||::..
Zfish   113 MIYTYSGLFCVTVNPYKWLPVYDADVVAAYRGKKRTEAPPHIFSISDNAYQYMLTDRENQSVLIT 177

  Fly   654 GRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTI----------LEAFGNTKTCLNSNA 708
            |.||:||:.:.|..:.|.|..|.|..:  ..:|.::..|:          ||||||.||..|.|:
Zfish   178 GESGAGKTVNTKRVIQYFASIAAAGGS--TGKKDSSKGTLEDQIIQANPALEAFGNAKTLRNDNS 240

  Fly   709 TRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENI 773
            :|..:.:.:.|..:|:::||.::..|.|:.|...:|..|.::||..::|:.....|...|.:.| 
Zfish   241 SRFGKFIRIHFGTSGKLSSADIETYLLEKSRVTFQLKSERNYHIFFQILSNEKPELLDMLLITN- 304

  Fly   774 TSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGT 838
             :...:.:||..:..........:.:.|.:||:.|...::...|::.:..||.|.|     .:..
Zfish   305 -NPYDYSYISQGEVTVSSINDNEELIATDKAFDVLGFTSEEKMGVYKLTGAIMHYG-----NMKF 363

  Fly   839 GSTARTQFANPTA---ARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWE 900
            ....|.:.|.|..   |.||:.|:|:|..||..   ||..|....|....:|..:.|.    .:.
Zfish   364 KQKQREEQAEPDGTEDADKAAYLMGLNSADLLK---GLCHPRVKVGNEYVTKGQSVDQ----VYY 421

  Fly   901 CLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLR 961
            .:.||...:|.:....:|..||:.:.|..|....|.::|..||:    |          |...|.
Zfish   422 SIGALAKSVYEKMFNWMVVRINQSLDTKQHRQYFIGVLDIAGFEIFDFN----------TFEQLC 476

  Fly   962 HNYLQERLQMLFHHTTLVAPRDRYAQ-----ELVEIEMDLASECHPGPLISLIDKAPQNHVVRSS 1021
            .|:..|:||..|:|...|..::.|.:     |.::..|||.| |     |.||:|.         
Zfish   477 INFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLQS-C-----IDLIEKP--------- 526

  Fly  1022 QRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ--FVLHHLQ 1083
                     .|::.:|:||.::|.::|.||..:|: :|.|........|...|..:  |.|.|..
Zfish   527 ---------LGIMSILEEECMFPKASDQTFKAKLYDNHLGKTNIFQKPRAVKGKAEAHFALSHYA 582

  Fly  1084 GTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQ 1148
            ||  |.|.:.||:..::: |.....|.|.|.||.:.::.|:              .|:||.:|.:
Zfish   583 GT--VDYNIAGWLVKNKD-PLNETVVGLYQKSSLKLLSLLF--------------SSYAGSDGGE 630

  Fly  1149 ------------SLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHN 1201
                        |.:.||::.|.                 .::.::..|:.|..|||.|.     
Zfish   631 KSGGKGAKKKGSSFQTVSALHRE-----------------NLNKLMTNLKTTHPHFVRCL----- 673

  Fly  1202 AGKHTKYTANGSPSSAAGQVSSEEEMVNVP---LLRSQLRGSQVLEAARLHRLGFPESVPLLEFV 1263
                               :.:|.::..:.   |:..|||.:.|||..|:.|.|||..:...:|.
Zfish   674 -------------------IPNESKIPGIMDNCLVMHQLRCNGVLEGIRICRKGFPNRILYGDFK 719

  Fly  1264 RRFGLL------AGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSD 1322
            :|..:|      .|....||. |.|::|...::|...|:.|.:::.|::|:|..||..||..|:.
Zfish   720 QRCRILNASAIPEGQFIENKK-SAEKLLGSLDIDHTQYKFGHTKVFFKAGLLGTLEEMRDDQLAR 783

  Fly  1323 RIIQLQAFCRGYLAR---KKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRT 1384
            .:..:|||.||.|.|   :|:.:||.   |:..:|.|:::||.|::|||.:|..::.|||....:
Zfish   784 ILTGIQAFARGLLMRVEYQKLVERRD---ALMVVQWNLRSFLGVKNWPWMKLFFKIKPLLKSAES 845

  Fly  1385 EEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLEAKLSELTVDLAEERSTAHIATER------ 1443
            |:::....:|...|:..|||.:..|.|::.:...|..:.::|.:.:..|:.|...|.||      
Zfish   846 EKEMANMKDEFNKLKEALEKSDARRKELEEKMVSLLQEKNDLLLQVQSEQDTLTDAEERCEQLIK 910

  Fly  1444 ----LEAE------------------TAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDL 1486
                |||:                  ||:|.|||.|..:....:.:|:.|..|:|.|....::.:
Zfish   911 SKIQLEAKVKELSERIEDEEEINADLTAKRRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 975

  Fly  1487 NGISEDEDAENEDGVGGGVYKLKYERVA---------RELEFTKRRLHT---------QHEHDLE 1533
            ..|:|:..:.:|:     :.||..|:.|         .:|:..:.:::|         |...|||
Zfish   976 KNITEEMASLDEN-----IMKLTKEKKALQEAHQQTLDDLQSEEDKVNTLTKAKVKLEQQVDDLE 1035

  Fly  1534 -----------QLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNAR 1587
                       .|...|:.||..:....|.|::......|.:.|.:|...|:|.|...:|::...
Zfish  1036 GSLEQEKKVRMDLERSKRKLEGDVKLTQENVMDLENDKQQLEDKLKKKDFEINQLNQRIEDEQMA 1100

  Fly  1588 NNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLAD----TRLDLEFKE 1648
            :..|:||.::..|..:.|::.:..||.|:.:..:::..:..|...:.:.|.:    |...:|..:
Zfish  1101 SVQLQKKLKENQARIEELEEELDAERAARAKVEKQRSDISRELEDISERLEEAGGATSAQVELNK 1165

  Fly  1649 EKLASLQ---RELEEMTFG----------------GGTEEEFAQLRRSKNETERRAKEQEEELDE 1694
            ::.|..|   |:|||.|..                ....|:...|:|.|.:.|:...|.:.|||:
Zfish  1166 KRDAEFQKIRRDLEESTLQHEATTASLRKKHADSVAELGEQIDNLQRVKQKLEKEKVELKLELDD 1230

  Fly  1695 MAGQIQLLEQAKLRLE---MTLETMRKEARRESQQRDEELEEV----------RGNGYKKIKALE 1746
            :|..::.:.:||:.||   .:||....|.|.::::....|.:|          .|...::::..|
Zfish  1231 LASNMESIVKAKVNLEKMCRSLEDQMNEHRSKAEEAQRALNDVSTQKAKLLTENGELGRQLEEKE 1295

  Fly  1747 CQLETEHEERTLLLREKHELERRL---------------SSMEDRDRVDRDAEEALNQKLRRDLR 1796
            |.:......:|...::..:|.|:|               |:..|.|.:....||  .|:.:.:|:
Zfish  1296 CLISQLTRGKTSYAQQLEDLRRQLEEEVKAKNALAHAVQSARHDCDLLREQFEE--EQEAKAELQ 1358

  Fly  1797 KYKALLKDAQTQLE--RLKADTPGKTLIRQLRNQLEDAESARSLAMK---ARQTAEAELTEVQAM 1856
            :   .|..|.|::.  |.:.:|.|    .|...:||||:  :.|..|   |.:..||...:..::
Zfish  1359 R---ALSKANTEVATWRARYETDG----IQRTEELEDAK--KKLVQKLQDAEEAVEAVNAKCSSL 1414

  Fly  1857 FDESHRARNDAE------ERANAA-----------HRDRAELQAQIEENE--------------E 1890
            ....||.:|:.|      ||:|||           .:..||.:.:.||::              .
Zfish  1415 EKTKHRLQNEIEDLMLDLERSNAASAALDKKQRSFDKVMAEWKQKYEESQCELEGAQKEARSLST 1479

  Fly  1891 ELGELMKKYSATVKQLNT---------EQIN-----VSEAEFKLNEMEAERNNLKEQVAELQHRL 1941
            ||.:|...|..|:..|.|         |:|:     |||....::|:|..|..|:::..|||..|
Zfish  1480 ELFKLKNSYEETLDHLETIKRENKNLQEEISDLTDQVSEGRKSVHELEKLRKQLEQEKTELQSAL 1544

  Fly  1942 DNVE-NLGDPSMAMMSKRLE-------LRTKELESRLELEQATR----------ARLEVQVNRHK 1988
            :..: ::......::..:||       ...|..|...|:|||.|          |.||.:.....
Zfish  1545 EEADASVEHEEGKILRAQLEFNQLKADFERKMSEKDEEMEQARRNYQRMIESLQASLEAETRSRN 1609

  Fly  1989 EAL---EKLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQM 2050
            |||   :|::.::.:.:::..||......:||.|:.::........:..::|....||::.:..:
Zfish  1610 EALRVKKKMEGDLNEMEIQLSQANRQAADAQKQLKMVQSCLKETQLQMDDTLHSNDDLKENITLL 1674

  Fly  2051 ESEGAALKNDLRLALQRIADLQQAMEEEGEEELSESDESLSSVGS 2095
            |.....::.:|. .|:.|.:..:.:.:..|:||:::.|.:..:.|
Zfish  1675 ERRNNLMQTELE-ELRGILEQTERVRKLAEQELTDATERMQLLHS 1718

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 208/806 (26%)
MYSc_Myo18 575..1305 CDD:276837 195/775 (25%)
GBP_C <1540..1750 CDD:303769 53/245 (22%)
COG1340 1565..1833 CDD:224259 69/320 (22%)
coiled coil 1723..1734 CDD:293879 1/10 (10%)
myh6NP_942118.1 Myosin_N 35..72 CDD:280832 10/53 (19%)
Myosin_head 87..766 CDD:278492 200/787 (25%)
MYSc_class_II 99..766 CDD:276951 195/775 (25%)
Myosin_tail_1 846..1923 CDD:279860 191/890 (21%)
RILP-like 961..1094 CDD:304877 28/137 (20%)
BAR 1298..1490 CDD:299863 44/202 (22%)
MreC 1493..>1578 CDD:302802 18/84 (21%)
TMPIT 1738..>1833 CDD:285135
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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