Protein Alignment Mhcl and Myo61F

DIOPT Version :9

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 1115
• Identity: 251/1115 - (22%)
• Similarity: 449/1115 - (40%)
• Gaps: 240/1115 - (21%)

  Fly   515 FTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLH 579
            |.:.:::.|....||........||.|                             |.:|.:.:.
  Fly    21 FNSQLKMETGLHERDRAGVQDFVLLEN-----------------------------YQSEEAFIG 56

  Fly   580 CLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVET 644
            .|::|:..:||:|..|..|:.|||...|.:|::..|..:|.....:||||::::...|:|||:|.
  Fly    57 NLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEE 121

  Fly   645 RRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINA-EKVNALCTILEAFGNTKTCLNSNA 708
            .|.|.::..|.|||||:.:.|..|.::|..:|........ :|:.....:||||||.||..|.|:
  Fly   122 NRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNS 186

  Fly   709 TRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENI 773
            :|..:.:.:.||..|.....::...|.|:.|...::|.|.:|||..:|||||...|.:||.||..
  Fly   187 SRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLERA 251

  Fly   774 TSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGT 838
            ....|:....|:..: .|...|:.|.:..||...::...:..|.|:.|:|:|.|||..|.|::..
  Fly   252 LDTYSYLTDGLNGTV-TRINDADSFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTEVEG 315

  Fly   839 GSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLE 903
            .:...::....||||    |||||..:|.:|   ||.......|    ...||....|.|....:
  Fly   316 NAKVNSRDLVVTAAR----LLGVNASELEAA---LTHRTIDARG----DVVTSPLNQELAIYARD 369

  Fly   904 ALVIGLYSEALAAVVALINRQICTSSHTIAS---IM-LIDTPGFQ----NPASCGQQVGATLADL 960
            ||...:|....:.:|..:|..: .:..|.||   :| ::|..||:    |          :....
  Fly   370 ALAKAVYDRLFSWLVQRLNISL-QAKETRASRNNVMGILDIYGFEIFQKN----------SFEQF 423

  Fly   961 RHNYLQERLQMLFHHTTLVAPRDRYAQELVE-IEMDLASECHPGPLISLIDKAPQNHVVRSSQRD 1024
            ..|:..|:||.||...||.:.:|.|.:|.:| |.::..                .|.|:    .:
  Fly   424 CINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYF----------------DNKVI----CN 468

  Fly  1025 LREHDRRGMLWLLDEEAIYPNS-NDDTFLERLFSHYGDREHH-------SLLRKCAGPRQFVLHH 1081
            |.|...:|::.:||||.:.|.. .|.||||:|........|:       :.::|.....:|.|.|
  Fly   469 LIEEKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVH 533

  Fly  1082 LQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEG 1146
            ..|  .|.|:|:|::..:.:         ||....:|.:::       .|:|.:..|  |...|
  Fly   534 YAG--EVTYSVNGFLDKNND---------LLFRDLKETLSK-------AGNGIVRNC--FPEKE- 577

  Fly  1147 TQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTAN 1211
                  :.|::|..|.        :.|.:.:::.::|.|......::.|  ::.|    ...|||
  Fly   578 ------LRSLKRPETA--------ITQFRASLNNLMDILMCKEPSYIRC--IKPN----DLQTAN 622

  Fly  1212 GSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLASN 1276
                           :.|..|:..|::...::|..|:.|.||........|:.|:..|:.....|
  Fly   623 ---------------VFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPN 672

  Fly  1277 ------KDVSVEQILAVNELDVASYRIGPSQILFR-------------------SGVLSE----- 1311
                  ....|:|::.....|...||:|.:::..|                   :.::..
  Fly   673 YKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGL 737

  Fly  1312 LEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWP--------- 1367
            ::.::.:.|..::|.:|::||..||::...:||.....:|..   :|.|:...|.|
  Fly   738 MQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAF---IKGFITRNDAPNGFNEEFIA 799

  Fly  1368 -----WWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDR----SEVKAENQKLEAK- 1422
                 |...|.:..|...:.::........||...:..:|.::...|    .....:.::.|.|
  Fly   800 NAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKV 864

  Fly  1423 LSELTVDLAEERSTAHIAT----ERLEAETAERLK--LEKELGDQTNKVKNLQETTEKLEMELIC 1481
            |:|......:....:.::|    :|:..|..:|:.  :....|            :|:|:.:..|
  Fly   865 LAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFG------------SEQLKYQSFC 917

  Fly  1482 AKSDLNGISEDEDAENEDG-----------VGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQL 1535
            .|.|.:|.      ::.|.           :.|..||.|:.....:::||.    |.|..|   |
  Fly   918 TKFDRHGY------KSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKIDFTL----TNHNDD---L 969

  Fly  1536 VALKKHLEMK 1545
            :.::..|::|
  Fly   970 MVIRIPLDLK 979

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	195/808 (24%)
		MYSc_Myo18	575..1305	CDD:276837	192/753 (25%)
		GBP_C	<1540..1750	CDD:303769	2/6 (33%)
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	200/815 (25%)
		MYSc_Myo1	52..707	CDD:276829	192/753 (25%)
		Myosin_TH1	863..1035	CDD:283635	27/142 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466249
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840