DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and Fife

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001261340.1	Gene:	Fife / 38337	FlyBaseID:	FBgn0264606	Length:	1314	Species:	Drosophila melanogaster

Alignment Length:	1288	Identity:	236/1288 - (18%)
Similarity:	380/1288 - (29%)	Gaps:	537/1288 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFNFMKKS-AGDEDKERRKREKKLRKEAKGTSGGPGM-GGVTGVTGSMSTDELLRLDEVRRSLKI 63
            :.:||||. |.||....|      ::.|..:.||... |.:..:..::|:..|...|:|.   |:
  Fly     6 VMSFMKKMVATDEQTSER------QQHAADSGGGASQTGALNKMKATISSSLLTVTDKVN---KM 61

  Fly    64 RGRRKEKEKLPSGITAD-----------YSA------DFFAALNADAN----------GGSNGGA 101
            ..|       ||.:..|           |.:      |:.::||.:.|          ||..|||
  Fly    62 SPR-------PSLVPTDADTSGSYGSPSYQSQQQQQQDYGSSLNNNNNNSSGGGTATTGGGGGGA 119

  Fly   102 VGAADP----------------------------------------------------------- 107
            ....:|
  Fly   120 AAKQEPGRRAGACRVCLKSFKPDDYHKTCFECQQRVCEDCASYSKLDEHEDATMWRCSVCRRKMA 184

  Fly   108 -----EQDRGNEEIVASVMTHIESR--------------ASNGAGVSV-------NYSEVT---- 142
                 .||..:..:...|:..::.|              .||||.::.       .:|:|:
  Fly   185 SRVCIPQDSTDSMLDVPVLEALQRRHSDAKLGSSTQTLAPSNGAALAPPRSPELRRHSDVSPASL 249

  Fly   143 ---HSLLSGGLKNRFLPPIPPKPPKRG-----------------ILKGSRSNMTNVHEEISFAGS 187
               ...|.||   |.:.|.....|.||                 ..:|||....:.:::....|.
  Fly   250 KELERQLKGG---RSMAPSRSNSPPRGEGPDGQPPFGAPLSRMQSRRGSRVARQHSYDDDMKTGP 311

  Fly   188 AGGA--GGTPEMLLRNTFQNESLYEGAARGAGSIGSNSSQH---------GTSFTSVESLRSDGE 241
            .||:  ||.|.:.|.        .:||..|..::....|.:         |.:..:.:..||.||
  Fly   312 VGGSMGGGGPALGLG--------ADGAGLGIPTMPRRKSAYDVFAPGLTQGGATPATQLQRSPGE 368

  Fly   242 QTGGQQRAMTLPANARYGALPQGNSQGSHLHVLTSPSPSADSLTDTTNSSFATPPFSLSPVGESQ 306
              ||....:.||              ||.......|.||.|...|.:..|    |...|||....
  Fly   369 --GGIMPPIQLP--------------GSRRPSFRVPHPSEDIQNDDSPGS----PDKGSPVLTVD 413

  Fly   307 GIDRWARVHAFEDVELP----------LPPVQLVKLPPP-------------------------- 335
            ...|..|    ...:||          ||.|....:|||
  Fly   414 DDRRMRR----RGSQLPDIAMLQNRGALPAVPPSSIPPPMASFTGPNLEDLEAPRRQTSMDGEAI 474

  Fly   336 ----------------RQLVIRRQKSPR--QDFGFSLRKAICLDRTESLTSPIFRPVIFAEPGAG 382
                            |::::||..:.:  :..||.:|   .:.........:|..:::..||..
  Fly   475 RIVIHDVDSGPICASKRRIILRRDPTDKAHRTRGFGMR---VVGGKTGADGRLFAYIVWTVPGGA 536

  Fly   383 GGATGLLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAVTVEVQPVAELVELSKRCMAPSTATVE 447
            ....||..||::::.||           :.:|..|.|.|...:....::|||.
  Fly   537 AEKNGLQQGDKILEWNG-----------MSLIDRSFEEVCSIMDRTGDVVELL------------ 578

  Fly   448 EIDHSITNGNCNTLRRSASKRFKRQSRHEN---GNGGGEEG------GAKGVG----HDLEADVA 499
             ::|:.....|:..             .||   ||.||:.|      |..|:|    .:...|.:
  Fly   579 -VEHATDFRMCDLF-------------DENLPPGNAGGQSGPRRSGDGPVGLGLIAEPETTTDKS 629

  Fly   500 DAS--------QPERVWLVHRGGFTAAIRLPTASSGR--------DEENKLSLRLLHNGEQLTVD 548
            .||        .||::         |..:|.|   ||        .|.::|.:.|: .|:.|...
  Fly   630 PASPTRRKLPKTPEQI---------AREKLVT---GRVQIQVWYHAERSELVVSLM-AGDDLAPR 681

  Fly   549 EDDVEKQNSPALDLVEDICELKYL---NEASVLHCLRQRYASNLI--------HTKAGPTLLVVN 602
            ::.....|.|     |...:::.|   .:.||......|...|.|        |.|| .||:|
  Fly   682 DEAYGHGNLP-----EAYAKVRILPKCGDGSVQQTEVSRPTQNPIWNATLTFGHVKA-DTLMV-- 738

  Fly   603 PMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHA 667
                          .:...:..|:.||..|                  ||:|..    |...:.|
  Fly   739 --------------RYIDIQLWDLVPHTES------------------IFLGEC----SIELQQA 767

  Fly   668 LNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQV 732
                         |::.:.:  .|.:.:..|.....::.         |......|.||:.
  Fly   768 -------------FLDDQAI--WCRLEDTKGLRGISISK---------SPSVSPRGSIAAG---- 804

  Fly   733 LLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSED-------------SHPFI-- 782
                   ||...|.      :||       ||:::.:::...|:|             .|.:|
  Fly   805 -------AGAPSGD------VTR-------LLRRDYNMQRSNSDDVDSIGDGTSLLHPDHAWIAG 849

  Fly   783 -----SLSQKLE-DRHRAANDFMRTV-----QAFE-----TLNIDA------------------- 812
                 |.|:.:| :.::...||.|::     .:|:     .|..||
  Fly   850 SRRGSSQSETMEVEVYQLGKDFSRSLPGSRRSSFQDAEKNRLEEDAMATPPTSYLVGRRRSSVAR 914

  Fly   813 ----------KAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVN----- 862
                      |||||   .|.....||.....::|:...:|....:..::||:| :|.::
  Fly   915 RDPDEILKSLKAVRG---ELGRTMSLGTEQHKRMGSRRASRVGLPSGPSSRKSS-VLDLSQQHQQ 975

  Fly   863 ----LEDLSSAAFGLTQPNAPNGGLSPSKSPTS---DTGHEWAWECLEALVIGLYSEALAAVVAL 920
                |:.|........|...|.|..:...||.|   |..:...|:       |..|
  Fly   976 QLQQLQQLQLQQQQYLQQQLPMGVGNADTSPPSEDEDKRYRPRWK-------GSVS--------- 1024

  Fly   921 INRQICTSSHTIASIMLIDTPGFQNPASCGQQVGATLADLRHNYLQERLQMLF 973
               |:...|...|...|.......|.|...|:.|..|..   |.||:|...:|
  Fly  1025 ---QLPPQSPKQALSRLKQAASASNVAQDTQRQGQLLTT---NPLQQRKSSMF 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	18/88 (20%)
		MYSc	556..1317	CDD:214580	92/501 (18%)
		MYSc_Myo18	575..1305	CDD:276837	88/479 (18%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
Fife	NP_001261340.1	FYVE_BSN_PCLO	130..187	CDD:277290	0/56 (0%)
		PDZ_signaling	491..580	CDD:238492	22/115 (19%)
		DegQ	<526..577	CDD:223343	13/61 (21%)
		C2A_RIM1alpha	651..779	CDD:175997	34/190 (18%)
		C2	1163..1304	CDD:301316
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900